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Conserved domains on  [gi|23397546|ref|NP_694987|]
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DNA helicase MCM9 isoform 2 [Homo sapiens]

Protein Classification

minichromosome maintenance protein MCM( domain architecture ID 1000350)

minichromosome maintenance protein MCM is one of the highly conserved MCM complex proteins, the complex may have helicase activity and is essential for the initiation of DNA replication

Gene Ontology:  GO:0005524|GO:0004386|GO:0003682

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
2-384 3.22e-65

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 219.67  E-value: 3.22e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241   2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241  70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241 141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241 202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397546 307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:COG1241 277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
2-384 3.22e-65

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 219.67  E-value: 3.22e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241   2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241  70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241 141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241 202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397546 307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:COG1241 277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM smart00350
minichromosome maintenance proteins;
116-384 3.29e-56

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 192.09  E-value: 3.29e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 23397546    346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
305-385 9.96e-49

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 166.95  E-value: 9.96e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760   1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                .
gi 23397546 385 I 385
Cdd:cd17760  81 L 81
MCM pfam00493
MCM P-loop domain;
304-387 1.42e-28

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 111.08  E-value: 1.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493  16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                  ....
gi 23397546   384 GIVC 387
Cdd:pfam00493  96 GLTA 99
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
140-385 2.76e-16

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 80.81  E-value: 2.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111 279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111 346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111 425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498
                        250       260       270
                 ....*....|....*....|....*....|....
gi 23397546  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:PTZ00111 499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
 
Name Accession Description Interval E-value
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
2-384 3.22e-65

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 219.67  E-value: 3.22e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241   2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241  70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241 141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241 202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397546 307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:COG1241 277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAG 354
MCM smart00350
minichromosome maintenance proteins;
116-384 3.29e-56

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 192.09  E-value: 3.29e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350   9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350  81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546    270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350 159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 23397546    346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVG 275
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
305-385 9.96e-49

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 166.95  E-value: 9.96e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760   1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                .
gi 23397546 385 I 385
Cdd:cd17760  81 L 81
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
306-386 8.69e-30

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 116.67  E-value: 8.69e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17706   2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                .
gi 23397546 386 V 386
Cdd:cd17706  82 T 82
MCM pfam00493
MCM P-loop domain;
304-387 1.42e-28

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 111.08  E-value: 1.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493  16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                  ....
gi 23397546   384 GIVC 387
Cdd:pfam00493  96 GLTA 99
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
116-243 8.52e-25

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 97.94  E-value: 8.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546   116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207   6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 23397546   192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207  70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
306-385 1.11e-24

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 102.53  E-value: 1.11e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17761   3 IISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
306-385 3.77e-22

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 95.51  E-value: 3.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17757   2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
306-385 4.66e-22

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 95.59  E-value: 4.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17753   2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
308-385 7.40e-19

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 86.31  E-value: 7.40e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23397546 308 ASLCPQVFGMYLVKLAVAMVLAGGIQRTdATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17758   4 ASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
305-385 9.57e-19

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 85.90  E-value: 9.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17756   1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                .
gi 23397546 385 I 385
Cdd:cd17756  81 L 81
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
306-385 1.94e-18

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 85.18  E-value: 1.94e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAT-GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17755   1 RLArSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                ..
gi 23397546 384 GI 385
Cdd:cd17755  81 GL 82
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
306-385 8.32e-17

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 79.88  E-value: 8.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546 306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRT--DATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17759   2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYadDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                ..
gi 23397546 384 GI 385
Cdd:cd17759  82 GL 83
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
309-385 9.52e-17

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 79.82  E-value: 9.52e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23397546 309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:cd17754   5 SLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
140-385 2.76e-16

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 80.81  E-value: 2.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111 279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111 346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23397546  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111 425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498
                        250       260       270
                 ....*....|....*....|....*....|....
gi 23397546  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGI 385
Cdd:PTZ00111 499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGL 532
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
347-375 1.60e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.43  E-value: 1.60e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 23397546   347 HLLLVGDPGTGKSQFLK-YAAKITPRSVLT 375
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErLAAALSNRPVFY 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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