NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|281182810|ref|NP_666079|]
View 

V-set and transmembrane domain-containing protein 2A isoform 2 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 7.75e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.74  E-value: 7.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLEQGteaagsqvellpdrdpdndgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 281182810   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 7.75e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.74  E-value: 7.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLEQGteaagsqvellpdrdpdndgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 281182810   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-138 2.34e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.23  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810   33 PRNVTATEGQNVEMSCAFQSGSASVYLEIQWwfLRGPEDLEQGTEAA----GSQVELLPDRdpdndgtkistVKVQGNDI 108
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEASTSVYW--YRQPPGKGPTFLIAyysnGSEEGVKKGR-----------FSGRGDPS 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 281182810  109 SHK--LQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:pfam07686  70 NGDgsLTIQNLTLSDSGTYTCAVIPSGEGVFG 101
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 30-127 9.19e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 46.17  E-value: 9.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810  30 TELPRNVTATEGQNVEMSCAFQSGSASVYleIQWWFLR---GPEDLEQGTEAAGSQVELLPDRdpdndgtkISTVKVQGN 106
Cdd:cd00099    2 TQSPRSLSVQEGESVTLSCEVSSSFSSTY--IYWYRQKpgqGPEFLIYLSSSKGKTKGGVPGR--------FSGSRDGTS 71

                         90       100
                 ....*....|....*....|.
gi 281182810 107 DIShkLQISKVRKKDEGLYEC 127
Cdd:cd00099   72 SFS--LTISNLQPEDSGTYYC 90
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 7.75e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.74  E-value: 7.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLEQGteaagsqvellpdrdpdndgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 281182810   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-138 2.34e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.23  E-value: 2.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810   33 PRNVTATEGQNVEMSCAFQSGSASVYLEIQWwfLRGPEDLEQGTEAA----GSQVELLPDRdpdndgtkistVKVQGNDI 108
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEASTSVYW--YRQPPGKGPTFLIAyysnGSEEGVKKGR-----------FSGRGDPS 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 281182810  109 SHK--LQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:pfam07686  70 NGDgsLTIQNLTLSDSGTYTCAVIPSGEGVFG 101
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 30-127 9.19e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 46.17  E-value: 9.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810  30 TELPRNVTATEGQNVEMSCAFQSGSASVYleIQWWFLR---GPEDLEQGTEAAGSQVELLPDRdpdndgtkISTVKVQGN 106
Cdd:cd00099    2 TQSPRSLSVQEGESVTLSCEVSSSFSSTY--IYWYRQKpgqGPEFLIYLSSSKGKTKGGVPGR--------FSGSRDGTS 71

                         90       100
                 ....*....|....*....|.
gi 281182810 107 DIShkLQISKVRKKDEGLYEC 127
Cdd:cd00099   72 SFS--LTISNLQPEDSGTYYC 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 28-130 3.87e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.71  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810   28 KFTELPRNVTATEGQNVEMSCAFQSGSASVYleiqWWFLRGPEDLEQgteaagsqvellpdrdpdndgtkiSTVKVQGND 107
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPTI----TWYKNGEPISSG------------------------STRSRSLSG 54

                          90       100
                  ....*....|....*....|...
gi 281182810  108 ISHKLQISKVRKKDEGLYECRVT 130
Cdd:pfam13927  55 SNSTLTISNVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
28-148 5.29e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 5.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810   28 KFTELPRNVTATEGQNVEMSCAFqSGSASvyLEIQWwfLRGPEDLEQGteaagsqvellpdrdpdndgtkiSTVKVQGND 107
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTV-TGTPD--PEVSW--FKDGQPLRSS-----------------------DRFKVTYEG 53

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 281182810  108 ISHKLQISKVRKKDEGLYECRVTDAnYGElQEHKAQayLKV 148
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVATNS-AGE-AEASAE--LTV 90
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 33-133 6.30e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 43.34  E-value: 6.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810   33 PRNVTATEGQNVEMSCAfqSGSASVYLEIQWWFlrgpedleqgteaAGSQVELLPDRDPDNDGTKISTvkvqgndishkL 112
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGPDVTWSK-------------EGGTLIESLKVKHDNGRTTQSS-----------L 56

                          90       100
                  ....*....|....*....|.
gi 281182810  113 QISKVRKKDEGLYECRVTDAN 133
Cdd:pfam00047  57 LISNVTKEDAGTYTCVVNNPG 77
IGv smart00406
Immunoglobulin V-Type;
43-127 8.27e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.36  E-value: 8.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810    43 NVEMSCAFqSGSASVYLEIQWwfLRgpedleqgtEAAGSQVELLPDRDPDNDGTKISTVK--VQGNDISHK----LQISK 116
Cdd:smart00406   1 SVTLSCKF-SGSTFSSYYVSW--VR---------QPPGKGLEWLGYIGSNGSSYYQESYKgrFTISKDTSKndvsLTISN 68

                           90
                   ....*....|.
gi 281182810   117 VRKKDEGLYEC 127
Cdd:smart00406  69 LRVEDTGTYYC 79
IgI_1_Neogenin_like cd05722
First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of ...
 29-143 8.71e-04

First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain in neogenin and related proteins. Neogenin is a cell surface protein which is expressed in the developing nervous system of vertebrate embryos in the growing nerve cells. It is also expressed in other embryonic tissues and may play a general role in developmental processes such as cell migration, cell-cell recognition, and tissue growth regulation. Included in this group is the tumor suppressor protein DCC which is deleted in colorectal carcinoma. DCC and neogenin each have four Ig-like domains followed by six fibronectin type III domains, a transmembrane domain, and an intracellular domain. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409387  Cd Length: 97  Bit Score: 37.46  E-value: 8.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810  29 FTELPRNVTATEGQNVEMSCAFQSGSASVyleIQWwflrgpedLEQGT---EAAGSQVELLPDrdpdndGTKIstvkvqg 105
Cdd:cd05722    4 FLSEPSDIVAMRGGPVVLNCSAESDPPPK---IEW--------KKDGVllnLVSDERRQQLPN------GSLL------- 59

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 281182810 106 ndISHkLQISKVRKKDEGLYECRVTDANYGELQEHKAQ 143
Cdd:cd05722   60 --ITS-VVHSKHNKPDEGFYQCVAQNESLGSIVSRTAR 94
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 27-131 1.63e-03

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 37.25  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810  27 AKFTELPRNVTATEGQNVEMSCafqSGSASVYLEIQWWFlrgpedLEQGTEAAGSQVEllpdrdpdnDGTKISTVKVQGN 106
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHC---EAVGSPIPEIQWWF------EGQEPNEICSQLW---------DGARLDRVHINAT 62

                         90       100
                 ....*....|....*....|....*...
gi 281182810 107 DISH---KLQISKVRKKDEGLYECRVTD 131
Cdd:cd20940   63 YHQHatsTISIDNLTEEDTGTYECRASN 90
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 33-138 2.49e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 36.22  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182810  33 PRNVTATEGQNVEMSCAFQSGSASV--YLEIQwwflrgpedleqgtEAAGSQveLLPDRDPDNDGTKIStVKVQGNDISH 110
Cdd:cd05716    4 PEVVTGVEGGSVTIQCPYPPKYASSrkYWCKW--------------GSEGCQ--TLVSSEGVVPGGRIS-LTDDPDNGVF 66

                         90       100
                 ....*....|....*....|....*...
gi 281182810 111 KLQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:cd05716   67 TVTLNQLRKEDAGWYWCGVGDDGDRGLT 94
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 94-136 3.41e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.38  E-value: 3.41e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281182810  94 DGTKISTVKVQGNDI---SHKLQISKVRKKDEGLYECRVTDANYGE 136
Cdd:cd00096   20 NGKPLPPSSRDSRRSelgNGTLTISNVTLEDSGTYTCVASNSAGGS 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH