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Conserved domains on  [gi|22749379|ref|NP_689900|]
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protein GAPT [Homo sapiens]

Protein Classification

GAPT domain-containing protein( domain architecture ID 10570326)

GAPT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAPT pfam11770
GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth ...
 1-143 2.43e-101

GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.


:

Pssm-ID: 463345  Cd Length: 144  Bit Score: 287.04  E-value: 2.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749379     1 MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTF-LGPRIIGLRHEISVETQD 79
Cdd:pfam11770   1 MLKSCGNTSVAISIGISLLLLLVICGIGCVWHWKHRNTTRFTLPKFLQRRSSRKKDYTKTLsLSPHVIGPKHKISVQTQD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22749379    80 HKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSE 143
Cdd:pfam11770  81 HRSAVKGTNIHDNYENVEVGPPKAKEETDKELYENTRQSNFEEHIYGNETSSEYYNFQKPSTSE 144
 
Name Accession Description Interval E-value
GAPT pfam11770
GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth ...
 1-143 2.43e-101

GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.


Pssm-ID: 463345  Cd Length: 144  Bit Score: 287.04  E-value: 2.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749379     1 MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTF-LGPRIIGLRHEISVETQD 79
Cdd:pfam11770   1 MLKSCGNTSVAISIGISLLLLLVICGIGCVWHWKHRNTTRFTLPKFLQRRSSRKKDYTKTLsLSPHVIGPKHKISVQTQD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22749379    80 HKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSE 143
Cdd:pfam11770  81 HRSAVKGTNIHDNYENVEVGPPKAKEETDKELYENTRQSNFEEHIYGNETSSEYYNFQKPSTSE 144
 
Name Accession Description Interval E-value
GAPT pfam11770
GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth ...
 1-143 2.43e-101

GRB2-binding adapter (GAPT); This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells. In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation. It associates with GRB2 constitutively through its proline-rich region.


Pssm-ID: 463345  Cd Length: 144  Bit Score: 287.04  E-value: 2.43e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749379     1 MSKSCGNNLAAISVGISLLLLLVVCGIGCVWHWKHRVATRFTLPRFLQRRSSRRKVCTKTF-LGPRIIGLRHEISVETQD 79
Cdd:pfam11770   1 MLKSCGNTSVAISIGISLLLLLVICGIGCVWHWKHRNTTRFTLPKFLQRRSSRKKDYTKTLsLSPHVIGPKHKISVQTQD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22749379    80 HKSAVRGNNTHDNYENVEAGPPKAKGKTDKELYENTGQSNFEEHIYGNETSSDYYNFQKPRPSE 143
Cdd:pfam11770  81 HRSAVKGTNIHDNYENVEVGPPKAKEETDKELYENTRQSNFEEHIYGNETSSEYYNFQKPSTSE 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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