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Conserved domains on  [gi|40255109|ref|NP_689620|]
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grpE protein homolog 2, mitochondrial precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 74-217 5.50e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 156.90  E-value: 5.50e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  74 QDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEpedqkltLEKVFRGLLLLEAK 153
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40255109 154 LKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEV 217
Cdd:cd00446  74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 74-217 5.50e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 156.90  E-value: 5.50e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  74 QDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEpedqkltLEKVFRGLLLLEAK 153
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40255109 154 LKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEV 217
Cdd:cd00446  74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
68-218 2.04e-41

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 138.51  E-value: 2.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109    68 KLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDqkltlekVFRGL 147
Cdd:pfam01025  22 ELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS-------LLEGV 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255109   148 LLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:pfam01025  95 EMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 68-218 9.68e-41

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 136.05  E-value: 9.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  68 KLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEpedqkltLEKVFRGL 147
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDED-------VKSLLEGV 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255109 148 LLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:COG0576  76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 47-218 1.49e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 111.98  E-value: 1.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   47 EDPPDELGPPLAERALR-VKAVKLEkeVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTe 125
Cdd:PRK14155   4 EQTPAEDGPFEADDAAQeIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRAT- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  126 ciseESEPEDQKLTLEKVF-RGLLLLEAKLKSVFAKHGLEKLTP-IGDKYDPHEHELICHVPaGVGVQPGTVALVRQDGY 203
Cdd:PRK14155  81 ----AASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGY 155

                        170
                 ....*....|....*
gi 40255109  204 KLHGRTIRLARVEVA 218
Cdd:PRK14155 156 ELMGRLVRPAMVAVA 170
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 74-217 5.50e-49

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 156.90  E-value: 5.50e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  74 QDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEpedqkltLEKVFRGLLLLEAK 153
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE-------LKNLLEGVEMTLKQ 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40255109 154 LKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEV 217
Cdd:cd00446  74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
68-218 2.04e-41

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 138.51  E-value: 2.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109    68 KLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDqkltlekVFRGL 147
Cdd:pfam01025  22 ELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS-------LLEGV 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255109   148 LLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:pfam01025  95 EMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 68-218 9.68e-41

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 136.05  E-value: 9.68e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  68 KLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEpedqkltLEKVFRGL 147
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDED-------VKSLLEGV 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255109 148 LLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:COG0576  76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 47-218 1.49e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 111.98  E-value: 1.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   47 EDPPDELGPPLAERALR-VKAVKLEkeVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTe 125
Cdd:PRK14155   4 EQTPAEDGPFEADDAAQeIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRAT- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  126 ciseESEPEDQKLTLEKVF-RGLLLLEAKLKSVFAKHGLEKLTP-IGDKYDPHEHELICHVPaGVGVQPGTVALVRQDGY 203
Cdd:PRK14155  81 ----AASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGY 155

                        170
                 ....*....|....*
gi 40255109  204 KLHGRTIRLARVEVA 218
Cdd:PRK14155 156 ELMGRLVRPAMVAVA 170
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 46-218 1.70e-29

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 108.99  E-value: 1.70e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   46 SEDPPDELGPPLAERALRVKAVK---------LEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 116
Cdd:PRK14141  11 PADAARDANNPVDREAKPYEMEDdpepdpleaLKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  117 ADILEKTTECISEES-EPEDQKLTleKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPaGVGVQPGTV 195
Cdd:PRK14141  91 SDNLRRALDAIPAEArAAADAGLK--ALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVP-NPDVPNNTV 167

                        170       180
                 ....*....|....*....|...
gi 40255109  196 ALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14141 168 VQVVQAGYTIGERVLRPAMVGVA 190
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 29-218 1.85e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 100.43  E-value: 1.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   29 PLPFSTATQRTAGEDCRSEDPPDELGPPLAEralrvkavkLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQS 108
Cdd:PRK14139  13 AEEAGAAAQAAAAAAAAAEDAAPALEAELAE---------AEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIES 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  109 FCKDLVEVADILEKTTeciseesepEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAgv 188
Cdd:PRK14139  84 FAESLLPVKDSLEAAL---------ADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA-- 152

                        170       180       190
                 ....*....|....*....|....*....|
gi 40255109  189 GVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14139 153 EQEPNTVVAVLQKGYTIADRVLRPALVTVA 182
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 42-218 2.26e-21

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 87.14  E-value: 2.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   42 EDCRSEDPPDELGPPLAERALRVKAvkLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILE 121
Cdd:PRK14151   7 LDLQAPEAAQAEAAAGDDLTARVQE--LEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  122 KTTECiseeSEPEDQklTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQD 201
Cdd:PRK14151  85 RGLEL----SSADDE--AIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESA-DVEPNSVLKVFQK 157

                        170
                 ....*....|....*..
gi 40255109  202 GYKLHGRTIRLARVEVA 218
Cdd:PRK14151 158 GYLLNGRLLRPAMVVVS 174
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 37-218 2.31e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 87.28  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   37 QRTAGEDCRSEDPPDELGPPLAEraLRVKAVKLEKEVQDLTVRyqrAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 116
Cdd:PRK14150  23 QQEEADEAELEDELDEADARIAE--LEAQLAEAQAEERDSVLR---ARAEVENIRRRAEQDVEKAHKFALEKFANELLPV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  117 ADILEKTTECISEESEpedqklTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVA 196
Cdd:PRK14150  98 IDNLERALQAADKENE------ALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESE-DHEPNTVM 170

                        170       180
                 ....*....|....*....|..
gi 40255109  197 LVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14150 171 MVMQKGYTLNGRLLRPAMVMVS 192
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 69-218 7.00e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 86.21  E-value: 7.00e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   69 LEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPEDQKLTLEKVFRGLL 148
Cdd:PRK14140  49 LEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKSLLKGVEMVHRQLL 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  149 lleaklkSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14140 129 -------EALKKEGVEVIEAVGEQFDPNLHQAVMQDEDE-DFESNEVVEELQKGYKLKDRVIRPSMVKVN 190
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 41-218 4.10e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 84.39  E-value: 4.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   41 GEDCRSEDPPDELGPPlAERALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADIL 120
Cdd:PRK14144  30 ETDEESQHQEPALGHP-SYTALEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  121 EKTTECISEESEP---EDQKLTLEkvfrglLLLEAklksvFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVAL 197
Cdd:PRK14144 109 EQALQLADKNSDPsmhEGLELTMK------LFLDA-----LQKFDVEQIDPLGQTFDPQQHEAMSMQPAP-GAPPNSVIT 176

                        170       180
                 ....*....|....*....|.
gi 40255109  198 VRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14144 177 VFQKGYKLSDRVIRPARVIVS 197
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 68-218 1.25e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 82.43  E-value: 1.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   68 KLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTtecISEESEPEDQKLTLEKVFRGL 147
Cdd:PRK14159  34 KLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAA---VNVECHDEISLKIKEGVQNTL 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 40255109  148 LLLEAKLKsvfaKHGLeKLTPIGDKYDPHEHELICHVPaGVGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14159 111 DLFLKKLE----KHGV-ALIKEEKEFDPNLHEAMFHVD-SENHQSGEVVQVLQKGYKIADRVIRPTKVSVA 175
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 37-218 1.34e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 83.32  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   37 QRTAGEDCRSEDPPDELGPPLAER-ALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVE 115
Cdd:PRK14154  31 QEEGGGDGSQEMEPHREGLEFPSReKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLP 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  116 VADILEKTTEciseesEPEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTP-IGDKYDPHEHELIcHVPAGVGVQPGT 194
Cdd:PRK14154 111 VADSLIHGLE------SPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAM-SVQAVPDAKPDT 183

                        170       180
                 ....*....|....*....|....
gi 40255109  195 VALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14154 184 IIQVLQKGYQLNGRVLRAARVIVA 207
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 71-215 6.89e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 80.95  E-value: 6.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   71 KEVQDLTVRYQ----RAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEkttECISEESEPEDQKLTLEkvfrG 146
Cdd:PRK14148  50 KELEDSCDQFKdealRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIE---QALKHEVKLEEAIAMKE----G 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40255109  147 LLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPaGVGVQPGTVALVRQDGYKLHGRTIRLARV 215
Cdd:PRK14148 123 IELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP-NPEFEDNTIFDVFQKGYMLNGRIVRAAKV 190
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 43-218 1.59e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 76.91  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   43 DCRSEDPPDElgpPLAERALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEK 122
Cdd:PRK14147   7 EFDSEDLAQN---PPETDPLKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  123 TTECISEESEPedqkltlekVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAgVGVQPGTVALVRQDG 202
Cdd:PRK14147  84 GLTAAGTEPSP---------LRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEA-EGVAPGHVVQVFQKG 153

                        170
                 ....*....|....*.
gi 40255109  203 YKLHGRTIRLARVEVA 218
Cdd:PRK14147 154 YLLNERLLRPALVVVA 169
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 48-218 2.05e-17

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 77.02  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   48 DPPDElgpplaeralrvKAVKLEKEVQDLTVRYQ----RAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKT 123
Cdd:PRK10325  38 DPRDE------------KIANLEAQLAEAQTRERdgilRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  124 TEcISEESEPEdqkltLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQPGTVALVRQDGY 203
Cdd:PRK10325 106 LE-VADKANPD-----MSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESD-DVAPGNVLGIMQKGY 178

                        170
                 ....*....|....*
gi 40255109  204 KLHGRTIRLARVEVA 218
Cdd:PRK10325 179 TLNGRTIRAAMVTVA 193
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 69-218 2.60e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 76.83  E-value: 2.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   69 LEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTEciSEESEPEDQKLTlekvfRGLL 148
Cdd:PRK14149  48 FELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALK--SAAEVDKESALT-----KGLE 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  149 LLEAKLKSVFAKHGLEKLTPIGDkYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14149 121 LTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSE-EKENGKIVQVLQQGYKYKGRVLRPAMVSIA 188
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 32-218 3.26e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 76.42  E-value: 3.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   32 FSTATQRTAGEDCRSEDPPDELGPPLAERALRVKAVKLEK---EVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQS 108
Cdd:PRK14153   5 EVGKDKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKcreEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  109 FCKDLVEVADILEKTTEcisEESEPEDqkltLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGv 188
Cdd:PRK14153  85 VLLDLLEVTDNFERALE---SARTAED----MNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETS- 156

                        170       180       190
                 ....*....|....*....|....*....|
gi 40255109  189 GVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14153 157 EVPDNTIVDVCKPGYALNSKVIRPAMVSVA 186
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 67-218 2.41e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 73.85  E-value: 2.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   67 VKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTeciseESEPEDQKLTLEKVFRG 146
Cdd:PRK14161  29 TALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRAL-----AHKPANSDVEVTNIIAG 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40255109  147 LLLLEAKLKSVFAKHGLEKLTP-IGDKYDPHEHELICHVpAGVGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14161 104 VQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQI-EHPDHAPNSIITLMQSGYKIRDRLLRPATVQVV 175
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 32-219 1.45e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 63.80  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   32 FSTATQRTAGEDCRSEDPPDELGPplAERALRVKavklEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCK 111
Cdd:PRK14158  21 KEAEAAQGKPEAAQPVAAADRIKE--LEEALAAK----EAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLIL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  112 DLVEVADILEKTTECISEESepedqkltLEKVFRGLLLLEAKLKSVFAKHGLEKL-TPIGDKYDPHEHELICHVPAGvGV 190
Cdd:PRK14158  95 EILPAVDNMERALDHADEES--------MSAIIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESA-EQ 165

                        170       180
                 ....*....|....*....|....*....
gi 40255109  191 QPGTVALVRQDGYKLHGRTIRLARVEVAV 219
Cdd:PRK14158 166 EPNTVVAVFQKGYLLNERLLRPAMVSVAT 194
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 33-218 2.93e-12

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 63.82  E-value: 2.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   33 STATQRTAGEDCRSEDPPDELGpplaeralrvkavKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKD 112
Cdd:PRK14157  66 KAAAEKTGEAQSDSDDTLTPLG-------------QAKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  113 LVEVADILEKttecISEESEPEDQkltlekvFRGLlllEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPaGVGVQP 192
Cdd:PRK14157 133 LLPALDDIDR----IREHSEMDDS-------FKAV---AAKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKP-DPDAEK 197

                        170       180
                 ....*....|....*....|....*.
gi 40255109  193 GTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14157 198 ETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 46-218 3.15e-12

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 63.59  E-value: 3.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   46 SEDPPDELGPPLAERALRVKAVK-----LEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADIL 120
Cdd:PRK14143  51 SPDSGSAASETAADNAARLAQLEqelesLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNF 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  121 EKTTECISEESEPEdqkLTLEKVFRGL--LLLEaklksVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQpGTVALV 198
Cdd:PRK14143 131 ERARQQLKPEGEEA---QALHRSYQGLykQLVD-----VLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPE-DVVLEE 201

                        170       180
                 ....*....|....*....|
gi 40255109  199 RQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14143 202 LQRGYHLGGRVLRHAMVKVS 221
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 55-218 3.92e-12

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 62.93  E-value: 3.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   55 PPLAERALRVKAVKLEKEVQDLTVR-------YQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECI 127
Cdd:PRK14162  30 PKEEDQEKQNPVEDLEKEIADLKAKnkdledkYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVK 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  128 SEESEPEDQKLTLEKVFRGLllleaklKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQPGTVALVRQDGYKLHG 207
Cdd:PRK14162 110 ADDEAAKQLKKGVQMTLDHL-------VKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQKDHVVQVLQKGYQYKD 182

                        170
                 ....*....|.
gi 40255109  208 RTIRLARVEVA 218
Cdd:PRK14162 183 RTLRPAMVVVA 193
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 42-218 1.17e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 56.29  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   42 EDCRSEDPPDELGPPLAERA----LRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVA 117
Cdd:PRK14163  21 DDAEPKAASEEGAAPAGDAAatagLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  118 DILEKTTEciseesepedqkltLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQPGTVAL 197
Cdd:PRK14163 101 DDVGRARE--------------HGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAI 166

                        170       180
                 ....*....|....*....|.
gi 40255109  198 VrQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14163 167 L-QPGYRIGERTIRPARVAVA 186
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 42-218 3.98e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 54.54  E-value: 3.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   42 EDCRSEDPPDEL--------GPPLAE-RALRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKD 112
Cdd:PRK14145  21 SNEQMEGPPEDEqaqqnqpqQQTVDEiEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  113 LVEVADILEKTtecISEESEPEDQKLTLEKVFRglllleaKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGvGVQP 192
Cdd:PRK14145 101 LLPVMDNFERA---LASSGDYNSLKEGIELIYR-------QFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVE-GKQP 169

                        170       180
                 ....*....|....*....|....*.
gi 40255109  193 GTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14145 170 NEIIEVFQKGYYLKDKVIRPSLVKVA 195
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 62-218 4.67e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 51.68  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   62 LRVKAVKLEKEVQDLTVRYQRAIADCENIRRRTQRcvEDAKIFgiQSFCKD-LVEVADILEKTTECISEESEPEDQKLTL 140
Cdd:PRK14160  66 LKEENKKLENELEALKDRLLRTVAEYDNYRKRTAK--EKEGIY--SDACEDvLKELLPVLDNLERAAAVEGSVEDLKKGI 141

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40255109  141 EKVFRGlllleakLKSVFAKHGLEKLTPIGDkYDPHEHELICHVPAGvGVQPGTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14160 142 EMTVKQ-------FKTSLEKLGVEEISTEGE-FDPNLHNAVMHVEDE-NYGENEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 70-217 2.45e-07

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 49.73  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   70 EKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEK--TTECISEESEPedqkltlekVFRGL 147
Cdd:PRK14146  67 KKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERvgATQNQSEELKP---------FVEGV 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 40255109  148 LLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHvPAGVGVQPGTVALVRQDGYKLH----GRTIRLARVEV 217
Cdd:PRK14146 138 KMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSS-EEGDQYSEETVIDVYQAGYYYKenedKFTLRPARVRI 210
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 66-217 3.85e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 46.15  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   66 AVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECISEESEPedqkltlekvfr 145
Cdd:PRK14142  42 AAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGP------------ 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40255109  146 gLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHV-PAGVGVQPGTVALVRQdGYKLHGRTIRLARVEV 217
Cdd:PRK14142 110 -LKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEgDGGQGSKPVIGTVMRQ-GYQLGEQVLRHALVGV 180
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 42-218 8.80e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 44.82  E-value: 8.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109   42 EDCRSEDPPDELGPPLAERALR--VKAVKLEKEVQ-------DLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKD 112
Cdd:PRK14156   3 EEIKNEEVEEEVEATETEETVEevVEETPEKSELElaneradEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40255109  113 LVEVADILEKTtecISEESEPEDQKltlekvfRGLLLLEAKLKSVFAKHGLEKLTpiGDKYDPHEHELICHVPAGVGVQP 192
Cdd:PRK14156  83 ILPSLDNLERA---LAVEGLTDDVK-------KGLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHPA 150

                        170       180
                 ....*....|....*....|....*.
gi 40255109  193 GTVALVRQDGYKLHGRTIRLARVEVA 218
Cdd:PRK14156 151 DSIAQVFQKGYKLHERLLRPAMVVVY 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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