NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|122056731|ref|NP_667227|]
View 

olfactory receptor 1049 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607552)

olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
26-303 1.88e-159

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320535  Cd Length: 279  Bit Score: 445.61  E-value: 1.88e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15413   82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15413  162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15413  242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
 
Name Accession Description Interval E-value
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
26-303 1.88e-159

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 445.61  E-value: 1.88e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15413   82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15413  162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15413  242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-305 2.64e-46

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 157.66  E-value: 2.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731   31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  191 HVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHSFEY 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 122056731  271 --DKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:pfam13853 241 llQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
26-303 1.88e-159

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 445.61  E-value: 1.88e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15413   82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15413  162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15413  242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-294 8.36e-141

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 398.03  E-value: 8.36e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241
                        250       260
                 ....*....|....*....|....*....
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15230  242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-305 5.38e-128

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 366.69  E-value: 5.38e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  11 EFILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKN 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  91 NITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 171 ANIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVV 250
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 251 FYGSLLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 5.70e-126

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 361.59  E-value: 5.70e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  12 FILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNN 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  92 ITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGA 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 172 NIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVF 251
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 122056731 252 YGSLLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:cd15410  241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-298 8.02e-125

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 358.17  E-value: 8.02e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  12 FILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNN 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  92 ITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGA 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 172 NIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVF 251
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 122056731 252 YGSLLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVK 298
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-304 2.55e-120

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 347.05  E-value: 2.55e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  16 GVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYY 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  96 ACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIIS 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 176 HFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSL 255
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 122056731 256 LFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRV 304
Cdd:cd15406  241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
25-303 6.94e-119

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 342.84  E-value: 6.94e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15412  241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
25-301 8.97e-119

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 342.51  E-value: 8.97e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-303 5.98e-118

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 340.45  E-value: 5.98e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15411    1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15411  161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15411  241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-294 1.23e-116

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 336.76  E-value: 1.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd13954  241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
25-303 1.21e-114

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 332.30  E-value: 1.21e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15417    1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15417   81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15417  161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15417  241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
25-303 1.51e-112

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 326.96  E-value: 1.51e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15419   81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15419  161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15419  241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 1.80e-112

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 327.09  E-value: 1.80e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  12 FILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNN 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  92 ITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGA 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 172 NIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVF 251
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 122056731 252 YGSLLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
25-303 1.04e-109

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 319.75  E-value: 1.04e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15407    1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15407   81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15407  161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15407  241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
25-303 1.12e-109

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 319.70  E-value: 1.12e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15416  161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15416  241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 2.10e-108

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 316.73  E-value: 2.10e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  12 FILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNN 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  92 ITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGA 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 172 NIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVF 251
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 122056731 252 YGSLLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
25-305 3.02e-108

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 316.29  E-value: 3.02e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15414    1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15414   81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15414  161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:cd15414  241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
26-303 1.08e-107

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 314.35  E-value: 1.08e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15409  242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
26-301 6.43e-107

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 312.62  E-value: 6.43e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15235   83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15235  163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15235  243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-303 2.71e-106

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 310.89  E-value: 2.71e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15415    2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15415   82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15415  162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHR 303
Cdd:cd15415  242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
25-294 6.72e-102

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 299.40  E-value: 6.72e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15912   81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15912  161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15912  241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
25-294 6.85e-101

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 296.88  E-value: 6.85e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15237  241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
26-301 3.21e-100

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 295.27  E-value: 3.21e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15229   82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15229  162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15229  242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-301 3.45e-100

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 295.33  E-value: 3.45e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15231  243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
27-301 1.28e-98

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 291.38  E-value: 1.28e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15421   83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15421  163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15421  243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-294 6.75e-98

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 289.13  E-value: 6.75e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15918    3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15918   83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15918  163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15918  243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
26-294 1.75e-97

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 288.35  E-value: 1.75e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLfPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQALL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                        250       260
                 ....*....|....*....|....*....
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15431  241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
28-294 1.49e-95

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 283.19  E-value: 1.49e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILF 107
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPL 187
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 188 ICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHS 267
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                        250       260
                 ....*....|....*....|....*..
gi 122056731 268 FEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15227  244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
25-300 4.75e-95

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 282.38  E-value: 4.75e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15405  161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15405  241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLA 276
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
24-304 1.01e-93

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 278.97  E-value: 1.01e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  24 KLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAC 103
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 104 FILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVP 183
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 184 LLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPK 263
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 122056731 264 SAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRV 304
Cdd:cd15418  241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
25-294 9.67e-93

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 276.29  E-value: 9.67e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15911    1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15911   81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15911  241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
27-301 4.51e-89

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 267.27  E-value: 4.51e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15420    3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15420   83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15420  163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15420  243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-294 1.77e-88

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 265.28  E-value: 1.77e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15232  241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
27-294 3.28e-87

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 262.22  E-value: 3.28e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15224   83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-301 2.79e-85

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 257.33  E-value: 2.79e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15429  243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
27-294 3.54e-83

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 251.75  E-value: 3.54e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15939    3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIP----YLYSIFQALLfpirYFTLSFCGANIISHFYCDVV 182
Cdd:cd15939   83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAwvggFLHSTIQILL----TLQLPFCGPNVIDHFFCDLF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 183 PLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQP 262
Cdd:cd15939  159 PLLKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRP 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 122056731 263 KSahSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15939  238 VT--TFPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 7.20e-83

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 251.00  E-value: 7.20e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15947    1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15947   81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15947  161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15947  241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
27-300 7.42e-83

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 251.15  E-value: 7.42e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15434  163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15434  243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGA 276
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-294 6.52e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 248.44  E-value: 6.52e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15430    3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15430   83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15430  163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15430  243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
28-300 3.59e-81

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 246.99  E-value: 3.59e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILF 107
Cdd:cd15236    4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPL 187
Cdd:cd15236   84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 188 ICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHS 267
Cdd:cd15236  164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 122056731 268 FEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15236  244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGA 276
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-300 1.50e-80

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 245.47  E-value: 1.50e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15428  163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15428  243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHA 276
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
27-300 5.20e-80

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 243.87  E-value: 5.20e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15424    3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15424   83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15424  163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15424  243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGA 276
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
27-300 1.07e-79

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 243.16  E-value: 1.07e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15233   83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15233  163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15233  243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGA 276
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-301 7.95e-79

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 240.94  E-value: 7.95e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLL 185
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15234  242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-294 2.20e-78

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 239.53  E-value: 2.20e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15913    3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSiFQALLFPIRYFT-LSFCGANIISHFYCDVVPLL 185
Cdd:cd15913   83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCG-FLWFLIPVVLISqLPFCGPNIIDHFLCDPGPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 PLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15913  162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241
                        250       260
                 ....*....|....*....|....*....
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15913  242 NSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
27-294 3.65e-77

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 236.43  E-value: 3.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQM-RSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSA 265
Cdd:cd15915  163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                        250       260
                 ....*....|....*....|....*....
gi 122056731 266 HSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15915  243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
25-301 1.39e-75

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 232.75  E-value: 1.39e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15432  241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-294 3.47e-73

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 226.48  E-value: 3.47e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15914    3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15914   83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15914  163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15914  243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
26-300 3.96e-73

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 226.56  E-value: 3.96e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFV-VDKNNITYYACATQMACF 104
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15916  162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 265 ahSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15916  242 --KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTA 275
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
25-294 3.57e-72

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 223.62  E-value: 3.57e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLI----GIPYLYSIFQALLfpirYFTLSFCGANIISHFYCD 180
Cdd:cd15226   81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVvaswIIGFIHSLSQLAF----VVNLPFCGPNVVDSFFCD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 181 VVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYV 260
Cdd:cd15226  157 LPLVIKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYV 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 261 QPKSAHSFeyDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15226  236 WPFSTFPV--DKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
25-294 8.83e-71

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 220.01  E-value: 8.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15940   81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMrSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15940  161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 ahSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15940  240 --SFSEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
27-294 1.43e-69

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 216.96  E-value: 1.43e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15946    3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15946   83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15946  163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15946  243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
25-294 5.02e-69

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 215.66  E-value: 5.02e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15936    1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYL----YSIFQ-ALLFPiryftLSFCGANIISHFYC 179
Cdd:cd15936   81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLggfaHSIVQvALLLQ-----LPFCGPNVLDNFYC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 180 DVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMY 259
Cdd:cd15936  156 DVPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIY 234
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 260 VQPksAHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15936  235 ARP--FQTFPMDKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
27-301 5.21e-69

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 215.76  E-value: 5.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15228    3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15228   83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSah 266
Cdd:cd15228  163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP-- 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15228  241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
27-300 1.21e-66

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 210.03  E-value: 1.21e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAH 266
Cdd:cd15433  163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15433  243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGA 276
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
27-294 8.34e-63

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 199.71  E-value: 8.34e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15938   83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfqmRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSah 266
Cdd:cd15938  163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFS-- 237
                        250       260
                 ....*....|....*....|....*...
gi 122056731 267 SFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15938  238 TFPVDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
27-301 3.18e-62

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 198.53  E-value: 3.18e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQT-PMYFFIRHLAFIDLGNSTAICPKMLVNFVV-DKNNITYYACATQMACF 104
Cdd:cd15941    3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15941   83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15941  163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 265 AHSfeYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15941  243 SQA--GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
25-300 5.82e-61

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 195.34  E-value: 5.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15942    1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15942   81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15942  161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 122056731 265 AHSFeyDKAASVFYTLVIPMLNPLIYSLRNKEVKNA 300
Cdd:cd15942  241 QDPL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDA 274
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
25-294 6.50e-61

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 194.98  E-value: 6.50e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRL-QTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAC 103
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 104 FILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGI----PYLYSIFQALLFpiryFTLSFCGANIISHFYC 179
Cdd:cd15935   81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAAcwagGFLHSATQAALV----LRLPFCGPNELDNFYC 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 180 DVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMY 259
Cdd:cd15935  157 DVPQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTL-RGRFREGGGKALSTCSSHLTVVSLIFVPCIFVY 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 122056731 260 VQPKSahSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15935  236 LRPFS--SSSVDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
27-301 8.77e-61

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 194.82  E-value: 8.77e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15223    3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15223   83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVqpksAH 266
Cdd:cd15223  163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL----TY 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 122056731 267 SFEYDKAA------SVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15223  239 RFGKTIPPdvhvllSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
31-297 1.70e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 183.74  E-value: 1.70e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVeETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQ-------PK 263
Cdd:cd15952  167 SI-RINIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLThrfghniPR 245
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 264 SAHSFeydkaASVFYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15952  246 YIHIL-----LANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
23-297 4.22e-56

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 182.49  E-value: 4.22e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  23 LKLPLFAvfltIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMA 102
Cdd:cd15917    3 LSIPFCA----MYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 103 CFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQrrcQVLIGIPyLYSIFQALL----FPIRYFTLSFCGANIISHFY 178
Cdd:cd15917   79 FIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTN---TVVGKIG-LAILLRAVAliipLPLLVRRLPYCGSNVISHSY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 179 CDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFM 258
Cdd:cd15917  155 CEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFS 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 122056731 259 YVqpksAHSFEYDKAASV------FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15917  235 FL----THRFGHHVPPHVhillanLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
25-294 1.63e-53

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 175.70  E-value: 1.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15937    1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPL 184
Cdd:cd15937   81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIfQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPks 264
Cdd:cd15937  161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKL-RTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARP-- 237
                        250       260       270
                 ....*....|....*....|....*....|
gi 122056731 265 AHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd15937  238 FRSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
31-297 2.01e-51

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 170.67  E-value: 2.01e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRcqvlIGIPYLYSIFQALLF--PIRYF--TLSFCGANIISHFYCDVVPLLP 186
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQV----IAQIGLAIVLRALLFmtPLTCLvtSLPYCGSRVVPHSYCEHMAVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFY-GSLLFMYVQpksa 265
Cdd:cd15950  163 LACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQ---- 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 266 hSFEYDKAASV------FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15950  239 -RFGQGVPPHTqvlladLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
31-297 3.10e-50

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 167.52  E-value: 3.10e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVEETELLTiLFSAFNLIS-SLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVqpksAHSFE 269
Cdd:cd15951  167 DTRVSRAYG-LSVAFLVGGlDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFL----THRFG 241
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 270 YDKAASV------FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15951  242 HNVPPHVhilianVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
31-297 8.09e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 166.28  E-value: 8.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVqpksAHSFEY 270
Cdd:cd15953  167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL----THRFGQ 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 122056731 271 DKAASV------FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15953  243 GIAPHIhiilanLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
31-297 8.58e-50

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 166.52  E-value: 8.58e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCqVLIGIPYLYSIFQALL-FPIRYFTLSFCGANIISHFYCDVVPLLPLIC 189
Cdd:cd15222   87 ESSVLLAMAFDRFVAICNPLRYASILTNSRI-AKIGLAIVLRSVLLLLpLPFLLKRLPFCHSNVLSHSYCLHQDVMKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 190 SHVEETEL--LTILFSAFNLISSLvvVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYG---SLLFMYVQPKS 264
Cdd:cd15222  166 SDTRVNSIygLFVVLSTMGLDSLL--ILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVpmiGLSMVHRFGKH 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 122056731 265 AHSFEYDKAASVfYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15222  244 ASPLVHVLMANV-YLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
31-297 3.48e-48

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 162.07  E-value: 3.48e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRrcqvLIGIPYLYSIFQ--ALLFPIRYFT--LSFCGANIISHFYCDVVPLLP 186
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHS----VIGKIGVAAVARsfCIVFPFVFLLkrLPYCGHNVIPHTYCEHMGIAR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETEL--LTILFSAFNLISSLVVVllSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQ--- 261
Cdd:cd15221  163 LACADITVNIWygLTVALLTVGLDVVLIAV--SYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrf 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 122056731 262 ----PKSAHSFEYDkaasvFYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15221  241 grhiPRHVHILLAN-----LYVLVPPMLNPIVYGVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-305 2.64e-46

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 157.66  E-value: 2.64e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731   31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  191 HVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHSFEY 270
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 122056731  271 --DKAASVFYTLVIPMLNPLIYSLRNKEVKNAFHRVF 305
Cdd:pfam13853 241 llQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
30-297 1.62e-44

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 152.71  E-value: 1.62e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIV 109
Cdd:cd15956    6 PFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 110 SELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLIC 189
Cdd:cd15956   86 MESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 190 SHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHSFE 269
Cdd:cd15956  166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVP 245
                        250       260       270
                 ....*....|....*....|....*....|..
gi 122056731 270 ydKAASV----FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15956  246 --SAAHVllsnLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
9-298 7.02e-42

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 146.46  E-value: 7.02e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731   9 PTEFILMGVTQTAELKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVD 88
Cdd:cd15949    1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  89 KNNITYYACATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSF 168
Cdd:cd15949   81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 169 CGANIISHFYCDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVV 248
Cdd:cd15949  161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 249 VVFY-----GSLLFMYVQPKSAHSfeyDKAASVFYTLVIPMLNPLIYSLRNKEVK 298
Cdd:cd15949  241 LAFYvpiavSSLIHRFGQNVPPPT---HILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
31-298 2.77e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 144.28  E-value: 2.77e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCqVLIGIPYL---YSIFQALLFPIRYFtlSFCGANIISHFYCDVVPLLPL 187
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVI-TKIGLAALaraVTLMTPLPFLLRRL--PYCRSHVIAHCYCEHMAVVKL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 188 ICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLlfmyVQPKSAHS 267
Cdd:cd15948  165 ACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPV----VLSSTMHR 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 268 FEYDKAASV------FYTLVIPMLNPLIYSLRNKEVK 298
Cdd:cd15948  241 FARHVAPHVhillanFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
31-297 1.41e-34

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 126.81  E-value: 1.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQrrcQVLIGI-------PYLYSIFQALLFPIRyftLSFCGANIISHFYCDVVP 183
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTP---QVLLGIgvlvvvrAVVLIIPCPLLIKLR---LHHFRSTVISHSYCEHMA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 184 LLPLICSHVEETELLTiLFSAFNLIS-SLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVqp 262
Cdd:cd15955  161 VVKLAADDVRVNKIYG-LFVAFSILGfDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFF-- 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 122056731 263 ksAHSFEYDKAASV------FYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15955  238 --AHRFGHHVAPYVhillsnLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
31-297 1.17e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 124.55  E-value: 1.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVPLLPLICS 190
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVqpksAHSFEY 270
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFF----AHRFGG 242
                        250       260       270
                 ....*....|....*....|....*....|....
gi 122056731 271 DKAA-------SVFYTLVIPMLNPLIYSLRNKEV 297
Cdd:cd15954  243 HHITphihiimANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-290 9.92e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 116.24  E-value: 9.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731   41 GNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNIT-YYACATQMACFILFIVSELSILSSMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFgSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  120 YDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANiisHFYCDVVPLLPLICShveetELLT 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKP-----VSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  200 ILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGR-------KKAFSTCGSHLTVVVVFYGSLLFMYVQPKSAHSFE--- 269
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCElsr 232
                         250       260
                  ....*....|....*....|....
gi 122056731  270 -YDKAASV--FYTLVIPMLNPLIY 290
Cdd:pfam00001 233 lLDKALSVtlWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-294 8.91e-18

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 81.18  E-value: 8.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALlfpiryftLSFCGANIISHFYCDVVpllP 186
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDYGGYCCC---C 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIF--------------QMRSAEGRKKAFSTCgshLTVVVVFY 252
Cdd:cd00637  150 LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTL---LIVVVVFL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 122056731 253 GS-------LLFMYVQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRN 294
Cdd:cd00637  227 LCwlpyfilLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-301 1.11e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 69.51  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd14967    2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLfpiRYFTLSFCGANIISHFYCDVVPLLP 186
Cdd:cd14967   82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP---PLVGWRDETQPSVVDCECEFTPNKI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LIcshveetelltILFSAFNLISSLVVVLLSYMLILLTifqmrsAEGRKKAFSTcgshLTVVVV--------FYGSLLFM 258
Cdd:cd14967  159 YV-----------LVSSVISFFIPLLIMIVLYARIFRV------ARRELKAAKT----LAIIVGafllcwlpFFIIYLVS 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 122056731 259 YVQPKSAHSFEYDKaasVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd14967  218 AFCPPDCVPPILYA---VFFWLGYlnSALNPIIYALFNRDFRRAF 259
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
25-301 2.82e-09

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 56.88  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPkmLVNFVVDKNNITYYACATqMACF 104
Cdd:cd14968    1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLF-MACL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILfIVSELSILSSMA--YDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYF----TLSFCGANIISHFY 178
Cdd:cd14968   78 VL-VLTQSSIFSLLAiaIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNngapLESGCGEGGIQCLF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 179 CDVVPLlplicshveeTELLTILFSAFNLISSLVVVLLsYMLILLTI-----------FQMRSAEGRKKAFSTCGSHLTV 247
Cdd:cd14968  157 EEVIPM----------DYMVYFNFFACVLVPLLIMLVI-YLRIFRVIrkqlrqiesllRSRRSRSTLQKEVKAAKSLAII 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122056731 248 VVVFYGSLL-------FMYVQPksahsfEYDKAASVFYTLVI-----PMLNPLIYSLRNKEVKNAF 301
Cdd:cd14968  226 LFLFALCWLplhiincITLFCP------ECKVPKILTYIAILlshanSAVNPIVYAYRIRKFRQTF 285
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-301 3.74e-09

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 56.18  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIyaITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15064    5 VLLSLIIL--ATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL--LFPIRyftlsfcGANIISHFYCdvvpl 184
Cdd:cd15064   83 CCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLppLFGWR-------TPDSEDPSEC----- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 lpLICSHVEETELLTilFSAFNLisSLVVVLLSYMLILltifqmRSAEGRKKAFSTCGSHLTVVVV-----FYGSLlfmy 259
Cdd:cd15064  151 --LISQDIGYTIFST--FGAFYI--PLLLMLILYWKIY------RAAARERKAAKTLGIILGAFIVcwlpfFLVAL---- 214
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 122056731 260 VQPKSAHSFEYDKAASVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15064  215 IVPLCSHCWIPLALKSFFLWLgyFNSLINPLIYTFFNKDFRKAF 258
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
34-152 1.76e-08

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 54.76  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELS 113
Cdd:cd15058   10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 122056731 114 ILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15058   90 TLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVS 128
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
28-301 1.99e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 54.42  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILF 107
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFqaLLFPiryftlSFCGANIISHFYCDVVPLLPL 187
Cdd:cd15063   84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV--ICFP------PLVGWNDGKDGIMDYSGSSSL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 188 ICSHVEETELLTILFSAfnlISSLVVVLLSYMLILLTIFqmRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMY-VQPKSAH 266
Cdd:cd15063  156 PCTCELTNGRGYVIYSA---LGSFYIPMLVMLFFYFRIY--RAARMETKAAKTVAIIVGCFIFCWLPFFTVYlVRAFCED 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 267 SFEyDKAASVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15063  231 CIP-PLLFSVFFWLgyCNSALNPCIYALFSRDFRFAF 266
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
30-301 2.00e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.22  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNityyACATQMACFILFIV 109
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTP----SPATWLLRKGSLVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 110 SELSILSSM---AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIryftlsfcGANIISHFYCDVVPLLP 186
Cdd:cd14972   80 SLLASAYSLlaiAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVL--------GWNCVLCDQESCSPLGP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICSHVeetellTILFSAFNLISSLVVVLLsYMLILLTIFQM--------------RSAEGRKKAFSTcgshLTVVVVF- 251
Cdd:cd14972  152 GLPKSY------LVLILVFFFIALVIIVFL-YVRIFWCLWRHanaiaarqeaavpaQPSTSRKLAKTV----VIVLGVFl 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 122056731 252 --YGSLLFMYVQPKSAHSFEyDKAASVFYTLVI----PMLNPLIYSLRNKEVKNAF 301
Cdd:cd14972  221 vcWLPLLILLVLDVLCPSVC-DIQAVFYYFLVLallnSAINPIIYAFRLKEMRRAV 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-158 6.59e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 52.98  E-value: 6.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAIT-VVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACatQMACFI- 105
Cdd:cd14969    3 LAVYLSLIGVLgVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGC--VIYGFAv 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 122056731 106 -LFIVSELSILSSMAYDRYVAICNPLLYSaIMSQRRCQVLIGIPYLYSIFQALL 158
Cdd:cd14969   81 tFLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWALP 133
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
39-182 9.20e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 52.25  E-value: 9.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  39 VVGN-LGMIILTK-LDSRLQTPMYFFIRHLAFIDLGNSTAICPkmlVNFVVDKNNITY----YACATQMACFILFIVSEL 112
Cdd:cd14981   15 VLGNlLALIVLARsSKSHKWSVFYRLVAGLAITDLLGILLTSP---VVLAVYASNFEWdggqPLCDYFGFMMSFFGLSSL 91
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122056731 113 SILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALL------FPIRYFTLSFCGANIISHFYCDVV 182
Cdd:cd14981   92 LIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLpllglgSYVLQYPGTWCFLDFYSKNTGDAA 167
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
32-301 9.69e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 52.22  E-value: 9.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  32 LTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKN-NITYYACATQMACFILFIVS 110
Cdd:cd15305    8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLFSTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSqrRCQVLIGIPYLYSIFQALLFPIRYFTLSfcganiishfyCDVVPLLPLICS 190
Cdd:cd15305   88 SIMHLCAISLDRYVAIRNPIEHSRFNS--RTKAMMKIAAVWTISIGISMPIPVIGLQ-----------DDEKVFVNGTCV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVEETELLTILFSAFNLisSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLF---MYVQPKSAHS 267
Cdd:cd15305  155 LNDENFVLIGSFVAFFI--PLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFItniLSVLCKEACD 232
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 268 FE-YDKAASVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15305  233 QKlMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRAF 269
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
29-159 1.24e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 51.85  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnSTAICpKMLVNFVVDknnITYYACATQMAC----F 104
Cdd:cd15196    5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL--LVALF-NVLPQLIWD---ITYRFYGGDLLCrlvkY 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122056731 105 ILFIVSELS--ILSSMAYDRYVAICNPLLySAIMSQRRCQVLIGIPY----LYSIFQALLF 159
Cdd:cd15196   79 LQVVGMYASsyVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWvlslLLSIPQLFIF 138
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
30-306 2.06e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 51.49  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIV 109
Cdd:cd15307    6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 110 SELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSfcgANIISHFYCDV-VPLLPLI 188
Cdd:cd15307   86 ASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIpDPVYKLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 189 CSHVeetelltilfsafNLISSLVVVLLSYMLILLTIFQMRSAEGR-----KKAFSTCGSHLTVVVVFYGSLLFMYVQPK 263
Cdd:cd15307  163 GSIV-------------CFYIPLGVMLLTYCLTVRLLARQRSRHGRiirleQKATKVLGVVFFTFVILWSPFFVLNLLPT 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 122056731 264 SAHSFEYDKAASVFYTLV-----IPMLNPLIYSLRNKEVKNAFHRVFK 306
Cdd:cd15307  230 VCAECEERISHWVFDVVTwlgyaSSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-162 3.06e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.95  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNST-AICPKMLVnfvvdknNITYYACATQMACFILF 107
Cdd:cd15386    5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIW-------EITYRFQGPDLLCRAVK 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 108 IVSELSILSS------MAYDRYVAICNPLLYSAIMSQRRCqVLIGIPYL----YSIFQALLFPIR 162
Cdd:cd15386   78 YLQVLSMFAStymlimMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLlsciLSLPQVFIFSLR 141
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
37-160 6.51e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 49.82  E-value: 6.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  37 ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAcfILFIVSELSILS 116
Cdd:cd15301   13 VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLA--IDYLASNASVLN 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 117 SM--AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIfqaLLFP 160
Cdd:cd15301   91 LLiiSFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISL---LLWP 133
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
27-154 9.19e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 49.47  E-value: 9.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnstaicpkmLVNFVVDKNNIT-------YYAcat 99
Cdd:cd15055    3 LYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADF----------LVGLLVMPFSMIrsietcwYFG--- 69
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122056731 100 QMAC----FILFIVSELSI--LSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIF 154
Cdd:cd15055   70 DTFCklhsSLDYILTSASIfnLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSAL 130
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
37-174 1.22e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 48.89  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  37 ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVvdkNNITYYA---CATQMACFILFIVSELS 113
Cdd:cd15312   13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV---ESCWYFGdlfCKIHSSLDMMLSTTSIF 89
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122056731 114 ILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAllfpiryFTLSFCGANII 174
Cdd:cd15312   90 HLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA-------FGVVFSEVNLE 143
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
29-152 1.43e-06

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 48.49  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd15059    5 SIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFC 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 122056731 109 VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15059   85 TASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIIS 128
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
30-301 2.67e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 47.98  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDL-----GNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMlvsvsNGSETVVITLLNGNDTDAQSFTVNIDNVIDSVI 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIryftlsfcganiishFYCDVVPL 184
Cdd:cd15353   86 CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFII---------------YSDSSVVI 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 185 LPLICSHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15353  151 ICLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAITLTILLGVFVVCWAPFFLHLIFYISCPRN 230
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 122056731 265 AHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15353  231 PYCVCFMSHFNMYLILIMcnSVIDPLIYAFRSQELRKTF 269
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
29-152 3.10e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.01  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICP---KMLVNFVVDknnitYYACATqMACFI 105
Cdd:cd15069    5 ALELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPfaiTISLGFCTD-----FHSCLF-LACFV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 122056731 106 LfIVSELSILS--SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15069   79 L-VLTQSSIFSllAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLA 126
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
26-230 3.69e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 47.73  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnsTAICPKMLVNFVvdkNNITYYACATQMA-CF 104
Cdd:cd14979    2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDL---LILLVGLPVELY---NFWWQYPWAFGDGgCK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSEL----SILS--SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFcganiisHFY 178
Cdd:cd14979   76 LYYFLFEActyaTVLTivALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYL-------NGP 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 179 CDVVPLLPLICSHVEETELLTILFSAFNLISSLV---VVLLSYMLILLTIFQMRS 230
Cdd:cd14979  149 LPGPVPDSAVCTLVVDRSTFKYVFQVSTFIFFVLpmfVISILYFRIGVKLRSMRN 203
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-301 4.26e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 47.10  E-value: 4.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMA------C 103
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 104 FILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFpIRYFTLSFCGANIISHFY----- 178
Cdd:cd15103   86 ICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILF-IIYSDSVPVIICLISMFFamlvl 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 179 --CDVVPLLPLICSHVEETELLTILFSAFNLISSLVVVLLSymlILLTIFQMRSAEgrkkafstcgshltvvvvFYGSLL 256
Cdd:cd15103  165 maSLYVHMFLLARSHVKKIAALPGQRSTRQRANMKGAVTLT---ILLGVFIFCWAP------------------FFLHLT 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 122056731 257 FMYVQPKSAHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15103  224 LMISCPSNPYCACYMSHFNVYLILIMcnSVIDPLIYAFRSQELRKTF 270
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-150 4.86e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 46.90  E-value: 4.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  33 TIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSEL 112
Cdd:cd15330    9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 122056731 113 SILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYL 150
Cdd:cd15330   89 LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWL 126
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
37-161 6.84e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 46.82  E-value: 6.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  37 ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELSILS 116
Cdd:cd15959   13 VIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLC 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 122056731 117 SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLfPI 161
Cdd:cd15959   93 AIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL-PI 136
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
27-301 9.93e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 46.20  E-value: 9.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYA-ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnstaicpkmLVNFVVDKNNITYYA--------- 96
Cdd:cd15067    1 LLGVVLSLFClVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADL----------LVGSIVMPFSILHEMtggywlfgr 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  97 --CATQMACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIfqALLFPiryftlsfcgaNII 174
Cdd:cd15067   71 dwCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSA--LISFP-----------AIA 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 175 SHFYCDVVPLLPLICSHVEETELLtilfsafnLISSLVVVLLSYMLILLTIFQM-RSAEGRKKAFSTCGshlTVVVVFYG 253
Cdd:cd15067  138 WWRAVDPGPSPPNQCLFTDDSGYL--------IFSSCVSFYIPLVVMLFTYYRIyRAAAKEQKAAKTLG---IVMGVFIL 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 122056731 254 SLL--FMYVQPKSAHSFEYDKAASVFYTLVI------PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15067  207 CWLpfFVTNILIGFCPSNCVSNPDILFPLVTwlgyinSGMNPIIYACSSRDFRRAF 262
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-152 1.04e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 46.26  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNStaicpkmLVNFVVDKN-NITYYACATQMAC-FI 105
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVG-------LINVLTDIIwRITVEWRAGDFACkVI 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 122056731 106 LFIVSELS-----ILSSMAYDRYVAICNPLLYSAimSQRRCQVLIGIPYLYS 152
Cdd:cd15197   77 RYLQVVVTyastyVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILS 126
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
32-301 1.09e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.08  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  32 LTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVD-KNNITYYACATQMACFILFIVS 110
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSqrRCQVLIGIPYLYSIFQALLFPIRYFTLSfcganiishfyCDVVPLLPLICS 190
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNS--RTKAFLKIIAVWTISVGISMPIPVFGLQ-----------DDSKVFKEGSCL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 191 HVEETELLTILFSAFNLisSLVVVLLSYMLILLTIFQMRSAEgrKKAFSTCGSHLTVVVV----FYGSLLFMYVQPKSAH 266
Cdd:cd15304  155 LADENFVLIGSFVAFFI--PLTIMVITYFLTIKSLQQSISNE--QKASKVLGIVFFLFVVmwcpFFITNVMAVICKESCN 230
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 122056731 267 SFEYDKAASVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15304  231 EVVIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSAF 267
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
29-301 1.13e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 45.88  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd15060    5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 109 VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIfqallfpiryftlsfcganIIShfycdVVPLLPLI 188
Cdd:cd15060   85 TASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSA-------------------LIS-----VPPLIGWN 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 189 CSHVEETE----LLT-----ILFSAFnliSSLVVVLLSYMLILLTIFQMRSAEgrKKAFSTCGSHLTVVVVFYGSLLFMY 259
Cdd:cd15060  141 DWPENFTEttpcTLTeekgyVIYSSS---GSFFIPLLIMTIVYVKIFIATSKE--RRAARTLGIIMGVFVVCWLPFFLMY 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 122056731 260 VQPKSAHSFEYDKAASVFYT---LVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15060  216 VILPFCETCSPSAKVVNFITwlgYVNSALNPVIYTIFNLDFRRAF 260
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
27-158 1.18e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 46.16  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAIT-VVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAIC-PKMLVNFVVDKNNITYYACatQMACF 104
Cdd:cd15337    2 LIGIYIAIVGILgVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVAC--ELYGF 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 122056731 105 I--LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALL 158
Cdd:cd15337   80 AggIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP 135
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
27-153 2.67e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 45.02  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAIT-VVGNlGMIILTKLDSR-LQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACatQMACF 104
Cdd:cd15083    2 VLGIFILIIGLIgVVGN-GLVIYAFCRFKsLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGF 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122056731 105 I--LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15083   79 SggLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSL 129
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
33-157 2.76e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 44.77  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  33 TIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVnfVVDKNNITYYACATqMACfILFIVSEL 112
Cdd:cd15070    9 LIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIV--VSLGVTIHFYSCLF-MSC-LLVVFTHA 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 122056731 113 SILS--SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL 157
Cdd:cd15070   85 SIMSllAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGL 131
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
30-301 2.79e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 44.93  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYY-ACATQM-----AC 103
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEdAFVRHIdnvfdSL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 104 FILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFpIRYFTLSFCGANIISHFYCDVVp 183
Cdd:cd15354   86 ICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIF-ILYSESTYVIICLITMFFAMLF- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 184 llplicshveeteLLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPK 263
Cdd:cd15354  164 -------------LMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAVTLTILLGIFIVCWAPFFLHLILMISCPQ 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 122056731 264 SAHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15354  231 NLYCVCFMSHFNMYLILIMcnSVIDPLIYAFRSQEMRKTF 270
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
29-157 5.06e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 43.94  E-value: 5.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd15336    5 SVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFG 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 122056731 109 VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL 157
Cdd:cd15336   85 ITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSL 133
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
32-153 5.16e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.16  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  32 LTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVnfVVDKNNITYYACATqMACFILfIVSE 111
Cdd:cd15068    8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLF-IACFVL-VLTQ 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 122056731 112 LSILS--SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15068   84 SSIFSllAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 127
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
27-152 7.09e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 43.41  E-value: 7.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15329    3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLS 128
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
23-153 7.49e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 43.63  E-value: 7.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  23 LKLPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMA 102
Cdd:cd15333    3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122056731 103 CFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15333   83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISI 133
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
30-163 7.76e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 43.63  E-value: 7.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI- 108
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTm 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 109 -----VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRY 163
Cdd:cd15351   86 icssvVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYY 145
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
29-301 8.34e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 43.49  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYA-ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICP-KMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15053    4 ALFLLLLPlLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfAVYVEVNGGKWYLGPILCDIYIAMDVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIfqALLFPIryftlsFCGANiishfycDVVPLLP 186
Cdd:cd15053   84 CSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSA--AIACPL------LFGLN-------NVPYRDP 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 187 LICShveetelltILFSAFNLISSLVVVLLSYMLILLTIFQMRSAEGR-KKAFSTCGSHLTVVVVFYgsLLFMYVQPKSA 265
Cdd:cd15053  149 EECR---------FYNPDFIIYSSISSFYIPCIVMLLLYYRIFRALRReKKATKTLAIVLGVFLFCW--LPFFTLNILNA 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 266 HSFEYDKAAS------VFYTL----VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15053  218 ICPKLQNQSChvgpalFSLTTwlgyVNSFLNPIIYTIFNIEFRKAF 263
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
37-152 1.05e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 43.03  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  37 ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAcfILFIVSELSILS 116
Cdd:cd17790   13 VTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLA--LDYVASNASVMN 90
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 122056731 117 SM--AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd17790   91 LLiiSFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLIS 128
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
30-301 1.17e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 42.98  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIY-AITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd15327    5 VFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 109 VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAlLFPIRYFTlsfcganiishfycDVVPLLPLI 188
Cdd:cd15327   85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVIS-IGPLLGWK--------------EPPPPDESI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 189 CSHVEETElLTILFSAFNLISSLVVVLLSYMLILLTIFQMRSaegRKKAFSTCGSHLTVVVVFYgsLLFMYVQPKSAHSF 268
Cdd:cd15327  150 CSITEEPG-YALFSSLFSFYLPLMVILVMYFRVYVVALKFSR---EKKAAKTLAIVVGVFILCW--FPFFFVLPLGSFFP 223
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 122056731 269 EYDKAASVFYTLVI-----PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15327  224 ALKPSEMVFKVIFWlgyfnSCVNPIIYPCSSKEFKRAF 261
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-178 1.30e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 42.89  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNST-AICPKMLVnfvvdknNITYYACATQMACFILF 107
Cdd:cd15385    5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCW-------DITYRFYGPDFLCRIVK 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 122056731 108 IVSELSILSS------MAYDRYVAICNPlLYSAIMSQRRCQVLIGIPYLYSIfqaLLFPIRYFTLSFCGANIISHFY 178
Cdd:cd15385   78 HLQVLGMFAStymlvmMTADRYIAICHP-LKTLQQPTKRSYLMIGSAWALSF---ILSTPQYFIFSLSEIENGSGVY 150
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
26-152 1.37e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 42.80  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  26 PLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACatQMACFI 105
Cdd:cd15050    2 PLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVC--LFWLSM 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 122056731 106 LFIVSELSILSS--MAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15050   80 DYVASTASIFSLfiLCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS 128
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
29-301 1.38e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 42.84  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd15102    5 VVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMFVALS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 109 VSELSILsSMAYDRYVAICNPLLYSAiMSQRRCQVLIGIPYLYSIFQALLfPIryftlsfCGANIISHFYcDVVPLLPLI 188
Cdd:cd15102   85 ASVFSLL-AIAIERHLTMAKMKPYGA-SKTSRVLLLIGACWLISLLLGGL-PI-------LGWNCLGALD-ACSTVLPLY 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 189 CSHVeetelltILFsafnLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSH--------LTVVVVF-------YG 253
Cdd:cd15102  154 SKHY-------VLF----CVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRslallktvLIVLLVFiacwgplFI 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 122056731 254 SLLFMYVQPksAHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15102  223 LLLLDVACP--VKTCPILYKADWFLALAVlnSALNPIIYTLRSRELRRAV 270
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
27-301 1.43e-04

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 42.75  E-value: 1.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAI-TVVGN-LGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAcf 104
Cdd:cd15104    1 AAGVILAVLSPlIITGNlLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMC-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 105 ILFIVSELSILSSM--AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLfPIRYFTLSFCGANIISHFYCDVV 182
Cdd:cd15104   79 FVITSCAASVLSLAaiAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFL-PLISPQFQQTSYKGKCSFFAAFH 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 183 PllplicshveetELLTILFSAFNLISSLVVVLLsYMLILLT-------IFQMRSAEGRK----------KAFSTCGSHL 245
Cdd:cd15104  158 P------------RVLLVLSCMVFFPALLLFVFC-YCDILKIarvhsraIYKVEHALARQihprrtlsdfKAARTVAVLI 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 122056731 246 TVVVVFYGSLLF-MYVQPKSAHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15104  225 GCFLLSWLPFQItGLVQALCDECKLYDVLEDYLWLLGLcnSLLNPWIYAFWQKEVRRAL 283
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
37-157 1.82e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 42.22  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  37 ITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELSILS 116
Cdd:cd15321   19 FTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLC 98
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 122056731 117 SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL 157
Cdd:cd15321   99 AISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISL 139
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
30-153 1.90e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 42.36  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnSTAICpKMLVNFVVD---KNNITYYACATQMACFIL 106
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADM--LVALC-AMTFNASVEitgRWMFGYFMCDVWNSLDVY 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15066   82 FSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPA 128
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
27-153 3.06e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 41.47  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLT--IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMAcf 104
Cdd:cd15299    4 VLIAFLTgiLALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS-- 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122056731 105 ILFIVSELSILSSM--AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15299   82 IDYVASNASVMNLLviSFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISF 132
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-301 3.20e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 41.53  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIyaITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICP-KMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15052    5 LLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFtlsFCGANIISHFYCdvvpll 185
Cdd:cd15052   83 LFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGI---IDTTNVLNNGTC------ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 186 plicshveetellTILFSAFNLISSLVVVLLSYMLILLTIF-QMRSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQPKS 264
Cdd:cd15052  154 -------------VLFNPNFVIYGSIVAFFIPLLIMVVTYAlTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGL 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 122056731 265 AHSFE---YDKAASVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15052  221 CEECNcriSPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRAF 262
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
30-301 3.48e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 41.39  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIV 109
Cdd:cd15324    6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 110 SELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIfqallfpiryftlsfcganiishfycdVVPLLPLIC 189
Cdd:cd15324   86 SSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISA---------------------------VISFPPLLM 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 190 SHVEETELLTILFSAFNLISSLVVVLLSYMLILLTIFQM-RSAEGRKKAFSTCgshLTVVVVFYGSLLFMYVQPKSAHSF 268
Cdd:cd15324  139 TKHDEWECLLNDETWYILSSCTVSFFAPGLIMILVYCKIyRVAKMREKRFTFV---LAVVMGVFVLCWFPFFFTYSLHAV 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 122056731 269 EYDKAA------SVFYTL--VIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15324  216 CRKRCGipdalfNLFFWIgyCNSSVNPIIYTIFNRDFRKAF 256
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-140 3.93e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 41.42  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  39 VVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELSILSSM 118
Cdd:cd15325   15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCII 94
                         90       100
                 ....*....|....*....|..
gi 122056731 119 AYDRYVAICNPLLYSAIMSQRR 140
Cdd:cd15325   95 SIDRYIGVSYPLRYPSIMTERR 116
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
29-152 3.98e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 41.17  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnstaICPKMLVNFVVDKNNITYYACATqMACFIL-- 106
Cdd:cd15300    5 AVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADL-----IIGIFSMNLYTSYILMGYWALGS-LACDLWla 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 122056731 107 --FIVSELSILSSM--AYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15300   79 ldYVASNASVMNLLviSFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLIS 128
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
28-162 5.17e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 40.97  E-value: 5.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAI--TVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKN-NITYYACATQMACF 104
Cdd:cd15306    2 WAALLILMVIipTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLD 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIR 162
Cdd:cd15306   82 VLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIK 139
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
30-229 5.26e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 41.08  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGN-LGMIILTKldSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFI 108
Cdd:cd14978    6 VLPVICIFGIIGNiLNLVVLTR--KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 109 VSELSILS-----SMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSFCGANIISHFYCDVVP 183
Cdd:cd14978   84 ANTFQTASvwltvALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 184 LLplicshveetELLTILFSAFNLISSLVVVLLSymLILLTIFQMR 229
Cdd:cd14978  164 LR----------QNETYLLKYYFWLYAIFVVLLP--FILLLILNIL 197
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
34-158 6.34e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 40.62  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELS 113
Cdd:cd15957   10 IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIE 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 122056731 114 ILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALL 158
Cdd:cd15957   90 TLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFL 134
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
27-302 8.26e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 40.32  E-value: 8.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAI-TVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15334    2 LISLTLSILALmTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL--LFpIRYFTLSFCGANIISHfycdvvp 183
Cdd:cd15334   82 TCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMppLF-WRHQTTSREDECIIKH------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 184 llplicSHVeetelltilfsAFNLISSLVVVLLSYMLILLTIFQM-RSAEGRKKAFSTCGSHLTVVVVFYGSLLFMYVQP 262
Cdd:cd15334  154 ------DHI-----------VFTIYSTFGAFYIPLALILILYYKIyRAATRERKAATTLGLILGAFVICWLPFFVKEVIV 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 122056731 263 KSAHSFEYDKAASVFYT---LVIPMLNPLIYSLRNKEVKNAFH 302
Cdd:cd15334  217 NTCDSCYISEEMSNFLTwlgYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
34-157 8.60e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.52  E-value: 8.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNStAICPKMLVNFVVDKNNITYYACATQMACF--ILFIVSE 111
Cdd:cd15005   10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRS-LACFPFVMASVRHGSGWIYGALSCKVIAFlaVLFCFHS 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 112 LSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQAL 157
Cdd:cd15005   89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAF 134
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
31-152 9.53e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 39.92  E-value: 9.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYaiTVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVS 110
Cdd:cd15323    9 FLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 122056731 111 ELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15323   87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLIS 128
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-159 1.13e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 40.05  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLgnstaicpkmLVNFVVDKNNITYYACATQMA------ 102
Cdd:cd14986    5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADL----------VVAFFTVLTQIIWEATGEWVAgdvlcr 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 103 ------CFILFivSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIG--IPYLYSIFQALLF 159
Cdd:cd14986   75 ivkylqVVGLF--ASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAwvLSFLFSIPQLVIF 137
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
34-154 1.22e-03

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 39.91  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELS 113
Cdd:cd15335   10 ITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSIL 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 122056731 114 ILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIF 154
Cdd:cd15335   90 HLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIF 130
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
30-159 1.47e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 39.49  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQ--------M 101
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQhmdnvfdsM 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 122056731 102 ACFILfiVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLF 159
Cdd:cd15352   86 ICISL--VASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVF 141
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
25-152 1.69e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 39.16  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYS 152
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIS 128
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-153 1.94e-03

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 39.01  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAI-TVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFI 105
Cdd:cd15062    2 VVGVALGAFILfAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDV 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 122056731 106 LFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSI 153
Cdd:cd15062   82 LCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSL 129
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-165 2.02e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 39.14  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDlgnSTAICPKMLVNFVVDKNNITYYA---CATQMACFILFIVS 110
Cdd:cd16003   10 VVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSD---ASMAAFNTLINFIYALHSEWYFGeayCRFHNFFPITSVFA 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122056731 111 ELSILSSMAYDRYVAICNPLlySAIMSQRRCQVLIGIPYLYSIFqaLLFPIRYFT 165
Cdd:cd16003   87 SIYSMTAIAVDRYMAIIDPL--KPRLSATATKVVIGSIWILAFL--LAFPQCLYS 137
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
33-154 2.30e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 39.02  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  33 TIYAITVVGNLGMIILTKLDSRLQ--TPMYFFIRHLAFIDLGNSTAICPKMLVNFVvdKNNITYYACATQMACFIL--FI 108
Cdd:cd15142    9 VMFIFGVVGNLIAIVVLCKSRKEQkeTTFYTLVCGLAVTDLLGTCLASPVTIATYL--KGRWPGGQPLCEYFSFILlfFS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 122056731 109 VSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIF 154
Cdd:cd15142   87 LSGLSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNIL 132
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
34-145 2.77e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 38.73  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIVSELS 113
Cdd:cd15958   10 IVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIE 89
                         90       100       110
                 ....*....|....*....|....*....|..
gi 122056731 114 ILSSMAYDRYVAICNPLLYSAIMSQRRCQVLI 145
Cdd:cd15958   90 TLCVIAIDRYLAITSPFRYQSLLTRARAKGIV 121
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
30-301 3.02e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 38.61  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAicpKMLVNFVVDKNNITYY----ACATQM---- 101
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLY---KTLENILIILADMGYLnrrgPFETKLddim 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 102 -ACFILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYlysifqallfpiryftlSFCGANIIshfycd 180
Cdd:cd15350   83 dSLFCLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW-----------------TFCGGSGI------ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 181 vvpLLPLICSHVEETELLTILFSafnLISSLVVVLLSYMLILLTIFQMRSAEGRKKAFSTCGSHL----TVVVV------ 250
Cdd:cd15350  140 ---LMILFFHFVATVICFTVLFF---LMLVLILCLYVHMFLLARSHARKIASLPNHHAQHQRSNMrgaiTLTILlgvfvc 213
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 122056731 251 ----FYGSLLFMYVQPKSAHSFEYDKAASVFYTLVI--PMLNPLIYSLRNKEVKNAF 301
Cdd:cd15350  214 cwapFVLHLLLMMFCPMNPYCACYRSLFQVNGTLIMshAVIDPAIYAFRSPELRNTF 270
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
25-140 3.99e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 38.33  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  25 LPLFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACF 104
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSAIMSQRR 140
Cdd:cd15326   81 VLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKR 116
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
28-157 4.09e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 38.04  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  28 FAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPkmlVNFVVDKNNITYYA---CATQMACF 104
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTV---FNFTYLLYNDWPFGlfyCKFSNFVA 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 122056731 105 ILFIVSELSILSSMAYDRYVAICNPLLYSaiMSQRRCQVLIGIPYLYSIFQAL 157
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLAL 131
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-165 4.21e-03

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 38.29  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  31 FLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAicpKMLVNFVVDKNNITYYA---CATQMACFILF 107
Cdd:cd16004    7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAF---NTAFNFVYASHNDWYFGlefCRFQNFFPITA 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLlySAIMSQRRCQVLIGIPYLYSIfqALLFPIRYFT 165
Cdd:cd16004   84 MFVSIYSMTAIAADRYMAIIHPF--KPRLSAGSTKVVIAGIWLVAL--ALAFPQCFYS 137
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
34-168 4.60e-03

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 38.16  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  34 IYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACAtqMACFILFIVSELS 113
Cdd:cd15393   10 ISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCP--FCPFVQVLSVNVS 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 122056731 114 I--LSSMAYDRYVAICNPLlySAIMSQRRCQVLIGIPYLYSIFQALLFPIRYFTLSF 168
Cdd:cd15393   88 VftLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVALPVALALRVEEL 142
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
27-158 5.42e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 37.85  E-value: 5.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15056    3 LSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAiMSQRRCQVLIGIPYLYSIFQALL 158
Cdd:cd15056   83 LTTASIMHLCCIALDRYYAICCQPLVYK-MTPLRVAVMLGGCWVIPTFISFL 133
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
30-156 5.97e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 37.52  E-value: 5.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  30 VFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILFIV 109
Cdd:cd15215    5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAF 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 122056731 110 SELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQA 156
Cdd:cd15215   85 AGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
27-298 6.21e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 37.83  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIyaiTVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGnstaiCPKMLVNFVVDKNNITYY-----ACATQM 101
Cdd:cd15075    6 IMAVFSIA---SVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLG-----TTVFGGLLSVVTNAVGYFnlgrvGCVLEG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 102 ACFILFIVSELSILSSMAYDRYVAICNPLlySAIMSQRRcQVLIGI--PYLYSIFQAL--LFPIRYFTLSFCGANIISHF 177
Cdd:cd15075   78 FAVAFFGIAALCTVAVIAVDRLFVVCKPL--GTLTFQTR-HALAGIasSWLWSLIWNTppLFGWGSYQLEGVMTSCAPDW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 178 YC-DVVPLLPLICshveetelltilFSAFNLISSLVVVLLSYMLILLTIFQ----MRSAEGRKKAFSTCGSHLTVVVVF- 251
Cdd:cd15075  155 YSrDPVNVSYILC------------YFSFCFAIPFAIILVSYGYLLWTLRQvaklGVAEGGSTAKAEVQVARMVVVMVMa 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 122056731 252 -------YGSLLF-------MYVQPKSAHSFEYDKAASVFYtlvipmlNPLIYSLRNKEVK 298
Cdd:cd15075  223 fllcwlpYAAFALtvvskpdVYINPLIATVPMYLAKSSTVY-------NPIIYIFMNKQFR 276
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
29-158 8.09e-03

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 37.41  E-value: 8.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNlGMIILTKLDSR-LQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFILF 107
Cdd:cd15073    5 AYLIVAGIISTISN-GIVLVTFVKFReLRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFF 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLLYSAiMSQRRCQVLIGIPYLYSIFQALL 158
Cdd:cd15073   84 GMASIGLLTVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAAM 133
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
27-159 9.05e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 37.04  E-value: 9.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  27 LFAVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGNSTAICPKMLVNFVVDKNNITYYACATQMACFIL 106
Cdd:cd15317    3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 122056731 107 FIVSELSILSSMAYDRYVAICNPLLYSAIMSQRRCQVLIGIPYLYSIFQALLF 159
Cdd:cd15317   83 LCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGL 135
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
29-301 9.49e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 37.02  E-value: 9.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731  29 AVFLTIYAITVVGNLGMIILTKLDSRLQTPMYFFIRHLAFIDLGnSTAICPKM-LVNFVVDKNNITYYACATQMACFILF 107
Cdd:cd15000    4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLL-TLLVCPWMfLVHDFFQNYVLGSVGCKLEGFLEGSL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 108 IVSELSILSSMAYDRYVAICNPLlySAIMSQRRCQVLIGIPYLYSIFQALLFPI---------RYFTLSFCGAN-IISHF 177
Cdd:cd15000   83 LLASVLALCAVSYDRLTAIVLPS--EARLTKRGAKIVIVITWIVGLLLALPLAIyrsyrerqwKNFLETYCAENtQVLPI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122056731 178 YCDV-------VPLLPLICSHVeetellTILFSafnlisslvvvLLSYMLILLTIFQMRSAEGRKKAFSTCGSHLTVVVV 250
Cdd:cd15000  161 YWHViitvlvwLPLGIMLICYS------AIFWK-----------LDKYERRVLRREHPSVVRYKKKAAKTLFIVLITFVV 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122056731 251 F---YGSLLFMY--------VQPKSAHSFEYDKAASVFYTLVIPMLNPLIYSLRNKEVKNAF 301
Cdd:cd15000  224 CripFTALIFYRyklvpndnTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH