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Conserved domains on  [gi|24584472|ref|NP_723924|]
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cyclin E, isoform C [Drosophila melanogaster]

Protein Classification

G1/S-specific cyclin-E( domain architecture ID 15334151)

G1/S-specific cyclin-E is essential for the control of the cell cycle at the G1/S (start) transition

Gene Ontology:  GO:0000082|GO:0016538|GO:0044772|GO:0097134

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 324-456 3.60e-87

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410223  Cd Length: 131  Bit Score: 269.57  E-value: 3.60e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 324 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 403
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24584472 404 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 460-573 2.53e-36

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 132.02  E-value: 2.53e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 460 PITITGWLGVYMQLNVNNRTPAsfsqigrqksaEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 539
Cdd:cd20520   1 PPTPNSWLNLYLQLAQLNPPPK-----------ENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYL 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24584472 540 TFSR-EMALRCSGLDWQVIQPCARWMEPFFRVISQ 573
Cdd:cd20520  70 VSPDdEAIEQVTGYSWEQLAPCVEWMTPFAEVLEE 104
 
Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 324-456 3.60e-87

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 269.57  E-value: 3.60e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 324 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 403
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24584472 404 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 330-459 2.70e-57

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 190.42  E-value: 2.70e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472   330 DVWRLMCHRDEQdsRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIG 409
Cdd:pfam00134   1 DIFQYLRELELK--YLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSK-KSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 24584472   410 ITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDIS 459
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 460-573 2.53e-36

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 132.02  E-value: 2.53e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 460 PITITGWLGVYMQLNVNNRTPAsfsqigrqksaEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 539
Cdd:cd20520   1 PPTPNSWLNLYLQLAQLNPPPK-----------ENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYL 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24584472 540 TFSR-EMALRCSGLDWQVIQPCARWMEPFFRVISQ 573
Cdd:cd20520  70 VSPDdEAIEQVTGYSWEQLAPCVEWMTPFAEVLEE 104
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
351-545 5.56e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 111.41  E-value: 5.56e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 430
Cdd:COG5024 202 LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGISALFIASKYEEVNCPSIKDL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 431 AYVTDGACTERDILNHEKILLQALDWDISpititgWlgvymqlnvnnRTPASFSqigRQKSAeADDafiYPQFSgfeFVQ 510
Cdd:COG5024 281 VYATDGAFTRDDIIRAERYMLEVLDFNIS------W-----------PSPMSFL---RRISK-ASD---YDIFS---RTP 333

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24584472 511 TSQLLDLCTLDVGMANYSYSVLAAAAisHTFSREM 545
Cdd:COG5024 334 AKFSSEISPVDYKFIQISPSWCAAAA--MYLSRKI 366
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 367-452 1.04e-22

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 92.27  E-value: 1.04e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472    367 DWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDgaCTERDILNH 446
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 24584472    447 EKILLQ 452
Cdd:smart00385  78 ERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 514-567 1.90e-06

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 47.23  E-value: 1.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584472   514 LLDLCTLDVGMANYSYSVLAAAAISHTFS-------REMALRCSGLDWQVIQPCARWMEPF 567
Cdd:pfam02984  29 LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHYTGYSEEDLKPCVKLLLEL 89
 
Name Accession Description Interval E-value
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 324-456 3.60e-87

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 269.57  E-value: 3.60e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 324 AWANAADVWRLMCHRDEQDSRLRSisMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKT 403
Cdd:cd20519   1 SWADSEEVWDLMLKKEELYKRDRD--FLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKT 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24584472 404 HLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20519  79 QLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 319-456 2.21e-67

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 217.82  E-value: 2.21e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 319 PLPALAWANAADVWRLMCHRDEqdSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAH 398
Cdd:cd20579   2 PLPVLGWANRDEVWKNMLNKDK--TYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQE 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24584472 399 KVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20579  80 NVVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 319-456 1.26e-60

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 199.69  E-value: 1.26e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 319 PLPALAWANAADVWRLMCHRDEQdsRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAH 398
Cdd:cd20580   2 PLPELSWGNSKDVWLNMLKKESK--YVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQK 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24584472 399 KVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20580  80 NINKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 330-459 2.70e-57

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 190.42  E-value: 2.70e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472   330 DVWRLMCHRDEQdsRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIG 409
Cdd:pfam00134   1 DIFQYLRELELK--YLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSK-KSVPKNKLQLVG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 24584472   410 ITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDIS 459
Cdd:pfam00134  78 VTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 336-455 2.28e-43

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 152.68  E-value: 2.28e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 336 CHRDEQDSRLRSiSMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFV 415
Cdd:cd20507  12 LRQLEKKYAIDP-DYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKK-QVPRKKLQLVGVTALLI 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 24584472 416 AAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALD 455
Cdd:cd20507  90 ASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 351-455 9.07e-39

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 139.69  E-value: 9.07e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYL-HVAhkVQKTHLQLIGITCLFVAAKVEEIYPPKIGE 429
Cdd:cd20504  24 MRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLsQMS--VLRSKLQLVGTACMFIAAKYEEIYPPEVEE 101

                        90       100
                ....*....|....*....|....*.
gi 24584472 430 FAYVTDGACTERDILNHEKILLQALD 455
Cdd:cd20504 102 FVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 460-573 2.53e-36

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 132.02  E-value: 2.53e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 460 PITITGWLGVYMQLNVNNRTPAsfsqigrqksaEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 539
Cdd:cd20520   1 PPTPNSWLNLYLQLAQLNPPPK-----------ENDSAFLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYL 69

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24584472 540 TFSR-EMALRCSGLDWQVIQPCARWMEPFFRVISQ 573
Cdd:cd20520  70 VSPDdEAIEQVTGYSWEQLAPCVEWMTPFAEVLEE 104
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 351-456 4.60e-36

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 132.42  E-value: 4.60e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 430
Cdd:cd20568  30 MDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLS-KRVVSLNKLQLVGISALFIASKYEEVNSPSIKNF 108

                        90       100
                ....*....|....*....|....*.
gi 24584472 431 AYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20568 109 AYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 338-456 5.32e-33

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 123.99  E-value: 5.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 338 RDEQDSRLRSISMLEQhPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAA 417
Cdd:cd20567  31 KVEPESCVPPYYMSQQ-PDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSV-KQVPRKELQLVGVTAMLIAS 108

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24584472 418 KVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDW 456
Cdd:cd20567 109 KYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 359-457 5.27e-31

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 117.90  E-value: 5.27e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 359 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGAC 438
Cdd:cd20562  39 PSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLS-GNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTY 117

                        90
                ....*....|....*....
gi 24584472 439 TERDILNHEKILLQALDWD 457
Cdd:cd20562 118 TKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 351-457 9.79e-31

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 117.08  E-value: 9.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 430
Cdd:cd20561  26 MKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLS-SMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEF 104

                        90       100
                ....*....|....*....|....*..
gi 24584472 431 AYVTDGACTERDILNHEKILLQALDWD 457
Cdd:cd20561 105 VYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 351-457 1.90e-30

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 117.25  E-value: 1.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 430
Cdd:cd20560  58 MRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCM-SVLRGKLQLVGTAAILLASKYEEIYPPEVDEF 136

                        90       100
                ....*....|....*....|....*..
gi 24584472 431 AYVTDGACTERDILNHEKILLQALDWD 457
Cdd:cd20560 137 VYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 361-454 3.19e-30

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 114.35  E-value: 3.19e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 361 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTE 440
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFL-ATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                        90
                ....*....|....
gi 24584472 441 RDILNHEKILLQAL 454
Cdd:cd20536  80 EQICNLECIILTKL 93
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 328-457 6.51e-30

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 115.04  E-value: 6.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 328 AADVWRLMCHRDEQdsrLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQL 407
Cdd:cd20508  17 AKDIFDYMKEREEK---FVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK-VVKKEKLQL 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24584472 408 IGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWD 457
Cdd:cd20508  93 LGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 361-456 2.68e-28

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 109.97  E-value: 2.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 361 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTE 440
Cdd:cd20565  35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQ-NNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTK 113

                        90
                ....*....|....*.
gi 24584472 441 RDILNHEKILLQALDW 456
Cdd:cd20565 114 HQIRQMEMKILRALDF 129
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 357-457 8.32e-27

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 106.61  E-value: 8.32e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 357 LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 436
Cdd:cd20515  51 IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSL-VPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDN 129

                        90       100
                ....*....|....*....|.
gi 24584472 437 ACTERDILNHEKILLQALDWD 457
Cdd:cd20515 130 SITLQELLDWELLVLTKLKWD 150
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
351-545 5.56e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 111.41  E-value: 5.56e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 351 LEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEF 430
Cdd:COG5024 202 LIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLS-SRVVSLEKYQLVGISALFIASKYEEVNCPSIKDL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 431 AYVTDGACTERDILNHEKILLQALDWDISpititgWlgvymqlnvnnRTPASFSqigRQKSAeADDafiYPQFSgfeFVQ 510
Cdd:COG5024 281 VYATDGAFTRDDIIRAERYMLEVLDFNIS------W-----------PSPMSFL---RRISK-ASD---YDIFS---RTP 333

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24584472 511 TSQLLDLCTLDVGMANYSYSVLAAAAisHTFSREM 545
Cdd:COG5024 334 AKFSSEISPVDYKFIQISPSWCAAAA--MYLSRKI 366
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 360-456 1.00e-25

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 103.02  E-value: 1.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 360 RMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACT 439
Cdd:cd20566  38 RMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQV-QPVSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYT 116

                        90
                ....*....|....*..
gi 24584472 440 ERDILNHEKILLQALDW 456
Cdd:cd20566 117 KAQIREMEMLILKELNF 133
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 362-458 1.13e-25

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 101.24  E-value: 1.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 362 RAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTER 441
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSR-QKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                        90
                ....*....|....*..
gi 24584472 442 DILNHEKILLQALDWDI 458
Cdd:cd20542  80 QVLRMERRVLRRLRFDL 96
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 460-573 3.87e-24

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 97.15  E-value: 3.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 460 PITITGWLGVYMQLNvnnrtpasfsqigrqkSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 539
Cdd:cd20582   1 PVTIISWLNLYLQVD----------------SLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCH 64

                        90       100       110
                ....*....|....*....|....*....|....
gi 24584472 540 TFSREMALRCSGLDWQVIQPCARWMEPFFRVISQ 573
Cdd:cd20582  65 FTSFEVVKKASGLEWDCISECVNWMVPFVRTVRE 98
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 367-452 1.04e-22

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 92.27  E-value: 1.04e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472    367 DWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDgaCTERDILNH 446
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFL-SDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 24584472    447 EKILLQ 452
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 460-571 4.42e-22

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 91.77  E-value: 4.42e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 460 PITITGWLGVYMQLNVNNRTpasfsqigrqksaeadDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISH 539
Cdd:cd20581   1 PLTIVSWLNVYMQVAYLNEL----------------QEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYH 64

                        90       100       110
                ....*....|....*....|....*....|..
gi 24584472 540 TFSREMALRCSGLDWQVIQPCARWMEPFFRVI 571
Cdd:cd20581  65 FSSSELMQKVSGYKWCEIEECVKWMVPFAMAI 96
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 357-457 8.21e-22

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 92.36  E-value: 8.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 357 LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 436
Cdd:cd20575  51 IKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCV-PTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDN 129

                        90       100
                ....*....|....*....|.
gi 24584472 437 ACTERDILNHEKILLQALDWD 457
Cdd:cd20575 130 SISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 359-457 1.12e-21

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 91.96  E-value: 1.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 359 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGAC 438
Cdd:cd20573  52 PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSV-EPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSI 130

                        90
                ....*....|....*....
gi 24584472 439 TERDILNHEKILLQALDWD 457
Cdd:cd20573 131 RPEELLQMELLVLNKLKWD 149
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 357-457 7.08e-20

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 86.58  E-value: 7.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 357 LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 436
Cdd:cd20574  51 IQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVV-PTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDN 129

                        90       100
                ....*....|....*....|.
gi 24584472 437 ACTERDILNHEKILLQALDWD 457
Cdd:cd20574 130 SIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 368-458 4.60e-18

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 79.66  E-value: 4.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 368 WLIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKVEE----IypPKIGEFAYVTDGACTERDI 443
Cdd:cd20526   8 WLAELNSQFKFYPETFALAVSILDRFLASV-KARPKYLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAEV 84

                        90
                ....*....|....*
gi 24584472 444 LNHEKILLQALDWDI 458
Cdd:cd20526  85 LRMERIILDKLHWDL 99
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 361-456 2.60e-17

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 77.64  E-value: 2.60e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 361 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYP--PKIGEF-AYVTDGA 437
Cdd:cd20528   6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMD-RYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnRYLCNSV 84

                        90
                ....*....|....*....
gi 24584472 438 CTERDILNHEKILLQALDW 456
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 361-456 5.10e-17

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 76.83  E-value: 5.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 361 MRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTE 440
Cdd:cd20517   5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLL-LKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                        90
                ....*....|....*.
gi 24584472 441 RDILNHEKILLQALDW 456
Cdd:cd20517  84 LELINQEKDILEALKW 99
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 359-436 1.47e-16

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 75.43  E-value: 1.47e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24584472 359 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDG 436
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMV-RKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDN 77
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 365-449 3.54e-16

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 73.98  E-value: 3.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 365 LLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQKTHLQLIGITCLFVAAKVEEIyPPKIGEFAYVTDgaCTERDIL 444
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSK-GLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELR 77


                ....*
gi 24584472 445 NHEKI 449
Cdd:cd00043  78 KAEKE 82
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 362-456 1.15e-13

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 67.34  E-value: 1.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 362 RAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVaHKVQ--KTH-LQLIGITCLFVAAKVEEIYPP-----KIGEFAYV 433
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSS-YDLPkdKPWmLQLLAVACLSLAAKMEETDVPllvdlQVEEPKYV 80

                        90       100
                ....*....|....*....|...
gi 24584472 434 tdgaCTERDILNHEKILLQALDW 456
Cdd:cd20543  81 ----FEAKTIQRMELLVLSTLEW 99
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 363-458 3.48e-12

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 64.54  E-value: 3.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 363 AILLDW----LIEVCEVYKLHRETFYLAVDYLDR-YLHvaHKVQKTHLQLIGITCLFVAAKVEEIYPPkIGEFAYVTDGA 437
Cdd:cd20524  52 LLLVRYyekkLLEFCRAFKLPDSVLATALTYFKRfYLK--NSVMEYHPKEIMLTCLYLACKVEEFNIS-IDQFVGNIKES 128

                        90       100
                ....*....|....*....|..
gi 24584472 438 -CTERDILNHEKILLQALDWDI 458
Cdd:cd20524 129 eKTAEIILEYELLLLQGLNFHL 150
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 365-457 1.02e-11

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 61.63  E-value: 1.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 365 LLDWLIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIYP--PKIGEFAYVTDGACTERD 442
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCS-KRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                        90
                ....*....|....*
gi 24584472 443 ILNHEKILLQALDWD 457
Cdd:cd20559  81 FIQMEMHILNTLNWD 95
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 373-454 1.43e-09

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 55.44  E-value: 1.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 373 CEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNHEKIL 450
Cdd:cd20523  12 HRFYGFSPETFALAVNLLDRFLSKV-KVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGII 90


                ....
gi 24584472 451 LQAL 454
Cdd:cd20523  91 LEKL 94
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 369-456 2.83e-09

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 54.83  E-value: 2.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 369 LIEVCEVYKLHRETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNH 446
Cdd:cd20583   9 LLSLTQFFGFSTETFSLAVNLLDRFLAKM-KVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRM 87

                        90
                ....*....|
gi 24584472 447 EKILLQALDW 456
Cdd:cd20583  88 EKIILEKLCW 97
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 381-454 6.61e-09

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 53.70  E-value: 6.61e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584472 381 ETFYLAVDYLDRYLHVAhKVQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNHEKILLQAL 454
Cdd:cd20584  21 ETFVLAVNILDRFLALM-KVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 514-567 1.90e-06

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 47.23  E-value: 1.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584472   514 LLDLCTLDVGMANYSYSVLAAAAISHTFS-------REMALRCSGLDWQVIQPCARWMEPF 567
Cdd:pfam02984  29 LLELTLLDYDFLKYPPSLIAAAAVYLARKtlnspewTETLEHYTGYSEEDLKPCVKLLLEL 89
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 371-458 7.84e-06

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 46.74  E-value: 7.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 371 EVCEVYKLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEIYpPKIGEFAYVTDGacTERDILNHEKIL 450
Cdd:cd20585  87 EVCRALRLPNKIQATALLYFKRF-YLQWSVMEHDPKRIMLTCIYLACKVEEYH-VSAEELGKGIQQ--DHQLILKNELAL 162


                ....*...
gi 24584472 451 LQALDWDI 458
Cdd:cd20585 163 LQGLNFDL 170
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 377-457 1.82e-04

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 41.45  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 377 KLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEIypPK----IGEFAYV--------TDGACTERDIL 444
Cdd:cd20530  26 GLPYDTIATGIVYFHRF-YMFHSFKDFDRYVTAACCLFLAGKVEET--PKkckdIIKTARSllndkqfaQFGDDPKEEVM 102

                        90
                ....*....|...
gi 24584472 445 NHEKILLQALDWD 457
Cdd:cd20530 103 VLERILLQTIKFD 115
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 368-421 1.15e-03

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 39.25  E-value: 1.15e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24584472 368 WLIEVCEVYKLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEE 421
Cdd:cd20547   8 FISQLCKKLKFPRRTLGTAMLLYQRF-HLFNPFTDSSNYEVALACLFLASKIED 60
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 386-457 2.09e-03

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 38.91  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 386 AVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEiYPPKIGEFAYVTDgACTER-----------------DILNHEK 448
Cdd:cd20538  52 AIVYMHRF-YMFHSFTKFHRNSIAAAALFLAAKVEE-QPRKLEHVIKVAH-ACLHRgepdldtkseaylqqaqELVINEN 128


                ....*....
gi 24584472 449 ILLQALDWD 457
Cdd:cd20538 129 ILLQTLGFE 137
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 514-561 2.98e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 37.29  E-value: 2.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24584472 514 LLDLCTLDVGMANYSYSVLAAAAI--------SHTFSREMALRCSGLDWQVIQPCA 561
Cdd:cd20537  27 LLELSLLDYEFLKYRPSLIAAAALylarkilgEPPPSPQLLQLVTGYSENDLQECA 82
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 368-457 3.73e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 40.10  E-value: 3.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 368 WLIEVCEVYKLHRETFYLAVDYLDRYlHVAHKVQKTHLQLIGITCLFVAAKVEEIyPPKIGEFAYVTDGACTERD----- 442
Cdd:COG5333  51 LIMDLCTRLNLPQTVLATAILFFSRF-YLKNSVEEISLYSVVTTCVYLACKVEDT-PRDISIESFEARDLWSEEPkssre 128

                        90
                ....*....|....*.
gi 24584472 443 -ILNHEKILLQALDWD 457
Cdd:COG5333 129 rILEYEFELLEALDFD 144
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 365-456 3.97e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 37.25  E-value: 3.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584472 365 LLDWLIEVCEVYKLHRETFYLAVDYLDRYLH---VAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACteR 441
Cdd:cd20557   2 LRSFIARLLRRTRLSPSVVLLALVYLERLRRrlpEALLGQEGSPYRLFLVALMLASKYLDDESYSNKSWAEISGLPV--R 79

                        90
                ....*....|....*
gi 24584472 442 DILNHEKILLQALDW 456
Cdd:cd20557  80 ELNAMEREFLEALDW 94
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 367-421 5.30e-03

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 37.40  E-value: 5.30e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24584472 367 DWLIEVCEVYKLHRETFYLAVDYLDRYLhVAHKVQKTHLQLIGITCLFVAAKVEE 421
Cdd:cd20545  10 NFIIRVGSRLKLPQTTLFTAATYFHRFY-MRNSLKKYHYYEIAATCLFLATKVEE 63
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 369-445 7.52e-03

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 36.76  E-value: 7.52e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584472 369 LIEVCEVYKLHRETFYLAVDYLDRYLHvAHKVQKTHLQLIGITCLFVAAKVEEIyPPKIgefayvtdgacteRDILN 445
Cdd:cd20534   9 IREAGLKLELSSVTIATACVLYHRFYR-ELSLEDYDPYLVAMACLYLAGKAEEQ-PRRL-------------RDIIN 70
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 407-454 9.62e-03

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 9.62e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24584472 407 LIGITCLFVAAKVEE--------------IYPPKIGEFAYvtdgacTERDILNHEKILLQAL 454
Cdd:cd20513  46 LVAPTCLYLASKVEEcpsharlivaeakvLKTKFSYEFPY------RVNDILECEFYLLEAL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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