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Conserved domains on  [gi|23308609|ref|NP_694517|]
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odorant receptor 111-8 [Danio rerio]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
51-315 1.27e-57

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd13954:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 270  Bit Score: 187.69  E-value: 1.27e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd13954   6 LFLLI-YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd13954  85 GTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA-TSTNSL 289
Cdd:cd13954 165 CSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRpSSSYSS 244
                       250       260
                ....*....|....*....|....*.
gi 23308609 290 SLNaRVISTSLAhALPPMLHPIIYVL 315
Cdd:cd13954 245 DLD-KVVSVFYT-VVTPMLNPIIYSL 268
 
Name Accession Description Interval E-value
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-315 1.27e-57

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 187.69  E-value: 1.27e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd13954   6 LFLLI-YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd13954  85 GTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA-TSTNSL 289
Cdd:cd13954 165 CSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRpSSSYSS 244
                       250       260
                ....*....|....*....|....*.
gi 23308609 290 SLNaRVISTSLAhALPPMLHPIIYVL 315
Cdd:cd13954 245 DLD-KVVSVFYT-VVTPMLNPIIYSL 268
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
53-327 1.16e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 151.89  E-value: 1.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609    53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIatsTNSLSLN 292
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSM---VHRFGHN 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 23308609   293 -ARVISTSLAHA---LPPMLHPIIYVLNTAEIKDIIIKI 327
Cdd:pfam13853 238 vPPLLQIMMANAylfFPPVLNPIVYSVKTKQIRDCVKRM 276
 
Name Accession Description Interval E-value
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-315 1.27e-57

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 187.69  E-value: 1.27e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd13954   6 LFLLI-YLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd13954  85 GTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA-TSTNSL 289
Cdd:cd13954 165 CSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRpSSSYSS 244
                       250       260
                ....*....|....*....|....*.
gi 23308609 290 SLNaRVISTSLAhALPPMLHPIIYVL 315
Cdd:cd13954 245 DLD-KVVSVFYT-VVTPMLNPIIYSL 268
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
51-321 1.27e-55

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 182.81  E-value: 1.27e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15235   7 LFLAM-YLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15235  86 NTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15235 166 CSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSA 245
                       250       260       270
                ....*....|....*....|....*....|.
gi 23308609 291 LNARVISTsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15235 246 DKDRVATV-MYTVVTPMLNPFIYSLRNKDVK 275
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
53-322 3.83e-55

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 181.72  E-value: 3.83e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:cd15223  87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATST-NSLSL 291
Cdd:cd15223 167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFgKTIPP 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 23308609 292 NARVISTSLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15223 247 DVHVLLSVLYILIPPALNPIIYGVRTKEIRQ 277
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
53-320 4.26e-52

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 173.46  E-value: 4.26e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15222   7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:cd15222  87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 213 D---NSICASMAQLSAalyVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICifiatstnsL 289
Cdd:cd15222 167 DtrvNSIYGLFVVLST---MGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIG---------L 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 23308609 290 SLNARV--ISTSLAHAL--------PPMLHPIIYVLNTAEI 320
Cdd:cd15222 235 SMVHRFgkHASPLVHVLmanvyllvPPVLNPIIYSVKTKQI 275
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
51-315 5.19e-52

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 173.18  E-value: 5.19e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15918   6 LFLGM-YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15918  85 DLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15918 165 CSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSA 244
                       250       260
                ....*....|....*....|....*
gi 23308609 291 LNARVISTSLAhALPPMLHPIIYVL 315
Cdd:cd15918 245 SKDSVAAVMYT-VVTPMLNPFIYSL 268
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
52-320 2.33e-51

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 171.70  E-value: 2.33e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15917   6 PFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMyFVFSIIWVFNASIVAFAVS-LITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15917  86 MESGVLLAMAFDRYVAICYPLRYTTILTNTVV-GKIGLAILLRAVALIIPLPlLVRRLPYCGSNVISHSYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSIcASMAQLSAALYVVA-PVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATST-NS 288
Cdd:cd15917 165 CGDTRV-NSIYGLFVALLIVGfDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFgHH 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 23308609 289 LSLNARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15917 244 VPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
51-315 4.44e-50

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 168.07  E-value: 4.44e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15230   6 LFLLI-YLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15230  85 TTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15230 165 CSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSL 244
                       250       260
                ....*....|....*....|....*
gi 23308609 291 LNARVISTSLAHALpPMLHPIIYVL 315
Cdd:cd15230 245 DQDKVVSVFYTVVI-PMLNPLIYSL 268
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
51-322 2.66e-49

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 166.48  E-value: 2.66e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15225   6 VFLLI-YLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15225  85 GTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15225 165 CADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSP 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 23308609 291 LNARVISTSLAHaLPPMLHPIIYVLNTAEIKD 322
Cdd:cd15225 245 ETDKLLSLFYTV-VTPMLNPIIYSLRNKEVKG 275
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
50-315 2.20e-48

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 163.81  E-value: 2.20e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15912   4 FLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15912  84 GTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLV----GSfflpiiCIFI--- 282
Cdd:cd15912 164 SCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVsifyGS------CIFMyvr 237
                       250       260       270
                ....*....|....*....|....*....|....*
gi 23308609 283 ATSTNSLSLN--ARVISTSLAhalpPMLHPIIYVL 315
Cdd:cd15912 238 PSQSSSLDLNkvVALLNTVVT----PLLNPFIYTL 268
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
51-321 1.08e-47

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 162.00  E-value: 1.08e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15229   6 VFLVI-YLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWvfnasIVAFAVSLI-----TRLSFCESNKVNGYYCDYGP 205
Cdd:cd15229  85 GTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAW-----ALGFLYALIntlllLNLHFCGPNEINHFSCELPS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 206 VYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS 285
Cdd:cd15229 160 LLPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPN 239
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 23308609 286 TNSLSLNARVISTSLAhALPPMLHPIIYVLNTAEIK 321
Cdd:cd15229 240 SASSSVLDRVFSIQYS-ILTPMLNPIIYSLKNKEVK 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
53-320 4.51e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 160.66  E-value: 4.51e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLP-IICIFIATSTNSLSL 291
Cdd:cd15950 167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPgLLSIYTQRFGQGVPP 246
                       250       260
                ....*....|....*....|....*....
gi 23308609 292 NARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15950 247 HTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
52-315 1.31e-46

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 158.96  E-value: 1.31e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15232   7 FLFL-YAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLAC 211
Cdd:cd15232  86 SELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 NDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSL 291
Cdd:cd15232 166 SDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPE 245
                       250       260
                ....*....|....*....|....
gi 23308609 292 NARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15232 246 KDKVVAV-LYSVVTPTLNPLIYSL 268
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
54-320 5.10e-46

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 157.84  E-value: 5.10e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15221   8 CSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACND 213
Cdd:cd15221  88 SAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACAD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 214 NSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS-TNSLSLN 292
Cdd:cd15221 168 ITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRfGRHIPRH 247
                       250       260
                ....*....|....*....|....*...
gi 23308609 293 ARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15221 248 VHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
49-315 8.68e-46

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 156.83  E-value: 8.68e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15940   3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15940  83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTwEGRLKALKTCVSHLLLVGSFFLPiiCIFIATSTnS 288
Cdd:cd15940 163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGP--CIFIYTRP-S 238
                       250       260
                ....*....|....*....|....*..
gi 23308609 289 LSLNARVISTSLAHALPPMLHPIIYVL 315
Cdd:cd15940 239 TSFSEDKVVSVFYTVVTPLLNPIIYTL 265
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
52-321 1.77e-45

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 156.27  E-value: 1.77e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15231   7 FLII-YLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV---FNASIVAFavsLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15231  86 TECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLcgfLNSAVHTV---LTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFI-ATSTN 287
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNrPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 288 SLSlNARVISTsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15231 243 SLD-KDTLISV-LYSIVTPMLNPIIYSLRNKEVK 274
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
55-321 1.80e-45

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 156.33  E-value: 1.80e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  55 ITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQS 134
Cdd:cd15420   9 LLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 135 FTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACNDN 214
Cdd:cd15420  89 VLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 215 SICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSLNAR 294
Cdd:cd15420 169 WINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEK 248
                       250       260
                ....*....|....*....|....*...
gi 23308609 295 VIstSLAHAL-PPMLHPIIYVLNTAEIK 321
Cdd:cd15420 249 IL--SLFYSLfNPMLNPLIYSLRNKQVK 274
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
52-315 2.83e-45

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 155.46  E-value: 2.83e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15431   6 LLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFnASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLAC 211
Cdd:cd15431  86 TECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVS-AFLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLAC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 NDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSL 291
Cdd:cd15431 165 SDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSD 244
                       250       260
                ....*....|....*....|....
gi 23308609 292 NARVISTSLAhALPPMLHPIIYVL 315
Cdd:cd15431 245 QDKIISVFYG-VVTPMLNPLIYSL 267
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
50-315 4.56e-45

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 155.16  E-value: 4.56e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15915   4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15915  84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYL--GIFLaLSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTN 287
Cdd:cd15915 164 ACGDTSLNLWLLNIVTGSIALGTFILTLLSYIyiISFL-LLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                       250       260
                ....*....|....*....|....*...
gi 23308609 288 SlSLNARVISTSLAHALPPMLHPIIYVL 315
Cdd:cd15915 243 D-SLEQDRIVALLYTVVTPVLNPLIYTL 269
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
54-320 4.84e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 155.23  E-value: 4.84e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15952   8 CAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGME 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACND 213
Cdd:cd15952  88 SAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACAS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 214 NSICAsMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS-TNSLSLN 292
Cdd:cd15952 168 IRINI-IYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRfGHNIPRY 246
                       250       260
                ....*....|....*....|....*...
gi 23308609 293 ARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15952 247 IHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
51-315 6.68e-45

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 154.56  E-value: 6.68e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15911   6 LFLVI-YIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15911  85 ATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15911 165 CSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSR 244
                       250       260
                ....*....|....*....|....*
gi 23308609 291 LNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15911 245 DLNKVFSL-FYTVLTPLVNPLIYSL 268
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
51-326 1.07e-44

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 154.40  E-value: 1.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15411   6 LFLVI-YVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15411  85 TTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15411 165 CSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSL 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 23308609 291 LNARVISTSLAhALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15411 245 GQDKVASVFYT-VVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
49-328 4.96e-44

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 152.91  E-value: 4.96e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15406  13 FLLFLGI-YVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15406  92 FAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLK 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15406 172 LSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSS 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 23308609 289 lSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIKIV 328
Cdd:cd15406 252 -SMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
50-322 4.97e-44

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 152.52  E-value: 4.97e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15416   4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15416  84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSL 289
Cdd:cd15416 164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 290 SLNARVISTsLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15416 244 MDQNKVVSV-FYMVVIPMLNPLIYSLRNKEVKG 275
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
49-326 7.02e-44

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 152.19  E-value: 7.02e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15407   4 FIIFTLI-YLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23308609 289 lSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15407 243 -SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
50-326 9.94e-44

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 151.79  E-value: 9.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15409   4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVN---YTFMYFVFSIIWVFNASIvafAVSLITRLSFCESNKVNGYYCDYGPV 206
Cdd:cd15409  84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSnrlCVQLITASYIGGFLHSMI---HVGLTFRLSFCGSNEINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATST 286
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 23308609 287 nSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15409 241 -LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
53-327 1.16e-43

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 151.89  E-value: 1.16e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609    53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIatsTNSLSLN 292
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSM---VHRFGHN 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 23308609   293 -ARVISTSLAHA---LPPMLHPIIYVLNTAEIKDIIIKI 327
Cdd:pfam13853 238 vPPLLQIMMANAylfFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
49-321 1.65e-43

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 151.06  E-value: 1.65e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFL-FDSQYISYNACLANMFFVH 127
Cdd:cd15916   4 FLIFLII-YLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVY 207
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 208 RLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPiiCIFIATSTN 287
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVP--CVFIYLRPG 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 288 SLSLNARVISTsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15916 241 SKEALDGVIAV-FYTVVTPLLNPLIYTLRNKEVK 273
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
51-328 1.68e-43

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 151.75  E-value: 1.68e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15943  20 VFLVI-YLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFA 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15943  99 TTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLS 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15943 179 CSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSSYSL 258
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23308609 291 LNARVISTsLAHALPPMLHPIIYVLNTAEIKDIIIKIV 328
Cdd:cd15943 259 DQDKVVSV-FYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
51-315 3.22e-43

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 150.30  E-value: 3.22e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15227   6 LFLLI-YLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15227  85 ASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15227 165 CSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPS 244
                       250       260
                ....*....|....*....|....*
gi 23308609 291 LNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15227 245 LLDLLLSV-FYSVVPPTLNPIIYSL 268
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
49-321 3.28e-43

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 150.27  E-value: 3.28e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15228   4 FVLFLAF-YLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 289 LSLNARVIstsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15228 243 VLVTPVQI---FNNVVTPMLNPLIYTLRNKEVK 272
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
52-322 1.28e-42

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 149.00  E-value: 1.28e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15419   7 FLVI-YMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVF--SIIWVFNASIVafAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15419  86 TEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVagSYLCGCINSII--QTSFTFSLSFCGSNEIDHFFCDVPPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFiATSTNSL 289
Cdd:cd15419 164 SCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMY-AQPGAVS 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 290 SLNARVISTSLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15419 243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKE 275
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
51-328 1.91e-42

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 148.96  E-value: 1.91e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15410  19 VFLAI-YGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIvnytfMYFVFSIIWVFNASIVAFAVSLIT-----RLSFCESNKVNGYYCDYGP 205
Cdd:cd15410  98 VTESFLLAVMAYDRYVAICNPLLYTVI-----MSRKLCVLLVAGSYLWGIVCSLIHtcgllRLSFCGSNVINHFFCDLPP 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 206 VYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS 285
Cdd:cd15410 173 LLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPS 252
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 23308609 286 TnSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIKIV 328
Cdd:cd15410 253 S-SYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
51-321 2.80e-42

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 148.11  E-value: 2.80e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15234   6 LFLSM-YLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15234  85 GLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIaTSTNSLS 290
Cdd:cd15234 165 CSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYI-SSAVTHS 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 23308609 291 LNARVISTSLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15234 244 SRKTAVASVMYTVVTPMLNPFIYSLRNKDMK 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
53-320 6.86e-42

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 147.02  E-value: 6.86e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTfMYFVFSIIWVFNASIVAFAVS-LITRLSFCESNKVNGYYCDYGPVYRLAC 211
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNS-RIAKLGLVGLIRGVLLILPLPlLLSRLPFCANRIIPHTYCEHMAVVKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 NDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS-TNSLS 290
Cdd:cd15953 166 GDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRfGQGIA 245
                       250       260       270
                ....*....|....*....|....*....|
gi 23308609 291 LNARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15953 246 PHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
48-321 8.03e-42

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 146.84  E-value: 8.03e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVH 127
Cdd:cd15236   3 FFALFLAM-YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVY 207
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 208 RLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTN 287
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 288 SLSLNARVISTSLAhALPPMLHPIIYVLNTAEIK 321
Cdd:cd15236 242 NSSDKDIVASVMYT-VVTPMLNPFIYSLRNRDIK 274
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
51-315 1.29e-41

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 146.27  E-value: 1.29e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLcITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15224   6 LFL-IAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15224  85 CTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFiATSTNSLS 290
Cdd:cd15224 165 CTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMY-ARPKAISS 243
                       250       260
                ....*....|....*....|....*
gi 23308609 291 LNARVISTSLAHALPPMLHPIIYVL 315
Cdd:cd15224 244 FDSNKLVSVLYTVVTPLLNPIIYCL 268
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
50-321 3.72e-41

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 145.54  E-value: 3.72e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15408  17 FVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTF--MYFVFS-IIWVFNASIvafAVSLITRLSFCESNKVNGYYCDYGPV 206
Cdd:cd15408  97 ATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVcvSLVAGSyLAGFLNSTV---HTGFILRLSFCGSNVINHFFCDGPPL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATST 286
Cdd:cd15408 174 LALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSS 253
                       250       260       270
                ....*....|....*....|....*....|....*
gi 23308609 287 NSlSLNARVISTSLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15408 254 RY-SLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
48-315 4.55e-41

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 144.82  E-value: 4.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVH 127
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVY 207
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 208 RLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTN 287
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241
                       250       260
                ....*....|....*....|....*...
gi 23308609 288 SLSLNARVISTSLAhALPPMLHPIIYVL 315
Cdd:cd15914 242 YSLDYDRAIAVVYA-VLTPFFNPIIYSL 268
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
57-321 1.61e-40

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 143.39  E-value: 1.61e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  57 YFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQSFT 136
Cdd:cd15233  11 YIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 137 LVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACNDNSI 216
Cdd:cd15233  91 LTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 217 CASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSLNARVI 296
Cdd:cd15233 171 NELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVI 250
                       250       260
                ....*....|....*....|....*
gi 23308609 297 STsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15233 251 GI-LNTVLSPMLNPLIYSLRNKDVK 274
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
52-315 1.73e-40

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 143.19  E-value: 1.73e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15237   6 LFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLAC 211
Cdd:cd15237  86 TECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 NDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSL 291
Cdd:cd15237 166 ADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPD 245
                       250       260
                ....*....|....*....|....
gi 23308609 292 NARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15237 246 QDKMISV-FYTIVTPMLNPLIYSL 268
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
51-315 1.74e-40

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 143.12  E-value: 1.74e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLcITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15939   6 VFL-LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15939  85 GAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTwEGRLKALKTCVSHLLLVGSFFLPiiCIFI---ATSTN 287
Cdd:cd15939 165 CTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSS-EGRRKALSTCGSHITVVVLFFVP--CIFIymrPVTTF 241
                       250       260
                ....*....|....*....|....*...
gi 23308609 288 SLSLNARVISTSLAhalpPMLHPIIYVL 315
Cdd:cd15939 242 PIDKVVAVFYTIIT----PMLNPLIYTL 265
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
51-322 2.50e-40

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 142.78  E-value: 2.50e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15417   6 LFLGI-YLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVfsiiwVFNASIVAFAVSLIT-----RLSFCESNKVNGYYCDYGP 205
Cdd:cd15417  85 LTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQL-----VAGAYLGGFLNSLIQtvsmfQLSFCGPNVIDHFFCDIPP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 206 VYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS 285
Cdd:cd15417 160 LLSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPS 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 23308609 286 TNSLSLNARVISTsLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15417 240 SSHSQDQDKVASV-FYTVVIPMLNPLIYSLRNKEIKD 275
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
50-322 5.00e-40

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 142.19  E-value: 5.00e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15942   4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15942  84 GCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATST-NS 288
Cdd:cd15942 164 ACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSqDP 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 289 LSLNARVISTSLAhalpPMLHPIIYVLNTAEIKD 322
Cdd:cd15942 244 LDGVVAVFYTTVT----PLLNPVIYTLRNKEMKD 273
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
53-320 5.72e-40

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 142.10  E-value: 5.72e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS-TNSLSL 291
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRfGHNVPP 246
                       250       260
                ....*....|....*....|....*....
gi 23308609 292 NARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15951 247 HVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
50-322 6.30e-40

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 142.08  E-value: 6.30e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15413   4 FGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15413  84 IISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLAL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSl 289
Cdd:cd15413 164 SCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH- 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 290 SLNARVISTSLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15413 243 SLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKD 275
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
50-315 7.99e-40

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 141.53  E-value: 7.99e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15421   4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFnASIVAFAVSLIT-RLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15421  84 GGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLG-GSLNSLIHTVYTmHFPYCGSREIHHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260
                ....*....|....*....|....*..
gi 23308609 289 LSLNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15421 243 SPEQDKVVSV-FYTILTPMLNPLIYSL 268
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
51-326 1.08e-39

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 141.38  E-value: 1.08e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15412   6 LFLVI-YLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLA 210
Cdd:cd15412  85 ITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 211 CNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLS 290
Cdd:cd15412 165 CSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESV 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 23308609 291 LNARVISTSLAhALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15412 245 EQSKIVAVFYT-FVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
49-315 2.11e-39

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 140.16  E-value: 2.11e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15936   4 FLVFLLV-YLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV--FNASIVafAVSLITRLSFCESNKVNGYYCDYGPV 206
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLggFAHSIV--QVALLLQLPFCGPNVLDNFYCDVPQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTwEGRLKALKTCVSHLLLVGSFFLPiiCIFIATST 286
Cdd:cd15936 161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVT-EGKRKALSTCASQITVVTLIFVP--CIYIYARP 237
                       250       260
                ....*....|....*....|....*....
gi 23308609 287 NSLSLNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15936 238 FQTFPMDKAVSV-LYTVITPMLNPMIYTL 265
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
51-322 5.89e-39

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 139.46  E-value: 5.89e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLcITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15429   6 LFL-VMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV--FNASIVAFAVSLitRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15429  85 GTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTsgFLNSLVQTAFTF--RLPFCGHNTINHFSCELLAVVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 289 LSLNARVISTSLAhALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15429 243 SALQEKMISLFYA-VVTPMLNPLIYSLRNKEVKG 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
49-331 1.02e-38

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 139.10  E-value: 1.02e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15414   4 FLLFLLV-YLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15414  83 FVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATStNS 288
Cdd:cd15414 163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPS-SS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 23308609 289 LSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIKIVRNK 331
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
49-315 1.79e-38

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 137.72  E-value: 1.79e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTwEGRLKALKTCVSHLLLVGSFFLPiiCIFIATSTNS 288
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSS-GGSSKALSTCSAHITVVVLFFGP--CIFIYVWPFS 239
                       250       260
                ....*....|....*....|....*..
gi 23308609 289 LSLNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15226 240 TFPVDKFLAV-FYTVITPLLNPIIYTL 265
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
48-321 3.04e-37

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 134.91  E-value: 3.04e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVH 127
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVY 207
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 208 RLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTN 287
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSS 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 23308609 288 SLSLNARVISTSLAhALPPMLHPIIYVLNTAEIK 321
Cdd:cd15428 242 TSKEYDKMISVFYI-IVTPMLNPLIYSLRNKEVK 274
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
49-321 3.04e-37

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 134.85  E-value: 3.04e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15405   4 FFLFLGI-YVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFsiiwvFNASIVAFAVSL-----ITRLSFCESNKVNGYYCDY 203
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLM-----LGSYVMGFAGAMahtgcMLRLTFCDSNIINHYMCDI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 204 GPVYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA 283
Cdd:cd15405 158 LPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLK 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23308609 284 TSTnSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15405 238 PSS-VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVK 274
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
49-315 4.27e-37

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 134.23  E-value: 4.27e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV--FNASIVafAVSLITRLSFCESNKVNGYYCDYGPV 206
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAggFLHSIV--QTLLTIQLPFCGPNQVNNFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIflaLSKITTWEGRLKALKTCVSHLLLVGSFFLPiiCIFIATST 286
Cdd:cd15938 161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGP--CIFIYARP 235
                       250       260
                ....*....|....*....|....*....
gi 23308609 287 NSLSLNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15938 236 FSTFPVDKHVSV-LYNVITPMLNPLIYTL 263
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
54-320 5.38e-37

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 134.22  E-value: 5.38e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15956   8 CFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAME 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACND 213
Cdd:cd15956  88 SGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 214 NSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLP-IICIFIATSTNSLSLN 292
Cdd:cd15956 168 TTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPgLLSVLMHRFGHSVPSA 247
                       250       260
                ....*....|....*....|....*...
gi 23308609 293 ARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15956 248 AHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
52-315 6.00e-37

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 133.90  E-value: 6.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15947   6 VVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLAC 211
Cdd:cd15947  86 TECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 NDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSL 291
Cdd:cd15947 166 VDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQD 245
                       250       260
                ....*....|....*....|....
gi 23308609 292 NARVIStSLAHALPPMLHPIIYVL 315
Cdd:cd15947 246 QGKFIS-LFYTVVTPTLNPLIYTL 268
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
53-321 9.08e-37

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 133.49  E-value: 9.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYtfmyfvfSIIWVFNASIVAFAVSLIT-------RLSFCESNKVNGYYCDYGP 205
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTN-------SVITKIGLAALARAVTLMTplpfllrRLPYCRSHVIAHCYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 206 VYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLP-IICIFIAT 284
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPvVLSSTMHR 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 23308609 285 STNSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15948 241 FARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
50-315 1.31e-36

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 132.99  E-value: 1.31e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15946   4 FAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLAL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15946  84 GITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSL 289
Cdd:cd15946 164 ACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYS 243
                       250       260
                ....*....|....*....|....*.
gi 23308609 290 SLNARVISTsLAHALPPMLHPIIYVL 315
Cdd:cd15946 244 PERDKKISL-FYNVFTALLNPVIYSL 268
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
48-321 2.99e-36

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 132.28  E-value: 2.99e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCItYFVTVTGNSLVLLLIALYRSLHS-PKYIGVFNLALADFGETNALIPNMMKTFL-FDSQYISYNACLANMFF 125
Cdd:cd15941   3 FFLLFLLI-YLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLtLSGRTISFEGCVVQLYA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 126 VHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGP 205
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 206 VYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATS 285
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 23308609 286 TNSLSLNARVISTSLahaLPPMLHPIIYVLNTAEIK 321
Cdd:cd15941 242 SSQAGAGAPAVFYTI---VTPMLNPFIYTLRNKEVK 274
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
55-315 6.45e-36

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 130.95  E-value: 6.45e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  55 ITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQS 134
Cdd:cd15430   9 IMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 135 FTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACNDN 214
Cdd:cd15430  89 VLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 215 SICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSLNAR 294
Cdd:cd15430 169 SLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDK 248
                       250       260
                ....*....|....*....|.
gi 23308609 295 VISTSLAhALPPMLHPIIYVL 315
Cdd:cd15430 249 LITLFYG-VVTPMLNPIIYSL 268
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
32-321 1.12e-35

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 131.05  E-value: 1.12e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  32 PEYFFIIGLSGIHNSNYYYMF-LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFD 110
Cdd:cd15949   1 PSTFILLGIPGLEPLHVWISIpFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 111 SQYISYNACLANMFFVHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSF 190
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 191 CESNKVNGYYCDYGPVYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLV 270
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 23308609 271 GSFFLPI-ICIFIATSTNSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15949 241 LAFYVPIaVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
50-326 1.37e-35

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 131.02  E-value: 1.37e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15945  17 FLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15945  97 ADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLAL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTnSL 289
Cdd:cd15945 177 SCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSS-SY 255
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 23308609 290 SLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15945 256 SLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
49-328 5.04e-35

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 129.52  E-value: 5.04e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15944  16 LFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVG 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15944  96 FVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLA 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIaTSTNS 288
Cdd:cd15944 176 LSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYL-RPTSV 254
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 23308609 289 LSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIKIV 328
Cdd:cd15944 255 YSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
49-322 6.70e-35

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 128.69  E-value: 6.70e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15415   4 FMLFLLI-YFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIvnytfMYFVFSIIWVFNASIVAFAVSLI-----TRLSFCESNKVNGYYCDY 203
Cdd:cd15415  83 FVTTEGFLLAVMAYDRYVAICNPLLYTVA-----MTKRVCVQLVAGSYLGGLINSLThtiglLKLSFCGPNVINHYFCDI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 204 GPVYRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA 283
Cdd:cd15415 158 PPLLKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQ 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 23308609 284 TSTnSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15415 238 PSS-QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKD 275
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
54-320 2.93e-34

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 126.81  E-value: 2.93e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15955   8 CIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLIT-RLSFCESNKVNGYYCDYGPVYRLACN 212
Cdd:cd15955  88 SGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAAD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 213 DNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFF-LPIICIFIATSTNSLSL 291
Cdd:cd15955 168 DVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYtLAFFSFFAHRFGHHVAP 247
                       250       260
                ....*....|....*....|....*....
gi 23308609 292 NARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15955 248 YVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
49-326 1.23e-33

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 125.28  E-value: 1.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCItYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15418   5 FVVFLLS-YILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15418  84 LAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFiATSTNS 288
Cdd:cd15418 164 LACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIY-SRPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23308609 289 LSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDIIIK 326
Cdd:cd15418 243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
49-321 1.37e-33

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 125.28  E-value: 1.37e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLcITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15432   4 FVVFL-IFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNS 288
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 289 LSLNARVISTSLAhALPPMLHPIIYVLNTAEIK 321
Cdd:cd15432 243 SHDRGKMVALFYG-IITPMLNPLIYTLRNKDVK 274
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
49-315 2.95e-33

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 123.97  E-value: 2.95e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 209 LACNDNS----ICASMaqlsAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIA- 283
Cdd:cd15913 163 LSCVPAPgtelICYTL----SSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSp 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 23308609 284 TSTNSLSLNArvISTSLAHALPPMLHPIIYVL 315
Cdd:cd15913 239 GSGNSTGMQK--IVTLFYSVVTPLLNPLIYSL 268
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
54-320 4.12e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 123.78  E-value: 4.12e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15954   8 CFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGME 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACND 213
Cdd:cd15954  88 SGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACAN 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 214 NSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIAT--STNSLSL 291
Cdd:cd15954 168 IRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfGGHHITP 247
                       250       260
                ....*....|....*....|....*....
gi 23308609 292 NARVISTSLAHALPPMLHPIIYVLNTAEI 320
Cdd:cd15954 248 HIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
50-324 5.24e-33

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 123.64  E-value: 5.24e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15434   4 SVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF---NASIVAfavSLITRLSFCESNKVNGYYCDYGPV 206
Cdd:cd15434  84 GGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIgfgNSLVLS---PLTLSLPRCGHHRVDHFFCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSt 286
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPK- 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23308609 287 NSLSLNARVISTSLAHALPPMLHPIIYVLNTAEIKDII 324
Cdd:cd15434 240 NSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
50-315 2.28e-31

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 119.07  E-value: 2.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15937   4 FVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15937  84 GAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYlGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFiATSTNSL 289
Cdd:cd15937 164 ACTNTYTVELLMFSNSGLVILLCFLLLLISY-AFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIY-ARPFRSF 241
                       250       260
                ....*....|....*....|....*..
gi 23308609 290 SLNARVistSLAHALP-PMLHPIIYVL 315
Cdd:cd15937 242 PMDKVV---AVFHTVIfPLLNPMIYTL 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
57-315 4.69e-31

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 118.33  E-value: 4.69e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  57 YFVTVTGNSLVLLLIALYRSL-HSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQSF 135
Cdd:cd15935  11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 136 TLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLACNDNS 215
Cdd:cd15935  91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTY 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 216 ICASMAQLSAALYVVAPVIIIVLSYlGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPiiCIFIATSTNSLSLNARV 295
Cdd:cd15935 171 VVEVLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVP--CIFVYLRPFSSSSVDKV 247
                       250       260
                ....*....|....*....|
gi 23308609 296 ISTsLAHALPPMLHPIIYVL 315
Cdd:cd15935 248 ASV-FYTLITPALNPLIYTL 266
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
50-322 1.81e-30

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 116.76  E-value: 1.81e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15424   4 FVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15424  84 GSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSL 289
Cdd:cd15424 164 ACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGST 243
                       250       260       270
                ....*....|....*....|....*....|...
gi 23308609 290 SLNARVISTsLAHALPPMLHPIIYVLNTAEIKD 322
Cdd:cd15424 244 PDRDKQIAV-FYIVITPLLNPIIYTLRNKDVHG 275
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
50-321 1.32e-24

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 101.02  E-value: 1.32e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15433   4 FVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLAL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRL 209
Cdd:cd15433  84 GSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSL 289
Cdd:cd15433 164 ACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYS 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 23308609 290 SLNARVISTsLAHALPPMLHPIIYVLNTAEIK 321
Cdd:cd15433 244 QAHGKFVSL-FYTVMTPALNPLIYTLRNKDVK 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
63-313 2.14e-22

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 94.29  E-value: 2.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609    63 GNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQY-ISYNACLANMFFVHFFSTVQSFTLVVLA 141
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   142 YDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVngyYCDYGPVYRLACNdnsicASMA 221
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVT---VCFIDFPEDLSKP-----VSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609   222 QLSAALYVVAPVIIIVLSYLGIFLALSKI-------TTWEGRLKALKTCVSHLLLVGSFFLPIICIFIATSTNSLSLNAR 294
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSaskqkssERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 23308609   295 VIST--SLAHALP---PMLHPIIY 313
Cdd:pfam00001 233 LLDKalSVTLWLAyvnSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
52-315 3.60e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 85.80  E-value: 3.60e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFnaSIVAFAVSLITRLSFCESNKVNGYYCDYGPVYRLAc 211
Cdd:cd00637  84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLL--SLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 212 ndnsicasMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEG--------------RLKALKTCVSHLLLVGSFFLPI 277
Cdd:cd00637 161 --------YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRssssnssrrrrrrrERKVTKTLLIVVVVFLLCWLPY 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 23308609 278 ICIFI----ATSTNSLSLNARVISTSLAHaLPPMLHPIIYVL 315
Cdd:cd00637 233 FILLLldvfGPDPSPLPRILYFLALLLAY-LNSAINPIIYAF 273
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
48-321 8.05e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 76.06  E-value: 8.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVH 127
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFnaSIVAFAVSLITRLSFCESNKVNGYYCD-YGPV 206
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVY--SLLISLPPLVGWRDETQPSVVDCECEFtPNKI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLacndnsicasmaqLSAALYVVAPVIIIVLSYLGIFLALSKittwegRLKALKTCVshlLLVGSFF---LPIICIFIA 283
Cdd:cd14967 159 YVL-------------VSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLA---IIVGAFLlcwLPFFIIYLV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 23308609 284 TS---TNSLSLNARVISTSLAHaLPPMLHPIIYVLNTAEIK 321
Cdd:cd14967 217 SAfcpPDCVPPILYAVFFWLGY-LNSALNPIIYALFNRDFR 256
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
52-173 1.68e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 63.76  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd14969   6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIvNYTFMYFVFSIIWVF 173
Cdd:cd14969  86 VSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLY 126
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
59-172 2.90e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.22  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADfgetnaLIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQSFT-- 136
Cdd:cd14972  11 FIVVENSLVLAAIIKNRRLHKPMYILIANLAAAD------LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLas 84
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23308609 137 ---LVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd14972  85 aysLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWV 123
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
52-175 4.96e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 53.49  E-value: 4.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15083   6 FILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGI 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNA 175
Cdd:cd15083  86 MSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSL 129
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
50-245 1.41e-07

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 52.24  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15314   4 YIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNAsIVAFAVslitrlSFCESNKVNGYYCDygpvyrL 209
Cdd:cd15314  84 CTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSA-LVGFGI------IFLELNIKGIYYNH------V 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 23308609 210 ACNDNSIcASMAQLSAALYVVA----PVIIIVLSYLGIFL 245
Cdd:cd15314 151 ACEGGCL-VFFSKVSSVVGSVFsfyiPAVIMLCIYLKIFL 189
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
47-249 2.17e-07

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 51.58  E-value: 2.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  47 NYYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQ-YISYNACLANMFF 125
Cdd:cd15053   1 NYWALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYIAM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 126 VHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVfnasiVAFAVSLITRLSFCESNKVNGYYCdygp 205
Cdd:cd15053  81 DVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWV-----VSAAIACPLLFGLNNVPYRDPEEC---- 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 23308609 206 vyRLACNDNSICASMAQLsaalyvVAPVIIIVLSYLGIFLALSK 249
Cdd:cd15053 152 --RFYNPDFIIYSSISSF------YIPCIVMLLLYYRIFRALRR 187
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
49-185 2.64e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 51.49  E-value: 2.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnmmKTFLFDSQY-ISYNACLANMFFVH 127
Cdd:cd14968   3 YIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP---LAILISLGLpTNFHGCLFMACLVL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVfnasiVAFAVSLI 185
Cdd:cd14968  80 VLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWV-----LSFLVGLT 132
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
53-178 3.70e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 50.83  E-value: 3.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSL-HSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15104   6 LAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCA 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIV 178
Cdd:cd15104  86 ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIG 132
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
53-172 5.95e-07

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 50.28  E-value: 5.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYnaCLANMFFVHFFSTV 132
Cdd:cd15960   7 LCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTL--CSAGLLLAAFSASV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 23308609 133 QSftLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15960  85 CS--LLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWL 122
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
50-173 7.23e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 49.86  E-value: 7.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15055   4 YIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYIL 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF 173
Cdd:cd15055  84 TSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFV 127
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
51-177 1.27e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 49.13  E-value: 1.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVT----VTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFV 126
Cdd:cd14993   1 IVLIVLYVVVfllaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 23308609 127 HFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIII 131
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
51-184 1.71e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 48.89  E-value: 1.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADF-----GETNALIPNMMKTFLFDSQYisynaCLANMFF 125
Cdd:cd15065   4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLlvallVMTFAVVNDLLGYWLFGETF-----CNIWISF 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23308609 126 VHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSL 184
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
50-173 3.72e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 47.83  E-value: 3.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15317   4 YIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLL 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF 173
Cdd:cd15317  84 CTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
49-257 5.65e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 47.48  E-value: 5.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVT---VTGNSLVLLLIALYRSLHSPKYIGVFNLALADF-----GETNALIPNMMKTFlfdsqYISYNACL 120
Cdd:cd15082  13 FTVLAALMFVVTslsLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFlvsltGGTISFLTNARGYF-----FLGVWACV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 121 ANMFFVHFFSTVQSFTLVVLAYDRFIAIFLPLR------YHAIVNYTFMYfVFSIIWVFNASI--VAFAVSLITrlSFCE 192
Cdd:cd15082  88 LEGFAVTFFGIVALWSLAVLAFERFFVICRPLGnirlqgKHAALGLLFVW-TFSFIWTIPPVLgwSSYTVSKIG--TTCE 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23308609 193 SNKVNGYYCD--YGPVYRLACndnsicasmaqlsaalyVVAPVIIIVLSYLGIFLALSKITTWEGRL 257
Cdd:cd15082 165 PNWYSGNMHDhtYIITFFTTC-----------------FILPLGVIFVSYGKLLQKLRKVSNTQGRL 214
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
50-249 8.69e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 46.83  E-value: 8.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCItyfVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD-----FGETNALIPNMMKTFLFDSqyisynaclanmF 124
Cdd:cd15203   7 YGLIIV---LGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDlllclVSLPFTLIYTLTKNWPFGS------------I 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 125 FVHFFSTVQ-------SFTLVVLAYDRFIAIFLPLRyhAIVNYTFMYFVFSIIWVF---NASIVAFAVSLITRLSFCESN 194
Cdd:cd15203  72 LCKLVPSLQgvsifvsTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILsllLSLPLAIFQELSDVPIEILPY 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23308609 195 kvNGYYCD---YGPVYRLAcndnsicasMAQLSAALYVVAPVIIIVLSYLGIFLALSK 249
Cdd:cd15203 150 --CGYFCTeswPSSSSRLI---------YTISVLVLQFVIPLLIISFCYFRISLKLRK 196
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-173 1.48e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 45.94  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADF-------GETNALIPNMMKTFLFDSQYISYnacLANMFFVHFFST 131
Cdd:cd15103  13 VSLLENILVILAIAKNKNLHSPMYFFICSLAVADMlvsvsnaLETIVIILLNNGYLVPRDSFEQH---IDNVIDSMICSS 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 132 VQS--FTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF 173
Cdd:cd15103  90 LLAsiCSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVF 133
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
54-276 1.61e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 45.90  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQ 133
Cdd:cd15012   7 TLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNAsivAFAVSLITRLSFCESNKVNGYYCDYGPVyrLACND 213
Cdd:cd15012  87 IGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSA---VYNTPYFVFSQTVEILVTQDGQEEEICV--LDREM 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308609 214 NSICAsMAQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRLKALKTCVSHLLLVGSFFLP 276
Cdd:cd15012 162 FNSKL-YDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLP 223
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
53-173 2.15e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 45.48  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITY----FVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHF 128
Cdd:cd15393   3 LSILYgiisLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVL 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRyhAIVNYTFMYFVFSIIWVF 173
Cdd:cd15393  83 SVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWIL 125
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
58-180 2.77e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 44.89  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609    58 FVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMktFLFDSQYISYNACLANMFFVHFFSTVQSFTL 137
Cdd:pfam10320   2 VIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVV--LLFTGTQLTRNECFWMISFYIFGQTAQGPLM 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 23308609   138 VVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAF 180
Cdd:pfam10320  80 LMIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITVY 122
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
53-245 5.08e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 44.36  E-value: 5.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnmmktflFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15058   7 LALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVP-------LGATIVVTGKWQLGNFWCELWTSV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSF-------TLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNAsIVAFavsLITRLSFCESNKVNGYYCDYGP 205
Cdd:cd15058  80 DVLcvtasieTLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSA-LVSF---VPIMNQWWRANDPEANDCYQDP 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 23308609 206 vyrlACNDNSICASMAQLSAALYVVAPVIIIVLSYLGIFL 245
Cdd:cd15058 156 ----TCCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFL 191
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
53-249 5.68e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 44.13  E-value: 5.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd15959   7 LSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVslitrlsfcesnkVNGYYCDYGPVYRLACN 212
Cdd:cd15959  87 SIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPI-------------MNQWWRDGADEEAQRCY 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 23308609 213 DNSICASMAQ------LSAALYVVAPVIIIVLSYLGIFLALSK 249
Cdd:cd15959 154 DNPRCCDFVTnmpyaiVSSTVSFYVPLLVMIFVYVRVFVVATR 196
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
59-177 5.83e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 44.15  E-value: 5.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLfdSQYISYNACLANMFFVHFFSTVQSFTLV 138
Cdd:cd15069  13 LSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL--GFCTDFHSCLFLACFVLVLTQSSIFSLL 90
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23308609 139 VLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15069  91 AVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGI 129
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
55-184 5.94e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 44.19  E-value: 5.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  55 ITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNAC--LANMFFVHFFSTV 132
Cdd:cd15001   8 ITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCkaVAYLQLLSFICSV 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23308609 133 qsFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFN---ASIVAFAVSL 184
Cdd:cd15001  88 --LTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSailASPVLFGQGL 140
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
59-246 6.01e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.16  E-value: 6.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnmMKTFLFDSQYISYNACLANMFFVHFFSTVQSFTLV 138
Cdd:cd15068  13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQSSIFSLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 139 VLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVfnasiVAFAVSLITRLSF--CESNKVNGYYCDYGPVYRLAC--NDN 214
Cdd:cd15068  91 AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWV-----LSFAIGLTPMLGWnnCGQPKEGKNHSQGCGEGQVAClfEDV 165
                       170       180       190
                ....*....|....*....|....*....|..
gi 23308609 215 SICASMAQLSAALYVVAPVIIIVLSYLGIFLA 246
Cdd:cd15068 166 VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLA 197
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
53-206 6.03e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 43.96  E-value: 6.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTV 132
Cdd:cd14992   7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYA 86
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23308609 133 QSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFN---ASIVAFAVSLITRLSFCesNKVNGYYCDYGPV 206
Cdd:cd14992  87 SSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSlllAIPQLYYATTEVLFSVK--NQEKIFCCQIPPV 161
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
53-171 8.37e-05

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 43.62  E-value: 8.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYnaCLANMFFVHFFSTV 132
Cdd:cd15100   7 LCVSGTLIACENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFRYCVYSEALSL--VSVGLLVAAFSASV 84
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23308609 133 qsFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIW 171
Cdd:cd15100  85 --CSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLW 121
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
59-156 1.02e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 43.60  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYI-SYNACLANMFFVHFFSTVQSFTL 137
Cdd:cd15005  13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTL 92
                        90
                ....*....|....*....
gi 23308609 138 VVLAYDRFIAIFLPlRYHA 156
Cdd:cd15005  93 FCIAVTRYMAIAHH-RFYA 110
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
49-201 1.11e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 43.12  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFgetnaLIPNMMKTFLFDS----QYISYNA--CLAN 122
Cdd:cd15392   3 IILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDI-----LMAVFCVPFSFIAllilQYWPFGEfmCPVV 77
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23308609 123 MFFVHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMyfVFSIIWVFnASIVAFAVSLITRLSFCESNKVNGYYC 201
Cdd:cd15392  78 NYLQAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALL--LIAVIWIF-ALATALPIAITSRLFEDSNASCGQYIC 153
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
55-178 1.14e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 43.26  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  55 ITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD-----FGETNALIPNMMKTFLFDSQyisynACLANMFFVHFF 129
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDlmlavFCMPFTLIPNLMGTFIFGEV-----ICKAVAYLMGVS 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIV 178
Cdd:cd15979  84 VSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIM 132
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
52-177 1.14e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 43.03  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15329   6 VLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCT 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15329  86 ASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALI 131
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
50-154 1.30e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 43.11  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15312   4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMML 83
                        90       100
                ....*....|....*....|....*
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRY 154
Cdd:cd15312  84 STTSIFHLCFIAVDRYYAVCDPLHY 108
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
51-152 1.98e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 42.56  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETnALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15079   5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83
                        90       100
                ....*....|....*....|..
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPL 152
Cdd:cd15079  84 IGSIWTNAAIAYDRYNVIVKPL 105
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
54-201 3.24e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 41.78  E-value: 3.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD-----FGETNALIPNMMKTFLFDSQyisynACLANMFFVHF 128
Cdd:cd15978   8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlmlclFCMPFTLIPNLLKDFIFGSA-----VCKTATYFMGI 82
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYC 201
Cdd:cd15978  83 SVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMC 155
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
48-173 3.53e-04

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 41.88  E-value: 3.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  48 YYYMFLCItyfVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVH 127
Cdd:cd15074   5 IYLTVIGI---LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSiIWVF 173
Cdd:cd15074  82 LFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVA-IWLY 126
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
54-172 4.29e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.22  E-value: 4.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  54 CITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD-----FGETNALIPNMMKTFLFDSQyisynACLANMFFVHF 128
Cdd:cd15206   8 SVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDlllavFCMPFTLVGQLLRNFIFGEV-----MCKLIPYFQAV 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15206  83 SVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWL 126
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
53-173 4.86e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 41.07  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFgeTNALIpNMMKTFLFDSQYISYN---ACLANMFFVHFF 129
Cdd:cd15196   7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL--LVALF-NVLPQLIWDITYRFYGgdlLCRLVKYLQVVG 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHaIVNYTFMYFVFSIIWVF 173
Cdd:cd15196  84 MYASSYVLVATAIDRYIAICHPLSSH-RWTSRRVHLMVAIAWVL 126
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
52-154 5.43e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 40.94  E-value: 5.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15054   6 FLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCS 85
                        90       100
                ....*....|....*....|...
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRY 154
Cdd:cd15054  86 ASILNLCVISLDRYLLIISPLRY 108
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
47-171 5.54e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 41.17  E-value: 5.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  47 NYYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQyiSYNACLANMFFV 126
Cdd:cd15961   1 NPWDIVLCTSGTLISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNFIFAYLLQSE--AAKLVTVGLIVA 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 23308609 127 HFFSTVqsFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIW 171
Cdd:cd15961  79 SFSASV--CSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLW 121
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
50-201 5.82e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 40.95  E-value: 5.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15202   4 IVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCS 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRyhAIVNYTFMYFVFSIIWVFnASIVAFAVSLITRL-SFCESNKVNGYYC 201
Cdd:cd15202  84 VHVSAYTLTAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTL-ALAFALPHAICSKLeTFKYSEDIVRSLC 153
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
61-177 8.18e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 40.65  E-value: 8.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  61 VTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDsqYISYNACLANMFFVH--FFSTVQSFTLV 138
Cdd:cd15325  15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILG--YWAFGRVFCNIWAAVdvLCCTASIMSLC 92
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23308609 139 VLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15325  93 IISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVI 131
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
59-173 8.68e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 40.53  E-value: 8.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNA--------CLANMFFVHFFS 130
Cdd:cd15350  13 VGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSLFCLSLLG 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23308609 131 TVqsFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF 173
Cdd:cd15350  93 SI--FSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTF 133
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
47-177 1.20e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.92  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  47 NYYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQY-ISYNACLANMFF 125
Cdd:cd15304   1 NWPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWpLPSKLCAVWIYL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23308609 126 VHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15304  81 DVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGI 132
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
58-153 1.22e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 40.11  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  58 FVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnMMKTFLFDSQyisynACLANMFFVHFFSTVQS--- 134
Cdd:cd15394  12 LVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVP-LTLAYAFEPR-----GWVFGRFMCYFVFLMQPvtv 85
                        90       100
                ....*....|....*....|...
gi 23308609 135 ----FTLVVLAYDRFIAIFLPLR 153
Cdd:cd15394  86 yvsvFTLTAIAVDRYYVTVYPLR 108
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
58-251 1.37e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 40.01  E-value: 1.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  58 FVT-VTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLfdSQY---ISYNACLANMFFVHFFSTVQ 133
Cdd:cd15134  11 FVTgVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW--QQYpwvFGEVFCKLRAFLSEMSSYAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 134 SFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVfnasivafaVSLITRLSFCESNKVNgyYCDYGPVYRLACND 213
Cdd:cd15134  89 VLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWI---------IAFVCALPFAIQTRIV--YLEYPPTSGEALEE 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 23308609 214 NSICA---------SMAQLSAALYVVAPVIIIVLSYLGIFLALSKIT 251
Cdd:cd15134 158 SAFCAmlneippitPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRST 204
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
52-177 1.48e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 40.01  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD---------FGETNALIPNMMKTFLFDSQYISYNACLan 122
Cdd:cd15051   6 VLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDlllgllvlpFSAIYELRGEWPLGPVFCNIYISLDVML-- 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 23308609 123 mffvhffSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15051  84 -------CTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAV 131
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
49-172 1.95e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 39.38  E-value: 1.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  49 YYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSqyISYNACLANMFFVHF 128
Cdd:cd15070   3 YISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVT--IHFYSCLFMSCLLVV 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15070  81 FTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWL 124
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-172 2.17e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 39.22  E-value: 2.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  47 NYYYMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQY-ISYNACLANMFF 125
Cdd:cd15052   1 NWAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWpLPLVLCLLWVTL 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 23308609 126 VHFFSTVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15052  81 DVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWL 127
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
50-154 2.28e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 39.07  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  50 YMFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFF 129
Cdd:cd15318   4 YLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLF 83
                        90       100
                ....*....|....*....|....*
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRY 154
Cdd:cd15318  84 CLTSIFHLCFISIDRHCAICDPLLY 108
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
51-177 2.36e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 39.23  E-value: 2.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnmmktflFDSQYISYNACLANMFFVHFF- 129
Cdd:cd15064   5 VLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMP-------LSAVYELTGRWILGQVLCDIWi 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308609 130 ------STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15064  78 sldvtcCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICI 131
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-177 2.56e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 39.01  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFS 130
Cdd:cd15062   5 VALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCC 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 23308609 131 TVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15062  85 TASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVI 131
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
59-201 2.59e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 38.94  E-value: 2.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSL--HSPKYIGVFNLALADFGETNALIP-----NMMKTFLFDSQYISynaclanmfFVHFFST 131
Cdd:cd15098  13 LGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPfqatiYSLPEWVFGAFMCK---------FVHYFFT 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23308609 132 VQS----FTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVfnASIVAFAVSLITRLSFCESNKVNGYYC 201
Cdd:cd15098  84 VSMlvsiFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWV--LSLAMASPVAVHQDLVHHWTASNQTFC 155
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
52-314 2.93e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADfGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd14975   6 LLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALAD-LAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIW----VFNASIVAF-AVSLITRLSFCEsnkvngyYCDYGPV 206
Cdd:cd14975  85 ASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWllavLLATPVIAFrHVEETVENGMCK-------YRHYSDG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 207 YRLACNdnsicasmaQLSAALYVVAPVIIIVLSYLGIFLALSKITTWEGRlKALKTCVSHLLLVGSFFLP---------- 276
Cdd:cd14975 158 QLVFHL---------LLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRR-RTGRLIASVVVAFAACWLPyhvgnllevv 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 23308609 277 ---IICIFIATSTNSLSLNARVISTSLAHaLPPMLHPIIYV 314
Cdd:cd14975 228 selIGGSKMAGTLGKVAEAGRPIAGALAF-LSSSINPLLYA 267
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
52-276 3.19e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 38.79  E-value: 3.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALiPNMMKTFLFDSQYISYNAC---LANMFFVHF 128
Cdd:cd14982   6 VYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTL-PFRIYYYLNGGWWPFGDFLcrlTGLLFYINM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 129 FSTVqsFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFnaSIVAFAVSLITRLSFCESNKVNGYYCDYGPVYR 208
Cdd:cd14982  85 YGSI--LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWIL--VLVASVPLLLLRSTIAKENNSTTCFEFLSEWLA 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23308609 209 LACNDNSIcasmaqLSAALYVVaPVIIIVLSYLGIFLALSKITT----WEGRLKALKTCVSHLLLVGSFFLP 276
Cdd:cd14982 161 SAAPIVLI------ALVVGFLI-PLLIILVCYSLIIRALRRRSKqsqkSVRKRKALRMILIVLAVFLVCFLP 225
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
57-241 3.60e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 38.79  E-value: 3.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  57 YFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQSFT 136
Cdd:cd15927  11 FLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 137 LVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVAFAVSLITRLSFCESNKVNGYYCDygpVYRLACNDNSI 216
Cdd:cd15927  91 LTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICY---PYPQELGPNYP 167
                       170       180
                ....*....|....*....|....*
gi 23308609 217 CAsMAQLSAALYVVAPVIIIVLSYL 241
Cdd:cd15927 168 KI-MVLLRFLVYYLIPLLIIGVFYV 191
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
57-171 3.82e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 38.65  E-value: 3.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  57 YFVTVTGNSLVL-LLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQSF 135
Cdd:cd15097  11 FLLGTVGNSLVLaVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSF 90
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 23308609 136 TLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIW 171
Cdd:cd15097  91 TLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIW 126
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
60-177 3.88e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 38.66  E-value: 3.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  60 TVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQY-ISYNACLANMFFVHFFSTVQSFTLV 138
Cdd:cd15306  14 TIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWpLPLVLCPIWLFLDVLFSTASIMHLC 93
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 23308609 139 VLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15306  94 AISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGI 132
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
61-179 4.15e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 38.28  E-value: 4.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  61 VTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKT-FLFDSQYISYNACLANMFFVHFFSTVQSFTLVV 139
Cdd:cd15308  15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSeFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 23308609 140 LAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASIVA 179
Cdd:cd15308  95 ISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVAS 134
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
55-153 4.26e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 38.40  E-value: 4.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  55 ITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALiPNMMKTFLFDSQYISYNACLANMFFVHFFSTVQS 134
Cdd:cd15091   9 VVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTM-PFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSI 87
                        90
                ....*....|....*....
gi 23308609 135 FTLVVLAYDRFIAIFLPLR 153
Cdd:cd15091  88 FTLTMMSVDRYIAVCHPVK 106
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-177 4.52e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 38.28  E-value: 4.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLH-SPKYIGVFNLALADFGETNALIPNMMKTFLFdSQYISYNACLANMFFVHFFSTVQSFTL 137
Cdd:cd15099  13 VTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVF-HQRDSRNLFLFKLGGVTMAFTASVGSL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 23308609 138 VVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15099  92 LLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIII 131
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
52-177 4.88e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 38.11  E-value: 4.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  52 FLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnMMKTFLFDSQYISYNACLANMF--FVHFF 129
Cdd:cd15067   5 VLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRDWCDVWhsFDVLA 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 23308609 130 STVQSFTLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNASI 177
Cdd:cd15067  84 STASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALI 131
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
46-172 5.08e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.24  E-value: 5.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  46 SNYYYMFLCItyfVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYISYNACLANMF- 124
Cdd:cd15351   3 PKGLFLFLGL---VSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMd 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 23308609 125 ----FVHFFSTVQSFT-LVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15351  80 nvidTMICSSVVSSLSfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL 132
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
53-152 5.60e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 38.15  E-value: 5.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPnMMKTFLFDSQYISYNA-CLANMFFVHFFST 131
Cdd:cd15195   7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP-MDAVWNYTVEWLAGDLmCRVMMFLKQFGMY 85
                        90       100
                ....*....|....*....|.
gi 23308609 132 VQSFTLVVLAYDRFIAIFLPL 152
Cdd:cd15195  86 LSSFMLVVIALDRVFAILSPL 106
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
59-176 5.78e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 5.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALIPNMMKTFLFDSQYIsynaCLANMFFVHFFSTVQSF--- 135
Cdd:cd15354  13 ISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL----VIEDAFVRHIDNVFDSLici 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 23308609 136 -------TLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVFNAS 176
Cdd:cd15354  89 svvasmcSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTG 136
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-171 5.82e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 37.92  E-value: 5.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  53 LCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALAD-----FGETNALIPNMMKTFLFDSQyisynACLANMFFVH 127
Cdd:cd15084  17 MGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADllvtlFGSSVSFSNNIVGFFVFGKT-----MCEFEGFMVS 91
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVQSFTLVVLAYDRFIAIFLPL------RYHAIVNYTFMYfVFSIIW 171
Cdd:cd15084  92 LTGIVGLWSLAILAFERYLVICKPMgdfrfqQRHAVSGCAFTW-GWSLLW 140
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
58-153 5.95e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 38.04  E-value: 5.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  58 FVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFgetnalipnMMKTF--LFDSQYISYNA-------CLANMFFVHF 128
Cdd:cd15390  12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADL---------LISAFntVFNFTYLLYNDwpfglfyCKFSNFVAIT 82
                        90       100
                ....*....|....*....|....*
gi 23308609 129 FSTVQSFTLVVLAYDRFIAIFLPLR 153
Cdd:cd15390  83 TVAASVFTLMAISIDRYIAIVHPLR 107
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
59-173 7.62e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 37.58  E-value: 7.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  59 VTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADF-------GETNALIPNMMKTFLFDSQYISYNACLANMFFVHFFST 131
Cdd:cd15353  13 VSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMlvsvsngSETVVITLLNGNDTDAQSFTVNIDNVIDSVICSSLLAS 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 23308609 132 VQSftLVVLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWVF 173
Cdd:cd15353  93 ICS--LLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTA 132
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
61-172 8.42e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 37.42  E-value: 8.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  61 VTGNSLVLLLIALYRSLHSPKYIGVFNLALADF--GETNALIPNMMktflFDSQyISYNACLANMFFVHFFSTVQSFTLV 138
Cdd:cd15905  13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLltGVALPFIPGMS----NESR-RGYHSCLFVYVAPNFLFLSFLANLL 87
                        90       100       110
                ....*....|....*....|....*....|....
gi 23308609 139 VLAYDRFIAIFLPLRYHAIVNYTFMYFVFSIIWV 172
Cdd:cd15905  88 MVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWA 121
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
51-249 8.82e-03

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 37.34  E-value: 8.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609  51 MFLCITYFVTVTGNSLVLLLIALYRSLHSPKYIGVFNLALADFGETNALipnMMKTFLFDSQYI-SYNAC--LANMFFVH 127
Cdd:cd15182   5 VFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTL---PFWASYHSSGWIfGEILCkaVTSIFYIG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308609 128 FFSTVqsFTLVVLAYDRFIAIFLPLRyhAIVNYTFMYFVFSIIWVFNASIVAFAVSLItrLSFCESNKVNGYYCDYGPVY 207
Cdd:cd15182  82 FYSSI--LFLTLMTIDRYLAVVHPLS--ALRSRKLRYASLVSVAVWVISILASLPELI--LSTVMKSDEDGSLCEYSSIK 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 23308609 208 RLacndnsicaSMAQLSAALYVVAPVIIIVLSYLGIFLALSK 249
Cdd:cd15182 156 WK---------LGYYYQQNLFFLIPLGIIVYCYVRILQTLMR 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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