uncharacterized protein Dmel_CG30291 [Drosophila melanogaster]
Protein Classification
CDK5RAP3 family protein( domain architecture ID 10528880)
CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) family protein is a DUF773 domain-containing protein similar to vertebrate CDK5RAP3 that acts as a tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||
| CDK5RAP3 | pfam05600 | CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ... |
3-506 | 0e+00 | ||||||||
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity. : Pssm-ID: 461688 Cd Length: 506 Bit Score: 593.12 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||
| CDK5RAP3 | pfam05600 | CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ... |
3-506 | 0e+00 | ||||||||
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity. Pssm-ID: 461688 Cd Length: 506 Bit Score: 593.12 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||
| CDK5RAP3 | pfam05600 | CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ... |
3-506 | 0e+00 | ||||||||
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity. Pssm-ID: 461688 Cd Length: 506 Bit Score: 593.12 E-value: 0e+00
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