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Conserved domains on  [gi|1883684610|ref|NP_660295|]
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pancreatic adenocarcinoma up-regulated factor precursor [Homo sapiens]

Protein Classification

jacalin family lectin; zinc metalloproteinase family protein( domain architecture ID 10176317)

jacalin family lectin is a sugar-binding protein containing a jacalin domain| zinc metalloproteinase family protein contains an HEXXH motif characteristic of metallopeptidases; contains a Jacalin-like lectin domain that may bind mono- or oligosaccharides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 21-148 7.51e-54

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


:

Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 166.73  E-value: 7.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610  21 GPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMY 100
Cdd:cd09611     1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1883684610 101 TSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWN 148
Cdd:cd09611    81 TNKGRYLSFGKLRGRSFNATPPPSNYVLRGISGRYGGLGIKSIGFHWG 128
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 21-148 7.51e-54

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 166.73  E-value: 7.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610  21 GPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMY 100
Cdd:cd09611     1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1883684610 101 TSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWN 148
Cdd:cd09611    81 TNKGRYLSFGKLRGRSFNATPPPSNYVLRGISGRYGGLGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 25-147 4.03e-23

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 88.44  E-value: 4.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610   25 GKYFSTTeDYDHeITGLRVSVGLLLVKSVQVKLGDS---WDVKLGALGGNTQEVTLQPGEYITKVFVAF--QAFLRGMVM 99
Cdd:smart00915   1 GTEWDDG-AFDG-VRKIYVGQGGEGIKSIQFDYDKGgkvWGDEHGGKGGTGEEILLYPGEYITSVEGTYdkSGVITSLTF 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1883684610  100 YTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEW 147
Cdd:smart00915  79 KTNKGRTSPFGGYEGGTKFVLESKEGKKIVGFHGRSSGDGLDSLGAYF 126
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 21-148 7.51e-54

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 166.73  E-value: 7.51e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610  21 GPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMY 100
Cdd:cd09611     1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWSDVYGGRGGNEQEIVLEPGESITKVSGSYKIYLHGLVFT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1883684610 101 TSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWN 148
Cdd:cd09611    81 TNKGRYLSFGKLRGRSFNATPPPSNYVLRGISGRYGGLGIKSIGFHWG 128
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 25-148 1.18e-27

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 100.17  E-value: 1.18e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610  25 GKYFSTTEDYDHEITGLRVSVGLLlVKSVQVKLGDSWDVKLGALGG-NTQEVTLQPGEYITKVFVAFQA-----FLRGMV 98
Cdd:cd09302     1 GKPFSDTGGDGARLTEIRVRSGGA-VDAIRVVLRDYTDGRHGGNGGpNTSSVFLDPGEYITITSVSSGDngggtRIDAIQ 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1883684610  99 MYTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQlLGIKSIGFEWN 148
Cdd:cd09302    80 FTTNKGRSGTYGTTSGALGTEFTVPVGGEIVGIYGRAG-DDVDAFGFILS 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 25-147 4.03e-23

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 88.44  E-value: 4.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883684610   25 GKYFSTTeDYDHeITGLRVSVGLLLVKSVQVKLGDS---WDVKLGALGGNTQEVTLQPGEYITKVFVAF--QAFLRGMVM 99
Cdd:smart00915   1 GTEWDDG-AFDG-VRKIYVGQGGEGIKSIQFDYDKGgkvWGDEHGGKGGTGEEILLYPGEYITSVEGTYdkSGVITSLTF 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1883684610  100 YTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEW 147
Cdd:smart00915  79 KTNKGRTSPFGGYEGGTKFVLESKEGKKIVGFHGRSSGDGLDSLGAYF 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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