|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
18-445 |
1.28e-160 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 460.55 E-value: 1.28e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 18 TFLLFLSIVVNYMAKFNAGVAVVAMTNAENTNPN-------------FPEYDWNEMERSYILSSFFWGYILTQFMGGWLC 84
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNnntstdkdtlpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 85 RRYGARITMFVSTIGSALLVVLIPWCVSWGgWQAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCG 164
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 165 TLVAMFASGLLAaSSIGWPGIFYVSCGVGVLWCIVWWIFGanqpreskfigeaelnyietsinssrkaeeaelkatgpip 244
Cdd:cd17318 160 TVIAMPLSGFLC-ESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 245 vpwkaiwtsVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMS 324
Cdd:cd17318 199 ---------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 325 ITGIRKSVNSIAFFVPAAALIGVSFlDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPI 404
Cdd:cd17318 270 TTTVRKLFTSIGFLGPGVFLIALGY-LGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGI 348
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 24658658 405 LTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17318 349 ISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
18-445 |
7.48e-82 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 258.25 E-value: 7.48e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 18 TFLLFLSIVVNYMAKFNAGVAVVAMTNaentnpnfpEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVST 97
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAK---------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 98 IGSALLVVLIPWCVSWGGWqAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAA 177
Cdd:cd17380 72 ALWSLATLLTPLLAYSSLP-LLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 178 SSiGWPGIFYVSCGVGVLWCIVWWIFganqpreskfigeaelnyietsinssrkaeeaelkatgpipvpwkaiwtSVPFW 257
Cdd:cd17380 151 YY-GWPSVFYFFGLLGLLWALVWLIY-------------------------------------------------LPPVW 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 258 ALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSnALYSALPYLTSWVMAFVYLIIADILLTRGiMSITGIRKSVNSIAF 337
Cdd:cd17380 181 AIIVAHFCMNWGFYILLSWLPTYFHEVLVPLAKG-WVFNVVPWLVMFPSSNVAGWLADHLISRG-WTVTSVRKLMQSIGF 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 338 FVPAAALIGVSFLDNTQktLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVkDD 417
Cdd:cd17380 259 LGPALFLLLLSHTDSFS--LALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL-EA 335
|
410 420
....*....|....*....|....*...
gi 24658658 418 HDReqWQIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17380 336 TGS--WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
19-456 |
1.07e-73 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 240.42 E-value: 1.07e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 19 FLLFLSIVVNYMAKFNAGVAVVAMTNAENTN--PNF-----------PEYDWNEMERSYILSSFFWGYILTQFMGGWLCR 85
Cdd:TIGR00894 22 FLLHICNVIIIAQRICLSLTMVAMVNKENSTdlACLsaeneldniknPNFKWSGALQGLILSSHFYGQIIIQIPVGYLAG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 86 RYGARITMFVSTIGSALLVVLIPWCVSwGGWQAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGT 165
Cdd:TIGR00894 102 KYVFKWSIGIGMFLSSVISIVIPWAAG-GGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGT 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 166 LVAMFASGLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPRESKFIGEAELNYIETSINSSrkaeeaelKATGPIPV 245
Cdd:TIGR00894 181 FIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ--------KGSTRQSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 246 PWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMSI 325
Cdd:TIGR00894 253 PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 326 TGIRKSVNSIAFFVPAAALIGVSFLDNTqKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPIL 405
Cdd:TIGR00894 333 TAARKIFNGIGGLGPGIFAYALPYLSAA-FYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLI 411
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 24658658 406 TPLLVGIIVKDDhDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDAPD 456
Cdd:TIGR00894 412 ASTLAGNILSQD-SKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEE 461
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
19-445 |
4.26e-68 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 223.50 E-value: 4.26e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 19 FLLFLSIVVNYMAKFNAGVAVVAMTNAENT---------------------NPNFPEYDWNEMERSYILSSFFWGYILTQ 77
Cdd:cd17381 3 LLAFFGFFVVYALRVNLSVALVDMVNSNSTlpsnnssnacpehssspsvehNETGKKYDWDAETQGWILGSFFYGYIITQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 78 FMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWG-GWqaYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGAL 156
Cdd:cd17381 83 IPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGaGY--LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 157 ANTGIDCGTLVAMFASGLLAaSSIGWPGIFYVSCGVGVLWCIVWwifganqpreskfigeaelnyietsinssrkaeeae 236
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLIC-YYLDWTYVFYIFGAVGLLWFFLW------------------------------------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 237 lkatgpipvpwkaIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADI 316
Cdd:cd17381 204 -------------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADN 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 317 LLTRGIMSITGIRKSVNSIAFFVPAAALIGVSFLdNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVN 396
Cdd:cd17381 271 LREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFT-GCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITN 349
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 24658658 397 TASNIVPILTPLLVGIIVKdDHDREQWQIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17381 350 TFATIPGMVGPVIAKSLTH-NNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
34-445 |
7.68e-60 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 201.41 E-value: 7.68e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 34 NAGVAVVAMTN------AENTNPNFPEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLI 107
Cdd:cd17382 17 NLGVAIVRMVNnftdayGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 108 PwCVSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAaSSIGWPGIFY 187
Cdd:cd17382 97 P-IAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILV-QYVGWSSPFY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 188 VSCGVGVLWCIVWWifganqpreskfigeaelnyietsinssrkaeeaelkatgpipvpwkaiWTSVPFWALMVTRCCQS 267
Cdd:cd17382 175 VYGVFGIIWYMFWM-------------------------------------------------LVSMPVYAIIVANFCRS 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 268 WGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLtswVMAFVYLI---IADILLTRGIMSITGIRKSVNSIAFFVPAAAL 344
Cdd:cd17382 206 WTFYLLLISQPAYFKEVFGFDISKVGILSALPHL---VMTIIVPIggqLADYLRSRGILSTTAVRKIFNCGGFGMEATFL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 345 IGVSFLDNtqKTLAVVLMCANVGInAGSTI-GSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVKdDHDREQW 423
Cdd:cd17382 283 LVVAFSHS--PTVAISFLVLAVGF-SGFAIsGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTK-HKTREEW 358
|
410 420
....*....|....*....|..
gi 24658658 424 QIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17382 359 QYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-443 |
3.58e-43 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 156.58 E-value: 3.58e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 14 RHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNaentnpnfpEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITM 93
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMK---------DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 94 FVSTIGSALLVVLIPWCVSWGGWqayCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASG 173
Cdd:cd17319 72 AVSMLLWSLFTALTGFATSLTSL---YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 174 LLAAsSIGWPGIFYVSCGVGVLWCIVWWIFGANqpreskfigeaelnyietsinssrkaeeaelkatgpipvpwkaiwts 253
Cdd:cd17319 149 WLLL-LFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 254 vpFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILltrgimsITGIRKSVN 333
Cdd:cd17319 181 --VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL-------LRGARRLVI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 334 SIAFFVPAAALIGVSFLDNTqkTLAVVLMC-ANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGI 412
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSP--VVAVILLSlAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGY 329
|
410 420 430
....*....|....*....|....*....|.
gi 24658658 413 IVKDDHDreqWQIVFIISAVIFCVGNIVYVA 443
Cdd:cd17319 330 LVDATGS---YTAAFLFLAAVALLAALLVLL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-446 |
2.68e-39 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 146.17 E-value: 2.68e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 14 RHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNaentnpnfpEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITM 93
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQA---------DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 94 FVSTIGSALLVVLIPWCVSWggWQAYcAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASG 173
Cdd:COG2271 79 AIGLLLWGLATLLFGFATSF--WQLL-LLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 174 LLAAsSIGWPGIFYVSCGVGVLWCIvwwifganqpreskfigeaelnyietsinssrkaeeaelkatgpipvpwkaiwts 253
Cdd:COG2271 156 WLLA-AFGWRAAFLILGLPGLLLAL------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 254 VPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMSITgirksvn 333
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA------- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 334 sIAFFVPAAALIGVSFLDNTQkTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGII 413
Cdd:COG2271 253 -IGLLLAALALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
410 420 430
....*....|....*....|....*....|...
gi 24658658 414 VkddhDREQWQIVFIISAVIFCVGNIVYVAFGK 446
Cdd:COG2271 331 L----DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-407 |
2.54e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 126.38 E-value: 2.54e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 21 LFLSIVVNYMAKFNAGVAVVAMTNAEntnpnfpeYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGS 100
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAED--------LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 101 ALLVVLIPWCVSWGGWqayCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSI 180
Cdd:pfam07690 73 ALGLLLLLFASSLWLL---LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL-ASLF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 181 GWPGIFYVSCGVGVLWCIVWWIFgaNQPRESKFIGEAElnyietsinssrkaeeaelKATGPIPVPWKAIWTSVPFWALM 260
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLP--RPPPESKRPKPAE-------------------EARLSLIVAWKALLRDPVLWLLL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 261 VTrCCQSWGYSTLQTEMPAYMNgVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMsitgirksvnSIAFFVP 340
Cdd:pfam07690 208 AL-LLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL----------LLALLLL 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 341 AAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLS--PNHAGILMGIVNTASNIVPILTP 407
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLapKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
63-414 |
2.59e-30 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 122.06 E-value: 2.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCvswGGWQAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:TIGR00893 32 GYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA---GAYVSLYILRVLLGAAEAPFFPGIILIVA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSiGWPGIFYVSCGVGVLWCIVWWIFGANQPRESKFIgEAELNYI 222
Cdd:TIGR00893 109 SWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF-SWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKWL-TEEEKYI 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 223 etsINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLT 302
Cdd:TIGR00893 187 ---VVGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIV 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 303 SWVMAFVYLIIADILLTRGiMSITGIRKSVnSIAFFVPAAALIGVSFLDNTQktLAVVLMCANVGINAGSTIGSTINTID 382
Cdd:TIGR00893 264 GFIGMILGGRLSDLLLRRG-KSLVFARKTA-IIAGLVLSLLMFATNYVNIPY--AALALVALGFFGLGAGAIGWALISDN 339
|
330 340 350
....*....|....*....|....*....|..
gi 24658658 383 LSPNHAGILMGIVNTASNIVPILTPLLVGIIV 414
Cdd:TIGR00893 340 APGNIAGLTGGLINSLGNLGGIVGPIVIGAIA 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
54-442 |
4.20e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.52 E-value: 4.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFL 133
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL---LLLGRFLLGLGSGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 134 FPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAAS-SIGWPGIFYVSCGVGVLWCIVWWIFGANQPRESK 212
Cdd:cd06174 102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 213 figeaelnyietsinssrkaEEAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSN 292
Cdd:cd06174 182 --------------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 293 ALYSALPYLTSWVMAFVYLIIADILLTRGIMSItgirksvnsIAFFVPAAALIGVSFLDNTQKTLAVVLMCAnVGINAGS 372
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL---------IGLLLMALGLALLLLAPSLLLLLLLLLLLG-FGLGGLL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 373 TIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDreqWQIVFIISAVIFCVGNIVYV 442
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG---LTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-437 |
1.38e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 105.35 E-value: 1.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 14 RHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNaentnpnfpEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITM 93
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAE---------EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 94 FVSTIGSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASG 173
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYWL---LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 174 LLAAsSIGWPGIFYVSCGVGVLWCIVWWIFGANQPREskfigeaelnyietsinsSRKAEEAELKAtgpipvpWKAIWTS 253
Cdd:COG2223 151 LLIA-AFGWRNAFLILGILLLVVAVLAWLFLRDPPAG------------------AAAAAKASLRD-------QLEALRD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 254 VPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILltrgimsitGIRKsVN 333
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI---------GGRR-VL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 334 SIAFFVPAAALIGVSFLDNTQkTLAVVLMCAnVGINAGSTIGSTINTI--DLSPNHAGILMGIVNTASNIVPILTPLLVG 411
Cdd:COG2223 275 LIVFALMALGLLLLALALGSL-WLFLVLFLL-LGLALGGGNGAVFALVpdIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
|
410 420
....*....|....*....|....*.
gi 24658658 412 IIVKDDHDreqWQIVFIISAVIFCVG 437
Cdd:COG2223 353 ALLDATGS---YTAAFLVFAVLALVA 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-401 |
2.00e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.57 E-value: 2.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 13 QRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNaentnpnfpEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARIT 92
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAA---------DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 93 MFVSTIGSALLVVLIPWCVSWGGWqayCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFAS 172
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLL---LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 173 GLLAAsSIGWPGIFYVSCGVGVLWCIVWWIFganqpreskfigeaelnyietsinssrkAEEAELKATGPIPVPWKAIWT 252
Cdd:COG2814 155 GLLAD-LFGWRWVFLVNAVLALLALLLLLRL----------------------------LPESRPAARARLRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 253 SVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMsitgirksv 332
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--------- 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 333 nSIAFFVPAAALIGVSFLDNTQkTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNI 401
Cdd:COG2814 277 -LIGLLLLALGLLLLALAGSLW-LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
54-415 |
3.46e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 86.28 E-value: 3.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWcvSWGGWQaYCAIRMSMGLFQGFL 133
Cdd:TIGR00881 24 EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF--STSLWV-MAALWALNGIFQGMG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 134 FPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPReSKF 213
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQ-SCG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 214 IGEAELNYIETSINSSRKAEEAELKATGPIP--VPWKAIW-TSVPFWALMVTR-CCQSWGystlqtemPAYMNGVLLMDM 289
Cdd:TIGR00881 180 LPPAEEMPNEEPDGDAEKKEEELTKKQIFLQyvLLNKVLWyISLGYVFVYVVRtGILDWS--------PLYLTQEKGFSK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 290 KSNALYSALPYLTSWVMAFVYLIIADILLTRGIMSITGIRKsvnsiaffvpaaALIGVSFLDNTQKTLAVVLMCANVGIN 369
Cdd:TIGR00881 252 EKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM------------ALIIVSLLVYWLNPAANPLMDLICLFA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 24658658 370 AGSTIGSTIN-----TIDLSP-NHAGILMGIVNTASNIVPILTPLLVGIIVK 415
Cdd:TIGR00881 320 LGFLVYGPQMligviASELAPkKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-444 |
5.43e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 5.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSwggWQAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS---YWQLLLARFLQGLASAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLwCIVWWIFganqpreskfigeaelnyi 222
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPFLVCAALALL-ALVLALL------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 223 etSINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDmksnalysalPYLT 302
Cdd:cd17325 170 --LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS----------PAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 303 SWVMAFVYLIIADILLTRGIMSITGIRKSVNSIAFFVPAAALIGVSFLDNTQkTLAVVLMCANVGINAGSTIGSTINTID 382
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFW-LLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24658658 383 LSPNHAGILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVGNIVYVAF 444
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY----DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
78-446 |
3.04e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 64.89 E-value: 3.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 78 FMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIrmsMGLFQGFLFPCIHAHLANWCPvKERNRLGALA 157
Cdd:COG2807 71 PLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL---IGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 158 NTGIDCGTLVAMFASGLLAASSiGWPGIFYVSCGVGVLWCIVWWIFGANQPRESkfigeaelnyietsinssrkaeeael 237
Cdd:COG2807 147 TAAMGLGAALAAGLTVPLAAAL-GWRGALAVWALLALLALLLWLPLLRRRPAAA-------------------------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 238 kATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYmngvlLMDMKSNALYSALpyLTSwVMAFVYL---IIA 314
Cdd:COG2807 200 -AAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPI-----LRDAGLSAATAGL--LLS-LFQLAGIpgsLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 315 DILLTRgimsiTGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMcanvGINAGSTIGSTINTIDL---SPNHAGIL 391
Cdd:COG2807 271 PLLADR-----LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL----GLGQGGLFPLALTLIGLrarTPAEAAAL 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 24658658 392 MGIVNTASNIVPILTPLLVGIIvkddHDREQ-WQIVFIISAVIFCVGNIVYVAFGK 446
Cdd:COG2807 342 SGMAQSVGYLLAALGPLLVGAL----HDATGsWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
19-407 |
5.26e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 61.11 E-value: 5.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 19 FLLFLSIVVNYMAKFNAGVAVVaMTNAENTNPNFPEYDWnemersyILSSFFWGYILTQFMGGWLCRRYGARITMFVSTI 98
Cdd:cd17327 8 PLLCILYFLQYLDKSNISNAAV-MGMKEDLKLVGNQYNW-------GNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 99 GSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERN-RLGALANTGIDCGTLVAMFASGLLAA 177
Cdd:cd17327 80 LWGLLTLLTAAVKNFGG---LIALRFFLGLFESGVFPGFILYLGMWYKREEQAkRIAFFYAAAGLGSIFGGLLAYGVFKI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 178 SSI----GWPGIFYVSCGVGVLWCIVWWIFGANQPRESKFIGEAELNYIETSI-NSSRKAEEAELKatgpipvpWKAIWT 252
Cdd:cd17327 157 LGVgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLrANQTGKGDQKFK--------WKQIKE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 253 SVPFWALMVtrCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRgimsiTGIRKSV 332
Cdd:cd17327 229 AFKDPRTWL--LFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDR-----FKKRGLF 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 333 NSIAFFVPAAALIGVSFLDNTQKTLAVVLMCAnvginAGSTIGSTINTIDLSPNHAG-----ILMGIVNTASNIVPILTP 407
Cdd:cd17327 302 AIFACVLALVGSIILLAAPNPPGAYFAAYILG-----GGSYAGFPILLSWISSNCAGytkraTVLAIMLIFYNVGNIVAP 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
65-199 |
5.38e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.60 E-value: 5.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGAR----ITMFVSTIGSALLVVL--IPWCVswggwqaycAIRMSMGLFQGFLFPCIH 138
Cdd:COG0477 54 IVSAYLLGRAIGLLLFGRLGDRYGRKrvllIGLLLFGLASLLCGLApsPELLI---------AARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24658658 139 AHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAAsSIGWPGIFYVSCGVGVLWCIV 199
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-ALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
54-205 |
1.94e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIrmsMGLFQGFL 133
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL---LGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24658658 134 FPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAAsSIGWPGIFYVsCGVGVLWCIVWWIFGA 205
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLA-AAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-445 |
4.35e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 4.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 74 ILTQFMGGWLCRRYGARITMFVSTIGSALLVVlipwcvsWGGW-QAYCAI---RMSMGLFQGFLFPCIHAHLANWCPVKE 149
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV-------AGLFlDSLYALlasRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 150 RNRLGALANTGIDCGTLVAMFASGLLAasSIGWPGIFYV-SCGVGVLWCIVWWIFganqpreskfigeaelnyiETSINS 228
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALA--EIGWRAPFLVyLLALPVLILVLLFLP-------------------EPARKS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 229 SRKAEEAELKATgpiPVPWKAIWtsvpfWALMVTrCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAF 308
Cdd:cd17473 181 KSAASPGAATAA---ALPWKRVL-----PIYFLA-FLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 309 VYLIIADILLTRGIMsitgirksvnSIAFFVPAAALIGVSFLDNtqktLAVVLMCANV-GINAGSTIGSTINTI--DLSP 385
Cdd:cd17473 252 LFGRLKRRLGKRRLL----------AIGFALMALGFLLLALASG----LWVVLLGAILaGLGFGLLLPTLNSWAmsLVPP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 386 NHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDReqwQIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17473 318 ELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL---SGAFLILGVLALVLAIVLLLLR 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
70-414 |
4.68e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 70 FWGYILTQFMGGW---LCRRYGARIT-MFVSTIGSALLVVLIPWCVSWGGWQA---YCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:COG2211 57 LWDAITDPLIGALsdrTRTRWGRRRPwILIGAIPLALSFVLLFTAPDLSPTGKliyALVTYLLLGLAYTLVNIPYSALGA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCP-VKERNRLGALANTGIDCGTLVAMFASGLLAA-----SSIGWPGIFYVSCGVGVLwCIVWWIFGAnqpRESKFIGE 216
Cdd:COG2211 137 ELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafggdAALGYRLTALIFAVLGLL-AFLLTFFGT---KERPVPEE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 217 AELNYIETsinssrkaeeaelkatgpipvpWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYS 296
Cdd:COG2211 213 EKVSLKES----------------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 297 ALPYLTSWVMAFVYLIIADILltrGimsitgiRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMC-ANVGINAGSTIG 375
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRF---G-------KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAAlAGIGLGAILVLP 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 24658658 376 STI--NTIDLS-----PNHAGILMGIVNTASNIVPILTPLLVGIIV 414
Cdd:COG2211 341 WAMlaDVVDYDewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
65-201 |
5.36e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 58.44 E-value: 5.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLANW 144
Cdd:pfam00083 51 IVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEI 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 145 CPVKERNRLGALANTGIDCGTLVA-MFASGL-LAASSIGWPGIFYVSCGVGVLWCIVWW 201
Cdd:pfam00083 131 APKKLRGALGSLYQLAITFGILLAyIFGLGLnKTSNSDGWRIPLGLQLVPALLLIIGLL 189
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
65-209 |
1.10e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.90 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMfvstIGSALLVVLIPWCVSWGGWQAYCAIRMSM-GLFQGFLFPCIHAHLAN 143
Cdd:cd17312 43 IGSAFLIAYAVGKFISGFLSDRSNIRRFM----SAGLLLSALANIFMGFSTSLWFFAVLWGLnGLFQSMGWPPCVKLLGN 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24658658 144 WCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPR 209
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASL-ASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
54-414 |
1.71e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.51 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSwgGWQAYCAIRMSMGLFQGFL 133
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS--LWQLYLLWGLLGGGGAGTL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 134 FPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPreskf 213
Cdd:cd17355 110 AAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL-IEAFGWRTALLVLALLALLVLVPVLLLLRRRP----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 214 igeaelnyietsinSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTR--CCQSWgySTLQTEMPAYMNGVLLMDMKS 291
Cdd:cd17355 184 --------------ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFflCGFAV--VGLIVHLVPYLADRGISPAAA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 292 NALYSALpyltsWVMAFVYLIIADILLTRgimsitGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCanVGINAG 371
Cdd:cd17355 248 AVALALI-----GLFNIVGRLLSGWLGDR------YSPRRLLAASYALRALGLALLLLLPFPPLALLLFAAL--FGLGWG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 24658658 372 STIGSTINTI--DLSPNHAGILMGIVNTASNIVPILTPLLVGIIV 414
Cdd:cd17355 315 ATVPLTAALAarYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
63-444 |
1.05e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 54.09 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL---LLLALFLLGLGLGLLDVAANPYVA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCPVKERNRLGAL-ANTGIdcGTLVAMFASGLLAASSIG--WPGIFYVSCGVGVLWCIVWWIfganqpreskfigeael 219
Cdd:COG0738 123 ALGPETAASRLNLLhAFFSL--GALLGPLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLR----------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 220 nyietsinSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALp 299
Cdd:COG0738 184 --------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 300 yltSWVMAFVYLIIADILLTRgimsiTGIRKSVnsIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGInagSTIGSTIN 379
Cdd:COG0738 255 ---FWGGMTIGRFLGGFLLKR-----FGPVRLL--RLSALLAAVGLLLALLAPGPWLALIGLALVGLGL---SLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24658658 380 --TIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVgnIVYVAF 444
Cdd:COG0738 322 slALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLA----DAFGLRAAFLVPLVCYLL--ILLLAL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
54-209 |
1.50e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.34 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGAR--ITMFVSTIGSALLVVLIPWCVSwgGWQAYCAIrMSMGLFQG 131
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPS--PALAIALL-FLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24658658 132 FLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSiGWPGIFYVSCGVGVLWCIVWWIFGANQPR 209
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
63-203 |
2.35e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 53.03 E-value: 2.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVAM-FASGLLAASSIGWPGIFYVSCGVGVLWCIVWWIF 203
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQvFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFF 193
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
65-269 |
6.42e-07 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 51.57 E-value: 6.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVS-WggwqAYCAIRMSMGLFQGFLFPCIHAHLAN 143
Cdd:cd17343 43 ITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSvW----VFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 144 WCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSiGWPGIFYVSCGVGVLWCIVWWIFGANQPreskfiGEAELNYIE 223
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSY-GWRSTLSISGTVAVVMSVVCLLFIKNEP------SDVGLNNIE 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 24658658 224 TSINSSRKAEEAELKATgpipvpWKAIWTSVPFWAL--------MVTRCCQSWG 269
Cdd:cd17343 192 EEESKGKKKKSPRGEST------LKELLLSPFLWLLslgylvvfGVKTAVTDWG 239
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
65-437 |
1.28e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 50.70 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSwggwqaYCAIRMSMgLFQGFLFPCIHAH---- 140
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS------YPVLLVLL-FLVGAGYGSVQPGggra 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 141 LANWCPVKERNRLGALANTGIDCGTLVAmfASGLLA-ASSIGWPGIFYVSCGVGVLWCIVWWIFganqpreskfigeael 219
Cdd:cd17475 109 IMRWFPPRERGLAMGIRQTGVPLGGALA--AALLPPlALHYGWRAAFVVAGLVSILAAVLFWLF---------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 220 nYIETSINSSRKAEEAELKATGpipvpwKAIWTSVPFWALMVTrccqswgystlqtempaymnGVLLMDMKSNALYSALP 299
Cdd:cd17475 171 -YREPPAASAATESASTLLRSL------KEVLRNRDVWLIAIA--------------------GALLVAPQFALLTFLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 300 YLT-----SWVMAFVYLIIADIL--LTR---GIMS---ITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANV 366
Cdd:cd17475 224 FLHdhlglSVVAAGALLAVAQLGgaLGRiglGRVSdrvFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24658658 367 GInagSTIG-STINTIDLS----PNHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDreqWQIVFIISAVIFCVG 437
Cdd:cd17475 304 GL---FAIGwNGLYLTLVAesagPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHS---YAPAWLALALLLVLA 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
63-436 |
1.83e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.91 E-value: 1.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGgwqAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:cd17316 39 GLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI---LLLVLRFLQGIGIGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPG--IFYVSCGVGVLwcIVWWIfganqpreskfigeaeln 220
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrILFLIGALPAL--LALLL------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 221 yietsinssRKAeeaelkatgpipvpwkaiwtsvpFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPY 300
Cdd:cd17316 176 ---------RRR-----------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLIS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 301 LTSWVMAFVYLIIADILltrGimsitgiRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINT 380
Cdd:cd17316 224 LGALVGALIAGLLSDRI---G-------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYL 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 24658658 381 IDLSPNHA-GILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCV 436
Cdd:cd17316 294 AELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
64-212 |
1.77e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.80 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 64 YILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWcvSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLAN 143
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL--ALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 144 WCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLwCIVWWIFGANQPRESK 212
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV-ALVLTLLLYRRPRRAA 390
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
56-345 |
2.74e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.58 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 56 DWN--EMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLipwCV-SWGGWQaYCAIRMSMGLFQGF 132
Cdd:TIGR00895 46 EWGldPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL---CAlATNVTQ-LLILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 133 LFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLWCIVWWIFganQPRESK 212
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL-IPVFGWRSLFYVGGIAPLLLLLLLMRF---LPESID 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 213 FIGEAE-------LNYIETSINSSRKAEEAELKATGPI-PVPWKAIWT------SVPFWALMVtrcCQSWGYSTLQTEMP 278
Cdd:TIGR00895 198 FLVSKRpetvrriVNAIAPQMQAEAQSALPEQKSTQGTkRSVFKALFQgktariTVLLWLLYF---MLLVGVYFLTNWLP 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 279 AYMNGvLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMS---ITGIRKSVNSIAFFVPAAALI 345
Cdd:TIGR00895 275 KLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALlllLGAVFAVLVGSTLFSPTLLLL 343
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
65-441 |
4.27e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGG---WQAYCAIrMSMGLFQGFLFPCIHAHL 141
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslWLLLVLA-FLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 142 ANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAAsSIGWPGIFYVSCG--VGVLWCIVWWIFGANQPRESKfigeael 219
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALsfLLSALLLLFIRRPPPAAPGES------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 220 nyietSINSSRKAEEAELKATGPIPVPWKAIWTSVpFWALmvtrccqswgYSTLQTEMPAYMNGVLLMDMKSNALYSALP 299
Cdd:cd06173 190 -----SSLLLRDLREGLRYLRRSPLLRLLLLALAL-FALL----------GGALTVLLPLLAKEVLGGGAAGYGLLLAAF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 300 YLTSWVMAFVYLIIADILLTRGIMsitgirksvnSIAFFVPAAALIGVSFLDNTqKTLAVVLMCANVGINAGSTIGSTIN 379
Cdd:cd06173 254 GVGALLGALLLGRLSKRRRRGRLL----------LIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24658658 380 TIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVGNIVY 441
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA----DALGLSAVFLLAGALLLLAALLL 380
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
63-200 |
1.02e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIpwCVSWGGWQAYCAIrMSMGLFQGFLFPCIHAHLA 142
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA--LLAPGPWLALIGL-ALVGLGLSLMFPTIFSLAL 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 143 NWCPVKERNRLGALANTGIdCGTLVAMFASGLLA-ASSIGWPGIFYVSCGVGVLWCIVW 200
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLAdAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
54-210 |
1.63e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.15 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIRMSM-GLFQGF 132
Cdd:cd17345 32 QYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLnGWFQGM 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 133 LFPCIHAHLANWCPVKERNRLGALANTG--IDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPRE 210
Cdd:cd17345 112 GWPPSGRTMVHWFSKKERGTWTSIWNIShnVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPES 191
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-164 |
1.70e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 55 YDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWcvsWGGWQAYCAIRMSMGLFQGFLF 134
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLF 314
|
90 100 110
....*....|....*....|....*....|
gi 24658658 135 PCIHAHLANWCPVKERNRLGALANTGIDCG 164
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
54-203 |
1.79e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.71 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 54 EYDWNEMERSYILSSFFWGYILTQF-MGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWgGWQAYCAIrmSMGLFQGF 132
Cdd:cd17474 228 LYGISPIIIGLLFAGWSVLLALGSLfVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL-ALLLIAIV--LFGLGLGL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24658658 133 LFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLWCIVWWIF 203
Cdd:cd17474 305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
65-445 |
2.26e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.35 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFLFPCIHAHLANW 144
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL---LLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 145 CPVKERNRLGALANTGIDCGTLVAMFAsGLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPreskfigeaelnyiet 224
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP---------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 225 sinssRKAEEAELKATGPIPVPWKAIWtsvPFWALMVtrcCQSWGYSTLQTEMPAYMNGVLlmdmksnalysalpyltsW 304
Cdd:cd17489 176 -----VAAEEAEAGTRAFRRLVEKKVL---PPALILF---LASIAYGAISTFLPLYAAERG------------------I 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 305 VMAFVYLIIADI--LLTR---GIMSITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCAnVGINAGSTIGSTIn 379
Cdd:cd17489 227 SNAGLFFTVYAIalLLSRpfsGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYG-LGFGLLFPALQAL- 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24658658 380 TIDLSPNHA-GILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVGNIVYVAFG 445
Cdd:cd17489 305 AVDLVPPHRrGAANGTFFIFFDLGIGLGGLLLGLVA----ELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
86-401 |
3.04e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 86 RYGARITMFVSTIGSALLVVLIPwcVSWGGWQAYCAiRMSMGLFQGFLFPCIHAHLANWCPVKERNR-LGALAnTGIDCG 164
Cdd:cd17321 57 RFGRKRVFLIGLALFGLASLLCA--LAPSLAFLIAA-RALQGIGAAAIMPASLALIAATFPGERRGRaLGLWG-AVVGIG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 165 TLVAMFASGLLAaSSIGWPGIFYVSCGVGVLwcivwwifganqpreskfigeaelnyietsinssrkaeeaelkatgpip 244
Cdd:cd17321 133 AALGPLLGGLLL-ELFGWRWIFLINVPIGLV------------------------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 245 vpwkAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDmksnALYSALPYLTSWVMAFVYLIIADILLTRgims 324
Cdd:cd17321 163 ----ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYS----PLQAGLALLPLALAMLVAAPLAGRLADR---- 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 325 iTGIRKsVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTI--DLSPNHAGILMGIVNTASNI 401
Cdd:cd17321 231 -FGPRL-VLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAlsSVPKEKAGAASGILNTARQL 307
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
74-444 |
4.06e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 74 ILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAYCAIrmsMGLFQGFLFPCIHAHLANWCPVKERNRL 153
Cdd:cd17329 49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL---TGFGGGLFEPASEAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 154 GALANTGIDCGTLVAMFASGLLAASSIGWP----GIFYVSCGVgvlwcIVWWIFGANQPRESKFIGEaelnyietsinss 229
Cdd:cd17329 126 FSLLYWAINLGVAIGPLLGGLLLLYSFRLLflaaAVLFLLAAL-----VLLFLLPETRPKRRAAEKT------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 230 rkaeeaelkatgPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLlmdmksnalysalpYLTSWVMAFV 309
Cdd:cd17329 188 ------------EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIL--------------GLGESLLGLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 310 YLI--IADILLTrgiMSITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGS-TINTI--DLS 384
Cdd:cd17329 242 LALnaLLIVLLQ---FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFpAVQTLvaALA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24658658 385 PNHA-GILMGIVNTASNIVPILTPLLVGIIVkdDHDREQWqIVFIISAVIFCVGNIVYVAF 444
Cdd:cd17329 319 PPDKrGSYMGFYALAWGLGRAIGPLVGGLLL--DLLGPGL-PWLILAALGLIAAALLLGLQ 376
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
63-437 |
1.31e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGgwqAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA---LLLLARALAGLAHGGFWAIAAAYAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVAMFASGLLaASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPreskfigeaelnyi 222
Cdd:cd17324 114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL-GQLLGWRAAFLAIAVLALLAALLLWRLLPSLP-------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 223 etsinssrkaeeAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLT 302
Cdd:cd17324 179 ------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 303 SWVMAFVYLIIADILLTRGIMsitgirksvnsIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTiD 382
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALL-----------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL-R 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 24658658 383 LSPNHAGILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVG 437
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGAALGGLVL----DHGGWAGVGWVGAALLLLA 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
80-362 |
1.35e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.13 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 80 GGWLCRRYGARITMFVSTIGSALLVVLipwCVSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANT 159
Cdd:cd17371 54 GGILADRFGRVRVLVITILLFAVFTLL---CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 160 GIDCGTLVAMFASGLL---AASSIGWPGIFYvscgVGVL-WCIVWWIfganqpreSKFIGEAElnyietsinsSRKAEEA 235
Cdd:cd17371 131 GWAVGWLLATLLAALLfplLPPEIAWRVLFL----LGALpALLVLFI--------RRFVKEPP----------QWQAARA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 236 ELKATGPIPVPW----KAIWTSVPFWALMVTrcCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYL 311
Cdd:cd17371 189 ARRHFADRPSLRelfsPPLLRTTLLASLLAT--GALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGG 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 24658658 312 IIADILLTRgimsitgirksVNSIAFFVPAAALIGVSFLDNTQKTLAVVLM 362
Cdd:cd17371 267 FLADRIGRR-----------NNFALFALGSAISILLYFFLPLSPTLILILG 306
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
259-444 |
2.20e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 259 LMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMSItgirksvnSIAFF 338
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI--------GLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 339 VPAAALIgvsFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVkddh 418
Cdd:pfam07690 73 ALGLLLL---LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---- 145
|
170 180
....*....|....*....|....*.
gi 24658658 419 DREQWQIVFIISAVIFCVGNIVYVAF 444
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
19-293 |
2.51e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.30 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 19 FLLFLSIVVNYMAKFNAGVAVVAMTNAENTNPnfpeydwneMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTI 98
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDD---------SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGIL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 99 ---GSALLVVLIPwcvswGGWQaYCAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLL 175
Cdd:cd17328 73 iwsAATLLSSFAP-----NFWQ-LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 176 AASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPReskfigeaelnyietsinSSRKAEEAELKATGPIPVPWKAIWTSVP 255
Cdd:cd17328 147 AQATGGWRWAFRVTGVLGVLLAILLLLFVREPPR------------------GAAEGGVMAKSTATSFLADLKALAKNPS 208
|
250 260 270
....*....|....*....|....*....|....*...
gi 24658658 256 FWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNA 293
Cdd:cd17328 209 FILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSA 246
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
63-200 |
2.91e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.86 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 63 SYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSwggWQAYCAIRMSMGLFQGFLFPCIHAHLA 142
Cdd:cd17315 37 GLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN---VWVLIVGRFLLGLGVGLASVLVPLYIS 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 143 NWCPVKERNRLGALANTGIDCGTLVA-MFASGLLAASSIGWPGIFYVSCGVGVLWCIVW 200
Cdd:cd17315 114 EIAPAKIRGALGTLNQLMITFGILLAyLLGLALSLSPPGWWRLMFALAAVPALLQLLLM 172
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
66-203 |
3.17e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.93 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 66 LSSFFwGYILTQFMGGWLCRRYGARITMFVSTIGSALLvvlipwCVSWGGWQAYCAIRMSMGLFQGFLFPCIHAHLANWC 145
Cdd:cd17356 56 LGSFF-GALISSFLSDRIGRKKSIQIGCVIYIIGAIIQ------VAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVA 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24658658 146 PVKERNRLGALANTGIDCGTLVAMFASglLAASSIGWPGIFYVSCGVGVLWCIVWWIF 203
Cdd:cd17356 129 PKHIRGTLVSLYQLAITIGILVAYCIN--YGTHKLDGSAQWRIPLGLQIVWGLLLLIG 184
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
67-410 |
4.85e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 67 SSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSwggWQAYCAIRMSMGLFQGFLFPCIHAHLANWCP 146
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPN---YTVFLVFRLLVGMGIGGIWVQAVVLNTEFLP 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 147 VKERNRlgalantgidCGTLVAMFASG------LLAASSIGWPGIFYVSCGVGVLWCIVWWIF----------GANQPRE 210
Cdd:TIGR00898 211 KKQRAI----------VGTLIQVFFSLglvllpLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVpesprwlisqGRIEEAL 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 211 SKFIGEAELNYIETSINSSRKAEEAELKATGPIPV------PWKAIWTSVPFWALMVtrcCQSWGYSTLQTEMPAymngv 284
Cdd:TIGR00898 281 KILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSfldlfrTPNLRKTTLCLMMLWF---TTAFSYYGLVLDLGN----- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 285 LLMDMKSNALYSAlpyLTSWVMAFVYLIIADILLTRGIMsitgirksvnSIAFFVPAAALIGVSFLDNTQKTLAVVLMCA 364
Cdd:TIGR00898 353 LGGNIYLDLFISG---LVELPAKLITLLLIDRLGRRYTM----------AASLLLAGVALLLLLFVPVDLYFLRTALAVL 419
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 24658658 365 NVGINAGSTIGSTINTIDLSP----NHAgilMGIVNTASNIVPILTPLLV 410
Cdd:TIGR00898 420 GKFGITSAFQMVYLYTAELYPtvvrNLG---VGVCSTMARVGSIISPFLV 466
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-212 |
6.87e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 6.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 65 ILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWqayCAIRMSMGLFQGFLFPCIHAHLANW 144
Cdd:cd17477 36 VASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW---FLLRFVMGIGLAGLFVVSESWLNAL 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24658658 145 CPVKERNRLGALANTGIDCGTLVAMFasgLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPRESK 212
Cdd:cd17477 113 ATNENRGRVLGLYSTVLGLGFALGPL---LLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEE 177
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
384-452 |
8.39e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.41 E-value: 8.39e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24658658 384 SPNHAGILMGIVNTASNIVPILTPLLVGIIVkddhDREQWQIVFIISAVIFCVGNIVYVAFgkMVNQPW 452
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLA----SYYGWRAAFLVPGIVGLVVAIILFFF--LRDSPP 183
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
62-203 |
9.59e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24658658 62 RSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGwqaYCAIRMSMGLFQGFLFPCIHAHL 141
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL---FLVLRFLVGVTSAGIFTVGFVLG 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24658658 142 ANWCPVKERNRLGALANTGIDCGT-LVAMFASGL----LAASSIGWPGIFYVSCgvgvLWCIVWWIF 203
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFWALGYmLLALLAYLIrdwrWLQLAISLPGLLFLLL----LWWLPRRTI 166
|
|
| |
