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Conserved domains on  [gi|110671321|ref|NP_666869|]
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olfactory receptor 1131 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11610421)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
11-302 4.55e-167

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320611  Cd Length: 292  Bit Score: 465.37  E-value: 4.55e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
 
Name Accession Description Interval E-value
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
11-302 4.55e-167

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 465.37  E-value: 4.55e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
30-303 5.22e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 138.40  E-value: 5.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321   30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSCL 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  190 DTQVNYL-ALFTIYGFLELSTISgVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF--RPSSSYS 266
Cdd:pfam13853 161 DIKVNNIyGLFVVTSTFGIDSLL-IVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVP 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 110671321  267 LDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
 
Name Accession Description Interval E-value
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
11-302 4.55e-167

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 465.37  E-value: 4.55e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
10-304 3.77e-152

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 427.94  E-value: 3.77e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  10 EFIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNK 89
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  90 SIPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCG 169
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 170 SNEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAI 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110671321 250 FQGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKIK 304
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
11-303 1.11e-151

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 426.69  E-value: 1.11e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:cd15410  241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-293 7.30e-151

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 423.46  E-value: 7.30e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15230    3 LFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15230   83 FGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15230  163 LSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSY 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15230  243 SLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
11-297 1.80e-143

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 405.55  E-value: 1.80e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVK 297
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
25-302 8.77e-139

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 393.55  E-value: 8.77e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15417  242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-302 2.22e-135

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 384.75  E-value: 2.22e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15411    2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15411   82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15411  162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15411  242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
26-293 1.82e-131

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 374.51  E-value: 1.82e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd13954    3 LFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd13954   83 LGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd13954  163 LSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSY 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd13954  243 SSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
25-302 8.92e-130

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 370.49  E-value: 8.92e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15419  242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
15-303 1.69e-129

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 370.16  E-value: 1.69e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  15 GVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFW 94
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  95 GCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEIN 174
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 175 HFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTL 254
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 110671321 255 LFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:cd15406  241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
26-302 2.96e-129

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 369.43  E-value: 2.96e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15409    3 LFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15409   83 SATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15409  163 ISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLY 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15409  243 ALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
11-303 3.21e-129

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 369.88  E-value: 3.21e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIF 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110671321 251 QGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
24-300 4.39e-129

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 368.71  E-value: 4.39e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  24 GTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPL 183
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 184 YLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSS 263
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 264 SYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
26-307 1.51e-128

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 367.52  E-value: 1.51e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15414    3 LFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15414   83 FVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15414  163 LSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSS 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKIKRKR 307
Cdd:cd15414  243 SLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
25-302 6.42e-128

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 365.88  E-value: 6.42e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15413   82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15413  162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15413  242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-302 6.07e-124

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 355.94  E-value: 6.07e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15412    3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15412   83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15412  163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15412  243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-302 3.73e-123

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 353.64  E-value: 3.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15415    3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15415   83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15415  163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15415  243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
26-300 1.55e-122

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 351.95  E-value: 1.55e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15231  243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
25-302 1.58e-122

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 352.05  E-value: 1.58e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15416    2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15416   82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15416  162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15416  242 YSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
26-300 7.27e-121

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 348.05  E-value: 7.27e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15229    3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15229   83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15229  163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15229  243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
24-300 1.82e-118

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 341.89  E-value: 1.82e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  24 GTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd15235    2 PLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPL 183
Cdd:cd15235   82 IAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 184 YLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSS 263
Cdd:cd15235  162 LKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSS 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 264 SYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15235  242 SYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
25-293 2.91e-112

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 325.77  E-value: 2.91e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15237    2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15237   82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15237  162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15237  242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
26-300 1.48e-111

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 324.12  E-value: 1.48e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15421   83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15421  163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15421  243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
26-302 3.79e-111

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 323.22  E-value: 3.79e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15407  243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
25-302 4.87e-110

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 320.58  E-value: 4.87e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15418    3 ILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15418   83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15418  163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKK 302
Cdd:cd15418  243 HTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
26-293 1.50e-109

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 318.79  E-value: 1.50e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15918    3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15918   83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15918  163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15918  243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
26-300 1.83e-107

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 313.95  E-value: 1.83e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALfTIYGFLELST-ISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15429  163 LACVDTSLNEVAI-LVSSVVVLLTpCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15429  242 SSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-293 8.88e-106

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 309.17  E-value: 8.88e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15947    2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15947   82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15947  162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15947  242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
26-293 2.76e-105

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 307.87  E-value: 2.76e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15911    3 LFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15911   83 LAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15911  163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15911  243 SRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
25-293 3.04e-104

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 305.30  E-value: 3.04e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTtLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15431  241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
26-300 5.40e-104

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 305.11  E-value: 5.40e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15405    3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15405   83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15405  243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
27-293 1.15e-103

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 303.99  E-value: 1.15e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  27 FTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVF 106
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 107 ADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLL 186
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 187 SCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSYS 266
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                        250       260
                 ....*....|....*....|....*..
gi 110671321 267 LDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15227  244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
26-293 1.14e-102

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 301.33  E-value: 1.14e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15912   83 LGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15912  163 LSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSS 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15912  243 SLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
26-300 3.77e-102

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 300.45  E-value: 3.77e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15434  163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15434  243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
26-293 1.37e-101

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 298.79  E-value: 1.37e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15232    3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15232   83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15232  163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15232  243 SPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
26-300 3.72e-101

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 297.85  E-value: 3.72e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15432    3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15432   83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15432  163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15432  243 SHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
26-300 1.27e-99

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 293.85  E-value: 1.27e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15420    3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15420   83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15420  163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15420  243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
24-293 1.58e-96

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 285.74  E-value: 1.58e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  24 GTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd15915    1 IFLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPL 183
Cdd:cd15915   81 HFLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 184 YLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKI-RSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPS 262
Cdd:cd15915  161 LKLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPS 240
                        250       260       270
                 ....*....|....*....|....*....|.
gi 110671321 263 SSYSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15915  241 SGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
24-300 4.77e-95

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 282.43  E-value: 4.77e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  24 GTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd15236    1 GVFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPL 183
Cdd:cd15236   81 IFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 184 YLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSS 263
Cdd:cd15236  161 LKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 264 SYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15236  241 NNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-300 6.99e-95

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 281.77  E-value: 6.99e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15234    3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15234   83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15234  163 LACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15234  243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
26-293 2.40e-94

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 280.32  E-value: 2.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15224   83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
26-300 2.95e-92

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 275.08  E-value: 2.95e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15424    3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15424   83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15424  163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15424  243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
25-293 3.62e-90

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 269.47  E-value: 3.62e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSiLKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15939  241 FPI--DKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
26-300 3.75e-90

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 269.70  E-value: 3.75e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMF-GKNKSIPFWGCALQLFIFC 104
Cdd:cd15916    3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFH 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15916   83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15916  163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110671321 265 YSLdqDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15916  243 EAL--DGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-293 6.67e-90

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 268.86  E-value: 6.67e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15430    2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15430   82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15430  162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15430  242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
26-300 3.61e-88

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 264.73  E-value: 3.61e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15233   83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15233  163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15233  243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
26-300 5.98e-88

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 264.34  E-value: 5.98e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15428  163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15428  243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
26-293 1.39e-86

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 260.38  E-value: 1.39e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15914    3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15914   83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15914  163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15914  243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
26-293 1.48e-85

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 257.79  E-value: 1.48e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15946    3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15946   83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15946  163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15946  243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
26-293 5.84e-85

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 256.21  E-value: 5.84e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15940    3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15940   83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKiRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15940  163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRK-RSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15940  242 SE--DKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
26-293 1.41e-84

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 255.21  E-value: 1.41e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15226    3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15226   83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKiRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15226  163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15226  242 PV--DKFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
26-300 1.41e-82

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 250.54  E-value: 1.41e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHT-PMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKN-KSIPFWGCALQLFIF 103
Cdd:cd15941    3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPL 183
Cdd:cd15941   83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 184 YLLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSS 263
Cdd:cd15941  163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110671321 264 SYSldQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15941  243 SQA--GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
25-300 1.20e-81

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 248.12  E-value: 1.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110671321 265 YSLdqDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15228  242 PVL--VTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
26-300 7.82e-81

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 246.24  E-value: 7.82e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15433  163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15433  243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
26-300 2.30e-77

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 237.33  E-value: 2.30e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15942  243 PL--DGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
26-293 6.18e-77

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 236.06  E-value: 6.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15913    3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15913   83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15913  163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15913  243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
26-293 3.06e-71

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 221.28  E-value: 3.06e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15938   83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIissILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15938  163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15938  240 PV--DKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
26-293 1.19e-70

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 219.90  E-value: 1.19e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15936    3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15936   83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCyIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15936  163 LACTDTFLLELLMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15936  242 PM--DKAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
26-293 2.03e-64

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 203.84  E-value: 2.03e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQL-HTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15935    3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15935   83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSiLKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSS 264
Cdd:cd15935  163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241
                        250       260
                 ....*....|....*....|....*....
gi 110671321 265 YSLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15935  242 SSV--DKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
26-293 2.41e-59

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 190.72  E-value: 2.41e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15937    3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15937   83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSiLKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSY 265
Cdd:cd15937  163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241
                        250       260
                 ....*....|....*....|....*...
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd15937  242 PM--DKVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
26-300 7.56e-55

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 179.80  E-value: 7.56e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15223    3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15223   83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNylalfTIYGFLELSTISG-----VLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF- 259
Cdd:cd15223  163 LACGDTTIN-----SIYGLAVAWLIVGsdiilIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLt 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 110671321 260 -RPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEAL 300
Cdd:cd15223  238 yRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
30-294 3.59e-49

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 164.77  E-value: 3.59e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSsrKCFMFMAGVYLVGTSDALI--HTTLAFRLCFCGSNEINHFFCDLPPLYLLS 187
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILT--NTVVGKIGLAILLRAVALIipLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 188 CLDTQVNylalfTIYGFLELSTISG-----VLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFrps 262
Cdd:cd15917  165 CGDTRVN-----SIYGLFVALLIVGfdllfIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFL--- 236
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 263 sSYSLDQDK------MTSLFYTLVIPMLNPLIYSLRNK 294
Cdd:cd15917  237 -THRFGHHVpphvhiLLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
30-296 2.29e-46

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 157.58  E-value: 2.29e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKcfmfMAGVYLVGTSDALIHTT----LAFRLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQV----IAQIGLAIVLRALLFMTpltcLVTSLPYCGSRVVPHSYCEHMAVVK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF--RPSS 263
Cdd:cd15950  163 LACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYtqRFGQ 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 110671321 264 SYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15950  243 GVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
30-294 4.51e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 156.89  E-value: 4.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 EC-VLLAvMAFDRYQAISNPLLYTANMSSRKcfMFMAGVYLVGTSdALIHTTLAF---RLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15222   87 ESsVLLA-MAFDRFVAICNPLRYASILTNSR--IAKIGLAIVLRS-VLLLLPLPFllkRLPFCHSNVLSHSYCLHQDVMK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNylalfTIYG-FLELSTI----SGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLL----- 255
Cdd:cd15222  163 LACSDTRVN-----SIYGlFVVLSTMgldsLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsmv 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 110671321 256 --FTYFRPSSSYSLdqdkmTSLFYTLVIPMLNPLIYSLRNK 294
Cdd:cd15222  238 hrFGKHASPLVHVL-----MANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
30-296 7.32e-46

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 156.39  E-value: 7.32e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSCL 189
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 190 DTQVNYLALFTIYGFLELSTISgVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRPSSSYSLDQ 269
Cdd:cd15952  167 SIRINIIYGLFAISVLVLDVIL-IALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPR 245
                        250       260
                 ....*....|....*....|....*....
gi 110671321 270 --DKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15952  246 yiHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
30-294 1.17e-44

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 153.21  E-value: 1.17e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF-IFCVFAD 108
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFfVHFVFVT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 109 SECVLLAvMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSC 188
Cdd:cd15221   87 ESAILLA-MAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 189 LDTQVNylalfTIYGFLE--LSTISGVL---VSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFR--- 260
Cdd:cd15221  166 ADITVN-----IWYGLTValLTVGLDVVliaVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrf 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 261 ----PSSSYSLDQDkmtslFYTLVIPMLNPLIYSLRNK 294
Cdd:cd15221  241 grhiPRHVHILLAN-----LYVLVPPMLNPIVYGVKTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
30-294 1.94e-44

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 152.42  E-value: 1.94e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMS-SRKCFMFMAGVyLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSC 188
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGL-IRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 189 LDTQVNylalfTIYGFLELSTISG-----VLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF--RP 261
Cdd:cd15953  166 GDTTIN-----RIYGLVVALLVVGldlllIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRF 240
                        250       260       270
                 ....*....|....*....|....*....|...
gi 110671321 262 SSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNK 294
Cdd:cd15953  241 GQGIAPHIHIILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
29-296 1.17e-43

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 150.57  E-value: 1.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFAD 108
Cdd:cd15951    6 PFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFST 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 109 SECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSC 188
Cdd:cd15951   86 MESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 189 LDTQVN-YLALFTIYGFLELSTISgVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTY--FRPSSSY 265
Cdd:cd15951  166 ADTRVSrAYGLSVAFLVGGLDVIF-IAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFltHRFGHNV 244
                        250       260       270
                 ....*....|....*....|....*....|.
gi 110671321 266 SLDQDKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15951  245 PPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
30-296 1.13e-40

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 142.70  E-value: 1.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15956    7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSCL 189
Cdd:cd15956   87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 190 DTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTY----FRPSSSY 265
Cdd:cd15956  167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVlmhrFGHSVPS 246
                        250       260       270
                 ....*....|....*....|....*....|.
gi 110671321 266 SLdqDKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15956  247 AA--HVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
30-297 1.24e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 142.74  E-value: 1.24e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRkcfmFMAGVYLVGTSDA-LIHTTLAF---RLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNS----VITKIGLAALARAvTLMTPLPFllrRLPYCRSHVIAHCYCEHMAVVK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLF--TYFRPSS 263
Cdd:cd15948  164 LACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLssTMHRFAR 243
                        250       260       270
                 ....*....|....*....|....*....|....
gi 110671321 264 SYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVK 297
Cdd:cd15948  244 HVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
30-303 5.22e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 138.40  E-value: 5.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321   30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSCL 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  190 DTQVNYL-ALFTIYGFLELSTISgVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF--RPSSSYS 266
Cdd:pfam13853 161 DIKVNNIyGLFVVTSTFGIDSLL-IVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHNVP 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 110671321  267 LDQDKMTSLFYTLVIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:pfam13853 240 PLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
11-297 6.00e-38

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 136.06  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  11 FIFVGVTNNPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKS 90
Cdd:cd15949    4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  91 IPFWGCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGS 170
Cdd:cd15949   84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 171 NEINHFFCDLPPLYLLSCLDTQVNYLALFTIyGFLELSTIS-GVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAI 249
Cdd:cd15949  164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTI-GFLVLIMDSlFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILA 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 110671321 250 FQGTLLFTYF--RPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDVK 297
Cdd:cd15949  243 FYVPIAVSSLihRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
30-296 5.21e-37

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 133.41  E-value: 5.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRLCFCGSNEINHFFCDLPPLYLLSCL 189
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 190 DTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYFRP---SSSYS 266
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfgGHHIT 246
                        250       260       270
                 ....*....|....*....|....*....|
gi 110671321 267 LDQDKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15954  247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
30-296 4.48e-34

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 125.65  E-value: 4.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCF-----MFMAGVYLVGTSDALIHTtlafRLCFCGSNEINHFFCDLPPLY 184
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLgigvlVVVRAVVLIIPCPLLIKL----RLHHFRSTVISHSYCEHMAVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYL----ALFTIYGFlelsTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF- 259
Cdd:cd15955  163 KLAADDVRVNKIyglfVAFSILGF----DIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFa 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110671321 260 -RPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRNKDV 296
Cdd:cd15955  239 hRFGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-289 1.32e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 118.55  E-value: 1.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321   40 GNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLD-MFGKNKSIPFWGCALQLFIFCVFADSECVLLAVMA 118
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  119 FDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTLAFRlcfCGSNEINHFFCDLPPLYLLSCLDTQVNYLAL 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  199 FTIYGFLelstiSGVLVSYCYIISSILKIRSAEGRF-------KAFSTCTSHLTAVAIFQG----TLLFTYFRPSSSYSL 267
Cdd:pfam00001 158 LGFLLPL-----LVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLpyhiVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 110671321  268 DQDKMTSL--FYTLVIPMLNPLIY 289
Cdd:pfam00001 233 LLDKALSVtlWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
26-293 7.46e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 84.26  E-value: 7.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALihttlafrLCFCGSNEINHFFCDLPPLYL 185
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDYGGYCCCCLCW 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTIsgvLVSYCYIISSILK--------------IRSAEGRFKAFSTCTSHLTAVAI-- 249
Cdd:cd00637  153 PDLTLSKAYTIFLFVLLFLLPLLVI---IVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLcw 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 250 --FQGTLLFTYFRPSSSYSLDQDKMTSLFYTLVIPMLNPLIYSLRN 293
Cdd:cd00637  230 lpYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-300 2.60e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 65.66  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVgtsdALIHTTLAFRLcfcgsneiNHFFCDLPPLY 184
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVY----SLLISLPPLVG--------WRDETQPSVVD 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 185 LLSCLDTQVNYLALFTIYGFLelstISGVLVSYCYIIssILKIRSAEgrFKAFSTctshltaVAIFQGTLLFTYFRPSSS 264
Cdd:cd14967  149 CECEFTPNKIYVLVSSVISFF----IPLLIMIVLYAR--IFRVARRE--LKAAKT-------LAIIVGAFLLCWLPFFII 213
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 265 YSLDQ----DKMTSLFYTLVI------PMLNPLIYSLRNKDVKEAL 300
Cdd:cd14967  214 YLVSAfcppDCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
29-300 4.69e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 59.23  E-value: 4.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFAD 108
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 109 SECVLLAVmAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALIHTTlafrlcfcGSNEINhffCDLPplyllSC 188
Cdd:cd14972   84 SAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVL--------GWNCVL---CDQE-----SC 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 189 LDTQ----VNYLALFTIYGFLELSTISGVlvsYCYIISSI------LKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTY 258
Cdd:cd14972  147 SPLGpglpKSYLVLILVFFFIALVIIVFL---YVRIFWCLwrhanaIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCW 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110671321 259 FrPSSSYSL-------DQDKMTSLFYTLVI----PMLNPLIYSLRNKDVKEAL 300
Cdd:cd14972  224 L-PLLILLVldvlcpsVCDIQAVFYYFLVLallnSAINPIIYAFRLKEMRRAV 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-149 3.03e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 53.75  E-value: 3.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLI-NLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd14969    1 YVLAVYLSLIGVlGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTaNMSSRKCFMFMAGVYL 149
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWL 125
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
31-150 3.64e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 50.39  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  31 LLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGP-KMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15052    8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLFCTA 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15052   88 SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLI 128
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
32-150 1.23e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.99  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCAL--QLFIFCVFADS 109
Cdd:cd15058    9 LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELwtSVDVLCVTASI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECvlLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15058   89 ET--LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIV 127
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
25-150 2.06e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 48.36  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd14993    2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI 127
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
32-150 3.73e-06

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 47.23  E-value: 3.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLcySTA---IGPKMLLDMFGKnksipFWG----CALQLF--I 102
Cdd:cd15196    9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADL--LVAlfnVLPQLIWDITYR-----FYGgdllCRLVKYlqV 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 110671321 103 FCVFADSecVLLAVMAFDRYQAISNPLLYTaNMSSRKCFMFMAGVYLV 150
Cdd:cd15196   82 VGMYASS--YVLVATAIDRYIAICHPLSSH-RWTSRRVHLMVAIAWVL 126
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
31-150 8.14e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 46.44  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  31 LLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLD-MFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15305    8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAiLYDYAWPLPRYLCPIWISLDVLFSTA 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15305   88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTI 128
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
25-150 9.97e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 46.29  E-value: 9.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPkmlLDMFGKNKSIPFWG---CALQLF 101
Cdd:cd15317    2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMP---FSMIRTVETCWYFGdlfCKFHTG 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 110671321 102 IFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15317   79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
32-148 1.73e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.53  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIP-FWGCALQLFIFCVFADSE 110
Cdd:cd15005    9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYgALSCKVIAFLAVLFCFHS 88
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 110671321 111 CVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVY 148
Cdd:cd15005   89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
32-150 2.00e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 45.04  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGP-KMLLDMFGKnksipFWgcalqLF--IFC---- 104
Cdd:cd15067    8 LFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGG-----YW-----LFgrDWCdvwh 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 ---VFADSECVL-LAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15067   78 sfdVLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWIC 127
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
31-150 2.32e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 44.92  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  31 LLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGP-KMLLDMFGKNKSIPFWGCALQLFIFCVFADS 109
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTI 128
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-129 2.56e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 45.19  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  28 TIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYST-AIGPKMLLDMfgknkSIPFWG----CALQLFI 102
Cdd:cd15387    5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDI-----TFRFYGpdflCRLVKYL 79
                         90       100
                 ....*....|....*....|....*..
gi 110671321 103 FCVFADSECVLLAVMAFDRYQAISNPL 129
Cdd:cd15387   80 QVVGMFASTYMLLLMSIDRCLAICQPL 106
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-149 2.68e-05

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 44.76  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKnKSIPF--WGCALQLFIFCVF 106
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSR-PGWLFgdRLCLANGFFNACF 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 110671321 107 ADSECVLLAVMAFDRYQAISNPLlyTANMSSRKCFMFMAGVYL 149
Cdd:cd15212   85 GIVSTLTMTLISFDRYYAIVRQP--QGKIGRRRALQLLAAAWL 125
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
25-149 2.73e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 45.02  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNiGMIILIRMDPQ-LHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFgkNKSIPFWGCALQLFIF 103
Cdd:cd15083    2 VLGIFILIIGLIGVVGN-GLVIYAFCRFKsLRTPANYLIINLAISDFLMCILNCPLMVISSF--SGRWIFGKTGCDMYGF 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 110671321 104 CV--FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYL 149
Cdd:cd15083   79 SGglFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL 126
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
32-129 3.50e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 44.67  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYS-TAIGPKMLLDMFGKNKSIPFwGCALQLFIFCVFADSE 110
Cdd:cd14986    9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWVAGDV-LCRIVKYLQVVGLFAS 87
                         90
                 ....*....|....*....
gi 110671321 111 CVLLAVMAFDRYQAISNPL 129
Cdd:cd14986   88 TYILVSMSLDRYQAIVKPM 106
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
29-150 4.33e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 44.11  E-value: 4.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF------I 102
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsM 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 110671321 103 FCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15352   86 ICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
29-150 5.93e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 43.88  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYsTAIGPKMLLDMFGKNKSIPF--WGCALQLFIFCVF 106
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLI-LLVGLPVELYNFWWQYPWAFgdGGCKLYYFLFEAC 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 110671321 107 ADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd14979   85 TYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLV 128
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
29-150 6.54e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 43.78  E-value: 6.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIgMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLL----DMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd14978    6 VLPVICIFGIIGNI-LNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLpyiaDYSSSFLSYFYAYFLPYIYPLA 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 110671321 105 VFADSECVLLAV-MAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd14978   85 NTFQTASVWLTVaLTVERYIAVCHPLKARTWCTPRRARRVILIIIIF 131
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
29-157 7.23e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 43.39  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF------I 102
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIdnvfdsL 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 110671321 103 FCV-FADSECVLLAVmAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALI 157
Cdd:cd15354   86 ICIsVVASMCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGII 140
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
32-139 7.29e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 43.40  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADSEC 111
Cdd:cd15299   12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASV 91
                         90       100
                 ....*....|....*....|....*...
gi 110671321 112 VLLAVMAFDRYQAISNPLLYTANMSSRK 139
Cdd:cd15299   92 MNLLVISFDRYFSITRPLTYRAKRTTKR 119
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
27-150 1.16e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 42.71  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  27 FTIFLLIYLInLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLD------MFGKnksipfWGCALQL 100
Cdd:cd15059    5 SIVSVVILLI-IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNelmgywYFGS------VWCEIWL 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 110671321 101 FIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15059   78 ALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWII 127
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
22-153 1.41e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 42.47  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  22 MKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF 101
Cdd:cd15333    3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110671321 102 IFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTS 153
Cdd:cd15333   83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISIS 134
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
19-150 2.02e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 42.22  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  19 NPEMKGTLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLldmfgKNKSIPFW---- 94
Cdd:cd15321    2 SVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSL-----ANELMGYWyfrk 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110671321  95 -GCALQLFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15321   77 tWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLI 133
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
27-152 2.04e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 42.28  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  27 FTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDM------FGKNksipfwGCALQL 100
Cdd:cd15390    4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLlyndwpFGLF------YCKFSN 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110671321 101 F--IFCVFAdSECVLLAvMAFDRYQAISNPLLytANMSSRKCFMFMAGVYLVGT 152
Cdd:cd15390   78 FvaITTVAA-SVFTLMA-ISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASF 127
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
26-149 2.57e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 41.92  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIY-LINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIG-PKMLLDMFGKNKSIPFWGCALQLFIF 103
Cdd:cd15337    2 LIGIYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVACELYGFAG 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYL 149
Cdd:cd15337   82 GIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWL 127
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
25-150 3.46e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 41.55  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTaigpkMLLDMFGKNKSIPFW-----GCALQ 99
Cdd:cd15300    2 TIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGI-----FSMNLYTSYILMGYWalgslACDLW 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 110671321 100 LFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15300   77 LALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLI 127
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
29-152 3.50e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 41.41  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNiGMIILIRMD-PQLHTPMYFFLSHLSFCDLCYSTAIgPKMLLDMFGKNKSIPFWGCALQLFIFCVFA 107
Cdd:cd15079    6 IYIFLGIVSLLGN-GLVIYIFSTtKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 110671321 108 DSECVLLAVMAFDRYQAISNPlLYTANMSSRKCFMFMAGVYLVGT 152
Cdd:cd15079   84 IGSIWTNAAIAYDRYNVIVKP-LNGNPLTRGKALLLILFIWLYAL 127
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
31-303 4.25e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 41.09  E-value: 4.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  31 LLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFADSE 110
Cdd:cd15307    8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 111 CVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDALihtTLAFRLCFCGSNEINHFFCDLP-PLYLLscl 189
Cdd:cd15307   88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL---PLSLMYSKDHASVLVNGTCQIPdPVYKL--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 190 dtqVNYLALFTIygflelsTISGVLVSYCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQGTLLFTYF-----RPSSS 264
Cdd:cd15307  162 ---VGSIVCFYI-------PLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFfvlnlLPTVC 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 265 YSLDQ-------DKMTSLFYTlvIPMLNPLIYSLRNKDVKEALKKI 303
Cdd:cd15307  232 AECEErishwvfDVVTWLGYA--SSMVNPIFYTIFNKVFRQAFKKV 275
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
29-150 4.34e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 41.36  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLD-MFGKNKSIPFWGCALQLFIFCVFA 107
Cdd:cd15306    6 LILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTiLFEAMWPLPLVLCPIWLFLDVLFS 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 110671321 108 DSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15306   86 TASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLI 128
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
28-151 4.76e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 41.18  E-value: 4.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  28 TIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIgpkMLLDMFgkNKSIPFWGCALQLFIFCVFA 107
Cdd:cd15065    4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLV---MTFAVV--NDLLGYWLFGETFCNIWISF 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 110671321 108 DSEC-----VLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVG 151
Cdd:cd15065   79 DVMCstasiLNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILS 127
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-148 4.97e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 40.94  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF------I 102
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsM 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 103 FCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVY 148
Cdd:cd15103   86 ICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
32-150 6.55e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 40.66  E-value: 6.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCAL--QLFIFCVFADS 109
Cdd:cd15959    9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELwtSVDVLCVTASI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECvlLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15959   89 ET--LCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAI 127
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
35-152 7.58e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 40.61  E-value: 7.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  35 LINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPkmlLDMFGKNKSIPFWG---CALQLFIFCVFADSEC 111
Cdd:cd15318   12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLP---FSTIRSVESCWYFGdsfCRLHTCLDTLFCLTSI 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 112 VLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGT 152
Cdd:cd15318   89 FHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPT 129
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
29-150 7.95e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 40.19  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLcystAIGpKMLLDMFGKNKSIPFWG-----CALQLFIF 103
Cdd:cd15301    6 VAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADF----AIG-VISMPLFTVYTALGYWPlgyevCDTWLAID 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 110671321 104 CVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWII 127
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
32-156 8.17e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 40.70  E-value: 8.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDM-FGKNKSIPFWGCALQLFIFCVFADSE 110
Cdd:cd15217    9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIrNGSAWTYSVLSCKIVAFMAVLFCFHA 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 111 CVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGTSDAL 156
Cdd:cd15217   89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAF 134
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
25-243 9.86e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 40.28  E-value: 9.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFC 104
Cdd:cd15203    2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLlyTANMSSRKCFMFMAGVYLVGtsdALIHTTLAFrlcfcgSNEINHFFCDLPPLY 184
Cdd:cd15203   82 VSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILS---LLLSLPLAI------FQELSDVPIEILPYC 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110671321 185 LLSCLD--TQVNYLALFTIYGFLELSTISGVLVSYCYI-ISSILKIRSAEGRFKAFSTCTSH 243
Cdd:cd15203  151 GYFCTEswPSSSSRLIYTISVLVLQFVIPLLIISFCYFrISLKLRKRVKKKRGKRTLSSRRR 212
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
31-152 2.67e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 38.78  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  31 LLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNksIPFWGCALQLFIFCVFADSE 110
Cdd:cd14968    8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLP--TNFHGCLFMACLVLVLTQSS 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 110671321 111 CVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGT 152
Cdd:cd14968   86 IFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSF 127
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
27-227 2.81e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 38.80  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  27 FTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVF 106
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 107 ADSECVLLAVMAFDRYQAISNPL-LYTANMSSRKCFMfMAGVYLVGtsdALIHTTLAFrlcfcGSNEINHFFCDLPPLYL 185
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMkAKSFCTIGRARKV-ALLIWILS---AILASPVLF-----GQGLVRYESENGVTVYH 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 110671321 186 LSCLDTQVNYLALFTIYGFLELSTISGVLVSYCYIISSILKI 227
Cdd:cd15001  154 CQKAWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARDTRKQV 195
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
29-139 3.11e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 38.74  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLL------DMFGKNKSIPFWGCALQLFI 102
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVitllngNDTDAQSFTVNIDNVIDSVI 85
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 110671321 103 FCVFADSECVLLAVmAFDRYQAISNPLLYTANMSSRK 139
Cdd:cd15353   86 CSSLLASICSLLSI-AVDRYFTIFYALQYHNIMTVRR 121
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
29-300 3.87e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.22  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCVFAD 108
Cdd:cd15102    6 VFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMFVALSA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 109 SECVLLAVmAFDRYQAISNPLLYTANMSSRkCFMFMAGVYLVGTSDALihttlafrLCFCGSNEINHF--FCDLPPLYll 186
Cdd:cd15102   86 SVFSLLAI-AIERHLTMAKMKPYGASKTSR-VLLLIGACWLISLLLGG--------LPILGWNCLGALdaCSTVLPLY-- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321 187 scldtqVNYLALFTIYGF-LELSTISGVLVS-YCYIISSILKIRSAEGRFKAFSTCTSHLTAVAIFQ-------GTLLFT 257
Cdd:cd15102  154 ------SKHYVLFCVTIFaGILAAIVALYARiYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIacwgplfILLLLD 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 110671321 258 YFRPSSSysldQDKMTSLFYTLVIPML----NPLIYSLRNKDVKEAL 300
Cdd:cd15102  228 VACPVKT----CPILYKADWFLALAVLnsalNPIIYTLRSRELRRAV 270
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
29-129 3.96e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 38.43  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKN---------KSIPFwgcalq 99
Cdd:cd14997    6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpwllgefmcKLVPF------ 79
                         90       100       110
                 ....*....|....*....|....*....|
gi 110671321 100 lFIFCVFADSECVLLAVmAFDRYQAISNPL 129
Cdd:cd14997   80 -VELTVAHASVLTILAI-SFERYYAICHPL 107
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
28-150 4.20e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  28 TIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYST-AIGPKMLLDMFGKNKSiPFWGCAL--QLFIFC 104
Cdd:cd15385    5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYG-PDFLCRIvkHLQVLG 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 105 VFADSecVLLAVMAFDRYQAISNPlLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15385   84 MFAST--YMLVMMTADRYIAICHP-LKTLQQPTKRSYLMIGSAWAL 126
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
32-150 4.87e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 38.03  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  32 LIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTaigpkMLLDMFGKNKSIPFWG-----CALQLFIFCVF 106
Cdd:cd17790    9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGA-----FSMNLYTTYILMGHWAlgtvaCDLWLALDYVA 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 110671321 107 ADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd17790   84 SNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLI 127
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
29-129 5.30e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 37.83  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLD------MFGKnksipfWGCALQLFI 102
Cdd:cd14971    6 FFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIyplpgwVFGD------FMCKFVHYF 79
                         90       100
                 ....*....|....*....|....*..
gi 110671321 103 FCVFADSECVLLAVMAFDRYQAISNPL 129
Cdd:cd14971   80 QQVSMHASIFTLVAMSLDRFLAVVYPL 106
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
30-150 5.48e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 37.61  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  30 FLLIYLInlLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLldmfgKNKSIPFW-----GCALQLFIFC 104
Cdd:cd15323    9 FLIVFTI--VGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSL-----ANELMGYWyfgqvWCNIYLALDV 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 110671321 105 VFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15323   82 LFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLI 127
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-152 6.25e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 37.46  E-value: 6.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  29 IFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLF------I 102
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtM 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 110671321 103 FCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLVGT 152
Cdd:cd15351   86 ICSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLAST 135
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
35-150 6.40e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 37.64  E-value: 6.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  35 LINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTaigpkMLLDMFGKNKSIPFWG-----CALQLFIFCVFADS 109
Cdd:cd15297   12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGV-----FSMNLYTLYTVIGYWPlgpvvCDLWLALDYVVSNA 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110671321 110 ECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15297   87 SVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVL 127
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
25-147 7.43e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 37.23  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  25 TLFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLldmfgKNKSIPFW-----GCALQ 99
Cdd:cd15322    2 TLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL-----ANEVMGYWyfgkvWCEIY 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 110671321 100 LFIFCVFADSECVLLAVMAFDRYQAISNPLLYTANMSSR--KCFMFMAGV 147
Cdd:cd15322   77 LALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRriKCIIFIVWV 126
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
26-150 8.62e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 37.02  E-value: 8.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110671321  26 LFTIFLLIYLINLLGNIGMIILIRMDPQLHTPMYFFLSHLSFCDLCYSTAIGPKMLLDMFGKNKSIPFWGCALQLFIFCV 105
Cdd:cd15050    3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYV 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 110671321 106 FADSECVLLAVMAFDRYQAISNPLLYTANMSSRKCFMFMAGVYLV 150
Cdd:cd15050   83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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