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Conserved domains on  [gi|22749279|ref|NP_689838|]
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zinc finger protein 366 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-549 1.51e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 253 WQCPTCEKSYTSKYNLVTHILGHSGIKPHACTH--CGKLFKQLSHLHTHMLTHQG----TRPHKCQVCH------KAFTQ 320
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNnpsdLNSKSLPLSNskasssSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 321 TSHLKRHMMQHSEVKPHNCRVCGRGFAYPSELKAHEAKHASGRENicVECGLDFPTLAQLKRHLT--------------- 385
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS--VNTPQSNSLHPPLPANSLskdpssnlsllissn 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 386 -THRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIrPYICSECGmeFVQPHHLKQHSLTHKGVKEHK--CGICGREFTLLA 462
Cdd:COG5048 192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNS--QLSPKSLLSQSPSSLSSSDSSssASESPRSSLPTA 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 463 NMKRHVLIHTNIRA-------YQCHLCYKSFVQKQTLKAHM--IVHS--DVKPFKC--KLCGKEFNRMHNLMGHMHLHSD 529
Cdd:COG5048 269 SSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                       330       340
                ....*....|....*....|
gi 22749279 530 SKPFKCLYCPSKFTLKGNLT 549
Cdd:COG5048 349 ISPAKEKLLNSSSKFSPLLN 368
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-549 1.51e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 253 WQCPTCEKSYTSKYNLVTHILGHSGIKPHACTH--CGKLFKQLSHLHTHMLTHQG----TRPHKCQVCH------KAFTQ 320
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNnpsdLNSKSLPLSNskasssSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 321 TSHLKRHMMQHSEVKPHNCRVCGRGFAYPSELKAHEAKHASGRENicVECGLDFPTLAQLKRHLT--------------- 385
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS--VNTPQSNSLHPPLPANSLskdpssnlsllissn 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 386 -THRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIrPYICSECGmeFVQPHHLKQHSLTHKGVKEHK--CGICGREFTLLA 462
Cdd:COG5048 192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNS--QLSPKSLLSQSPSSLSSSDSSssASESPRSSLPTA 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 463 NMKRHVLIHTNIRA-------YQCHLCYKSFVQKQTLKAHM--IVHS--DVKPFKC--KLCGKEFNRMHNLMGHMHLHSD 529
Cdd:COG5048 269 SSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                       330       340
                ....*....|....*....|
gi 22749279 530 SKPFKCLYCPSKFTLKGNLT 549
Cdd:COG5048 349 ISPAKEKLLNSSSKFSPLLN 368
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 309-331 2.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|...
gi 22749279   309 HKCQVCHKAFTQTSHLKRHMMQH 331
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 283-333 3.98e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22749279 283 CTHCGKLFKQLSHLHTHmlthQGTRPHKCQVCHKAFTQTSHLKRHMMQ-HSE 333
Cdd:cd20908   4 CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHCLQvHKE 51
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-549 1.51e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 253 WQCPTCEKSYTSKYNLVTHILGHSGIKPHACTH--CGKLFKQLSHLHTHMLTHQG----TRPHKCQVCH------KAFTQ 320
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNnpsdLNSKSLPLSNskasssSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 321 TSHLKRHMMQHSEVKPHNCRVCGRGFAYPSELKAHEAKHASGRENicVECGLDFPTLAQLKRHLT--------------- 385
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSS--VNTPQSNSLHPPLPANSLskdpssnlsllissn 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 386 -THRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIrPYICSECGmeFVQPHHLKQHSLTHKGVKEHK--CGICGREFTLLA 462
Cdd:COG5048 192 vSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNS--QLSPKSLLSQSPSSLSSSDSSssASESPRSSLPTA 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 463 NMKRHVLIHTNIRA-------YQCHLCYKSFVQKQTLKAHM--IVHS--DVKPFKC--KLCGKEFNRMHNLMGHMHLHSD 529
Cdd:COG5048 269 SSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                       330       340
                ....*....|....*....|
gi 22749279 530 SKPFKCLYCPSKFTLKGNLT 549
Cdd:COG5048 349 ISPAKEKLLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
193-495 2.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 2.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 193 SSPFPFSRHTFLPKQPPEPLLPRKAEPQESEETKQKVERVDVNVQIDDSYYVDVGGSQKRWQcptcekSYTSKYNLVTHI 272
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP------SSLSSSDSSSSA 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 273 lghsgIKPHACTHCGKLFKQLSHLHTHMLTHQG-TRPHKCQVCHKAFTQTSHLKRHM--MQHS--EVKPHNCRV--CGRG 345
Cdd:COG5048 258 -----SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKL 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 346 FAYPSELKAHEAKHASGRENICVecgldfptlaqLKRHLTTHRGPIQYNCSECDKTFQYPSQLQNHM-MKHKDIRPyics 424
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSEtLSNSCIRN---- 397

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22749279 425 ecgmeFVQPHHLKQHSLTHKGVKEH--KCGICGREFTLLANMKRHVLIHTNiRAYQCHLCYKSFVQKQTLKAH 495
Cdd:COG5048 398 -----FKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTN-HAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-551 2.64e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 392 QYNCSECDKTFQYPSQLQNHM--MKH--KDIRPYICSE--CGMEFVQPHHLKQHSLTHKGVKEHKC--GICGREFTLLAN 463
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLrsVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 464 MKRHVLIH-----TNIRAYQC--HLCYKSFVQKQTLKAHMIVH--SDVKPFKCKLCGKEFNRMHNLMGHMHLHSDSKPFk 534
Cdd:COG5048 369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL- 447

                       170
                ....*....|....*..
gi 22749279 535 cLYCPSKFTLKGNLTRH 551
Cdd:COG5048 448 -LCSILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-553 3.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 383 HLTTHRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIR-PYICSECGMEFVQPHHLKQH----SLTHKGVKEHKCGI--CG 455
Cdd:COG5048 251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHlrsvNHSGESLKPFSCPYslCG 330

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22749279 456 REFTLLANMKRHVLIHTNIRAYQCHL--CYKSFVQ----KQTLKAHMIVHSDVKPFKCKL---CGKEFNRMHNLMGH--M 524
Cdd:COG5048 331 KLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPllnnEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDSNLSLHiiT 410

                       170       180
                ....*....|....*....|....*....
gi 22749279 525 HLHSDSKPFKCLYCPSKFTLKGNLTRHMK 553
Cdd:COG5048 411 HLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 309-331 2.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|...
gi 22749279   309 HKCQVCHKAFTQTSHLKRHMMQH 331
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 283-333 3.98e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 22749279 283 CTHCGKLFKQLSHLHTHmlthQGTRPHKCQVCHKAFTQTSHLKRHMMQ-HSE 333
Cdd:cd20908   4 CYYCDREFDDEKILIQH----QKAKHFKCHICHKKLYTAGGLAVHCLQvHKE 51
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-320 6.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.36e-03
                          10        20
                  ....*....|....*....|..
gi 22749279   299 HMLTHQGTRPHKCQVCHKAFTQ 320
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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