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Conserved domains on  [gi|62484369|ref|NP_724098|]
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uncharacterized protein Dmel_CG17681 [Drosophila melanogaster]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10552919)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to the C-terminal region of the D. melanogaster hypothetical protein FR47

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
SCOP:  3000403

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
189-277 2.99e-33

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


:

Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 117.05  E-value: 2.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369   189 NVGLYEKELGSLCAWCLRLQSGFLGALEVLPTHQRRGLGLVVAAAISKAIATdLQQDITALVNINNSAACRVFEKLNFRL 268
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAE-RGITPFAVVVAGNTPSRRLYEKLGFRK 79

                  ....*....
gi 62484369   269 IqdEHYYWS 277
Cdd:pfam08445  80 I--DETYWV 86
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
189-277 2.99e-33

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 117.05  E-value: 2.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369   189 NVGLYEKELGSLCAWCLRLQSGFLGALEVLPTHQRRGLGLVVAAAISKAIATdLQQDITALVNINNSAACRVFEKLNFRL 268
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAE-RGITPFAVVVAGNTPSRRLYEKLGFRK 79

                  ....*....
gi 62484369   269 IqdEHYYWS 277
Cdd:pfam08445  80 I--DETYWV 86
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
210-276 2.35e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.03  E-value: 2.35e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484369 210 GFLGALEVLPTHQRRGLG-LVVAAAISKAIATDLQQdITALVNINNSAACRVFEKLNFRLIQDEHYYW 276
Cdd:COG0456  14 AEIEDLAVDPEYRGRGIGrALLEAALERARERGARR-LRLEVREDNEAAIALYEKLGFEEVGERPNYY 80
PRK10562 PRK10562
putative acetyltransferase; Provisional
193-292 1.09e-03

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 38.51  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369  193 YEKElGSLCAWCLRLQSGFLGALEVLPTHQRRGLGlvvaaaisKAIATDLQQDITAL---VNINNSAACRVFEKLNFRLI 269
Cdd:PRK10562  53 WEED-GKLLGFVSVLEGRFVGALFVAPKAVRRGIG--------KALMQHVQQRYPHLsleVYQKNQRAVNFYHAQGFRIV 123
                         90       100
                 ....*....|....*....|....*....
gi 62484369  270 ----QDE--HYYWSMikpaaggqiSWPCD 292
Cdd:PRK10562 124 dsawQEEtqHPTWIM---------SWQAD 143
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
189-277 2.99e-33

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 117.05  E-value: 2.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369   189 NVGLYEKELGSLCAWCLRLQSGFLGALEVLPTHQRRGLGLVVAAAISKAIATdLQQDITALVNINNSAACRVFEKLNFRL 268
Cdd:pfam08445   1 VLGIYRGDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAE-RGITPFAVVVAGNTPSRRLYEKLGFRK 79

                  ....*....
gi 62484369   269 IqdEHYYWS 277
Cdd:pfam08445  80 I--DETYWV 86
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
210-276 2.35e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.03  E-value: 2.35e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484369 210 GFLGALEVLPTHQRRGLG-LVVAAAISKAIATDLQQdITALVNINNSAACRVFEKLNFRLIQDEHYYW 276
Cdd:COG0456  14 AEIEDLAVDPEYRGRGIGrALLEAALERARERGARR-LRLEVREDNEAAIALYEKLGFEEVGERPNYY 80
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
210-275 5.78e-05

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 41.05  E-value: 5.78e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62484369 210 GFLGALEVLPTHQRRGLGLVVAAAISKAIATDLQQDITALVNINNSAACRVFEKLNFRLIQDEHYY 275
Cdd:COG3393  16 AEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATV 81
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
210-266 2.12e-04

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 40.19  E-value: 2.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 62484369   210 GFLGALEVLPTHQRRGLG-LVVAAAISKAIATDLQQdITALVNINNSAACRVFEKLNF 266
Cdd:pfam00583  60 GEIEGLAVAPEYRGKGIGtALLQALLEWARERGCER-IFLEVAADNLAAIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
154-278 5.23e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 39.27  E-value: 5.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369 154 LDKVRLEHADLINDL--WSARhpgsLKLIQMLITYNTNVGLYEKE--LGSLCAWCLRLQSGFLGALEVLPTHQRRGLG-L 228
Cdd:COG0454   3 IRKATPEDINFILLIeaLDAE----LKAMEGSLAGAEFIAVDDKGepIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGkA 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62484369 229 VVAAAISKAIATDLQQdITALVNINNSAACRVFEKLNFRLIQDEHYYWSM 278
Cdd:COG0454  79 LLEALLEWARERGCTA-LELDTLDGNPAAIRFYERLGFKEIERYVAYVGG 127
PRK10562 PRK10562
putative acetyltransferase; Provisional
193-292 1.09e-03

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 38.51  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369  193 YEKElGSLCAWCLRLQSGFLGALEVLPTHQRRGLGlvvaaaisKAIATDLQQDITAL---VNINNSAACRVFEKLNFRLI 269
Cdd:PRK10562  53 WEED-GKLLGFVSVLEGRFVGALFVAPKAVRRGIG--------KALMQHVQQRYPHLsleVYQKNQRAVNFYHAQGFRIV 123
                         90       100
                 ....*....|....*....|....*....
gi 62484369  270 ----QDE--HYYWSMikpaaggqiSWPCD 292
Cdd:PRK10562 124 dsawQEEtqHPTWIM---------SWQAD 143
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
217-269 3.56e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 37.28  E-value: 3.56e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 62484369 217 VLPTHQRRGLG-LVVAAAISKAIATDLQQdITALVNINNSAACRVFEKLNFRLI 269
Cdd:COG1247  88 VDPDARGRGIGrALLEALIERARARGYRR-LVAVVLADNEASIALYEKLGFEEV 140
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
197-274 5.41e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 36.60  E-value: 5.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484369 197 LGSLCAWCLRLQS----GFLGALEVLPTHQRRGLG-LVVAAAISKAIAtdlqQDITALVNINNSAACRVFEKLNFRLIQD 271
Cdd:COG3153  51 VGHVALSPVDIDGegpaLLLGPLAVDPEYRGQGIGrALMRAALEAARE----RGARAVVLLGDPSLLPFYERFGFRPAGE 126

                ...
gi 62484369 272 EHY 274
Cdd:COG3153 127 LGL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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