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Conserved domains on  [gi|23308737|ref|NP_666016|]
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zinc finger protein 23 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-606 8.51e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 186 HQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKC--VECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKafSV 263
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LS 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 264 NGSLSRHQRIHTGEKP-YQCKECGNGFSCSSAYITHQRVHTGEKPYEC------NDCGKAFNVNAKLIQHQRIHTGEKPY 336
Cdd:COG5048 102 NSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnSSSVNTPQSNSLHPPLPANSLSKDPS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 337 ECNecgkgfrcssQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTG 416
Cdd:COG5048 182 SNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 417 EKPYECNECGKAFRCNSQFRQHLRIHTGE-------KPYECNECGKAFSVNGKLMRHQR--IHTGE--KPFECNE--CGR 483
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 484 CFTSKRNLLDHHRIHTGEKPYQCK--ECGKAFSI-----NAKLTRHQRIHTGEKPFKCM--ECEKAFSCSSNYIVHQRIH 554
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITH 411

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 555 TGEKP--FQCKECGKAFHVNAHLIRHQRSHTGEKPFRCveCGKGFSFSSDYIIH 606
Cdd:COG5048 412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
KRAB super family cl42959
krueppel associated box;
1-31 6.27e-08

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 6.27e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 23308737      1 MLENYGNVASLGFPLLKPAVISQLEGGSELG 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-606 8.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 186 HQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKC--VECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKafSV 263
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LS 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 264 NGSLSRHQRIHTGEKP-YQCKECGNGFSCSSAYITHQRVHTGEKPYEC------NDCGKAFNVNAKLIQHQRIHTGEKPY 336
Cdd:COG5048 102 NSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnSSSVNTPQSNSLHPPLPANSLSKDPS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 337 ECNecgkgfrcssQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTG 416
Cdd:COG5048 182 SNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 417 EKPYECNECGKAFRCNSQFRQHLRIHTGE-------KPYECNECGKAFSVNGKLMRHQR--IHTGE--KPFECNE--CGR 483
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 484 CFTSKRNLLDHHRIHTGEKPYQCK--ECGKAFSI-----NAKLTRHQRIHTGEKPFKCM--ECEKAFSCSSNYIVHQRIH 554
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITH 411

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 555 TGEKP--FQCKECGKAFHVNAHLIRHQRSHTGEKPFRCveCGKGFSFSSDYIIH 606
Cdd:COG5048 412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
KRAB smart00349
krueppel associated box;
1-31 6.27e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 6.27e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 23308737      1 MLENYGNVASLGFPLLKPAVISQLEGGSELG 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-543 8.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.84e-05
                          10        20
                  ....*....|....*....|....*
gi 23308737   519 LTRHQRIHTGEKPFKCMECEKAFSC 543
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 558-610 3.92e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.92e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 558 KPFqCKECGKAFHVNAHLIRHQRSHTgekpFRCVECGKGFSFSSDYIIH-QTVH 610
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-606 8.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 8.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 186 HQENNTEEKPYQCSECGKAFSINEKLIWHQRLHSGEKPFKC--VECGKSFSYSSHYITHQTIHSGEKPYQCKMCGKafSV 263
Cdd:COG5048  24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LS 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 264 NGSLSRHQRIHTGEKP-YQCKECGNGFSCSSAYITHQRVHTGEKPYEC------NDCGKAFNVNAKLIQHQRIHTGEKPY 336
Cdd:COG5048 102 NSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNplpgnnSSSVNTPQSNSLHPPLPANSLSKDPS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 337 ECNecgkgfrcssQLRQHQSIHTGEKPYQCKECGKGFNNNTKLIQHQRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTG 416
Cdd:COG5048 182 SNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 417 EKPYECNECGKAFRCNSQFRQHLRIHTGE-------KPYECNECGKAFSVNGKLMRHQR--IHTGE--KPFECNE--CGR 483
Cdd:COG5048 252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGK 331

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 484 CFTSKRNLLDHHRIHTGEKPYQCK--ECGKAFSI-----NAKLTRHQRIHTGEKPFKCM--ECEKAFSCSSNYIVHQRIH 554
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITH 411

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 555 TGEKP--FQCKECGKAFHVNAHLIRHQRSHTGEKPFRCveCGKGFSFSSDYIIH 606
Cdd:COG5048 412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-640 1.16e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 222 KPFKCVECGKSFSYSSHYITHQTIHSGEKPYQC--KMCGKAFSVNGSLSRHQRIHTGEKPYQC--KECGNGFSCSSAYIT 297
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 298 HQRVHTgekPYECNDCGKAFNVNAKLIQHQRIHTGEKpYECNECGKGFRCSSQLRQHQSIHtGEKPYQCKeCGKGFNNNT 377
Cdd:COG5048 112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSNLS 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 378 KLIQHQRIHTGEKPYECTECGKaFSVKGKLIQHQRIHTGEKPYECNECGKAFRCNSQFRQHLRIHTGEKPYECNECGkaF 457
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP--R 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 458 SVNGKLMRHQRIHTG---------EKPFECNECGRCFTSKRNLLDH--HRIHTGE--KPYQCKE--CGKAFSINAKLTRH 522
Cdd:COG5048 263 SSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 523 QRIHTGEKPFKCM--ECEKAFSCSSNYIVHQRIHtgekpfqckecgkafhvnahlirHQRSHTGEKPFRCVECGKGFSFS 600
Cdd:COG5048 343 ILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ-----------------------QYKDLKNDKKSETLSNSCIRNFK 399

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 23308737 601 SDYII--HQTVHTWKKPYMC--SVCGKAFRFSFQLSQHQSVHSE 640
Cdd:COG5048 400 RDSNLslHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
161-545 6.91e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 161 INSEERPFKCEELVEPFRCDSQLIQHQENNTEEKPYQCS--ECGKAFSINEKLIWHQRLHSGEKPFKC-VECGKSFSYSS 237
Cdd:COG5048  27 LSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKAS 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 238 HYITHQTIHSGEKPYQCKMCGKAFSVNGSLSRHQRIHTGEKPYQCKECGNGFSCSSAY---------------------- 295
Cdd:COG5048 107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanslskdpssnlsl 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 296 ITHQRVHTGEKPYECNDCGKAFNVNAKLIQHQRIHTGEKPYECNECGKGFRCSSQLRQHQSIHTGEKPYQCKECGKGFNN 375
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 376 NTKLIQHQRIHTGE-------KPYECTECGKAFSVKGKLIQHQR--IHTGE--KPYECNE--CGKAFRCNSQFRQHLRIH 442
Cdd:COG5048 267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23308737 443 TGEKPYECNECGKAFSVNGKL-------MRHQRIHTGEKPFEC--NECGRCFTSKRNLLDHHRIHTGEKPYQCK--ECGK 511
Cdd:COG5048 347 TSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                       410       420       430
                ....*....|....*....|....*....|....
gi 23308737 512 AFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSS 545
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
KRAB smart00349
krueppel associated box;
1-31 6.27e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 49.51  E-value: 6.27e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 23308737      1 MLENYGNVASLGFPLLKPAVISQLEGGSELG 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-543 8.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.84e-05
                          10        20
                  ....*....|....*....|....*
gi 23308737   519 LTRHQRIHTGEKPFKCMECEKAFSC 543
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 1.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.62e-04
                          10        20
                  ....*....|....*....|....*
gi 23308737   463 LMRHQRIHTGEKPFECNECGRCFTS 487
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-458 2.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.36e-04
                          10        20
                  ....*....|....*....|....
gi 23308737   435 FRQHLRIHTGEKPYECNECGKAFS 458
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-431 2.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|....*
gi 23308737   407 LIQHQRIHTGEKPYECNECGKAFRC 431
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 3.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 23308737   266 SLSRHQRIHTGEKPYQCKECGNGFSC 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-402 3.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.74e-04
                          10        20
                  ....*....|....*....|....
gi 23308737   379 LIQHQRIHTGEKPYECTECGKAFS 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-514 4.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.04e-04
                          10        20
                  ....*....|....*....|....*
gi 23308737   490 NLLDHHRIHTGEKPYQCKECGKAFS 514
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-347 7.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.96e-04
                          10        20
                  ....*....|....*....|....*
gi 23308737   323 LIQHQRIHTGEKPYECNECGKGFRC 347
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 9.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.13e-04
                          10        20
                  ....*....|....*....|....*
gi 23308737   351 LRQHQSIHTGEKPYQCKECGKGFNN 375
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
550-569 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|
gi 23308737   550 HQRIHTGEKPFQCKECGKAF 569
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 558-610 3.92e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.92e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 558 KPFqCKECGKAFHVNAHLIRHQRSHTgekpFRCVECGKGFSFSSDYIIH-QTVH 610
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-598 4.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.40e-03
                          10        20
                  ....*....|....*....|....*
gi 23308737   574 HLIRHQRSHTGEKPFRCVECGKGFS 598
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-318 4.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.90e-03
                          10        20
                  ....*....|....*....|.
gi 23308737   298 HQRVHTGEKPYECNDCGKAFN 318
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 362-414 6.33e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 23308737 362 KPYqCKECGKGFNNNTKLIQHQRIHTgekpYECTECGKAFSVKGKLIQH-QRIH 414
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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