lethal (2) k01209, isoform C [Drosophila melanogaster]
uridine kinase family protein( domain architecture ID 10113994)
uridine kinase family protein similar to human uridine-cytidine kinase-like 1 (UCKL1), which may contribute to UTP accumulation needed for blast transformation and proliferation
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
UMPK | cd02023 | Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ... |
188-387 | 3.08e-104 | ||||
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine. : Pssm-ID: 238981 [Multi-domain] Cd Length: 198 Bit Score: 313.72 E-value: 3.08e-104
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UPRTase | pfam14681 | Uracil phosphoribosyltransferase; This family includes the enzyme uracil ... |
417-620 | 2.27e-103 | ||||
Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis. : Pssm-ID: 434124 Cd Length: 204 Bit Score: 311.73 E-value: 2.27e-103
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Name | Accession | Description | Interval | E-value | ||||
UMPK | cd02023 | Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ... |
188-387 | 3.08e-104 | ||||
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine. Pssm-ID: 238981 [Multi-domain] Cd Length: 198 Bit Score: 313.72 E-value: 3.08e-104
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UPRTase | pfam14681 | Uracil phosphoribosyltransferase; This family includes the enzyme uracil ... |
417-620 | 2.27e-103 | ||||
Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis. Pssm-ID: 434124 Cd Length: 204 Bit Score: 311.73 E-value: 2.27e-103
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PRK05480 | PRK05480 | uridine/cytidine kinase; Provisional |
186-389 | 1.84e-82 | ||||
uridine/cytidine kinase; Provisional Pssm-ID: 235492 [Multi-domain] Cd Length: 209 Bit Score: 258.17 E-value: 1.84e-82
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Udk | COG0572 | Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ... |
185-384 | 8.23e-79 | ||||
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage Pssm-ID: 440337 [Multi-domain] Cd Length: 206 Bit Score: 248.22 E-value: 8.23e-79
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udk | TIGR00235 | uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ... |
186-389 | 6.81e-76 | ||||
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides] Pssm-ID: 272977 Cd Length: 207 Bit Score: 240.75 E-value: 6.81e-76
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PRK | pfam00485 | Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ... |
188-376 | 7.09e-62 | ||||
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain. Pssm-ID: 425711 [Multi-domain] Cd Length: 196 Bit Score: 203.78 E-value: 7.09e-62
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Upp | COG0035 | Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ... |
408-620 | 2.16e-49 | ||||
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage Pssm-ID: 439805 Cd Length: 209 Bit Score: 170.63 E-value: 2.16e-49
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upp | TIGR01091 | uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ... |
419-621 | 2.25e-38 | ||||
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides] Pssm-ID: 273438 Cd Length: 207 Bit Score: 140.84 E-value: 2.25e-38
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upp | PRK00129 | uracil phosphoribosyltransferase; Reviewed |
426-620 | 1.20e-32 | ||||
uracil phosphoribosyltransferase; Reviewed Pssm-ID: 234653 Cd Length: 209 Bit Score: 124.82 E-value: 1.20e-32
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PRTases_typeI | cd06223 | Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
470-593 | 1.72e-10 | ||||
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22. Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 58.95 E-value: 1.72e-10
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Name | Accession | Description | Interval | E-value | |||||
UMPK | cd02023 | Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ... |
188-387 | 3.08e-104 | |||||
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine. Pssm-ID: 238981 [Multi-domain] Cd Length: 198 Bit Score: 313.72 E-value: 3.08e-104
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UPRTase | pfam14681 | Uracil phosphoribosyltransferase; This family includes the enzyme uracil ... |
417-620 | 2.27e-103 | |||||
Uracil phosphoribosyltransferase; This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis. Pssm-ID: 434124 Cd Length: 204 Bit Score: 311.73 E-value: 2.27e-103
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PRK05480 | PRK05480 | uridine/cytidine kinase; Provisional |
186-389 | 1.84e-82 | |||||
uridine/cytidine kinase; Provisional Pssm-ID: 235492 [Multi-domain] Cd Length: 209 Bit Score: 258.17 E-value: 1.84e-82
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Udk | COG0572 | Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ... |
185-384 | 8.23e-79 | |||||
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage Pssm-ID: 440337 [Multi-domain] Cd Length: 206 Bit Score: 248.22 E-value: 8.23e-79
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udk | TIGR00235 | uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ... |
186-389 | 6.81e-76 | |||||
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides] Pssm-ID: 272977 Cd Length: 207 Bit Score: 240.75 E-value: 6.81e-76
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PRK | pfam00485 | Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ... |
188-376 | 7.09e-62 | |||||
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain. Pssm-ID: 425711 [Multi-domain] Cd Length: 196 Bit Score: 203.78 E-value: 7.09e-62
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Upp | COG0035 | Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil ... |
408-620 | 2.16e-49 | |||||
Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage Pssm-ID: 439805 Cd Length: 209 Bit Score: 170.63 E-value: 2.16e-49
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upp | TIGR01091 | uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees ... |
419-621 | 2.25e-38 | |||||
uracil phosphoribosyltransferase; A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides] Pssm-ID: 273438 Cd Length: 207 Bit Score: 140.84 E-value: 2.25e-38
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PTZ00301 | PTZ00301 | uridine kinase; Provisional |
188-377 | 1.63e-35 | |||||
uridine kinase; Provisional Pssm-ID: 140322 [Multi-domain] Cd Length: 210 Bit Score: 132.82 E-value: 1.63e-35
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upp | PRK00129 | uracil phosphoribosyltransferase; Reviewed |
426-620 | 1.20e-32 | |||||
uracil phosphoribosyltransferase; Reviewed Pssm-ID: 234653 Cd Length: 209 Bit Score: 124.82 E-value: 1.20e-32
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UMPK_like | cd02028 | Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ... |
188-367 | 1.64e-24 | |||||
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK). Pssm-ID: 238986 [Multi-domain] Cd Length: 179 Bit Score: 100.84 E-value: 1.64e-24
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PRK | cd02026 | Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ... |
188-367 | 6.74e-24 | |||||
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis. Pssm-ID: 238984 [Multi-domain] Cd Length: 273 Bit Score: 101.65 E-value: 6.74e-24
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PRK07429 | PRK07429 | phosphoribulokinase; Provisional |
186-401 | 2.05e-20 | |||||
phosphoribulokinase; Provisional Pssm-ID: 180975 Cd Length: 327 Bit Score: 92.76 E-value: 2.05e-20
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PLN02348 | PLN02348 | phosphoribulokinase |
143-367 | 3.90e-18 | |||||
phosphoribulokinase Pssm-ID: 215198 Cd Length: 395 Bit Score: 86.82 E-value: 3.90e-18
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PLN02318 | PLN02318 | phosphoribulokinase/uridine kinase |
188-365 | 2.30e-17 | |||||
phosphoribulokinase/uridine kinase Pssm-ID: 177952 [Multi-domain] Cd Length: 656 Bit Score: 86.07 E-value: 2.30e-17
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PLN02541 | PLN02541 | uracil phosphoribosyltransferase |
417-621 | 3.36e-17 | |||||
uracil phosphoribosyltransferase Pssm-ID: 215297 Cd Length: 244 Bit Score: 81.37 E-value: 3.36e-17
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CoaA | COG1072 | Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ... |
186-375 | 3.51e-16 | |||||
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis Pssm-ID: 440690 Cd Length: 309 Bit Score: 79.56 E-value: 3.51e-16
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PRK08233 | PRK08233 | hypothetical protein; Provisional |
186-393 | 7.27e-14 | |||||
hypothetical protein; Provisional Pssm-ID: 181310 [Multi-domain] Cd Length: 182 Bit Score: 70.16 E-value: 7.27e-14
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PanK | cd02025 | Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ... |
188-375 | 5.37e-12 | |||||
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis. Pssm-ID: 238983 Cd Length: 220 Bit Score: 65.80 E-value: 5.37e-12
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NRK1 | cd02024 | Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ... |
188-325 | 6.25e-11 | |||||
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside. Pssm-ID: 238982 [Multi-domain] Cd Length: 187 Bit Score: 61.96 E-value: 6.25e-11
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PRTases_typeI | cd06223 | Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
470-593 | 1.72e-10 | |||||
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22. Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 58.95 E-value: 1.72e-10
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PRK09270 | PRK09270 | nucleoside triphosphate hydrolase domain-containing protein; Reviewed |
187-368 | 9.03e-10 | |||||
nucleoside triphosphate hydrolase domain-containing protein; Reviewed Pssm-ID: 236442 Cd Length: 229 Bit Score: 59.18 E-value: 9.03e-10
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PRK06696 | PRK06696 | uridine kinase; Validated |
186-367 | 9.61e-09 | |||||
uridine kinase; Validated Pssm-ID: 180660 Cd Length: 223 Bit Score: 56.14 E-value: 9.61e-09
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AAA_17 | pfam13207 | AAA domain; |
193-336 | 2.60e-06 | |||||
AAA domain; Pssm-ID: 463810 [Multi-domain] Cd Length: 136 Bit Score: 47.23 E-value: 2.60e-06
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PRK07667 | PRK07667 | uridine kinase; Provisional |
187-326 | 1.33e-04 | |||||
uridine kinase; Provisional Pssm-ID: 169051 Cd Length: 193 Bit Score: 43.18 E-value: 1.33e-04
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PLN03046 | PLN03046 | D-glycerate 3-kinase; Provisional |
181-360 | 5.19e-04 | |||||
D-glycerate 3-kinase; Provisional Pssm-ID: 178608 Cd Length: 460 Bit Score: 42.98 E-value: 5.19e-04
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CoaE | COG0237 | Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the ... |
186-215 | 7.76e-03 | |||||
Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis Pssm-ID: 440007 Cd Length: 193 Bit Score: 38.12 E-value: 7.76e-03
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Blast search parameters | ||||
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