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Conserved domains on  [gi|24652669|ref|NP_725020|]
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F-box and leucine-rich repeat protein 6, isoform C [Drosophila melanogaster]

Protein Classification

F-box/LRR-repeat protein( domain architecture ID 17778532)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|3.80.10.10
Gene Ontology:  GO:0005515|GO:0016567|GO:0019005|GO:0006511|GO:0031146|GO:0000209
PubMed:  11751054|31898225|11178263|14747988|10581972|7583641
SCOP:  4001927|4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 291-336 9.48e-19

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438891  Cd Length: 47  Bit Score: 79.99  E-value: 9.48e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 291 QKLPEEVLFRIFEHAVDTQGCLPTLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22119   2 QRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47
PLN03237 super family cl33668
DNA topoisomerase 2; Provisional
 3-254 1.75e-07

DNA topoisomerase 2; Provisional


The actual alignment was detected with superfamily member PLN03237:

Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 54.87  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669     3 ESLSSQVEETKvSDDDGVKEKAEVSTAKDSAETAMEVEADDtggqqpEQSELLDKEKSATVDIntlTPSTPSQTPPQLLA 82
Cdd:PLN03237 1222 ETYGSSAMETE-NVAEVVKPKGRAGAKKKAPAAAKEKEEED------EILDLKDRLAAYNLDS---APAQSAKMEETVKA 1291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    83 VETATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDGQRSPAADQQSSAPPPqvqAQATPAPVNgSVPKSGKPL 162
Cdd:PLN03237 1292 VPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLKKKGGRKPAAANKKAAKPP---AAAKKRGPA-TVQSGQKLL 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   163 STALsgkKTSKAATTSPRaSRCRKTKALPMYESEISDNKMGIRLCIKKSDAGEGAPAGVTSPPVAVPAATKTVRKRVRKP 242
Cdd:PLN03237 1368 TEML---KPAEAIGISPE-KKVRKMRASPFNKKSGSVLGRAATNKETESSENVSGSSSSEKDEIDVSAKPRPQRANRKQT 1443

                         250
                  ....*....|..
gi 24652669   243 KQQDSDEAEYEP 254
Cdd:PLN03237 1444 TYVLSDSESESA 1455
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
366-521 1.57e-06

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 366 TDLNVSNWKISDINCFLAKLssgcPNLAGITLSGwkgftsDHLTYL---VDNMHKLQRLDLSSinvemNAsksavgVNSL 442
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNL----TNLKELDLSN------NQITDLpepLGNLTNLEELDLSG-----NQ------LTDL 220

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24652669 443 CNALQTMgSRLTHLYLAHNRLAGIPQIvgilsTHCPNLTLLDLSNvtTQATShgvlhIEKLQrGCQKLKVLRVTNSHIT 521
Cdd:COG4886 221 PEPLANL-TNLETLDLSNNQLTDLPEL-----GNLTNLEELDLSN--NQLTD-----LPPLA-NLTNLKTLDLSNNQLT 285
 
Name Accession Description Interval E-value
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 291-336 9.48e-19

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 79.99  E-value: 9.48e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 291 QKLPEEVLFRIFEHAVDTQGCLPTLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22119   2 QRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 293-339 2.50e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 50.17  E-value: 2.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 24652669   293 LPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWRTMD 339
Cdd:pfam12937   4 LPDEILLQIFSY-------LDPkdLLRLALVCRRWRELASDDSLWRRLC 45
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 3-254 1.75e-07

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 54.87  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669     3 ESLSSQVEETKvSDDDGVKEKAEVSTAKDSAETAMEVEADDtggqqpEQSELLDKEKSATVDIntlTPSTPSQTPPQLLA 82
Cdd:PLN03237 1222 ETYGSSAMETE-NVAEVVKPKGRAGAKKKAPAAAKEKEEED------EILDLKDRLAAYNLDS---APAQSAKMEETVKA 1291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    83 VETATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDGQRSPAADQQSSAPPPqvqAQATPAPVNgSVPKSGKPL 162
Cdd:PLN03237 1292 VPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLKKKGGRKPAAANKKAAKPP---AAAKKRGPA-TVQSGQKLL 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   163 STALsgkKTSKAATTSPRaSRCRKTKALPMYESEISDNKMGIRLCIKKSDAGEGAPAGVTSPPVAVPAATKTVRKRVRKP 242
Cdd:PLN03237 1368 TEML---KPAEAIGISPE-KKVRKMRASPFNKKSGSVLGRAATNKETESSENVSGSSSSEKDEIDVSAKPRPQRANRKQT 1443

                         250
                  ....*....|..
gi 24652669   243 KQQDSDEAEYEP 254
Cdd:PLN03237 1444 TYVLSDSESESA 1455
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-521 1.57e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 366 TDLNVSNWKISDINCFLAKLssgcPNLAGITLSGwkgftsDHLTYL---VDNMHKLQRLDLSSinvemNAsksavgVNSL 442
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNL----TNLKELDLSN------NQITDLpepLGNLTNLEELDLSG-----NQ------LTDL 220

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24652669 443 CNALQTMgSRLTHLYLAHNRLAGIPQIvgilsTHCPNLTLLDLSNvtTQATShgvlhIEKLQrGCQKLKVLRVTNSHIT 521
Cdd:COG4886 221 PEPLANL-TNLETLDLSNNQLTDLPEL-----GNLTNLEELDLSN--NQLTD-----LPPLA-NLTNLKTLDLSNNQLT 285
Orthopox_A5L pfam06193
Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The ...
 24-155 2.45e-04

Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion.


Pssm-ID: 283778 [Multi-domain]  Cd Length: 216  Bit Score: 43.05  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    24 AEVSTAKDSAETAMEVEADdTGGQQPE-------------QSELLDKEKSATVDINTLTPSTPSQTPPQLLAVETATSGS 90
Cdd:pfam06193  12 AEDATAKNSAYYSEEDDLD-ILGKKDEageigfesqerqyQQQLIEQLAKDNMLAASRQPIQPLQPTIHITPIEIPTPAP 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24652669    91 TavipenilspPKSETQtdETNTATsTSCSPASDGQRSPAADQQSSAPPPQVQAQATPAPVNGSV 155
Cdd:pfam06193  91 T----------PKPRQQ--ELGTPS-TSCTQNSDASIACSTDIVTPPQPPIVATVCTPTPTDGRI 142
FBOX smart00256
A Receptor for Ubiquitination Targets;
293-338 8.17e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 8.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 24652669    293 LPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWRTM 338
Cdd:smart00256   1 LPDEILEEILSK-------LDPkdLLRLRKVSRKWRSLIDSHDFWFKL 41
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 98-166 1.18e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 41.80  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24652669    98 ILSPPKSETQTDETNTATSTSC---------SPASDGQRSPAADQQSSAPPPQVQAQATPAPVNGSVPKSGKPLSTAL 166
Cdd:TIGR00601  73 MVSKPKTGTGKVAPPAATPTSAptptpsppaSPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTL 150
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 452-487 2.40e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 24652669   452 RLTHLYLAHNRLAGIPQIVGilsthCPNLTLLDLSN 487
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAK-----LPNLETLDLSG 32
 
Name Accession Description Interval E-value
F-box_FBXL6 cd22119
F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also ...
 291-336 9.48e-19

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438891  Cd Length: 47  Bit Score: 79.99  E-value: 9.48e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 291 QKLPEEVLFRIFEHAVDTQGCLPTLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22119   2 QRLPPEILVKIFQFAVATEGAVPLLCRLSRVCRLWREVALDPSLWT 47
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 293-339 2.50e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 50.17  E-value: 2.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 24652669   293 LPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWRTMD 339
Cdd:pfam12937   4 LPDEILLQIFSY-------LDPkdLLRLALVCRRWRELASDDSLWRRLC 45
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 3-254 1.75e-07

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 54.87  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669     3 ESLSSQVEETKvSDDDGVKEKAEVSTAKDSAETAMEVEADDtggqqpEQSELLDKEKSATVDIntlTPSTPSQTPPQLLA 82
Cdd:PLN03237 1222 ETYGSSAMETE-NVAEVVKPKGRAGAKKKAPAAAKEKEEED------EILDLKDRLAAYNLDS---APAQSAKMEETVKA 1291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    83 VETATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDGQRSPAADQQSSAPPPqvqAQATPAPVNgSVPKSGKPL 162
Cdd:PLN03237 1292 VPARRAAARKKPLASVSVISDSDDDDDDFAVEVSLAERLKKKGGRKPAAANKKAAKPP---AAAKKRGPA-TVQSGQKLL 1367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   163 STALsgkKTSKAATTSPRaSRCRKTKALPMYESEISDNKMGIRLCIKKSDAGEGAPAGVTSPPVAVPAATKTVRKRVRKP 242
Cdd:PLN03237 1368 TEML---KPAEAIGISPE-KKVRKMRASPFNKKSGSVLGRAATNKETESSENVSGSSSSEKDEIDVSAKPRPQRANRKQT 1443

                         250
                  ....*....|..
gi 24652669   243 KQQDSDEAEYEP 254
Cdd:PLN03237 1444 TYVLSDSESESA 1455
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-521 1.57e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 366 TDLNVSNWKISDINCFLAKLssgcPNLAGITLSGwkgftsDHLTYL---VDNMHKLQRLDLSSinvemNAsksavgVNSL 442
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNL----TNLKELDLSN------NQITDLpepLGNLTNLEELDLSG-----NQ------LTDL 220

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24652669 443 CNALQTMgSRLTHLYLAHNRLAGIPQIvgilsTHCPNLTLLDLSNvtTQATShgvlhIEKLQrGCQKLKVLRVTNSHIT 521
Cdd:COG4886 221 PEPLANL-TNLETLDLSNNQLTDLPEL-----GNLTNLEELDLSN--NQLTD-----LPPLA-NLTNLKTLDLSNNQLT 285
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
28-206 2.24e-05

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 47.43  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   28 TAKDSAETAMEVEADDTGGQQPEQSELLDKEKSATVDINTLTPSTPSQ--------TPPQLLAVETATSGSTAVIPENIL 99
Cdd:PRK13335  17 TTGAITVTTQSVKAEKIQSTKVDKVPTLKAERLAMINITAGANSATTQaantrqerTPKLEKAPNTNEEKTSASKIEKIS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669  100 SPPKSETQtdetntaTSTSCSPASDGQRSPAADQQSSAPPPQVqaqATPAPVNGSVPKSGKPLSTALSgkKTSKAATT-- 177
Cdd:PRK13335  97 QPKQEEQK-------SLNISATPAPKQEQSQTTTESTTPKTKV---TTPPSTNTPQPMQSTKSDTPQS--PTIKQAQTdm 164

                        170       180
                 ....*....|....*....|....*....
gi 24652669  178 SPRASRCRKTKALPMYESEisdNKMGIRL 206
Cdd:PRK13335 165 TPKYEDLRAYYTKPSFEFE---KQFGFLL 190
PRK13914 PRK13914
invasion associated endopeptidase;
5-179 7.36e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 45.95  E-value: 7.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    5 LSSQVEETKVSDDDGVKEKAEVSTAKDSAETAMEVEadDTGGQQPEQSELLDKEKSATVDINTLTPSTPSQTPPQLLAVE 84
Cdd:PRK13914 139 LTDKVTSTPVAPTQEVKKETTTQQAAPAAETKTEVK--QTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVK 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   85 TATS-----------GSTAVIPENIL-------SPPKSETQTD----ETNTA----TSTSCSPASDGQRSPAADQQSSAP 138
Cdd:PRK13914 217 YGVSvqdimswnnlsSSSIYVGQKLAikqtantATPKAEVKTEapaaEKQAApvvkENTNTNTATTEKKETTTQQQTAPK 296

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 24652669  139 PPQVQAQATPAPvngsVPKSGKPLSTALSGKKTSKAATTSP 179
Cdd:PRK13914 297 APTEAAKPAPAP----STNTNANKTNTNTNTNTNNTNTSTP 333
PRK10856 PRK10856
cytoskeleton protein RodZ;
74-176 1.00e-04

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 45.02  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   74 SQTPPQLLAVETATSGSTAVIPENILSPPKSETQTDETNTATSTScspasdgqrsPAADQQSSAPPPQVQAQATPA---- 149
Cdd:PRK10856 155 SQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPA----------PAVDPQQNAVVAPSQANVDTAatpa 224

                         90       100
                 ....*....|....*....|....*..
gi 24652669  150 PVNGSVPKSGKPLSTALSGKKTSKAAT 176
Cdd:PRK10856 225 PAAPATPDGAAPLPTDQAGVSTPAADP 251
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
366-671 1.01e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 366 TDLNVSNWKISDINCFLAKLSSGCPNLAGITLSGWKGFTSDHLTYLVdnmhKLQRLDLSSINVEMNASKsavgvnslcna 445
Cdd:COG4886  50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT----NLTELDLSGNEELSNLTN----------- 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 446 lqtmgsrLTHLYLAHNRLAGIPQIVGilstHCPNLTLLDLSNvtTQATShgvlhIEKLQRGCQKLKVLRVTNSHIT--PS 523
Cdd:COG4886 115 -------LESLDLSGNQLTDLPEELA----NLTNLKELDLSN--NQLTD-----LPEPLGNLTNLKSLDLSNNQLTdlPE 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669 524 TASmqeimdspGFPELEELSVA--ALTDESRIISD-DHLQRIlksssklkllDVRNcTRLTH--ESLIRLPAwdIKHLFL 598
Cdd:COG4886 177 ELG--------NLTNLKELDLSnnQITDLPEPLGNlTNLEEL----------DLSG-NQLTDlpEPLANLTN--LETLDL 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24652669 599 SGCSVTRdmgsgLELIASkwAHSLIELDLAwanmqqpiDNALRALAEKGRDSPLAHLNLCGSSVSDEAVKEIL 671
Cdd:COG4886 236 SNNQLTD-----LPELGN--LTNLEELDLS--------NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 293-336 1.24e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 40.03  E-value: 1.24e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 293 LPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22123   4 LPENVLLEILSY-------LPVrdLLRISRVCKRWRRLVYDKTLWR 42
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 289-339 1.90e-04

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 39.51  E-value: 1.90e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24652669 289 WaQKLPEEVLFRIFE--HAVDTqgclptLFRLGRVCSLWRQVSLRPTLWRTMD 339
Cdd:cd22164   2 W-LDLPDDLTASILSrlGAIDI------LTNAQKVCKLWRRICKDPSMWRVID 47
Orthopox_A5L pfam06193
Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The ...
 24-155 2.45e-04

Orthopoxvirus A5L protein-like; This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion.


Pssm-ID: 283778 [Multi-domain]  Cd Length: 216  Bit Score: 43.05  E-value: 2.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    24 AEVSTAKDSAETAMEVEADdTGGQQPE-------------QSELLDKEKSATVDINTLTPSTPSQTPPQLLAVETATSGS 90
Cdd:pfam06193  12 AEDATAKNSAYYSEEDDLD-ILGKKDEageigfesqerqyQQQLIEQLAKDNMLAASRQPIQPLQPTIHITPIEIPTPAP 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24652669    91 TavipenilspPKSETQtdETNTATsTSCSPASDGQRSPAADQQSSAPPPQVQAQATPAPVNGSV 155
Cdd:pfam06193  91 T----------PKPRQQ--ELGTPS-TSCTQNSDASIACSTDIVTPPQPPIVATVCTPTPTDGRI 142
F-box_unchar cd22138
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 ...
 291-339 4.99e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 13 (FBXO13); The family corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 13 (FBXO13). FBXO13, also called FBX13, or F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438910  Cd Length: 45  Bit Score: 38.08  E-value: 4.99e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 24652669 291 QKLPEEVLFRIFEHAVDTQGCLPTlfrlgRVCSLWRQVSLRPTLWRTMD 339
Cdd:cd22138   2 QSLPVECQLKIFSFLSEVDKCLAA-----TVCRSWSELIRSPRLWRTVD 45
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 293-341 5.06e-04

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 38.55  E-value: 5.06e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 24652669 293 LPEEVLFRIFEHAVDTQGCLptlfRLGRVCSLWRQVSLRPTLWRTMDLT 341
Cdd:cd22092   5 LPDSILLKIFSYLSLQERCL----SASLVCKYWRDLCLDSQFWKQIDLS 49
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 293-338 5.17e-04

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 38.13  E-value: 5.17e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 293 LPEEVLFRIFEHAVDTQGClptlfRLGRVCSLWRQVSLRPTLWRTM 338
Cdd:cd22120   4 LPDDVILQIFSHLPTNQLC-----RCARVCRRWYNLAWDPRLWTTI 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 292-329 6.47e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 37.81  E-value: 6.47e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24652669 292 KLPEEVLFRIFEHaVDtqgcLPTLFRLGRVCSLWRQVS 329
Cdd:cd09917   2 DLPDEILLKILSY-LD----PRDLLRLSLVCKRWRELA 34
FBOX smart00256
A Receptor for Ubiquitination Targets;
293-338 8.17e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 8.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 24652669    293 LPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWRTM 338
Cdd:smart00256   1 LPDEILEEILSK-------LDPkdLLRLRKVSRKWRSLIDSHDFWFKL 41
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 63-179 9.06e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 42.74  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   63 VDINTLTPSTPSQTPPQLLAVETATSGSTAVIpenilsPPKSETQTDETNTATSTSCSPASDGQRSPAADQQSSAP---- 138
Cdd:PRK14959 366 MPVESLRPSGGGASAPSGSAAEGPASGGAATI------PTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRVPwdda 439

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 24652669  139 ---PPQVQAQATPAP-VNGSVPKSGKPLSTA-LSGKKTSKAATTSP 179
Cdd:PRK14959 440 ppaPPRSGIPPRPAPrMPEASPVPGAPDSVAsASDAPPTLGDPSDT 485
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 292-336 1.10e-03

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 37.59  E-value: 1.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 24652669 292 KLPEEVLFRIFEHAVDTQGcLPTLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22089   5 ALPSEILLYILRWVVSDLD-LRSLEQLSLVCRKFYLLARDPSIWR 48
PRK10856 PRK10856
cytoskeleton protein RodZ;
46-139 1.13e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 41.94  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   46 GQQPEQSELLDKEKSATVDINTLTPSTPSQTPPQLLAVETATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDG 125
Cdd:PRK10856 155 SQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGA 234

                         90
                 ....*....|....
gi 24652669  126 QRSPAADQQSSAPP 139
Cdd:PRK10856 235 APLPTDQAGVSTPA 248
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 98-166 1.18e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 41.80  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24652669    98 ILSPPKSETQTDETNTATSTSC---------SPASDGQRSPAADQQSSAPPPQVQAQATPAPVNGSVPKSGKPLSTAL 166
Cdd:TIGR00601  73 MVSKPKTGTGKVAPPAATPTSAptptpsppaSPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSSGSDAASTL 150
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 292-337 1.28e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24652669   292 KLPEEVLFRIFEHavdtqgcLPT--LFRLGRVCSLWRQVSLRPTLWRT 337
Cdd:pfam00646   3 DLPDDLLLEILSR-------LDPkdLLRLSLVSKRWRSLVDSLKLWKK 43
PRK12495 PRK12495
hypothetical protein; Provisional
 41-183 1.44e-03

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 41.01  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   41 ADDTGGQQPEQSELLDKEKSATVDINTlTPSTPSQTPPQLLAVETATSGSTaviPENILSPPksETQTDETNTATSTSCS 120
Cdd:PRK12495  74 AGDDAGDGAEATAPSDAGSQASPDDDA-QPAAEAEAADQSAPPEASSTSAT---DEAATDPP--ATAAARDGPTPDPTAQ 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24652669  121 PASDGQRSPAaDQQSSAPPPQVQAQATPAPVNGSVPKSGKPLSTALSGKKTSKAATTSPRASR 183
Cdd:PRK12495 148 PATPDERRSP-RQRPPVSGEPPTPSTPDAHVAGTLQAARESLVETLARFARRAAATDDPRRAR 209
PHA03247 PHA03247
large tegument protein UL36; Provisional
 70-294 1.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    70 PSTPSQTPPQLLAveTATSGSTAVIPENILSPPKSETQTDETNTATSTSCSPASDGQRSPAAdQQSSAPPPQVQAQATPA 149
Cdd:PHA03247 2676 ASSPPQRPRRRAA--RPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL-PAAPAPPAVPAGPATPG 2752

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   150 PVN--GSVP-KSGKPLSTALSGKKTS--KAATTSPRASRCRKTKALPMyESEISDNKMGIRLCIKKSDAGEGAPAGVTSP 224
Cdd:PHA03247 2753 GPArpARPPtTAGPPAPAPPAAPAAGppRRLTRPAVASLSESRESLPS-PWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   225 PVAVPAATKTVRKRVRKPKQQDSDEAEYEPRKKKGGGGGSGGEKKVSTSPDAAEAAGDPVEQSVWAQKLP 294
Cdd:PHA03247 2832 TSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALP 2901
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 291-340 1.51e-03

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 36.83  E-value: 1.51e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 24652669 291 QKLPEEVLFRIFEHaVDtqgcLPTLFRLGRVCSLWRQVSLRPTLWRTMDL 340
Cdd:cd22117   2 DLLPYELIQLILSY-LD----LPSLCRLSQTCKLFRKHCYDPLLWKELNL 46
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 293-336 1.92e-03

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 36.81  E-value: 1.92e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24652669 293 LPEEVLFRIFEHaVDTQgclpTLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd20090   5 LPDDLLFLIFSY-LDPA----SLGRLSQVCRRLYRLISRDAVWR 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 452-487 2.40e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 24652669   452 RLTHLYLAHNRLAGIPQIVGilsthCPNLTLLDLSN 487
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAK-----LPNLETLDLSG 32
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
18-173 3.64e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 40.30  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    18 DGVKEKAEVSTAKDSAETAmEVEA-DDTGGQQPEQSELLDKEKSATVDINTLTPSTPSQTPPQLLAVETATSGSTAVIPE 96
Cdd:pfam16014  18 EGAKPKPDIHVAVAPPVTV-AVEAlPGQNSEQQTASASPPSQHPAQAIPTILAPAAPPSQPSVVLSTLPAAMAVTPPIPA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    97 ---NILSPPKSETQTDETNTATSTSCSPASDGQRSPAADQQSSAPPPQVQAQATPAPVNGS--VPKSGKPLSTALSGKKT 171
Cdd:pfam16014  97 smaNVVAPPTQPAASSTAACAVSSVLPEIKIKQEAEPMDTSQSVPPLTPTSISPALTSLANnlSVPAGDLLPGASPRKKP 176


                  ..
gi 24652669   172 SK 173
Cdd:pfam16014 177 RK 178
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 291-338 3.67e-03

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 35.86  E-value: 3.67e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 24652669 291 QKLPEEVLFRIFEHAVDTQGClptlfRLGRVCSLWRQVSLRPTLWRTM 338
Cdd:cd22091   2 EELPDEVLLKIFSYLLEQDLC-----RAAQVCKRFNTLANDPELWKRL 44
PRK08581 PRK08581
amidase domain-containing protein;
2-182 3.89e-03

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 40.54  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    2 SESLSSQVEETKVSDDDGVKEKAEVSTAKDSAETAMEVEADDTggqqpeqsELLDKEKSATVDINTLTPST----PSQTP 77
Cdd:PRK08581  33 DSTAKTTSHDSKKSNDDETSKDTSSKDTDKADNNNTSNQDNND--------KKFSTIDSSTSDSNNIIDFIyknlPQTNI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669   78 PQLLAVETA-TSGSTAVIPENILS-----------------PPKSETQTDETNTA-TSTSCSPASDGQRSPAADQQSSAP 138
Cdd:PRK08581 105 NQLLTKNKYdDNYSLTTLIQNLFNlnsdisdyeqprnseksTNDSNKNSDSSIKNdTDTQSSKQDKADNQKAPSSNNTKP 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 24652669  139 PPQVQAQATPAPVNGSVPKSgKPLSTALSGKKTSKAATTSPRAS 182
Cdd:PRK08581 185 STSNKQPNSPKPTQPNQSNS-QPASDDTANQKSSSKDNQSMSDS 227
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 291-338 4.68e-03

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 35.71  E-value: 4.68e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24652669 291 QKLPEEVLFRIFehavdtqGCLPT--LFR-LGRVCSLWRQVSLRPT--LWRTM 338
Cdd:cd22095   3 QQLPEELLRNIF-------AFLPAedLYQnISLVCRHWRDIVSDPLfiPWKKL 48
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 293-336 5.56e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 5.56e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24652669 293 LPEEVLFRIFEH--AVDtqgclptLFRLGRVCSLWRQVSLRPTLWR 336
Cdd:cd22132   4 LPDSLLLHIFSYlsPKD-------LLAAGQVCKQWYRVSRDEFLWK 42
F-box_ScDIA2-like cd22142
F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and ...
 292-340 6.72e-03

F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; ScDIA2 is a replication origin-binding protein that plays a role in regulating DNA replication. It is a component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438914  Cd Length: 48  Bit Score: 35.14  E-value: 6.72e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 24652669 292 KLPEEVLFRIFEhavdtQGCLPTLFRLGRVCSLWRQVSL-RPTLWRTMDL 340
Cdd:cd22142   4 NLPLDILPLIFQ-----KFSTKELITLSHVCSSWRAKILdFPHLWKTVEL 48
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 15-225 7.59e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    15 SDDDGVKEKAEVSTAKDSAETAMEVEaDDTGGQQPEQSELLDKEKSATVDIN--TLTPSTPSQTPPQLLAVETATSGSTA 92
Cdd:PHA03307  227 SAADDAGASSSDSSSSESSGCGWGPE-NECPLPRPAPITLPTRIWEASGWNGpsSRPGPASSSSSPRERSPSPSPSSPGS 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669    93 VIPENILSPPKSETQTDETNTATSTSCSPASDGQR-SPAADQQSSAPPpqvqaQATPAPVNGSVPKSGKPLSTALSGKKT 171
Cdd:PHA03307  306 GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAvSPGPSPSRSPSP-----SRPPPPADPSSPRKRPRPSRAPSSPAA 380

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24652669   172 SKAATTSPRASRCRKTKALPMYESEISDnkmGIRLCIKKSDAGEGAPAGVTSPP 225
Cdd:PHA03307  381 SAGRPTRRRARAAVAGRARRRDATGRFP---AGRPRPSPLDAGAASGAFYARYP 431
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
 298-335 7.74e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 35.01  E-value: 7.74e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24652669 298 LFRIFEHAVDtqgcLPTLFRLGRVCSLWRQVSLRPTLW 335
Cdd:cd22163   9 LMHIFSFLTP----LPDRFNAARVCKRWRALALDPRSW 42
motB PRK12799
flagellar motor protein MotB; Reviewed
 107-231 8.96e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 39.31  E-value: 8.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24652669  107 QTDETNTATSTSCSPASdgqrspAADQQSSAPPPQvqAQATPAPVNGSVPKSGKPLSTALSGKKTSKAATTSPRASRCRK 186
Cdd:PRK12799 291 KQIDTHGTVPVAAVTPS------SAVTQSSAITPS--SAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPG 362

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 24652669  187 TKALPMYESEISDNKMGIRLCIKKSDAGEGAPaGVTSPPVAVPAA 231
Cdd:PRK12799 363 TVALPAAEPVNMQPQPMSTTETQQSSTGNITS-TANGPTTSLPAA 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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