NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|161086992|ref|NP_663599|]
View 

zinc finger protein 709 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.53e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.53e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 161086992    3 SVSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-693 4.16e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 251 KPYRCNICDKAFTCSTNFQEHERTHTGEKPYLCTQ--CGKSFSFLSNIRRHERTHTGEKPYRCNACGKAFSYLTNFQDHE 328
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 329 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvCKLCAKAFTTLSS 407
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 408 LRYHERIHSGEKPHVCLqcgkgfNSSSTLRIHERTHTGEKPYKCKKCGKVF---SVDSSLRCHERIHSGEKPYVCKQcgk 484
Cdd:COG5048  174 NSLSKDPSSNLSLLISS------NVSTSIPSSSENSPLSSSYSIPSSSSDQnleNSSSSLPLTTNSQLSPKSLLSQS--- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 485 aftrHTSLRCHERIHCGEKPYICKQCGKGFISSSNFRKHEWTHSGEKL-CVCKLCGKAFTGHSSLQRHER--IHSGE--K 559
Cdd:COG5048  245 ----PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 560 PYVCKH--CGKDFSSLSGCQRHEQIHTGEKPYVCKNC-------GKAFTNPSALRNHERIHSGEKPYVC-GQCGKGFI-- 627
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlSNSCIRNFkr 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161086992 628 -SFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKHCGKSFYTLSDCQRHEQ 693
Cdd:COG5048  401 dSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.53e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.53e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 161086992    3 SVSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 6.46e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.46e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 161086992     4 VSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-693 4.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 251 KPYRCNICDKAFTCSTNFQEHERTHTGEKPYLCTQ--CGKSFSFLSNIRRHERTHTGEKPYRCNACGKAFSYLTNFQDHE 328
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 329 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvCKLCAKAFTTLSS 407
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 408 LRYHERIHSGEKPHVCLqcgkgfNSSSTLRIHERTHTGEKPYKCKKCGKVF---SVDSSLRCHERIHSGEKPYVCKQcgk 484
Cdd:COG5048  174 NSLSKDPSSNLSLLISS------NVSTSIPSSSENSPLSSSYSIPSSSSDQnleNSSSSLPLTTNSQLSPKSLLSQS--- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 485 aftrHTSLRCHERIHCGEKPYICKQCGKGFISSSNFRKHEWTHSGEKL-CVCKLCGKAFTGHSSLQRHER--IHSGE--K 559
Cdd:COG5048  245 ----PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 560 PYVCKH--CGKDFSSLSGCQRHEQIHTGEKPYVCKNC-------GKAFTNPSALRNHERIHSGEKPYVC-GQCGKGFI-- 627
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlSNSCIRNFkr 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161086992 628 -SFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKHCGKSFYTLSDCQRHEQ 693
Cdd:COG5048  401 dSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 3.43e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.80  E-value: 3.43e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 161086992   4 VSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 4.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 161086992  295 NIRRHERTHTGEKPYRCNACGKAFSY 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 2.53e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.53e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 161086992    3 SVSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 6.46e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 6.46e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 161086992     4 VSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLAAIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-693 4.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.58  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 251 KPYRCNICDKAFTCSTNFQEHERTHTGEKPYLCTQ--CGKSFSFLSNIRRHERTHTGEKPYRCNACGKAFSYLTNFQDHE 328
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 329 RTHTGE-KPYVCTQCGKAFTYYYSFQthkrchtgeKPYVckqcgkaFSYYNSIQTHKRCHTGEKPyvCKLCAKAFTTLSS 407
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQL---------PDLL-------SISNLRNNPLPGNNSSSVN--TPQSNSLHPPLPA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 408 LRYHERIHSGEKPHVCLqcgkgfNSSSTLRIHERTHTGEKPYKCKKCGKVF---SVDSSLRCHERIHSGEKPYVCKQcgk 484
Cdd:COG5048  174 NSLSKDPSSNLSLLISS------NVSTSIPSSSENSPLSSSYSIPSSSSDQnleNSSSSLPLTTNSQLSPKSLLSQS--- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 485 aftrHTSLRCHERIHCGEKPYICKQCGKGFISSSNFRKHEWTHSGEKL-CVCKLCGKAFTGHSSLQRHER--IHSGE--K 559
Cdd:COG5048  245 ----PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 560 PYVCKH--CGKDFSSLSGCQRHEQIHTGEKPYVCKNC-------GKAFTNPSALRNHERIHSGEKPYVC-GQCGKGFI-- 627
Cdd:COG5048  321 PFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlSNSCIRNFkr 400

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161086992 628 -SFSKFRIHERIHTGEKPYKCKQCGKAFTGHSSLRRHERIHSGEKPFVCKHCGKSFYTLSDCQRHEQ 693
Cdd:COG5048  401 dSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 3.43e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.80  E-value: 3.43e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 161086992   4 VSFQDVAVTFTVEEWALLDPSQKKLHKDVMEETFRNLA 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-704 5.65e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 391 KPYVCKLCAKAFTTLSSLRYHERIHSGEKPHVCLQ--CGKGFNSSSTLRIHERTHTGEKPYKCKKCGKVFSVDSSLRCHE 468
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 469 RIHSGE-KPYVCKQCGKAFTRHTSLRCHERIHCGEKPYICKQCGKGFISSSN-FRKHEWTHSGEklcvckLCGKAFTGHS 546
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 547 SLQRHERIHSGEKPYVCKHCGKDFSSLSGCQRHEQIH-TGEKPYVCKNCGKAFTNPSALRNHE----RIHSGEKPYVCGQ 621
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLsssdSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 622 CGKGFISFSKFRIHERIHTG-EKPYKCKQCGKAFTGHSSLRRHER--IHSGE--KPFVCKH--CGKSFYTLSDCQRHEQI 694
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 161086992 695 HTGEKPFICK 704
Cdd:COG5048  346 HTSISPAKEK 355
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 641-724 4.05e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 4.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 641 GEKPYKCK--QCGKAFTGHSSLRRHeRIHSgekpfvckHCGKSFYTLSDCQRHEQIHTGEKPFICKQCGKAFTRSSSLKI 718
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 161086992 719 HdKTHS 724
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 4.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 161086992  295 NIRRHERTHTGEKPYRCNACGKAFSY 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-264 7.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 161086992  239 NIKRHERIHSGEKPYRCNICDKAFTC 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 7.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 161086992  547 SLQRHERIHSGEKPYVCKHCGKDFSS 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
659-684 9.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 161086992  659 SLRRHERIHSGEKPFVCKHCGKSFYT 684
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-348 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 161086992  323 NFQDHERTHTGEKPYVCTQCGKAFTY 348
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-291 1.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....*
gi 161086992  267 NFQEHERTHTGEKPYLCTQCGKSFS 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-459 2.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.37e-03
                          10        20
                  ....*....|....*....|....
gi 161086992  436 LRIHERTHTGEKPYKCKKCGKVFS 459
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
632-655 2.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.81e-03
                          10        20
                  ....*....|....*....|....
gi 161086992  632 FRIHERIHTGEKPYKCKQCGKAFT 655
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 333-416 2.98e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 333 GEKPYVC--TQCGKAFTYYYSFQTHKRcHtgekpyvcKQCGKAFSYYNSIQTHKRCHTGEKPYVCKLCAKAFTTLSSLRY 410
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 161086992 411 HeRIHS 416
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 249-332 3.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161086992 249 GEKPYRCNI--CDKAFTCSTNFQEHeRTHTGEKPYLCTQCGKSfsflsnirRHERTHTGEKPYRCNACGKAFSYLTNFQD 326
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 161086992 327 HeRTHT 332
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-376 3.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 161086992  351 SFQTHKRCHTGEKPYVCKQCGKAFSY 376
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-600 5.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....
gi 161086992  577 QRHEQIHTGEKPYVCKNCGKAFTN 600
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH