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Conserved domains on  [gi|24584867|ref|NP_724068|]
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Cadherin-N, isoform H [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2380-2565 1.20e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.30  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2380 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdetliSDFIALELERGYPRLLIDFGSGTLELR 2458
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2459 VKTkkTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEmedgtppefddmscqargqiPPFNEYLNVNAPLQVGGLYREQ 2538
Cdd:cd00110   73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                        170       180
                 ....*....|....*....|....*..
gi 24584867 2539 FDQSLyfwhymPTAKGFDGCIRNLVHN 2565
Cdd:cd00110  131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3023-3082 1.93e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 1.93e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   3023 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3082
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 973-1074 2.81e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  973 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1052
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 24584867 1053 QGDPSLEGVCSFTVEITDVNDN 1074
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1866-1961 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1866 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1944
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24584867 1945 KTATATLTVIVQDINDN 1961
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1083-1175 5.60e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 5.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1083 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1159
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                         90
                 ....*....|....*.
gi 24584867 1160 YPPLSRTVEVQIDVVD 1175
Cdd:cd11304   79 GPPLSSTATVTITVLD 94
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2632-2792 3.30e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2632 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNAI 2711
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2712 V-VNDGQWHVVKVNRYGSAATLELDGGegrRYNETFEFVGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2790
Cdd:cd00110   75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                 ..
gi 24584867 2791 RL 2792
Cdd:cd00110  149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1419-1509 7.22e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1419 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1494
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                         90
                 ....*....|....*.
gi 24584867 1495 -ENQTTIVINVRDVND 1509
Cdd:cd11304   82 lSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1633-1736 1.11e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1633 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1712
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*.
gi 24584867 1713 VVAMDGGG--LKGTGTASIRVKDIND 1736
Cdd:cd11304   72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 765-853 6.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 6.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  765 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 839
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....
gi 24584867  840 GVATVRVYTKNKND 853
Cdd:cd11304   84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1518-1625 1.25e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1518 SYERTLDEgmtNTP--FTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQW 1595
Cdd:cd11304    1 SYEVSVPE---NAPpgTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24584867 1596 RFTVFAQDEGGEGLVGYADVQVNLKDINDN 1625
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1306-1410 1.43e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1306 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1385
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                         90       100
                 ....*....|....*....|....*
gi 24584867 1386 arpnsNGPNSVTKFIRIGIADKNDN 1410
Cdd:cd11304   79 -----GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 655-752 9.92e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  655 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 731
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                         90       100
                 ....*....|....*....|...
gi 24584867  732 DSGG--FSTSVDLTIRVTDVNDN 752
Cdd:cd11304   76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 862-964 7.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  862 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHNkaiSLD---KDKYELNVTAMD 935
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAK---PLDreeQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*....
gi 24584867  936 DGSccvngdqTIHTSTAVVVVFITDVNDN 964
Cdd:cd11304   77 GGG-------PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1191-1294 1.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1191 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1269
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*
gi 24584867 1270 RVENNGAQQLASEATVYIMLEDVND 1294
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-301 1.28e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  178 SGEVRENQPAGTRVrgvPLMQAFsgsilDEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingDDESGVw 257
Cdd:cd11304    3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 24584867  258 LVTNRPLDREERAHYDLSVEASDVDGLDRTVS-KIQITVLDENDN 301
Cdd:cd11304   54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1969-2078 6.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1969 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2047
Cdd:cd11304    2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24584867 2048 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2078
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 549-625 2.15e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  549 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 622
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                 ...
gi 24584867  623 QNG 625
Cdd:cd11304   77 GGG 79
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2345-2375 5.24e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 56.62  E-value: 5.24e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24584867   2345 CRTTPCHNGGRCVDTRFGPHCSCPVGYTGPR 2375
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2864-2900 5.58e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 5.58e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 24584867 2864 NECLLF-PCRNGGRCRDHhpPKKYECHCPMGFTGMHCE 2900
Cdd:cd00054    3 DECASGnPCQNGGTCVNT--VGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1765-1858 3.87e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.87e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1765 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1844
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 24584867    1845 WVVVKLRDINDNKP 1858
Cdd:smart00112   68 TVTITVLDVNDNAP 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2600-2626 2.27e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.27e-04
                           10        20
                   ....*....|....*....|....*..
gi 24584867   2600 CWEHGNCVGSlsEARCHCRPGWTGPAC 2626
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
EGF_CA smart00179
Calcium-binding EGF-like domain;
2821-2861 3.67e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.67e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24584867    2821 CPSNKPCSNVicpdpFECVDLWNVYECTCPAGYkSSGSTCV 2861
Cdd:smart00179    5 CASGNPCQNG-----GTCVNTVGSYRCECPPGY-TDGRNCE 39
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 449-541 4.21e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.21e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     449 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 528
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 24584867     529 VIILVKDVNDEPP 541
Cdd:smart00112   69 VTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2380-2565 1.20e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.30  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2380 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdetliSDFIALELERGYPRLLIDFGSGTLELR 2458
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2459 VKTkkTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEmedgtppefddmscqargqiPPFNEYLNVNAPLQVGGLYREQ 2538
Cdd:cd00110   73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                        170       180
                 ....*....|....*....|....*..
gi 24584867 2539 FDQSLyfwhymPTAKGFDGCIRNLVHN 2565
Cdd:cd00110  131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3023-3082 1.93e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 1.93e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   3023 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3082
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 973-1074 2.81e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  973 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1052
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 24584867 1053 QGDPSLEGVCSFTVEITDVNDN 1074
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1866-1961 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1866 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1944
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24584867 1945 KTATATLTVIVQDINDN 1961
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2401-2567 1.67e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 1.67e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2401 HLSLEFITRKPDGLIIYNGPIVPperdetliSDFIALELERGYPRLLIDFGSGTLELRVKTKKtLDDGEWHRIDLFWDTE 2480
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2481 SIRMVVDFCKSAEiaemedgtppefddmscqarGQIPPFNEYLNVNAPLQVGGLYREQFDQSLyfwhymPTAKGFDGCIR 2560
Cdd:smart00282   72 SVTLSVDGGNRVS--------------------GESPGGLTILNLDGPLYLGGLPEDLKLPPL------PVTPGFRGCIR 125


                    ....*..
gi 24584867    2561 NLVHNSK 2567
Cdd:smart00282  126 NLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2406-2567 8.09e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.59  E-value: 8.09e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2406 FITRKPDGLIIYNGPivpperdetLISDFIALELERGYPRLLIDFGSGTLELRVkTKKTLDDGEWHRIDLFWDTESIRMV 2485
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2486 VDFCKsaeiaemedgtppefddmscQARGQIPPFNEYLNVNAPLQVGGLyreqfdQSLYFWHYMPTAKGFDGCIRNLVHN 2565
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 24584867   2566 SK 2567
Cdd:pfam02210  125 GE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1083-1175 5.60e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 5.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1083 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1159
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                         90
                 ....*....|....*.
gi 24584867 1160 YPPLSRTVEVQIDVVD 1175
Cdd:cd11304   79 GPPLSSTATVTITVLD 94
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2632-2792 3.30e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2632 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNAI 2711
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2712 V-VNDGQWHVVKVNRYGSAATLELDGGegrRYNETFEFVGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2790
Cdd:cd00110   75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                 ..
gi 24584867 2791 RL 2792
Cdd:cd00110  149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1419-1509 7.22e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1419 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1494
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                         90
                 ....*....|....*.
gi 24584867 1495 -ENQTTIVINVRDVND 1509
Cdd:cd11304   82 lSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 992-1076 3.89e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.89e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     992 VATDEDKGVNGQVKYSIVQQPNqkGTKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPSLEGVCSFTVEITDV 1071
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 24584867    1072 NDNPP 1076
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1883-1963 8.39e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 8.39e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1883 KATDPDQGGKSKVSYSIDRSSDrQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDN 1961
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24584867    1962 AP 1963
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1633-1736 1.11e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1633 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1712
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*.
gi 24584867 1713 VVAMDGGG--LKGTGTASIRVKDIND 1736
Cdd:cd11304   72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 765-853 6.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 6.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  765 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 839
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....
gi 24584867  840 GVATVRVYTKNKND 853
Cdd:cd11304   84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1518-1625 1.25e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1518 SYERTLDEgmtNTP--FTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQW 1595
Cdd:cd11304    1 SYEVSVPE---NAPpgTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24584867 1596 RFTVFAQDEGGEGLVGYADVQVNLKDINDN 1625
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1306-1410 1.43e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1306 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1385
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                         90       100
                 ....*....|....*....|....*
gi 24584867 1386 arpnsNGPNSVTKFIRIGIADKNDN 1410
Cdd:cd11304   79 -----GPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2655-2795 3.52e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 3.52e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2655 QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrtEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLEL 2734
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584867    2735 DGGEgRRYNETFEfvGHQWLLVDkqEGVYAGGKAEyTGVRTFEVYADYQKSCLDDIRLEGK 2795
Cdd:smart00282   78 DGGN-RVSGESPG--GLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
978-1069 2.21e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 2.21e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    978 VEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPS 1057
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIDPDTGDISTTKPLDRE--SIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 24584867   1058 LEGVCSFTVEIT 1069
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 655-752 9.92e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  655 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 731
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                         90       100
                 ....*....|....*....|...
gi 24584867  732 DSGG--FSTSVDLTIRVTDVNDN 752
Cdd:cd11304   76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1083-1173 3.15e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1083 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRE---TYKLEAMAQDKG 1159
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDREsigEYELTVEATDSG 77

                           90
                   ....*....|....
gi 24584867   1160 YPPLSRTVEVQIDV 1173
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1419-1504 6.66e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 6.66e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1419 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLNEN 1496
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 24584867   1497 Q---TTIVINV 1504
Cdd:pfam00028   81 LsstATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 862-964 7.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  862 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHNkaiSLD---KDKYELNVTAMD 935
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAK---PLDreeQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*....
gi 24584867  936 DGSccvngdqTIHTSTAVVVVFITDVNDN 964
Cdd:cd11304   77 GGG-------PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1538-1627 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1538 TATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADVQV 1617
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 24584867    1618 NLKDINDNAP 1627
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1101-1181 1.02e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.02e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1101 SASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRET---YKLEAMAQDKGYPPLSRTVEVQIDVVDRA 1177
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEqpeYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 24584867    1178 NNPP 1181
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1866-1956 1.23e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1866 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIdRSSDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILAIDDGSPP 1944
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 24584867   1945 KTATATLTVIVQ 1956
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1191-1294 1.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1191 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1269
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*
gi 24584867 1270 RVENNGAQQLASEATVYIMLEDVND 1294
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2660-2795 3.77e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.85  E-value: 3.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2660 FRTREEYGELFrVSDQHNREYGILEIKDGHLHFRYNLNSLRTEekdLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEG 2739
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVNGRLVLRYDLGSGPES---LLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24584867   2740 RRYNETFEFvghqwLLVDKQEGVYAGGkAEYTGVRTFEVYADYQKSCLDDIRLEGK 2795
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1658-1739 6.83e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.83e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1658 DPNEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDIN 1735
Cdd:smart00112    4 DADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVN 77


                    ....
gi 24584867    1736 DMPP 1739
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1435-1512 1.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.11e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1435 TVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN---ENQTTIVINVRDVNDLP 1511
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNA 80


                    .
gi 24584867    1512 P 1512
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-301 1.28e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  178 SGEVRENQPAGTRVrgvPLMQAFsgsilDEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingDDESGVw 257
Cdd:cd11304    3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 24584867  258 LVTNRPLDREERAHYDLSVEASDVDGLDRTVS-KIQITVLDENDN 301
Cdd:cd11304   54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
766-846 1.56e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.56e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    766 VDEDIPLGTSILRVKAMDSDSGSNAEIEYLVS----DDHFAVD-SNGIIVNNKQLDADNNNaYYEFIVTAKDKGEPPKSG 840
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggpGGNFRIDpDTGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*.
gi 24584867    841 VATVRV 846
Cdd:pfam00028   84 TATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1969-2078 6.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1969 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2047
Cdd:cd11304    2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24584867 2048 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2078
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1321-1412 1.34e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.34e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1321 NAIDKDGTfPNNQVYYYIVDsprNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSarpnsngPNSVTKFI 1400
Cdd:smart00112    1 SATDADSG-ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-------PLSSTATV 69

                            90
                    ....*....|..
gi 24584867    1401 RIGIADKNDNPP 1412
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 780-856 1.68e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.68e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     780 KAMDSDSGSNAEIEYLVS----DDHFAVDSN-GIIVNNKQLDADNNnAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDE 854
Cdd:smart00112    1 SATDADSGENGKVTYSILsgndDGLFSIDPEtGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24584867     855 EP 856
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 206-303 1.89e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     206 DEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingDDESGvWLVTNRPLDREERAHYDLSVEASDVDGLD 285
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSI--------------------DPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP 62

                            90
                    ....*....|....*....
gi 24584867     286 R-TVSKIQITVLDENDNRP 303
Cdd:smart00112   63 LsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1306-1387 2.12e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1306 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPRNEgkeFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPS 1385
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 24584867   1386 AR 1387
Cdd:pfam00028   80 PL 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 549-625 2.15e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  549 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 622
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                 ...
gi 24584867  623 QNG 625
Cdd:cd11304   77 GGG 79
Cadherin pfam00028
Cadherin domain;
1634-1732 6.69e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1634 YFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIeknvIEEETGsPIFEIEPDTGVIKTAVCcLDRERTPDYSIQV 1713
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 24584867   1714 VAMDGGGLKGTGTASIRVK 1732
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 682-754 7.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 7.19e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24584867     682 EIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQphvYSLIVTATeDSGG--FSTSVDLTIRVTDVNDNAP 754
Cdd:smart00112   12 KVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPE---YTLTVEAT-DGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1519-1619 9.88e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 9.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1519 YERTLDEGMTNTPFtIMQVTATDgdKDRPQN--IVYFLTGQGIDPdnpansKFDINRTTGEIFVLKPLDRDQpngRPQWR 1596
Cdd:pfam00028    1 YSASVPENAPVGTE-VLTVTATD--PDLGPNgrIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYE 68

                           90       100
                   ....*....|....*....|...
gi 24584867   1597 FTVFAQDEGGEGLVGYADVQVNL 1619
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1190-1287 2.77e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1190 PIYVKENMPVGGKVVSIKASSGIEG-NPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLT 1268
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-----GPGGNFRID--PDTGD----ISTTKPLDRESIGEYELT 70

                           90
                   ....*....|....*....
gi 24584867   1269 IRVENNGAQQLASEATVYI 1287
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1987-2078 6.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1987 ATDDDDRSKSNgppFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTS 2066
Cdd:smart00112    2 ATDADSGENGK---VTYSILSGNDDGL---FSIDPE----TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 24584867    2067 TLTVIIGDVNDN 2078
Cdd:smart00112   68 TVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
557-626 3.26e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 3.26e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584867    557 NAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 626
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK----PLDREsigeYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 881-966 3.52e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 3.52e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     881 VASDKD-GDN--VRFGFVGGGTSsGQFVIEDITGVIRLhnkAISLD---KDKYELNVTAMDdgsccvnGDQTIHTSTAVV 954
Cdd:smart00112    1 SATDADsGENgkVTYSILSGNDD-GLFSIDPETGEITT---TKPLDreeQPEYTLTVEATD-------GGGPPLSSTATV 69

                            90
                    ....*....|..
gi 24584867     955 VVFITDVNDNKP 966
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1215-1297 4.36e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 4.36e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1215 NPTVFYRLMPGSTAQtnkfhtfYLQQRPDNGDtwadIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLEDVND 1294
Cdd:smart00112   10 NGKVTYSILSGNDDG-------LFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 24584867    1295 EIP 1297
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
178-296 3.01e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 3.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    178 SGEVRENQPAGTRVRGVplmqafsgSILDEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingdDESGVW 257
Cdd:pfam00028    2 SASVPENAPVGTEVLTV--------TATDPDLGPNGRIFYSILGGGPGGNFRI---------------------DPDTGD 52

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 24584867    258 LVTNRPLDREERAHYDLSVEASDVDGLDRT-VSKIQITVL 296
Cdd:pfam00028   53 ISTTKPLDRESIGEYELTVEATDSGGPPLSsTATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2345-2375 5.24e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 56.62  E-value: 5.24e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24584867   2345 CRTTPCHNGGRCVDTRFGPHCSCPVGYTGPR 2375
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2345-2377 1.48e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.34  E-value: 1.48e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24584867 2345 CRTT-PCHNGGRCVDTRFGPHCSCPVGYTGPRCQ 2377
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
863-959 4.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    863 YTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLhnkAISLD---KDKYELNVTAMDD 936
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNgrIFYSILGGG-PGGNFRIDPDTGDIST---TKPLDresIGEYELTVEATDS 76

                           90       100
                   ....*....|....*....|...
gi 24584867    937 GSccvngdqTIHTSTAVVVVFIT 959
Cdd:pfam00028   77 GG-------PPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2864-2900 5.58e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 5.58e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 24584867 2864 NECLLF-PCRNGGRCRDHhpPKKYECHCPMGFTGMHCE 2900
Cdd:cd00054    3 DECASGnPCQNGGTCVNT--VGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
656-747 1.97e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    656 YEAEIPENQKKDSDIISIKAKSfADRE----IRYTLKAQGQGaGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 731
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGpngrIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRE---SIGEYELTVEAT- 74

                           90
                   ....*....|....*...
gi 24584867    732 DSGGF--STSVDLTIRVT 747
Cdd:pfam00028   75 DSGGPplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1765-1858 3.87e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.87e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1765 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1844
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 24584867    1845 WVVVKLRDINDNKP 1858
Cdd:smart00112   68 TVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
2864-2900 6.61e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 6.61e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 24584867    2864 NECLLF-PCRNGGRCRDHhpPKKYECHCPMGFT-GMHCE 2900
Cdd:smart00179    3 DECASGnPCQNGGTCVNT--VGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1973-2072 1.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1973 LPEHVPP-RKVVEILATDDDDrsKSNGPPFQFRLDPSADDIirasFKVEQDqkgaNGDgmavISSLRSFDREQQKEYMIP 2051
Cdd:pfam00028    5 VPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN----FRIDPD----TGD----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|.
gi 24584867   2052 IVIKDHGSPAMTGTSTLTVII 2072
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITV 91
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2866-2896 4.30e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 4.30e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24584867   2866 CLLFPCRNGGRCRDhhPPKKYECHCPMGFTG 2896
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
2349-2377 1.16e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 1.16e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 24584867    2349 PCHNGGRCVDTRFGPHCSCPVGYT-GPRCQ 2377
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 568-626 5.35e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.57  E-value: 5.35e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24584867     568 QARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 626
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTK----PLDREeqpeYTLTVEATDGGGP 61
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2600-2626 2.27e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.27e-04
                           10        20
                   ....*....|....*....|....*..
gi 24584867   2600 CWEHGNCVGSlsEARCHCRPGWTGPAC 2626
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
EGF_CA smart00179
Calcium-binding EGF-like domain;
2821-2861 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.67e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24584867    2821 CPSNKPCSNVicpdpFECVDLWNVYECTCPAGYkSSGSTCV 2861
Cdd:smart00179    5 CASGNPCQNG-----GTCVNTVGSYRCECPPGY-TDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 449-541 4.21e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.21e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     449 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 528
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 24584867     529 VIILVKDVNDEPP 541
Cdd:smart00112   69 VTITVLDVNDNAP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2821-2861 9.00e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 9.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24584867 2821 CPSNKPCSNvicpdPFECVDLWNVYECTCPAGYKSSGsTCV 2861
Cdd:cd00053    2 CAASNPCSN-----GGTCVNTPGSYRCVCPPGYTGDR-SCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2821-2854 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24584867   2821 CPSNkPCSNVIcpdpfECVDLWNVYECTCPAGYK 2854
Cdd:pfam00008    1 CAPN-PCSNGG-----TCVDTPGGYTCICPEGYT 28
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 445-538 5.61e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.83  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  445 RIEFTEADGDTEGKSVFQLEKETDKETFKIRddnpwvtvETNGAVRVKKKWDYEELgpeKTIDFWVIITNMGHNAgikYT 524
Cdd:cd11304   18 TVSATDPDSGENGEVTYSIVSGNEDGLFSID--------PSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LS 83

                         90
                 ....*....|....
gi 24584867  525 DNQRVIILVKDVND 538
Cdd:cd11304   84 STATVTITVLDVND 97
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2380-2565 1.20e-33

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 128.30  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2380 TRSFRGNGWAWYPPLEM-CDESHLSLEFITRKPDGLIIYNGPIVPperdetliSDFIALELERGYPRLLIDFGSGTLELR 2458
Cdd:cd00110    1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2459 VKTkkTLDDGEWHRIDLFWDTESIRMVVDFCKSAEIAEmedgtppefddmscqargqiPPFNEYLNVNAPLQVGGLYREQ 2538
Cdd:cd00110   73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGERVVESGS--------------------PGGSALLNLDGPLYLGGLPEDL 130

                        170       180
                 ....*....|....*....|....*..
gi 24584867 2539 FDQSLyfwhymPTAKGFDGCIRNLVHN 2565
Cdd:cd00110  131 KSPGL------PVSPGFVGCIRDLKVN 151
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 3023-3082 1.93e-32

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 1.93e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   3023 ADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGPRFDKLANMYG 3082
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 973-1074 2.81e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 2.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  973 TYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATD 1052
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 24584867 1053 QGDPSLEGVCSFTVEITDVNDN 1074
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1866-1961 1.09e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 1.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1866 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDrSSDRQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPP 1944
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 24584867 1945 KTATATLTVIVQDINDN 1961
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2401-2567 1.67e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.82  E-value: 1.67e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2401 HLSLEFITRKPDGLIIYNGPIVPperdetliSDFIALELERGYPRLLIDFGSGTLELRVKTKKtLDDGEWHRIDLFWDTE 2480
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2481 SIRMVVDFCKSAEiaemedgtppefddmscqarGQIPPFNEYLNVNAPLQVGGLYREQFDQSLyfwhymPTAKGFDGCIR 2560
Cdd:smart00282   72 SVTLSVDGGNRVS--------------------GESPGGLTILNLDGPLYLGGLPEDLKLPPL------PVTPGFRGCIR 125


                    ....*..
gi 24584867    2561 NLVHNSK 2567
Cdd:smart00282  126 NLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2406-2567 8.09e-28

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 110.59  E-value: 8.09e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2406 FITRKPDGLIIYNGPivpperdetLISDFIALELERGYPRLLIDFGSGTLELRVkTKKTLDDGEWHRIDLFWDTESIRMV 2485
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2486 VDFCKsaeiaemedgtppefddmscQARGQIPPFNEYLNVNAPLQVGGLyreqfdQSLYFWHYMPTAKGFDGCIRNLVHN 2565
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 24584867   2566 SK 2567
Cdd:pfam02210  125 GE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1083-1175 5.60e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 5.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1083 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRET---YKLEAMAQDKG 1159
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEqssYTLTVTATDGG 78

                         90
                 ....*....|....*.
gi 24584867 1160 YPPLSRTVEVQIDVVD 1175
Cdd:cd11304   79 GPPLSSTATVTITVLD 94
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2632-2792 3.30e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 104.04  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2632 PTTFKAQSYVKYALSFEPdRFSTQVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrteeKDLWLNAI 2711
Cdd:cd00110    1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS-----GSLVLSSK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 2712 V-VNDGQWHVVKVNRYGSAATLELDGGegrRYNETFEFVGHQWLlvDKQEGVYAGGKAEYTGVRtFEVYADYQKSCLDDI 2790
Cdd:cd00110   75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSP-GLPVSPGFVGCIRDL 148


                 ..
gi 24584867 2791 RL 2792
Cdd:cd00110  149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1419-1509 7.22e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 7.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1419 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN-- 1494
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                         90
                 ....*....|....*.
gi 24584867 1495 -ENQTTIVINVRDVND 1509
Cdd:cd11304   82 lSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 992-1076 3.89e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 3.89e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     992 VATDEDKGVNGQVKYSIVQQPNqkGTKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPSLEGVCSFTVEITDV 1071
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 24584867    1072 NDNPP 1076
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1883-1963 8.39e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 8.39e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1883 KATDPDQGGKSKVSYSIDRSSDrQRQFAINQN-GSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDN 1961
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24584867    1962 AP 1963
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1633-1736 1.11e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1633 VYFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQ 1712
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*.
gi 24584867 1713 VVAMDGGG--LKGTGTASIRVKDIND 1736
Cdd:cd11304   72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 765-853 6.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 6.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  765 NVDEDIPLGTSILRVKAMDSDSGSNAEIEY-LVSDD---HFAVDSN-GIIVNNKQLDADnNNAYYEFIVTAKDKGEPPKS 839
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNedgLFSIDPStGEITTAKPLDRE-EQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....
gi 24584867  840 GVATVRVYTKNKND 853
Cdd:cd11304   84 STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1518-1625 1.25e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1518 SYERTLDEgmtNTP--FTIMQVTATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQW 1595
Cdd:cd11304    1 SYEVSVPE---NAPpgTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSY 68

                         90       100       110
                 ....*....|....*....|....*....|
gi 24584867 1596 RFTVFAQDEGGEGLVGYADVQVNLKDINDN 1625
Cdd:cd11304   69 TLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1306-1410 1.43e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1306 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPrneGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAps 1385
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                         90       100
                 ....*....|....*....|....*
gi 24584867 1386 arpnsNGPNSVTKFIRIGIADKNDN 1410
Cdd:cd11304   79 -----GPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
2655-2795 3.52e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 3.52e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    2655 QVQLRFRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNLNSlrtEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLEL 2734
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584867    2735 DGGEgRRYNETFEfvGHQWLLVDkqEGVYAGGKAEyTGVRTFEVYADYQKSCLDDIRLEGK 2795
Cdd:smart00282   78 DGGN-RVSGESPG--GLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
978-1069 2.21e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 2.21e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    978 VEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKgtKFTVDEETGEVSTNKVFDREgdDGKFVSVTVKATDQGDPS 1057
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIDPDTGDISTTKPLDRE--SIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 24584867   1058 LEGVCSFTVEIT 1069
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 655-752 9.92e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 9.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  655 SYEAEIPENQKKDSDIISIKAK---SFADREIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 731
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSI-VSGNEDGLFSIDPSTGEITTAKPLDRE---EQSSYTLTVTAT- 75

                         90       100
                 ....*....|....*....|...
gi 24584867  732 DSGG--FSTSVDLTIRVTDVNDN 752
Cdd:cd11304   76 DGGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1083-1173 3.15e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 3.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1083 YVENVKQDASIGTNILRVSASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRE---TYKLEAMAQDKG 1159
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDREsigEYELTVEATDSG 77

                           90
                   ....*....|....
gi 24584867   1160 YPPLSRTVEVQIDV 1173
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1419-1504 6.66e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 6.66e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1419 YEAEVDENEDIQHTVLTVTAKDHDES--SRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLNEN 1496
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 24584867   1497 Q---TTIVINV 1504
Cdd:pfam00028   81 LsstATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 862-964 7.43e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 7.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  862 VYTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLHNkaiSLD---KDKYELNVTAMD 935
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDsGENgeVTYSIVSGN-EDGLFSIDPSTGEITTAK---PLDreeQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*....
gi 24584867  936 DGSccvngdqTIHTSTAVVVVFITDVNDN 964
Cdd:cd11304   77 GGG-------PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1538-1627 1.01e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.01e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1538 TATDGDKDRPQNIVYFLTGqgidpdNPANSKFDINRTTGEIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADVQV 1617
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 24584867    1618 NLKDINDNAP 1627
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1101-1181 1.02e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 1.02e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1101 SASDEDADNNGAIVYSLTapfNPNDLEYFEIQAESGWIVLKKPLDRET---YKLEAMAQDKGYPPLSRTVEVQIDVVDRA 1177
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEqpeYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 24584867    1178 NNPP 1181
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
1866-1956 1.23e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1866 EVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIdRSSDRQRQFAINQ-NGSVTIQRSLDREVVPRHQVKILAIDDGSPP 1944
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGGNFRIDPdTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 24584867   1945 KTATATLTVIVQ 1956
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1191-1294 1.97e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1191 IYVKENMPVGGKVVSIKASSG-IEGNPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLTI 1269
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSG-----NEDGLFSID--PSTGE----ITTAKPLDREEQSSYTLTV 72

                         90       100
                 ....*....|....*....|....*
gi 24584867 1270 RVENNGAQQLASEATVYIMLEDVND 1294
Cdd:cd11304   73 TATDGGGPPLSSTATVTITVLDVND 97
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2660-2795 3.77e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.85  E-value: 3.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2660 FRTREEYGELFrVSDQHNREYGILEIKDGHLHFRYNLNSLRTEekdLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEG 2739
Cdd:pfam02210    1 FRTRQPNGLLL-YAGGGGSDFLALELVNGRLVLRYDLGSGPES---LLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24584867   2740 RRYNETFEFvghqwLLVDKQEGVYAGGkAEYTGVRTFEVYADYQKSCLDDIRLEGK 2795
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1658-1739 6.83e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 6.83e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1658 DPNEGSNARLVYSIEknvieEETGSPIFEIEPDTGVIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDIN 1735
Cdd:smart00112    4 DADSGENGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVN 77


                    ....
gi 24584867    1736 DMPP 1739
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1435-1512 1.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.11e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1435 TVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRRRYELKLVASDSLN---ENQTTIVINVRDVNDLP 1511
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNA 80


                    .
gi 24584867    1512 P 1512
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 178-301 1.28e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  178 SGEVRENQPAGTRVrgvPLMQAFsgsilDEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingDDESGVw 257
Cdd:cd11304    3 EVSVPENAPPGTVV---LTVSAT-----DPDSGENGEVTYSIVSGNEDGLFSI--------------------DPSTGE- 53

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 24584867  258 LVTNRPLDREERAHYDLSVEASDVDGLDRTVS-KIQITVLDENDN 301
Cdd:cd11304   54 ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTaTVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
766-846 1.56e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 1.56e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    766 VDEDIPLGTSILRVKAMDSDSGSNAEIEYLVS----DDHFAVD-SNGIIVNNKQLDADNNNaYYEFIVTAKDKGEPPKSG 840
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggpGGNFRIDpDTGDISTTKPLDRESIG-EYELTVEATDSGGPPLSS 83


                   ....*.
gi 24584867    841 VATVRV 846
Cdd:pfam00028   84 TATVTI 89
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1969-2078 6.38e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 6.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867 1969 YRPVLPEHVPP-RKVVEILATDDDdrSKSNGPpFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKE 2047
Cdd:cd11304    2 YEVSVPENAPPgTVVLTVSATDPD--SGENGE-VTYSIVSGNEDGL---FSIDPS----TG----EITTAKPLDREEQSS 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24584867 2048 YMIPIVIKDHGSPAMTGTSTLTVIIGDVNDN 2078
Cdd:cd11304   68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1321-1412 1.34e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 1.34e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1321 NAIDKDGTfPNNQVYYYIVDsprNEGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSarpnsngPNSVTKFI 1400
Cdd:smart00112    1 SATDADSG-ENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-------PLSSTATV 69

                            90
                    ....*....|..
gi 24584867    1401 RIGIADKNDNPP 1412
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 780-856 1.68e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.68e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     780 KAMDSDSGSNAEIEYLVS----DDHFAVDSN-GIIVNNKQLDADNNnAYYEFIVTAKDKGEPPKSGVATVRVYTKNKNDE 854
Cdd:smart00112    1 SATDADSGENGKVTYSILsgndDGLFSIDPEtGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 24584867     855 EP 856
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 206-303 1.89e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 1.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     206 DEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingDDESGvWLVTNRPLDREERAHYDLSVEASDVDGLD 285
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSI--------------------DPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP 62

                            90
                    ....*....|....*....
gi 24584867     286 R-TVSKIQITVLDENDNRP 303
Cdd:smart00112   63 LsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1306-1387 2.12e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 2.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1306 TVLEGEPIGTKVTQVNAIDKDGTfPNNQVYYYIVDSPRNEgkeFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPS 1385
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 24584867   1386 AR 1387
Cdd:pfam00028   80 PL 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 549-625 2.15e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.19  E-value: 2.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  549 PMQAVVQLNAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGTdlfqLDME----YVLYVKAED 622
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP----LDREeqssYTLTVTATD 76


                 ...
gi 24584867  623 QNG 625
Cdd:cd11304   77 GGG 79
Cadherin pfam00028
Cadherin domain;
1634-1732 6.69e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 6.69e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1634 YFGNVTENGTAGMVVMTMTAVDYDdpnEGSNARLVYSIeknvIEEETGsPIFEIEPDTGVIKTAVCcLDRERTPDYSIQV 1713
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD---LGPNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 24584867   1714 VAMDGGGLKGTGTASIRVK 1732
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 682-754 7.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 7.19e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24584867     682 EIRYTLkAQGQGAGTFNIGPTSGIVKLAKELDFEDLRQphvYSLIVTATeDSGG--FSTSVDLTIRVTDVNDNAP 754
Cdd:smart00112   12 KVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPE---YTLTVEAT-DGGGppLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1519-1619 9.88e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 9.88e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1519 YERTLDEGMTNTPFtIMQVTATDgdKDRPQN--IVYFLTGQGIDPdnpansKFDINRTTGEIFVLKPLDRDQpngRPQWR 1596
Cdd:pfam00028    1 YSASVPENAPVGTE-VLTVTATD--PDLGPNgrIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYE 68

                           90       100
                   ....*....|....*....|...
gi 24584867   1597 FTVFAQDEGGEGLVGYADVQVNL 1619
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITV 91
Laminin_G_1 pfam00054
Laminin G domain;
2406-2570 4.85e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 68.50  E-value: 4.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2406 FITRKPDGLIIYNGPIVPPerdetlisDFIALELERGYPRLLIDFGSGTLELRVKTKktLDDGEWHRIDLFWDTESIRMV 2485
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--------DFLALELRDGRLEVSYDLGSGAAVVRSGDK--LNDGKWHSVELERNGRSGTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2486 VDFCksaeiaEMEDGTPPefddmscqargqiPPFNEYLNVNAPLQVGGLYREQFDQSLyfwhyMPTAKGFDGCIRNLVHN 2565
Cdd:pfam00054   71 VDGE------ARPTGESP-------------LGATTDLDVDGPLYVGGLPSLGVKKRR-----LAISPSFDGCIRDVIVN 126


                   ....*
gi 24584867   2566 SKLYD 2570
Cdd:pfam00054  127 GKPLD 131
Cadherin pfam00028
Cadherin domain;
1190-1287 2.77e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.01  E-value: 2.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1190 PIYVKENMPVGGKVVSIKASSGIEG-NPTVFYRLMPGstaqtNKFHTFYLQqrPDNGDtwadIKVNHPLDYESIKEYNLT 1268
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGpNGRIFYSILGG-----GPGGNFRID--PDTGD----ISTTKPLDRESIGEYELT 70

                           90
                   ....*....|....*....
gi 24584867   1269 IRVENNGAQQLASEATVYI 1287
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1987-2078 6.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 6.14e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1987 ATDDDDRSKSNgppFQFRLDPSADDIIrasFKVEQDqkgaNGdgmaVISSLRSFDREQQKEYMIPIVIKDHGSPAMTGTS 2066
Cdd:smart00112    2 ATDADSGENGK---VTYSILSGNDDGL---FSIDPE----TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 24584867    2067 TLTVIIGDVNDN 2078
Cdd:smart00112   68 TVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
557-626 3.26e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 3.26e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584867    557 NAPPNTPVFTLQARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 626
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK----PLDREsigeYELTVEATDSGGP 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 881-966 3.52e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 3.52e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     881 VASDKD-GDN--VRFGFVGGGTSsGQFVIEDITGVIRLhnkAISLD---KDKYELNVTAMDdgsccvnGDQTIHTSTAVV 954
Cdd:smart00112    1 SATDADsGENgkVTYSILSGNDD-GLFSIDPETGEITT---TKPLDreeQPEYTLTVEATD-------GGGPPLSSTATV 69

                            90
                    ....*....|..
gi 24584867     955 VVFITDVNDNKP 966
Cdd:smart00112   70 TITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1215-1297 4.36e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 4.36e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1215 NPTVFYRLMPGSTAQtnkfhtfYLQQRPDNGDtwadIKVNHPLDYESIKEYNLTIRVENNGAQQLASEATVYIMLEDVND 1294
Cdd:smart00112   10 NGKVTYSILSGNDDG-------LFSIDPETGE----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 24584867    1295 EIP 1297
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
178-296 3.01e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 3.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    178 SGEVRENQPAGTRVRGVplmqafsgSILDEELATPKKVRYTIIDGNVDDAFALqerkankniqisakslvingdDESGVW 257
Cdd:pfam00028    2 SASVPENAPVGTEVLTV--------TATDPDLGPNGRIFYSILGGGPGGNFRI---------------------DPDTGD 52

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 24584867    258 LVTNRPLDREERAHYDLSVEASDVDGLDRT-VSKIQITVL 296
Cdd:pfam00028   53 ISTTKPLDRESIGEYELTVEATDSGGPPLSsTATVTITVL 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2345-2375 5.24e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 56.62  E-value: 5.24e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24584867   2345 CRTTPCHNGGRCVDTRFGPHCSCPVGYTGPR 2375
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2345-2377 1.48e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.34  E-value: 1.48e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 24584867 2345 CRTT-PCHNGGRCVDTRFGPHCSCPVGYTGPRCQ 2377
Cdd:cd00054    5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
2660-2738 1.63e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.48  E-value: 1.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   2660 FRTREEYGELFRVSDQHNREYGILEIKDGHLHFRYNL--NSLRTEEKDLwlnaivVNDGQWHVVKVNRYGSAATLELDGG 2737
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLgsGAAVVRSGDK------LNDGKWHSVELERNGRSGTLSVDGE 74


                   .
gi 24584867   2738 E 2738
Cdd:pfam00054   75 A 75
Cadherin pfam00028
Cadherin domain;
863-959 4.14e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 4.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    863 YTPNVDENAGPNTLVTTVVASDKD-GDN--VRFGFVGGGtSSGQFVIEDITGVIRLhnkAISLD---KDKYELNVTAMDD 936
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNgrIFYSILGGG-PGGNFRIDPDTGDIST---TKPLDresIGEYELTVEATDS 76

                           90       100
                   ....*....|....*....|...
gi 24584867    937 GSccvngdqTIHTSTAVVVVFIT 959
Cdd:pfam00028   77 GG-------PPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2864-2900 5.58e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 5.58e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 24584867 2864 NECLLF-PCRNGGRCRDHhpPKKYECHCPMGFTGMHCE 2900
Cdd:cd00054    3 DECASGnPCQNGGTCVNT--VGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2345-2377 1.40e-08

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 52.86  E-value: 1.40e-08
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 24584867 2345 CRTT-PCHNGGRCVDTRFGPHCSCPVGYTGP-RCQ 2377
Cdd:cd00053    2 CAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
Cadherin pfam00028
Cadherin domain;
656-747 1.97e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    656 YEAEIPENQKKDSDIISIKAKSfADRE----IRYTLKAQGQGaGTFNIGPTSGIVKLAKELDFEdlrQPHVYSLIVTATe 731
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGpngrIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRE---SIGEYELTVEAT- 74

                           90
                   ....*....|....*...
gi 24584867    732 DSGGF--STSVDLTIRVT 747
Cdd:pfam00028   75 DSGGPplSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1765-1858 3.87e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.74  E-value: 3.87e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    1765 TVTVHDEDETNKFQYKVIDNSGygADKFTMvrnNDGTGSLKIVQPLDYEDQLQsngFRFRIQVNDKGEDNdndkyHVAYS 1844
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND--DGLFSI---DPETGEITTTKPLDREEQPE---YTLTVEATDGGGPP-----LSSTA 67

                            90
                    ....*....|....
gi 24584867    1845 WVVVKLRDINDNKP 1858
Cdd:smart00112   68 TVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
2864-2900 6.61e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 6.61e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 24584867    2864 NECLLF-PCRNGGRCRDHhpPKKYECHCPMGFT-GMHCE 2900
Cdd:smart00179    3 DECASGnPCQNGGTCVNT--VGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1973-2072 1.25e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867   1973 LPEHVPP-RKVVEILATDDDDrsKSNGPPFQFRLDPSADDIirasFKVEQDqkgaNGDgmavISSLRSFDREQQKEYMIP 2051
Cdd:pfam00028    5 VPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGN----FRIDPD----TGD----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|.
gi 24584867   2052 IVIKDHGSPAMTGTSTLTVII 2072
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITV 91
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2865-2900 2.21e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 49.40  E-value: 2.21e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 24584867 2865 ECLLF-PCRNGGRCRDHHPPkkYECHCPMGFTG-MHCE 2900
Cdd:cd00053    1 ECAASnPCSNGGTCVNTPGS--YRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2866-2896 4.30e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 4.30e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 24584867   2866 CLLFPCRNGGRCRDhhPPKKYECHCPMGFTG 2896
Cdd:pfam00008    1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
2349-2377 1.16e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 1.16e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 24584867    2349 PCHNGGRCVDTRFGPHCSCPVGYT-GPRCQ 2377
Cdd:smart00179   10 PCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 568-626 5.35e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.57  E-value: 5.35e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24584867     568 QARDPDTDHN--IHYFIVRDRTGGRFEVDERSGVVRTRGtdlfQLDME----YVLYVKAEDQNGK 626
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTK----PLDREeqpeYTLTVEATDGGGP 61
EGF smart00181
Epidermal growth factor-like domain;
2349-2377 1.67e-05

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 44.04  E-value: 1.67e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 24584867    2349 PCHNGgRCVDTRFGPHCSCPVGYTG-PRCQ 2377
Cdd:smart00181    7 PCSNG-TCINTPGSYTCSCPPGYTGdKRCE 35
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 653-752 3.95e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.03  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  653 MPSYEAeiPENQKKDSDIISIKAKSFADREIRYTLKAQGQGA--GTFNIGPTSGIVKLAKELDFEDLRQPHVYSLIVTAT 730
Cdd:cd00031    1 IPDGSA--VEGRSRGSFRVSIPTDLIASSGEIIKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                         90       100
                 ....*....|....*....|..
gi 24584867  731 EDSggFSTSVDLTIRVTDVNDN 752
Cdd:cd00031   79 ANV--PQTSSVFSIEVYDENDN 98
Cadherin_3 pfam16184
Cadherin-like;
529-618 4.91e-05

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 44.90  E-value: 4.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867    529 VIILVKDVNDEPPY-FINRPLPMQ--AVVQLNAppntpvFTLQARDPDT-DHNIHYFIVRDRTGGRFEVDERSGVVRTRG 604
Cdd:pfam16184    7 FNITIIPVNDEAPVlTTNTGLRLWegSSRPITP------DLLQAEDPDTpPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90
                   ....*....|....
gi 24584867    605 TdLFQLDMEYVLYV 618
Cdd:pfam16184   81 T-QADIDSGLVVYV 93
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2350-2371 1.03e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 41.55  E-value: 1.03e-04
                           10        20
                   ....*....|....*....|..
gi 24584867   2350 CHNGGRCVDTRFGPHCSCPVGY 2371
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2600-2626 2.27e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 2.27e-04
                           10        20
                   ....*....|....*....|....*..
gi 24584867   2600 CWEHGNCVGSlsEARCHCRPGWTGPAC 2626
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
EGF_CA smart00179
Calcium-binding EGF-like domain;
2821-2861 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.67e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24584867    2821 CPSNKPCSNVicpdpFECVDLWNVYECTCPAGYkSSGSTCV 2861
Cdd:smart00179    5 CASGNPCQNG-----GTCVNTVGSYRCECPPGY-TDGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 449-541 4.21e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 4.21e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867     449 TEADGDTEGKSVFQLEKETDKETFKIRDDNpwvtvetnGAVRVKKKWDYEELgpeKTIDFWVIITNMGhnaGIKYTDNQR 528
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPET--------GEITTTKPLDREEQ---PEYTLTVEATDGG---GPPLSSTAT 68

                            90
                    ....*....|...
gi 24584867     529 VIILVKDVNDEPP 541
Cdd:smart00112   69 VTITVLDVNDNAP 81
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 2871-2894 5.64e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 5.64e-04
                           10        20
                   ....*....|....*....|....
gi 24584867   2871 CRNGGRCRDHHPPkkYECHCPMGF 2894
Cdd:pfam12661    1 CQNGGTCVDGVNG--YKCQCPPGY 22
EGF smart00181
Epidermal growth factor-like domain;
2865-2900 6.77e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.42  E-value: 6.77e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 24584867    2865 ECLLF-PCRNGgRCRDHhpPKKYECHCPMGFTGM-HCE 2900
Cdd:smart00181    1 ECASGgPCSNG-TCINT--PGSYTCSCPPGYTGDkRCE 35
EGF smart00181
Epidermal growth factor-like domain;
2821-2861 6.77e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.42  E-value: 6.77e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 24584867    2821 CPSNKPCSNvicpdpFECVDLWNVYECTCPAGYKSSGsTCV 2861
Cdd:smart00181    2 CASGGPCSN------GTCINTPGSYTCSCPPGYTGDK-RCE 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 2821-2861 9.00e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 9.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24584867 2821 CPSNKPCSNvicpdPFECVDLWNVYECTCPAGYKSSGsTCV 2861
Cdd:cd00053    2 CAASNPCSN-----GGTCVNTPGSYRCVCPPGYTGDR-SCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2821-2861 1.05e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24584867 2821 CPSNKPCSNvicpdPFECVDLWNVYECTCPAGYksSGSTCV 2861
Cdd:cd00054    5 CASGNPCQN-----GGTCVNTVGSYRCSCPPGY--TGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2350-2376 2.35e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 2.35e-03
                           10        20
                   ....*....|....*....|....*..
gi 24584867   2350 CHNGGRCVDTRFGphCSCPVGYTGPRC 2376
Cdd:pfam07974    2 CSGRGTCVNQCGK--CVCDSGYQGATC 26
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2821-2854 2.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 24584867   2821 CPSNkPCSNVIcpdpfECVDLWNVYECTCPAGYK 2854
Cdd:pfam00008    1 CAPN-PCSNGG-----TCVDTPGGYTCICPEGYT 28
EGF_MSP1_1 pfam12946
MSP1 EGF domain 1; This EGF-like domain is found at the C-terminus of the malaria parasite ...
 2827-2861 3.73e-03

MSP1 EGF domain 1; This EGF-like domain is found at the C-terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite.


Pssm-ID: 403985  Cd Length: 37  Bit Score: 37.44  E-value: 3.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24584867   2827 CSNVICPDPFECV-DLWNVYECTCPAGYKSSGSTCV 2861
Cdd:pfam12946    2 CVKVACPANAGCFrHADGREECRCLLGYKKEGGKCV 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 445-538 5.61e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 38.83  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584867  445 RIEFTEADGDTEGKSVFQLEKETDKETFKIRddnpwvtvETNGAVRVKKKWDYEELgpeKTIDFWVIITNMGHNAgikYT 524
Cdd:cd11304   18 TVSATDPDSGENGEVTYSIVSGNEDGLFSID--------PSTGEITTAKPLDREEQ---SSYTLTVTATDGGGPP---LS 83

                         90
                 ....*....|....
gi 24584867  525 DNQRVIILVKDVND 538
Cdd:cd11304   84 STATVTITVLDVND 97
Cadherin_3 pfam16184
Cadherin-like;
1284-1344 6.08e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.12  E-value: 6.08e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24584867   1284 TVYIMLEDVNDEIPLFTEREQETVLEGE--PIGTKvtQVNAIDKDgTfPNNQVYYYIVDSPRN 1344
Cdd:pfam16184    6 TFNITIIPVNDEAPVLTTNTGLRLWEGSsrPITPD--LLQAEDPD-T-PPEDLTYTVVQGPSH 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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