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Conserved domains on  [gi|32189378|ref|NP_700459|]
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G-protein-signaling modulator 1 isoform 1 [Mus musculus]

Protein Classification

TPR and TPR_12 domain-containing protein( domain architecture ID 11421204)

protein containing domains TPR, TPR_12, and GoLoco

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.98  E-value: 2.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457  79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457 133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                       250
                ....*....|....
gi 32189378 309 HLRHLVIAQELADR 322
Cdd:COG0457 207 LRKKLAILTLAALA 220
GoLoco pfam02188
GoLoco motif;
494-515 2.29e-07

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.29e-07
                          10        20
                  ....*....|....*....|..
gi 32189378   494 ECFFDLLSKFQSSRMDDQRCPL 515
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
547-567 1.60e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.60e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   547 EEFFDLIASSQSRRLDDQRAS 567
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
629-650 1.62e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.62e-05
                          10        20
                  ....*....|....*....|..
gi 32189378   629 EDFFSLIQRVQAKRMDEQRVDL 650
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
595-615 1.78e-05

GoLoco motif;


:

Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.64  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   595 DEFFNMLIKYQSSRIDDQRCP 615
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 1.84e-04

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.45  E-value: 1.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32189378   290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.98  E-value: 2.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457  79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457 133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                       250
                ....*....|....
gi 32189378 309 HLRHLVIAQELADR 322
Cdd:COG0457 207 LRKKLAILTLAALA 220
TPR_12 pfam13424
Tetratricopeptide repeat;
207-278 1.50e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 54.70  E-value: 1.50e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32189378   207 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
GoLoco pfam02188
GoLoco motif;
494-515 2.29e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.29e-07
                          10        20
                  ....*....|....*....|..
gi 32189378   494 ECFFDLLSKFQSSRMDDQRCPL 515
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
547-567 1.60e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.60e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   547 EEFFDLIASSQSRRLDDQRAS 567
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
629-650 1.62e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.62e-05
                          10        20
                  ....*....|....*....|..
gi 32189378   629 EDFFSLIQRVQAKRMDEQRVDL 650
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
595-615 1.78e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.64  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   595 DEFFNMLIKYQSSRIDDQRCP 615
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 493-515 1.82e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.82e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    493 EECFFDLLSKFQSSRMDDQRCPL 515
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 594-616 1.93e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.93e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    594 GDEFFNMLIKYQSSRIDDQRCPP 616
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 546-568 3.68e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 3.68e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    546 TEEFFDLIASSQSRRLDDQRASV 568
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 628-650 1.15e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|...
gi 32189378    628 DEDFFSLIQRVQAKRMDEQRVDL 650
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 40-431 1.50e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.91  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   40 KAGDFKAGVAFFEAAVQV-----GTEDLKTLSAiYSQLGNAYFYLKEYARALQfhkhdllLARTIGDRMGEAK------- 107
Cdd:NF040586 404 LRGDYESARDLAERALERwrerlGPDDRQTLRL-RFHLANALRSLGRYEEARE-------LDEDTLERQRRVLglgedhp 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  108 ----ASGNLGNTLKVLGRFDEAivccqrhLDIAQEqgdkvgearalynignvyhakgkqlSWNAAQDPghLPPDVRETLh 183
Cdd:NF040586 476 htlmTAGGLGADLRALGRFREA-------LELDEE-------------------------TLERHRRV--FGEDHPRTL- 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  184 rasefyernlslvkelgdraaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGR 261
Cdd:NF040586 521 -----------------------RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGR 577

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  262 FDVAAEHYKKTLQLSRQLR---DQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLG 333
Cdd:NF040586 578 YAEALDLLEEALERYREVLggpDHPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLA 654

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  334 NAYVSMGSPAQALTFAKKHLQISQEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEkpdlagyeaqgarpkrtqR 408
Cdd:NF040586 655 NDLRALGDADEARELAREVLDRYRR---VLGEdhpftLACRNNLAVLLRALGD---PEEAR------------------E 710

                        410       420
                 ....*....|....*....|...
gi 32189378  409 LSAETWDLLrlpldREQNGETHH 431
Cdd:NF040586 711 LAEAALEGL-----RERLGPDHP 728
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 1.84e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.45  E-value: 1.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32189378   290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-138 4.46e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32189378    106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-312 8.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   120 GRFDEAIVccqrHLDIAQEQGDKVGEARalYNIGNVYHAKGKQLS----WNAAQDPGHLPPDVRETLHRA---SEFYERN 192
Cdd:TIGR02917  36 NKYKAAII----QLKNALQKDPNDAEAR--FLLGKIYLALGDYAAaekeLRKALSLGYPKNQVLPLLARAyllQGKFQQV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   193 LSLV--KELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIakefgdkaAERRAYSNLGNAHIFL--GRFDVAAEH 268
Cdd:TIGR02917 110 LDELpgKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAI--------DPRSLYAKLGLAQLALaeNRFDEARAL 181

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 32189378   269 YKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRH 312
Cdd:TIGR02917 182 IDEVLTADPGNVDAlLLKGDLLLSLGNIELALAAYRKAIALRPNN 226
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
69-322 2.73e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.98  E-value: 2.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  69 YSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARA 148
Cdd:COG0457  11 YNNLGLAYRRLGRYEEAIEDYEKALELDP------DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD------AEA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 149 LYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTF 228
Cdd:COG0457  79 LNNLGLALQALGR--------------------YEEALEDYDKALEL------DPDDAEALYNLGLALLELGRYDEAIEA 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 229 HKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG0457 133 YERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206

                       250
                ....*....|....
gi 32189378 309 HLRHLVIAQELADR 322
Cdd:COG0457 207 LRKKLAILTLAALA 220
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-389 2.86e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.98  E-value: 2.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 105 EAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEqgdkvgEARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHR 184
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPD------DAEALYNLGLAYLRLGR--------------------YEE 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 185 ASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDV 264
Cdd:COG0457  61 ALADYEQALEL------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAE------ALYNLGLALLELGRYDE 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 265 AAEHYKKTLQLSRQLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLviAQELADRVGEGRACWSLGNAYVSMGSPAQ 344
Cdd:COG0457 129 AIEAYERALELDPDD------ADALYNLGIALEKLGRYEEALELLEKLE--AAALAALLAAALGEAALALAAAEVLLALL 200

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 32189378 345 ALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAE 389
Cdd:COG0457 201 LALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-424 5.62e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 78.12  E-value: 5.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 145 EARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLVKELGDraaqgrAYGNLGNTHYLLGNFTE 224
Cdd:COG0457   7 DAEAYNNLGLAYRRLGR--------------------YEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEE 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 225 ATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLrdqaveAQACYSLGNTYTLLQDYER 304
Cdd:COG0457  61 ALADYEQALELDPDDAE------ALNNLGLALQALGRYEEALEDYDKALELDPDD------AEALYNLGLALLELGRYDE 128

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 305 AAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQisQEIGDRNGELTARMNIAHLQLALGRLTS 384
Cdd:COG0457 129 AIEAYERALELDPDDAD------ALYNLGIALEKLGRYEEALELLEKLEA--AALAALLAAALGEAALALAAAEVLLALL 200

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 32189378 385 PAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRE 424
Cdd:COG0457 201 LALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 33-354 9.97e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.77  E-value: 9.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  33 LEGERLCKAGDFKAGVAFFEAAVQVGTEDLKTlsaiYSQLGNAYFYLKEYARALQFHKHdlLLARTiGDRmgeAKASGNL 112
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEA----HLALGNLYRRRGEYDRAIRIHQK--LLERD-PDR---AEALLEL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 113 GNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERn 192
Cdd:COG2956  83 AQDYLKAGLLDRAEELLEKLLELDPDD------AEALRLLAEIYEQEGD--------------------WEKAIEVLER- 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 193 lsLVKELGDRAaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFgdkaaeRRAYSNLGNAHIFLGRFDVAAEHYKKT 272
Cdd:COG2956 136 --LLKLGPENA---HAYCELAELYLEQGDYDEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERA 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 273 LQLSRQLrdqaveAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVgegracwSLGNAYVSMGSPAQALTFAKKH 352
Cdd:COG2956 205 LEQDPDY------LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQ 271


                ..
gi 32189378 353 LQ 354
Cdd:COG2956 272 LR 273
TPR_12 pfam13424
Tetratricopeptide repeat;
207-278 1.50e-09

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 54.70  E-value: 1.50e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32189378   207 RAYGNLGNTHYLLGNFTEATTFHKERLAIAKEF--GDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 184-382 6.71e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 6.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 184 RASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFD 263
Cdd:COG3914  16 ALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYE 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 264 VAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPA 343
Cdd:COG3914  96 EALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAE------AYLNLGEALRRLGRLE 163

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 32189378 344 QALTFAKKHLQIsqeigdRNGELTARMNIAHLQLALGRL 382
Cdd:COG3914 164 EAIAALRRALEL------DPDNAEALNNLGNALQDLGRL 196
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-285 7.00e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 7.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   2 ASPAPPVAEELPGPASRRLYSRMEASCLELALEGERLCKAGDFKAGVAFFEAAvqvgtEDLKTLSAIYSQLGNAYFYLKE 81
Cdd:COG3914  19 AAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAA-----AALLLLAALLELAALLLQALGR 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  82 YARALQFHKHDLLLARTigdrmgEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGK 161
Cdd:COG3914  94 YEEALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGR 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 162 qlswnaaqdpghlppdvretLHRASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFgd 241
Cdd:COG3914 162 --------------------LEEAIAALRRALEL------DPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN-- 213

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 32189378 242 kaaeRRAYSNLgnahIFLGRFDVAAEHYKKTLQLSRQLRDQAVE 285
Cdd:COG3914 214 ----ADAHSNL----LFALRQACDWEVYDRFEELLAALARGPSE 249
COG3899 COG3899
Predicted ATPase [General function prediction only];
122-424 2.57e-08

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 57.56  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  122 FDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKqlswnaaqdpghlPPDVRETLHRASEFYERNLSLVKELGD 201
Cdd:COG3899  721 YAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGR-------------FEEAEALLERALAARALAALAALRHGN 787

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  202 RAAQGRAYGNLGntHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRD 281
Cdd:COG3899  788 PPASARAYANLG--LLLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGD 865

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  282 QAVEAQACYSLGNTyTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGD 361
Cdd:COG3899  866 AALALLALAAAAAA-AAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAA 944

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32189378  362 RNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLDRE 424
Cdd:COG3899  945 LAAAAAAAALAAALALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAA 1007
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 203-358 6.71e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 6.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 203 AAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdq 282
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPE------AFALLGEILLQLGDLDEAIVLLHEALELDPD---- 70

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32189378 283 avEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADrvgegrACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:COG4783  71 --EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKALELDPD 138
GoLoco pfam02188
GoLoco motif;
494-515 2.29e-07

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 47.03  E-value: 2.29e-07
                          10        20
                  ....*....|....*....|..
gi 32189378   494 ECFFDLLSKFQSSRMDDQRCPL 515
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-161 1.60e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  35 GERLCKAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQfhkhdlLLARTIGDRMGEAKASGNLGN 114
Cdd:COG0457  49 GLAYLRLGRYEEALADYEQALELDPDD----AEALNNLGLALQALGRYEEALE------DYDKALELDPDDAEALYNLGL 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 32189378 115 TLKVLGRFDEAIVCCQRHLDIaqeqgdKVGEARALYNIGNVYHAKGK 161
Cdd:COG0457 119 ALLELGRYDEAIEAYERALEL------DPDDADALYNLGIALEKLGR 159
TPR_12 pfam13424
Tetratricopeptide repeat;
247-318 2.07e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 45.84  E-value: 2.07e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32189378   247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLR--DQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 318
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_12 pfam13424
Tetratricopeptide repeat;
106-162 5.97e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 44.69  E-value: 5.97e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 32189378   106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQ--GDKVGEARALYNIGNVYHAKGKQ 162
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRY 61
COG3899 COG3899
Predicted ATPase [General function prediction only];
174-418 6.90e-06

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 49.47  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  174 LPPDVRETLH-RASEFYERNLSLVKEL------------GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG 240
Cdd:COG3899  660 LPPEERRALHrRIARALEARGPEPLEErlfelahhlnraGERDRAARLLLRAARRALARGAYAEALRYLERALELLPPDP 739

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  241 DKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYT-----LLQDYERAAEYHLRHLVI 315
Cdd:COG3899  740 EEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYAnlgllLLGDYEEAYEFGELALAL 819

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  316 AQELADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAG 395
Cdd:COG3899  820 AERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAAALAAAAAAAARLLAA 899

                        250       260
                 ....*....|....*....|...
gi 32189378  396 YEAQGARPKRTQRLSAETWDLLR 418
Cdd:COG3899  900 AAAALAAAAAAAALAAAELARLA 922
GoLoco pfam02188
GoLoco motif;
547-567 1.60e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.60e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   547 EEFFDLIASSQSRRLDDQRAS 567
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco pfam02188
GoLoco motif;
629-650 1.62e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 42.02  E-value: 1.62e-05
                          10        20
                  ....*....|....*....|..
gi 32189378   629 EDFFSLIQRVQAKRMDEQRVDL 650
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCSL 22
GoLoco pfam02188
GoLoco motif;
595-615 1.78e-05

GoLoco motif;


Pssm-ID: 460481  Cd Length: 22  Bit Score: 41.64  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|.
gi 32189378   595 DEFFNMLIKYQSSRIDDQRCP 615
Cdd:pfam02188   1 EDFFDLLARVQSSRLDDQRCS 21
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 493-515 1.82e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.82e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    493 EECFFDLLSKFQSSRMDDQRCPL 515
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 594-616 1.93e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 41.72  E-value: 1.93e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    594 GDEFFNMLIKYQSSRIDDQRCPP 616
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
146-238 2.20e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 43.14  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   146 ARALYNIGNVYHAKGKqlswnaaqdpghlppdvretLHRASEFYERNLSLVKEL--GDRAAQGRAYGNLGNTHYLLGNFT 223
Cdd:pfam13424   3 ATALNNLAAVLRRLGR--------------------YDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYE 62

                          90
                  ....*....|....*
gi 32189378   224 EATTFHKERLAIAKE 238
Cdd:pfam13424  63 EALELLERALALAEK 77
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 546-568 3.68e-05

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 40.95  E-value: 3.68e-05
                           10        20
                   ....*....|....*....|...
gi 32189378    546 TEEFFDLIASSQSRRLDDQRASV 568
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
TPR_12 pfam13424
Tetratricopeptide repeat;
65-138 4.11e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 4.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32189378    65 LSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTI--GDRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
COG3899 COG3899
Predicted ATPase [General function prediction only];
29-480 5.29e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 46.78  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   29 LELALE-GERLCKAGDFKAGVAFFEAAVQVGT-------EDLKTLSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTIG 100
Cdd:COG3899  745 LALLLElAEALYLAGRFEEAEALLERALAARAlaalaalRHGNPPASARAYANLGLLLLGDYEEAYEFGELALALAERLG 824

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  101 DRMGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYnignvyhakgkQLSWNAAQDPGHLPPDVRE 180
Cdd:COG3899  825 DRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALA-----------AAAAAAAAAAALAAAAAAA 893

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  181 TLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLG 260
Cdd:COG3899  894 ARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAALALAAAAAAAAAAALA 973

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  261 RFDVAAEHY---KKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGNAYV 337
Cdd:COG3899  974 AAAAAAAAAaaaAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALLAAAAALALLAALAAAA 1053

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  338 SMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPDLAGYEAQGARPKRTQRLSAETWDLL 417
Cdd:COG3899 1054 AAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALAAALAALALAAAARAAA 1133

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32189378  418 RLPLDREQNGETHHTGDWRGPGRDSLPLPMRSRKYQEGPDAIERRPREGSHSPLDSADVRVQV 480
Cdd:COG3899 1134 ALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALL 1196
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 243-382 6.16e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 6.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 243 AAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYhlrhlvIAQELADR 322
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVL------LHEALELD 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 323 VGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQEIGDrngeltARMNIAHLQLALGRL 382
Cdd:COG4783  69 PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRP 122
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 199-316 1.00e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 199 LGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQ 278
Cdd:COG5010  47 RDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPE------LYYNLALLYSRSGDKDEAKEYYEKALALSPD 120

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 32189378 279 lrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIA 316
Cdd:COG5010 121 ------NPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 30-161 1.04e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  30 ELALEGERLCKAGDFKAGVAFFEAAVQVGTEDLktlsAIYSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKAS 109
Cdd:COG4783   6 ALYALAQALLLAGDYDEAEALLEKALELDPDNP----EAFALLGEILLQLGDLDEAIVLLHEALELDP------DEPEAR 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 32189378 110 GNLGNTLKVLGRFDEAIVCCQRHLDIAQEQgdkvgeARALYNIGNVYHAKGK 161
Cdd:COG4783  76 LNLGLALLKAGDYDEALALLEKALKLDPEH------PEAYLRLARAYRALGR 121
GoLoco smart00390
LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins
 628-650 1.15e-04

LGN motif, putative GEFs specific for G-alpha GTPases; GEF specific for Galpha_i proteins


Pssm-ID: 214645  Cd Length: 23  Bit Score: 39.41  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|...
gi 32189378    628 DEDFFSLIQRVQAKRMDEQRVDL 650
Cdd:smart00390   1 DEDLFDLLLRMQSSRMDDQRCEL 23
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 40-431 1.50e-04

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 44.91  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   40 KAGDFKAGVAFFEAAVQV-----GTEDLKTLSAiYSQLGNAYFYLKEYARALQfhkhdllLARTIGDRMGEAK------- 107
Cdd:NF040586 404 LRGDYESARDLAERALERwrerlGPDDRQTLRL-RFHLANALRSLGRYEEARE-------LDEDTLERQRRVLglgedhp 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  108 ----ASGNLGNTLKVLGRFDEAivccqrhLDIAQEqgdkvgearalynignvyhakgkqlSWNAAQDPghLPPDVRETLh 183
Cdd:NF040586 476 htlmTAGGLGADLRALGRFREA-------LELDEE-------------------------TLERHRRV--FGEDHPRTL- 520

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  184 rasefyernlslvkelgdraaqgRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFG--DKAAERRAYSNLGNAHIFLGR 261
Cdd:NF040586 521 -----------------------RAANNLAVSLRLLGDYREALELDREVLRRRRRVLgpDHPRTLLSANNLARDLRELGR 577

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  262 FDVAAEHYKKTLQLSRQLR---DQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEG----RAC-WSLG 333
Cdd:NF040586 578 YAEALDLLEEALERYREVLggpDHPDTLRAAKSLAVALRRAGRLEEALELAED---TYERYRRRFGPDhpdtLAAaLSLA 654

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  334 NAYVSMGSPAQALTFAKKHLQISQEigdRNGE-----LTARMNIAHLQLALGRltsPAAAEkpdlagyeaqgarpkrtqR 408
Cdd:NF040586 655 NDLRALGDADEARELAREVLDRYRR---VLGEdhpftLACRNNLAVLLRALGD---PEEAR------------------E 710

                        410       420
                 ....*....|....*....|...
gi 32189378  409 LSAETWDLLrlpldREQNGETHH 431
Cdd:NF040586 711 LAEAALEGL-----RERLGPDHP 728
TPR_12 pfam13424
Tetratricopeptide repeat;
290-358 1.84e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.45  E-value: 1.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32189378   290 YSLGNTYTLLQDYERAAEYHLRHLVIAQEL--ADRVGEGRACWSLGNAYVSMGSPAQALTFAKKHLQISQE 358
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLlgPDHPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_7 pfam13176
Tetratricopeptide repeat;
288-322 1.94e-04

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 39.06  E-value: 1.94e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 32189378   288 ACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADR 322
Cdd:pfam13176   1 ALLNLGRIYRKLGDYDEAISLYEQALALAKDPYDR 35
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
145-328 3.52e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 3.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 145 EARALYNIGNVYHAKGKqlsWNAAqdpghlppdvRETLHRAsefyernLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTE 224
Cdd:COG4785  72 LAQLYYERGVAYDSLGD---YDLA----------IADFDQA-------LEL------DPDLAEAYNNRGLAYLLLGDYDA 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 225 AttfhkerlaiAKEFgDKAAERR-----AYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYslgntytLL 299
Cdd:COG4785 126 A----------LEDF-DRALELDpdyayAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAE-------RK 187

                       170       180
                ....*....|....*....|....*....
gi 32189378 300 QDYERAAEYHLRHLVIAQELADRVGEGRA 328
Cdd:COG4785 188 LDPEKALALLLEDWATAYLLQGDTEEARE 216
TPR_1 pfam00515
Tetratricopeptide repeat;
106-138 3.55e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.17  E-value: 3.55e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 32189378   106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 106-138 4.46e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.81  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32189378    106 AKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQE 138
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
184-281 6.70e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.38  E-value: 6.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 184 RASEFYERNLSLvkelgdRAAQGRAYGNLGNTHYLLGNFTEATTFHKerlAIAKEFGDKaaerRAYSNLGNAHIFLGRFD 263
Cdd:COG3063  10 EAEEYYEKALEL------DPDNADALNNLGLLLLEQGRYDEAIALEK---ALKLDPNNA----EALLNLAELLLELGDYD 76

                        90
                ....*....|....*...
gi 32189378 264 VAAEHYKKTLQLSRQLRD 281
Cdd:COG3063  77 EALAYLERALELDPSALR 94
TPR_1 pfam00515
Tetratricopeptide repeat;
247-275 9.39e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.02  E-value: 9.39e-04
                          10        20
                  ....*....|....*....|....*....
gi 32189378   247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQL 275
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALEL 30
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
35-205 1.01e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  35 GERLCKAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQFHKHDLLLARtigdrmGEAKASGNLGN 114
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALELDPDD----AEALYNLGLALLELGRYDEAIEAYERALELDP------DDADALYNLGI 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 115 TLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAQDPGHLPPDVRETLHRASEFYERNLS 194
Cdd:COG0457 153 ALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLA 232

                       170
                ....*....|.
gi 32189378 195 LVKELGDRAAQ 205
Cdd:COG0457 233 LRLAALALYQY 243
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 247-356 1.11e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.60  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 247 RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQEladrvgEG 326
Cdd:COG4235  18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------NADALLDLAEALLAAGDTEEAEELLERALALDPD------NP 85

                        90       100       110
                ....*....|....*....|....*....|
gi 32189378 327 RACWSLGNAYVSMGSPAQALTFAKKHLQIS 356
Cdd:COG4235  86 EALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
255-358 1.46e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 255 AHIFLGRFDVAAEHYKKTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEYHlRHLVIAQELADrvgegrACWSLGN 334
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPD------NADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAE------ALLNLAE 67

                        90       100
                ....*....|....*....|....
gi 32189378 335 AYVSMGSPAQALTFAKKHLQISQE 358
Cdd:COG3063  68 LLLELGDYDEALAYLERALELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 195-308 1.69e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 195 LVKELGDRAAQ----GRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDVAAEHYK 270
Cdd:COG4235   2 AIARLRQALAAnpndAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNAD------ALLDLAEALLAAGDTEEAEELLE 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 32189378 271 KTLQLSRQlrdqavEAQACYSLGNTYTLLQDYERAAEY 308
Cdd:COG4235  76 RALALDPD------NPEALYLLGLAAFQQGDYAEAIAA 107
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
216-308 2.25e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 216 HYLLGNFTEATTFHKERLAIAKEFGDkaaerrAYSNLGNAHIFLGRFDvAAEHYKKTLQLSRQlrdqavEAQACYSLGNT 295
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNAD------ALNNLGLLLLEQGRYD-EAIALEKALKLDPN------NAEALLNLAEL 68

                        90
                ....*....|...
gi 32189378 296 YTLLQDYERAAEY 308
Cdd:COG3063  69 LLELGDYDEALAY 81
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 220-382 2.69e-03

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 40.37  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   220 GNFTEATTFHKERLAIAKEfgDKAAER-RAYSNLGNAHIFLGRFDVAAEHYKKTLQLSRQLRDQAVEAQACYSLGNTYTl 298
Cdd:pfam17874  15 GDAERALELAEQALALLPE--DDLLARgLATFVLGEAYLCLGDLDAALQAMREAEALARRADSPHVTLWALLQQGEILR- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   299 LQDYERAAEYHLRHlviAQELADRVGE------GRACWSLGNAYVSMGSPAQALTFAKKHLQISQEiGDRNGELTARMNI 372
Cdd:pfam17874  92 AQGRLHQALETYQQ---ALQLARDHGLqhlplhGFLLVGLADLLYEWNDLEEAEQHAQQGIQLGRQ-WEPDAAVDAYVLL 167

                         170
                  ....*....|
gi 32189378   373 AHLQLALGRL 382
Cdd:pfam17874 168 ARIALAQGEL 177
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 255-351 3.50e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.66  E-value: 3.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 255 AHIFLGRFDVAAEHYKktlQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRhlvIAQELADRVGEGRACWSLGN 334
Cdd:COG1729   2 ALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEK---LLKRYPDSPKAPDALLKLGL 75

                        90
                ....*....|....*..
gi 32189378 335 AYVSMGSPAQALTFAKK 351
Cdd:COG1729  76 SYLELGDYDKARATLEE 92
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
40-138 4.08e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 4.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378  40 KAGDFKAGVAFFEAAVQVGTEDlktlSAIYSQLGNAYFYLKEYARALQFHKhdlllARTIGDRMGEAKAsgNLGNTLKVL 119
Cdd:COG3063   4 KLGDLEEAEEYYEKALELDPDN----ADALNNLGLLLLEQGRYDEAIALEK-----ALKLDPNNAEALL--NLAELLLEL 72

                        90
                ....*....|....*....
gi 32189378 120 GRFDEAIVCCQRHLDIAQE 138
Cdd:COG3063  73 GDYDEALAYLERALELDPS 91
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 194-274 4.29e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378 194 SLVKELGDRAAQGRAYGNLGNTHYLLGNFTEA-TTFhkerLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKT 272
Cdd:COG1729  18 AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAaEAF----EKLLKRYPDSPKAPDALLKLGLSYLELGDYDKARATLEEL 93


                ..
gi 32189378 273 LQ 274
Cdd:COG1729  94 IK 95
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 286-318 6.87e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 6.87e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 32189378    286 AQACYSLGNTYTLLQDYERAAEYHLRHLVIAQE 318
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-312 8.84e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   120 GRFDEAIVccqrHLDIAQEQGDKVGEARalYNIGNVYHAKGKQLS----WNAAQDPGHLPPDVRETLHRA---SEFYERN 192
Cdd:TIGR02917  36 NKYKAAII----QLKNALQKDPNDAEAR--FLLGKIYLALGDYAAaekeLRKALSLGYPKNQVLPLLARAyllQGKFQQV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32189378   193 LSLV--KELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIakefgdkaAERRAYSNLGNAHIFL--GRFDVAAEH 268
Cdd:TIGR02917 110 LDELpgKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAI--------DPRSLYAKLGLAQLALaeNRFDEARAL 181

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 32189378   269 YKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRH 312
Cdd:TIGR02917 182 IDEVLTADPGNVDAlLLKGDLLLSLGNIELALAAYRKAIALRPNN 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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