BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  32 FTDVTLACEGQTCKAHKMVLSACSPYFKALLEE-NPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADR 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24654834 111 LKVKG 115
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  32 FTDVTLACEGQTCKAHKMVLSACSPYFKALLEE-NPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADR 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24654834 111 LKVKG 115
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834     34 DVTLACEGQTCKAHKMVLSACSPYFKALLEENP--SKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADRL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24654834    112 KVKGLAE 118
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  32 FTDVTLACEGQTCKAHKMVLSACSPYFKALLEE-NPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADR 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24654834 111 LKVKG 115
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834     34 DVTLACEGQTCKAHKMVLSACSPYFKALLEENP--SKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADRL 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*..
gi 24654834    112 KVKGLAE 118
Cdd:smart00225  81 QIPGLVE 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  21 TSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLE--ENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQ 98
Cdd:cd18240   6 NVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTngWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITA 85

                        90
                ....*....|....*...
gi 24654834  99 EQLPAFLKTADRLKVKGL 116
Cdd:cd18240  86 ENVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  22 SFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALL--EENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQE 99
Cdd:cd18235  11 VMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFtgDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEE 90

                        90
                ....*....|...
gi 24654834 100 QLPAFLKTADRLK 112
Cdd:cd18235  91 NVQVLLPAANLLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  32 FTDVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHP---IIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTA 108
Cdd:cd18293  15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGqkvVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAA 94

                ....*...
gi 24654834 109 DRLKVKGL 116
Cdd:cd18293  95 RRLQISEL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  19 MVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALL--EENPSKHPIIILKDVSYIHLQAILEFMYAGEVNV 96
Cdd:cd18242   8 ILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsEMSEKGKSEVELQGLTASTMEILLDFVYTETVHV 87

                        90       100
                ....*....|....*....|..
gi 24654834  97 SQEQLPAFLKTADRLKVKGLAE 118
Cdd:cd18242  88 TVENVQELLPAACLLQLKGVKQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  22 SFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHP----IIILKDVSYIHLQAILEFMYAGEVNVS 97
Cdd:cd18245   4 ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQIKLS 83

                        90
                ....*....|....
gi 24654834  98 QEQLPAFLKTADRL 111
Cdd:cd18245  84 EDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  17 TNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHpIIILKDVSYIHLQAILEFMYAGEVNV 96
Cdd:cd18260   3 ANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ-RVELNDISPLGLATVITYAYTGKLTL 81

                        90       100
                ....*....|....*....|
gi 24654834  97 SQEQLPAFLKTADRLKVKGL 116
Cdd:cd18260  82 SLYTIGSTISAASYLQIHAL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  21 TSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQ 98
Cdd:cd18238   4 KVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKQDSITIKDIDEEAVELLVDFAYTGKLTLTV 83

                        90       100
                ....*....|....*....|
gi 24654834  99 EQLPAFLKTADRLKVKGLAE 118
Cdd:cd18238  84 DNVQSLLYAASLLQVEEVAK 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  26 LRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALL--EENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPA 103
Cdd:cd18339  15 LRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFtgDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQV 94

                        90
                ....*....|
gi 24654834 104 FLKTADRLKV 113
Cdd:cd18339  95 LLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654834  31 SFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHpIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTA 108
Cdd:cd18226  21 SFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD-AVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  17 TNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALL--EENPSKHPIIILKDVSYIHLQAILEFMYAGEV 94
Cdd:cd18253   3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFcnDHRESREMLVEINGILAEAMDCFLQYVYTGKV 82

                        90       100
                ....*....|....*....|....
gi 24654834  95 NVSQEQLPAFLKTADRLKVKGLAE 118
Cdd:cd18253  83 KITTENVQYLFETSSLFQISPLRD 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  23 FRHLRDEKSFTDVTLACEGQTC-KAHKMVLSACSPYFKALLeenpSKHPIIIL-KDVSYIHLQAILEFMYAGEVNVSQEQ 100
Cdd:cd18299   3 LRNLLHSPSCADVVFILQGGVRiFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                        90
                ....*....|....*...
gi 24654834 101 LPAFLKTADRLKVKGLAE 118
Cdd:cd18299  79 LKELKDAAELLELFDLVM 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  14 DFQTNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEE--NPSKHPIIILKDVSYIHLQAILEFMYA 91
Cdd:cd18270   8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSglSESKQTHVHLRNVDAATLQIIITYAYT 87

                        90       100
                ....*....|....*....|...
gi 24654834  92 GEVNVSQEQLPAFLKTADRLKVK 114
Cdd:cd18270  88 GNLAINDSTVEQLYETACFLQVE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  22 SFRHLRDEKSFTDVTLAC-EGQTCKAHKMVLSACSPYFKALLEENPSK--HPIIILKDVSYIHLQAILEFMYAGEVNVSQ 98
Cdd:cd18252  11 AFRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFKVMFTADMKEksNNVIKLSGIDHDILEALVNYVYTSQICITE 90

                        90
                ....*....|....
gi 24654834  99 EQLPAFLKTADRLK 112
Cdd:cd18252  91 RNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  19 MVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEVNV 96
Cdd:cd18259  19 ILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvESISARVEIKDVDPAVMESLIDFAYTGKLTI 98

                        90
                ....*....|....*
gi 24654834  97 SQEQLPAFLKTADRL 111
Cdd:cd18259  99 NQGNVEALIRTSNRL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  17 TNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENpSKHPIIILKDVSYIH---LQAILEFMYAGE 93
Cdd:cd18332   4 SDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR-VGEGVSVLTLPSGLEargFQLLLDFMYTSR 82

                        90       100
                ....*....|....*....|....*.
gi 24654834  94 VNVSQEQLPAFLKTADRLKVKGLAET 119
Cdd:cd18332  83 LPLTPRTVPAVLAAATYLQMEHVVET 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  19 MVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALL-EENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVS 97
Cdd:cd18212  10 VLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFaDEGEVGQSIYMLEGMVAETFGALLEFIYTGCLQVG 89

                        90
                ....*....|....*....
gi 24654834  98 QEQLPAFLKTADRLKVKGL 116
Cdd:cd18212  90 EKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654834  27 RDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENpSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQ 100
Cdd:cd18221  13 RELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDF-TQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEE 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654834  23 FRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQ 98
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmvESKQDEITMQGIEPSALEALINFAYSGRIAIDT 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  25 HLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEV----NVSQ 98
Cdd:cd18345  11 LLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEmeERKQNRVEITDVDHEVMREMLRFIYTGKApnldKMAD 90

                        90
                ....*....|....*.
gi 24654834  99 EQLPAFLKTA-DRLKV 113
Cdd:cd18345  91 DLLAAADKYAlERLKV 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  30 KSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENPSKHPI--IILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKT 107
Cdd:cd18314   4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLML 83

                        90
                ....*....|..
gi 24654834 108 ADRLKVKGLAET 119
Cdd:cd18314  84 ASKYQVPDLEKL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  13 NDFQTNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYF--KALLEENPSKHPIIilkdVSYIHLQAILEFMY 90
Cdd:cd18208   6 HNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFqdKLLLGYSDIEIPSV----VSVQSVQKLIDFMY 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 24654834  91 AGEVNVSQEQLPAFLKTADRLKVKGLAETPSSI 123
Cdd:cd18208  82 SGVLRVSQSEALQILTAASILQIKTVIDECTRI 114

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  33 TDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFL-KTAD 109
Cdd:cd18286  18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSwaESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDVNLGELlSLAD 97

                        90
                ....*....|....*...
gi 24654834 110 RLKVKGLAE-TPSSIKRE 126
Cdd:cd18286  98 MYGLDGLKDvVAYTLRRD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  28 DEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEEN--PSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFL 105
Cdd:cd18272  28 EDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNlkEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETY 107

                        90
                ....*....|....*.
gi 24654834 106 KTADRLKVKGLAETPS 121
Cdd:cd18272 108 EVADMYQLTALFEECS 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  14 DFQTNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENP--SKHPIIILKDVSYIHLQAILEFMYA 91
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAvvDQQNVYEIDFVSPEALTALLEFAYT 86

                        90       100
                ....*....|....*....|..
gi 24654834  92 GEVNVSQEQLPAFLKTADRLKV 113
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834   6 QQFFLKWNDFQTNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLEENpSKHPIIILKDVSYIHLQAI 85
Cdd:cd18289   3 QMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-SKSAFELPATVPPACFQQI 81

                        90       100       110
                ....*....|....*....|....*....|...
gi 24654834  86 LEFMYAGEVNVSQEQLPAFLKTADRLKVKGLAE 118
Cdd:cd18289  82 LSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  26 LRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKALLE---ENPSKHPIIILkDVSYIHLQAILEFMYAGEVNVSQEQLP 102
Cdd:cd18279  12 LWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEhemEESKKNRVEIN-DVDPEVFKEMMRFIYTGKAPNLDKMAD 90

                        90
                ....*....|....*.
gi 24654834 103 AFLKTAD-----RLKV 113
Cdd:cd18279  91 DLLAAADkyaleRLKV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654834  26 LRDEKSfTDVTLACEGQTCKAHKMVLSACSPYFKALL-----EENPSKhpiIILKDVSYIHLQAILEFMYAGEVNVSQEQ 100
Cdd:cd18280   9 LESEEG-ADVTFNVDGEKFRAHKLVLAARSPVFRSMLfgpmrEENEGE---IVIEDVEPPVFKALLHFIYKDELPDDVEP 84