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Conserved domains on  [gi|25140993|ref|NP_705938|]
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zinc finger protein PLAGL2 [Danio rerio]

Protein Classification

zinc finger family protein( domain architecture ID 706824)

zinc finger family protein may be involved in transcriptional regulation; similar to Schizosaccharomyces pombe E3 ubiquitin-protein ligase hel2, which that plays a key role in the ribosome quality control (RQC), and Homo sapiens histone H4 transcription factor

Gene Ontology:  GO:0008270
PubMed:  11179890

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
130-256 3.66e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 43.47  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 130 HLQTHDPNKEAFKCEECGKHYNTKlGYKRHMAMHSATAGDLTCKVCLQSYESTPALLE-----HLKSHSGKSSGGAKEKK 204
Cdd:COG5236 141 DVRDEMEDLLSFKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKG 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 205 HP-CDHCDRRFYTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 256
Cdd:COG5236 220 HPlCIFCKIYFYDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 78-159 1.17e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993  78 GEKPFHCSQPHCPKAFSSKYKLFRHMAT-HSPQKTHQCSFCEKMfhrkdhlknhlQTHDPNKEAFKCEECGKHYNTKLGY 156
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKM-----------NIFSAKDKPYRCEVCDKRYKNLNGL 414


                ...
gi 25140993 157 KRH 159
Cdd:COG5189 415 KYH 417
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
130-256 3.66e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 43.47  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 130 HLQTHDPNKEAFKCEECGKHYNTKlGYKRHMAMHSATAGDLTCKVCLQSYESTPALLE-----HLKSHSGKSSGGAKEKK 204
Cdd:COG5236 141 DVRDEMEDLLSFKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKG 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 205 HP-CDHCDRRFYTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 256
Cdd:COG5236 220 HPlCIFCKIYFYDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 78-159 1.17e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993  78 GEKPFHCSQPHCPKAFSSKYKLFRHMAT-HSPQKTHQCSFCEKMfhrkdhlknhlQTHDPNKEAFKCEECGKHYNTKLGY 156
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKM-----------NIFSAKDKPYRCEVCDKRYKNLNGL 414


                ...
gi 25140993 157 KRH 159
Cdd:COG5189 415 KYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
99-121 5.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.35e-03
                          10        20
                  ....*....|....*....|...
gi 25140993    99 LFRHMATHSPQKTHQCSFCEKMF 121
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
130-256 3.66e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 43.47  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 130 HLQTHDPNKEAFKCEECGKHYNTKlGYKRHMAMHSATAGDLTCKVCLQSYESTPALLE-----HLKSHSGKSSGGAKEKK 204
Cdd:COG5236 141 DVRDEMEDLLSFKCPKSKCHRRCG-SLKELKKHYKAQHGFVLCSECIGNKKDFWNEIRlfrssTLRDHKNGGLEEEGFKG 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993 205 HP-CDHCDRRFYTRKDVRRHMVVHTGRkdflCQYC-------AQRFGRKDHLTRHVKKSH 256
Cdd:COG5236 220 HPlCIFCKIYFYDDDELRRHCRLRHEA----CHICdmvgpirYQYFKSYEDLEAHFRNAH 275
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 78-159 1.17e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25140993  78 GEKPFHCSQPHCPKAFSSKYKLFRHMAT-HSPQKTHQCSFCEKMfhrkdhlknhlQTHDPNKEAFKCEECGKHYNTKLGY 156
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKM-----------NIFSAKDKPYRCEVCDKRYKNLNGL 414


                ...
gi 25140993 157 KRH 159
Cdd:COG5189 415 KYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
99-121 5.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.35e-03
                          10        20
                  ....*....|....*....|...
gi 25140993    99 LFRHMATHSPQKTHQCSFCEKMF 121
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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