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Conserved domains on  [gi|24308494|ref|NP_714953|]
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zinc finger protein 14 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-51 3.35e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24308494    10 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-701 1.57e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 259 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 336
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 337 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 415
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 416 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 495
Cdd:COG5048 171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 496 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 566
Cdd:COG5048 238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 567 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCK--SCGKAFTNPSALRNHERIH-----------SGEKPCICEQ 629
Cdd:COG5048 318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308494 630 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 701
Cdd:COG5048 398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-51 3.35e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24308494    10 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
11-51 6.48e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.48e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24308494     11 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 51
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-48 3.03e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.03e-15
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24308494  11 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLA 48
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-701 1.57e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 259 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 336
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 337 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 415
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 416 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 495
Cdd:COG5048 171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 496 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 566
Cdd:COG5048 238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 567 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCK--SCGKAFTNPSALRNHERIH-----------SGEKPCICEQ 629
Cdd:COG5048 318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308494 630 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 701
Cdd:COG5048 398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 3.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 24308494   247 NIRRHERTHTGEKPYRCNTCDKAFTC 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 10-51 3.35e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 3.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24308494    10 SVTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 51
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
11-51 6.48e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.48e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24308494     11 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLAAIG 51
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 11-48 3.03e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.89  E-value: 3.03e-15
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24308494  11 VTFEDVAVNFTVEEWALLGPSQKKLHRDVMEETFRNLA 48
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-701 1.57e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 259 KPYRCNTCDKAFTCLTNFQEHERTHTGEKPYLCTQ--CGKAFSFLSNIRRHERTHTGEKPYRCNICGKAFSYLTNFQDHE 336
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 337 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvcklCEKAFTTLSS 415
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN-----TPQSNSLHPP 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 416 LRYHERIHSGEKPHvclqcgkgfnsssTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFT 495
Cdd:COG5048 171 LPANSLSKDPSSNL-------------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 496 RH------TSLRCHERIHCGEKPYKCKQCGKGFISSSNFRKHEWTHSG-EKHCVCKLCGKAFTGHSSLRRHER--IHSGE 566
Cdd:COG5048 238 KSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 567 --KPYVCKH--CGKGFSSLSGCQRHEQIHTGEKPHVCK--SCGKAFTNPSALRNHERIH-----------SGEKPCICEQ 629
Cdd:COG5048 318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlkndkksETLSNSCIRN 397

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24308494 630 CGKGfiSFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKQCGKSFYTLSDCQRHEQ 701
Cdd:COG5048 398 FKRD--SNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
399-736 2.55e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 399 KPYVCKLCEKAFTTLSSLRYHERIHSGEKPHVCLQ--CGKGFNSSSTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRCHE 476
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 477 RIHSGE-KPYVCKQCGKAFTRHTSLRCHERIHCGEKPYKCKQCGKGFISSSN-FRKHEWTHSGEkhcvckLCGKAFTGHS 554
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANS------LSKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 555 SLRRHERIHSGEKPYVCKHCGK--GFSSLSGCQRHEQIHTGEKPHVCkSCGKAFTNPSALRNHE----RIHSGEKPCICE 628
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSsySIPSSSSDQNLENSSSSLPLTTN-SQLSPKSLLSQSPSSLsssdSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 629 QCGKGFISFSKFRIHERIHTG-EKPYKCKQCGKAFTGHSSLRRHER--IHSGE--KPFVC--KQCGKSFYTLSDCQRHEQ 701
Cdd:COG5048 265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 24308494 702 IHTGEKPFICK--QCGKAFTRSSSLKIHEKTHSRRNS 736
Cdd:COG5048 345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
371-735 1.74e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 371 KPYVCKQCGKAFSYYNSIQTHKRCHTGEKPYVC--KLCEKAFTTLSSLRYHERIHSGEKPHVCLQCGKGFNSSSTLRIHE 448
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 449 RTHTGE-KPYKCKQCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAF----------------------TRHTSLRCHER 505
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 506 IHCGEKPYKCKQCGKGFISSSNFRKHEWTHSGEKHCVCKLCGKAFTGHSSLRRHERIHSGEKPYVCKHCGKGFSSLSGCQ 585
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 586 RHEQIHTGE-------KPHVCKSCGKAFTNPSALRNHER--IHSGE--KPCIC--EQCGKGFISFSKFRIHERIHTGEKP 652
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 653 YKCK--QCGKAFTG-----HSSLRRHERIHSGEKPFVC--KQCGKSFYTLSDCQRHEQIHTGEKP--FICKQCGKAFTRS 721
Cdd:COG5048 352 AKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                       410
                ....*....|....
gi 24308494 722 SSLKIHEKTHSRRN 735
Cdd:COG5048 432 YNLIPHKKIHTNHA 445
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 3.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 24308494   247 NIRRHERTHTGEKPYRCNTCDKAFTC 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 649-732 3.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 649 GEKPYKCK--QCGKAFTGHSSLRRHeRIHSgekpfvckQCGKSFYTLSDCQRHEQIHTGEKPFICKQCGKAFTRSSSLKI 726
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 24308494 727 HeKTHS 732
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 3.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 24308494   303 NIRRHERTHTGEKPYRCNICGKAFSY 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 509-587 7.56e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 509 GEKPYKCK--QCGKGFISSSNFRKHEWthsgEKHCVCKLcgkafTGHSSLRRHERIHSGEKPYVCKHCGKGFSSLSGCQR 586
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGHQNQKL-----HENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 24308494 587 H 587
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
667-692 8.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 24308494   667 SLRRHERIHSGEKPFVCKQCGKSFYT 692
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-480 9.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 397 GEKPYVCKL--CEKAFTTLSSLRYHeRIHSgekphvclQCGKGFNSSSTLRIHERTHTGEKPYKCKQCGKVFSVDSSLRC 474
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 24308494 475 HeRIHS 480
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
555-580 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 24308494   555 SLRRHERIHSGEKPYVCKHCGKGFSS 580
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 24308494   331 NFQDHERTHTGEKPYVCTQCGKAFTY 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
444-467 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....
gi 24308494   444 LRIHERTHTGEKPYKCKQCGKVFS 467
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 341-424 1.98e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308494 341 GEKPYVC--TQCGKAFTYYYSFQTHKRcHtgekpyvcKQCGKAFSYYNSIQTHKRCHTGEKPYVCKLCEKAFTTLSSLRY 418
Cdd:COG5189 346 DGKPYKCpvEGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 24308494 419 HeRIHS 424
Cdd:COG5189 417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-299 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|....*
gi 24308494   275 NFQEHERTHTGEKPYLCTQCGKAFS 299
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
640-663 2.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|....
gi 24308494   640 FRIHERIHTGEKPYKCKQCGKAFT 663
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-384 3.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 24308494   359 SFQTHKRCHTGEKPYVCKQCGKAFSY 384
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-608 6.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.55e-03
                          10        20
                  ....*....|....*....|....
gi 24308494   585 QRHEQIHTGEKPHVCKSCGKAFTN 608
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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