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Conserved domains on  [gi|23199974|ref|NP_690596|]
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pre-mRNA-splicing regulator WTAP isoform 2 [Homo sapiens]

Protein Classification

WTAP/Mum2p family protein( domain architecture ID 12181585)

WTAP/Mum2p (Wtap) family protein similar to Homo sapiens pre-mRNA-splicing regulator WTAP which is an associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wtap pfam17098
WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and ...
 68-150 2.75e-26

WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and pre-mRNA-splicing regulator WTAP from mammals. The former is required for female-specific splicing of Sex-lethal RNA, and the latter is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. The family also includes the yeast Mum2p protein which is part of the Mis complex.


:

Pssm-ID: 465345 [Multi-domain]  Cd Length: 155  Bit Score: 96.60  E-value: 2.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199974    68 ESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKF 147
Cdd:pfam17098   1 ESKRRENLLLARLAEKEQEIQELKAQLQDLKQSLQPPSSQLRSLLLDPAVNLEFLRLKKELEEKKKKLKEAQLELAAWKF 80


                  ...
gi 23199974   148 TPD 150
Cdd:pfam17098  81 TPD 83
 
Name Accession Description Interval E-value
Wtap pfam17098
WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and ...
 68-150 2.75e-26

WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and pre-mRNA-splicing regulator WTAP from mammals. The former is required for female-specific splicing of Sex-lethal RNA, and the latter is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. The family also includes the yeast Mum2p protein which is part of the Mis complex.


Pssm-ID: 465345 [Multi-domain]  Cd Length: 155  Bit Score: 96.60  E-value: 2.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199974    68 ESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKF 147
Cdd:pfam17098   1 ESKRRENLLLARLAEKEQEIQELKAQLQDLKQSLQPPSSQLRSLLLDPAVNLEFLRLKKELEEKKKKLKEAQLELAAWKF 80


                  ...
gi 23199974   148 TPD 150
Cdd:pfam17098  81 TPD 83
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
24-142 1.22e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.97  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199974   24 DELILRWKQYEAYVQALEGKYTDL--NSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQ 101
Cdd:COG4913  657 SWDEIDVASAEREIAELEAELERLdaSSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL 736

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 23199974  102 QPSV------------AQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNEL 142
Cdd:COG4913  737 EAAEdlarlelralleERFAAALGDAVERELRENLEERIDALRARLNRAEEEL 789
 
Name Accession Description Interval E-value
Wtap pfam17098
WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and ...
 68-150 2.75e-26

WTAP/Mum2p family; The Wtap family includes female-lethal(2)D from Drosophila and pre-mRNA-splicing regulator WTAP from mammals. The former is required for female-specific splicing of Sex-lethal RNA, and the latter is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. The family also includes the yeast Mum2p protein which is part of the Mis complex.


Pssm-ID: 465345 [Multi-domain]  Cd Length: 155  Bit Score: 96.60  E-value: 2.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199974    68 ESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKF 147
Cdd:pfam17098   1 ESKRRENLLLARLAEKEQEIQELKAQLQDLKQSLQPPSSQLRSLLLDPAVNLEFLRLKKELEEKKKKLKEAQLELAAWKF 80


                  ...
gi 23199974   148 TPD 150
Cdd:pfam17098  81 TPD 83
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
24-142 1.22e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 37.97  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199974   24 DELILRWKQYEAYVQALEGKYTDL--NSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQ 101
Cdd:COG4913  657 SWDEIDVASAEREIAELEAELERLdaSSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL 736

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 23199974  102 QPSV------------AQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNEL 142
Cdd:COG4913  737 EAAEdlarlelralleERFAAALGDAVERELRENLEERIDALRARLNRAEEEL 789
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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