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Conserved domains on  [gi|125656167|ref|NP_666136|]
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ankyrin repeat domain-containing protein 40 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 3.29e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 3.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 3.29e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 3.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
Ank_4 pfam13637
Ankyrin repeats (many copies);
14-64 2.31e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 2.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 125656167   14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLL 64
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-92 7.21e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 7.21e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKI 92
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-69 1.07e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.42  E-value: 1.07e-05
                           10        20
                   ....*....|....*....|....*..
gi 125656167    43 NGWTCLHWACKRNHGQVVSYLLQSGAD 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 3.29e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 3.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666  157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-80 3.18e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.13  E-value: 3.18e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMP 80
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-80 1.93e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 1.93e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMP 80
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
Ank_4 pfam13637
Ankyrin repeats (many copies);
14-64 2.31e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 2.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 125656167   14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLL 64
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
14-65 5.69e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 5.69e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 125656167   14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQ 65
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLE 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
17-69 1.64e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.57  E-value: 1.64e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 125656167   17 AAALGDIREVQKLVESgVDVNSQNevNGWTCLHWACKRNHGQVVSYLLQSGAD 69
Cdd:pfam12796  37 AAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARSGHLEIVKLLLEKGAD 86
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-92 3.30e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.11  E-value: 3.30e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKI 92
Cdd:COG0666  190 LHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-92 7.21e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.67  E-value: 7.21e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125656167  14 LREAAALGDIREVQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKI 92
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-74 3.64e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.05  E-value: 3.64e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 125656167   43 NGWTCLHWACKR-NHGQVVSYLLQSGADREILT 74
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02741 PHA02741
hypothetical protein; Provisional
 23-95 4.32e-06

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 46.19  E-value: 4.32e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125656167  23 IREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLL-QSGADREILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02741  77 AEIIDHLIELGADINAQEMLEGDTALHLAAHRRDHDLAEWLCcQPGIDLHFCNADNKSPFELAIDNEDVAMMQI 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 26-93 4.62e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 4.62e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 125656167  26 VQKLVESGVDVNSQNeVNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIM 93
Cdd:PHA03095 240 VLPLLIAGISINARN-RYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 26-92 5.57e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.74  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  26 VQKLVESGVDVNSQNEVN---------------GWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIR 90
Cdd:PHA03100 159 LKLLIDKGVDINAKNRVNyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238


                 ..
gi 125656167  91 KI 92
Cdd:PHA03100 239 EI 240
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-69 1.07e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.42  E-value: 1.07e-05
                           10        20
                   ....*....|....*....|....*..
gi 125656167    43 NGWTCLHWACKRNHGQVVSYLLQSGAD 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGAD 27
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 23-95 2.11e-05

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 44.10  E-value: 2.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125656167  23 IREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLL-QSGADREILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02736  71 QEKLKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCnQPGVNMEILNYAFKTPYYVACERHDAKMMNI 144
Ank_5 pfam13857
Ankyrin repeats (many copies);
29-83 3.14e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 3.14e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 125656167   29 LVESG-VDVNSQNEvNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQL 83
Cdd:pfam13857   1 LLEHGpIDLNRLDG-EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-69 9.15e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.16  E-value: 9.15e-05
                          10        20
                  ....*....|....*....|....*..
gi 125656167   43 NGWTCLHWACKRNHGQVVSYLLQSGAD 69
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-93 1.36e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167   3 ALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQ 82
Cdd:COG0666   46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125

                         90
                 ....*....|.
gi 125656167  83 LTSRREIRKIM 93
Cdd:COG0666  126 LAAYNGNLEIV 136
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-95 2.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 2.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  26 VQKLVESGVDVNSQNEVNGwTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 4-77 9.59e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 9.59e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125656167   4 LLEQKEQQERLREAaalgdirevQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLQSGADREILTTKG 77
Cdd:PHA02876 148 LIKERIQQDELLIA---------EMLLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDD 211
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 26-81 2.23e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 2.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 125656167  26 VQKLVESGVDVNSQNEVNGwTCLHWACKRN-HGQVVSYLLQSGADREILTTKGEMPV 81
Cdd:PHA02876 425 VKTLIDRGANVNSKNKDLS-TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
Ank_2 pfam12796
Ankyrin repeats (3 copies);
48-93 3.17e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.25  E-value: 3.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 125656167   48 LHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQLTSRREIRKIM 93
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV 46
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 22-81 3.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.71  E-value: 3.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656167  22 DIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNhgQVVSYLLQSGADREILTTKGEMPV 81
Cdd:PHA02878 247 DYDILKLLLEHGVDVNAKSYILGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPL 304
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 20-80 8.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 37.72  E-value: 8.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125656167  20 LGDIREVQK-LVESGVDVNSQNeVNGWTCLHWA--CKRNHGQVVSYLLQSGADREILTTKGEMP 80
Cdd:PHA03100  82 LTDVKEIVKlLLEYGANVNAPD-NNGITPLLYAisKKSNSYSIVEYLLDNGANVNIKNSDGENL 144
Ank_4 pfam13637
Ankyrin repeats (many copies);
44-82 9.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 9.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 125656167   44 GWTCLHWACKRNHGQVVSYLLQSGADREILTTKGEMPVQ 82
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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