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Conserved domains on  [gi|21553315|ref|NP_660150|]
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GPI mannosyltransferase 1 [Homo sapiens]

Protein Classification

glycosyltransferase family protein; YfhO family protein( domain architecture ID 10523334)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein| YfhO family protein is an integral membrane protein similar to Bacillus subtilis YfhO that is essential to lipoteichoic acid (LTA) glycosylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mannosyl_trans pfam05007
Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many ...
 140-408 1.77e-109

Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilize nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates.


:

Pssm-ID: 252941  Cd Length: 259  Bit Score: 322.82  E-value: 1.77e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   140 VSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNdkslrqfrytfqaCLYELL 219
Cdd:pfam05007   1 ISTRGNADSIVAFLVLLTLYLLQKRKIYQAALVLGFAVHFKIYPIIYALPIALSLSTVREQ-------------SVAAKL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   220 KRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESK--WSFSLGIAAFLP 297
Cdd:pfam05007  68 NSLLSIAVLVSILGTLISFAACTWLFYYKYGQEFLDEAYLYHVYRTDHRHNFSPYFLLLYLYSASKhaPSQILGLVAFAP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   298 QLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRM-PWKRAVVLLMLWFIGQAMWLAPAY 376
Cdd:pfam05007 148 QFVLLSFVSLKFRRNLPFCCFVQTFAFVTFNKVCTSQYFVWYLVFLPLLLPNFKMlSWKKALGLLLLWFATQALWLLPAY 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 21553315   377 VLEFQGKNTFLFIWLAGLFFLLINCSILIQII 408
Cdd:pfam05007 228 LLEFHGKNTFYPLWLASCLFFLANVYILKQIL 259
 
Name Accession Description Interval E-value
Mannosyl_trans pfam05007
Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many ...
 140-408 1.77e-109

Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilize nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates.


Pssm-ID: 252941  Cd Length: 259  Bit Score: 322.82  E-value: 1.77e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   140 VSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNdkslrqfrytfqaCLYELL 219
Cdd:pfam05007   1 ISTRGNADSIVAFLVLLTLYLLQKRKIYQAALVLGFAVHFKIYPIIYALPIALSLSTVREQ-------------SVAAKL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   220 KRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESK--WSFSLGIAAFLP 297
Cdd:pfam05007  68 NSLLSIAVLVSILGTLISFAACTWLFYYKYGQEFLDEAYLYHVYRTDHRHNFSPYFLLLYLYSASKhaPSQILGLVAFAP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   298 QLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRM-PWKRAVVLLMLWFIGQAMWLAPAY 376
Cdd:pfam05007 148 QFVLLSFVSLKFRRNLPFCCFVQTFAFVTFNKVCTSQYFVWYLVFLPLLLPNFKMlSWKKALGLLLLWFATQALWLLPAY 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 21553315   377 VLEFQGKNTFLFIWLAGLFFLLINCSILIQII 408
Cdd:pfam05007 228 LLEFHGKNTFYPLWLASCLFFLANVYILKQIL 259
PLN02841 PLN02841
GPI mannosyltransferase
 24-421 7.99e-106

GPI mannosyltransferase


Pssm-ID: 178434  Cd Length: 440  Bit Score: 319.82  E-value: 7.99e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   24 VAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCD 103
Cdd:PLN02841  14 ASALLRVALIVYGEWQDAHMEVRYTDVDYLVFSDAAALVASGKSPFARDTYRYSPLLALLLVPNSLLHRSWGKFLFSAAD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  104 LLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYP 183
Cdd:PLN02841  94 LLVGLFIHTILRLRGVPEKVCTWSVMVWLFNPFTFTIGTRGNCEPIVCAVILWILICLMNGRLLQAAFWYGLVVHFRIYP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  184 VTYILPITLHLLPD----------------RDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYY 247
Cdd:PLN02841 174 IIYALPIILVLDKQyfgpggrpaltkwnskQNKTPSSNTEATSFLFNLWTFLTSLFSRERIMFGLISGGVFFALTGVSFY 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  248 EYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTF 327
Cdd:PLN02841 254 LYGWEFLNEALLYHLTRTDPRHNFSIYFYHIYLHHEQGFSLVERLASFLPQFLVQLALILCFSQDLPFCLFLQTVAFVAF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  328 NKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLML-WFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQ 406
Cdd:PLN02841 334 NKVITAQYFVWFFCLLPLILPWSRMKLKWKGLLCILvWMGSQLHWLMWAYLLEFKGRNVFLQLWIASLLFLAANTFVLLM 413

                        410
                 ....*....|....*
gi 21553315  407 IISHYKEEPLTERIK 421
Cdd:PLN02841 414 IIQHHRFSPLFQRLE 428
COG5650 COG5650
Uncharacterized membrane protein [Function unknown];
150-373 3.27e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444371  Cd Length: 411  Bit Score: 39.52  E-value: 3.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315 150 VASLVLMVLYLIKKRLVAcAAVFYGFAVHMKIYPVTYILPITLHLLpdrdndkslRQFRYtfqaclyellkrlcnRAVLL 229
Cdd:COG5650 149 VALAAAALLAWARRRPVL-AGVLLGLGAAAKLYPLLLLGPLLVLCL---------RAGRL---------------RAWLR 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315 230 FVAVAGLTFFALSFGFYYEY--GWEflehtYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFL-PQLILLSAVS 306
Cdd:COG5650 204 TAGAAAATWLAVNLPVALLYpeGWL-----EFFRLNSERGADPGSIWYVLSLLTGFDGPGEPPEVLNTLsLVLFVLACAA 278

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21553315 307 ------FAYYR-DLVFCCFLHTSIFVTFNKVCTSQYFLWylcLLPLVMpLVRMPWkRAVVLLM----LWFIGQAMWLA 373
Cdd:COG5650 279 iaalalTAPRRpRLAQLAFLVVAAFLLTNKVWSPQYSLW---LVPLAV-LARPRW-RDLLAWQaaeaLYWVAIWLYLL 351
 
Name Accession Description Interval E-value
Mannosyl_trans pfam05007
Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many ...
 140-408 1.77e-109

Mannosyltransferase (PIG-M); PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilize nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates.


Pssm-ID: 252941  Cd Length: 259  Bit Score: 322.82  E-value: 1.77e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   140 VSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYPVTYILPITLHLLPDRDNdkslrqfrytfqaCLYELL 219
Cdd:pfam05007   1 ISTRGNADSIVAFLVLLTLYLLQKRKIYQAALVLGFAVHFKIYPIIYALPIALSLSTVREQ-------------SVAAKL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   220 KRLCNRAVLLFVAVAGLTFFALSFGFYYEYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESK--WSFSLGIAAFLP 297
Cdd:pfam05007  68 NSLLSIAVLVSILGTLISFAACTWLFYYKYGQEFLDEAYLYHVYRTDHRHNFSPYFLLLYLYSASKhaPSQILGLVAFAP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   298 QLILLSAVSFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRM-PWKRAVVLLMLWFIGQAMWLAPAY 376
Cdd:pfam05007 148 QFVLLSFVSLKFRRNLPFCCFVQTFAFVTFNKVCTSQYFVWYLVFLPLLLPNFKMlSWKKALGLLLLWFATQALWLLPAY 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 21553315   377 VLEFQGKNTFLFIWLAGLFFLLINCSILIQII 408
Cdd:pfam05007 228 LLEFHGKNTFYPLWLASCLFFLANVYILKQIL 259
PLN02841 PLN02841
GPI mannosyltransferase
 24-421 7.99e-106

GPI mannosyltransferase


Pssm-ID: 178434  Cd Length: 440  Bit Score: 319.82  E-value: 7.99e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315   24 VAFLARVALVFYGVFQDRTLHVRYTDIDYQVFTDAARFVTEGRSPYLRATYRYTPLLGWLLTPNIYLSELFGKFLFISCD 103
Cdd:PLN02841  14 ASALLRVALIVYGEWQDAHMEVRYTDVDYLVFSDAAALVASGKSPFARDTYRYSPLLALLLVPNSLLHRSWGKFLFSAAD 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  104 LLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLMVLYLIKKRLVACAAVFYGFAVHMKIYP 183
Cdd:PLN02841  94 LLVGLFIHTILRLRGVPEKVCTWSVMVWLFNPFTFTIGTRGNCEPIVCAVILWILICLMNGRLLQAAFWYGLVVHFRIYP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  184 VTYILPITLHLLPD----------------RDNDKSLRQFRYTFQACLYELLKRLCNRAVLLFVAVAGLTFFALSFGFYY 247
Cdd:PLN02841 174 IIYALPIILVLDKQyfgpggrpaltkwnskQNKTPSSNTEATSFLFNLWTFLTSLFSRERIMFGLISGGVFFALTGVSFY 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  248 EYGWEFLEHTYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFLPQLILLSAVSFAYYRDLVFCCFLHTSIFVTF 327
Cdd:PLN02841 254 LYGWEFLNEALLYHLTRTDPRHNFSIYFYHIYLHHEQGFSLVERLASFLPQFLVQLALILCFSQDLPFCLFLQTVAFVAF 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315  328 NKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLML-WFIGQAMWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQ 406
Cdd:PLN02841 334 NKVITAQYFVWFFCLLPLILPWSRMKLKWKGLLCILvWMGSQLHWLMWAYLLEFKGRNVFLQLWIASLLFLAANTFVLLM 413

                        410
                 ....*....|....*
gi 21553315  407 IISHYKEEPLTERIK 421
Cdd:PLN02841 414 IIQHHRFSPLFQRLE 428
COG5650 COG5650
Uncharacterized membrane protein [Function unknown];
150-373 3.27e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444371  Cd Length: 411  Bit Score: 39.52  E-value: 3.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315 150 VASLVLMVLYLIKKRLVAcAAVFYGFAVHMKIYPVTYILPITLHLLpdrdndkslRQFRYtfqaclyellkrlcnRAVLL 229
Cdd:COG5650 149 VALAAAALLAWARRRPVL-AGVLLGLGAAAKLYPLLLLGPLLVLCL---------RAGRL---------------RAWLR 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21553315 230 FVAVAGLTFFALSFGFYYEY--GWEflehtYFYHLTRRDIRHNFSPYFYMLYLTAESKWSFSLGIAAFL-PQLILLSAVS 306
Cdd:COG5650 204 TAGAAAATWLAVNLPVALLYpeGWL-----EFFRLNSERGADPGSIWYVLSLLTGFDGPGEPPEVLNTLsLVLFVLACAA 278

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21553315 307 ------FAYYR-DLVFCCFLHTSIFVTFNKVCTSQYFLWylcLLPLVMpLVRMPWkRAVVLLM----LWFIGQAMWLA 373
Cdd:COG5650 279 iaalalTAPRRpRLAQLAFLVVAAFLLTNKVWSPQYSLW---LVPLAV-LARPRW-RDLLAWQaaeaLYWVAIWLYLL 351
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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