NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21489987|ref|NP_659553|]
View 

prenylcysteine oxidase 1 precursor [Rattus norvegicus]

Protein Classification

prenylcysteine oxidase family protein( domain architecture ID 10602892)

prenylcysteine oxidase family protein similar to Arabidopsis thaliana farnesylcysteine lyase that cleaves specifically the thioether bond of S-farnesyl-L-cysteine and has no activity with S-geranylgeranyl-L-cysteine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 128-493 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


:

Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 615.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   128 FEESSWFIINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAG 207
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   208 FSETFLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMSIEktrTKQTGT 287
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIE---LKQSGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   288 PPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLS 367
Cdd:pfam07156 158 STSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   368 AILVTDDSDMFINSLSIVASVSHKEGP-PPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPS 446
Cdd:pfam07156 238 TILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFPP 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 21489987   447 IILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 493
Cdd:pfam07156 318 FILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
39-106 1.65e-12

NAD(P)-binding Rossmann-like domain;


:

Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 62.55  E-value: 1.65e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    39 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEIGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 106
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
 
Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 128-493 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 615.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   128 FEESSWFIINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAG 207
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   208 FSETFLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMSIEktrTKQTGT 287
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIE---LKQSGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   288 PPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLS 367
Cdd:pfam07156 158 STSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   368 AILVTDDSDMFINSLSIVASVSHKEGP-PPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPS 446
Cdd:pfam07156 238 TILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFPP 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 21489987   447 IILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 493
Cdd:pfam07156 318 FILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
31-343 3.29e-15

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 77.65  E-value: 3.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987  31 RAPPEKIAIVGAGIGGTSSAYYLRKKfGKDVKidVFE-REEIGGRLATLKVQGHDY--EAGGSVIHPLNLHMKRFVKELG 107
Cdd:COG1231   4 RARGKDVVIVGAGLAGLAAARELRKA-GLDVT--VLEaRDRVGGRVWTLRFGDDGLyaELGAMRIPPSHTNLLALARELG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 108 LSSVP---ASGGLVGVYNGKSLVFEESSWFIINVIKLVWRygfqslrmhmwVEDLLDKFMRIYRyqshdyafssveklmy 184
Cdd:COG1231  81 LPLEPfpnENGNALLYLGGKRVRAGEIAADLRGVAELLAK-----------LLRALAAALDPWA---------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 185 aiggDDYVRLLNQTLRENLKKAGFSETfLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAA---DSNLWAVEGGNKVVCSGL 261
Cdd:COG1231 134 ----HPAAELDRESLAEWLRRNGASPS-ARRLLGLLGAGEYGADPDELSLLDLLRYAASaggGAQQFRIVGGMDQLPRAL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 262 LQASNSNLISGS-VMSIEKTRTKqtgtppkmYEVVYKTGSEIHSDFydiVLVAAPLNrKMSNITfrnFDPPieeFNDPYQ 340
Cdd:COG1231 209 AAELGDRIRLGApVTRIRQDGDG--------VTVTTDDGGTVRADA---VIVTVPPS-VLRRIE---FDPP---LPAAKR 270


                ...
gi 21489987 341 QLV 343
Cdd:COG1231 271 AAI 273
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
39-106 1.65e-12

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 62.55  E-value: 1.65e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    39 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEIGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 106
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 36-108 9.31e-12

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 66.78  E-value: 9.31e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFEREE-IGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGL 108
Cdd:COG1232   3 RVAVIGGGIAGLTAAYRLAK---AGHEVTVLEASDrVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELLRELGL 73
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 36-128 3.37e-10

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 62.17  E-value: 3.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   36 KIAIVGAGIGGTSSAYYLRKKFGkDVKIDVFEREE-IGGRLATLKVQGHDYEAGGS---VIHPlnlHMKRFVKELGLssv 111
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGP-DADITLLEASDrLGGKIQTVRKDGFPIELGPEsflARKP---SAPALVKELGL--- 74

                         90
                 ....*....|....*..
gi 21489987  112 paSGGLVGVYNGKSLVF 128
Cdd:PRK11883  75 --EDELVANTTGQSYIY 89
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 33-114 3.50e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 55.61  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    33 PPEKIAIVGAGIGGTSSAYYLRKKF-GKDVKIDVFEREE-IGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 110
Cdd:TIGR00562   1 GKKHVVIIGGGISGLCAAYYLEKEIpELPVELTLVEASDrVGGKIQTVKEDGYLIERGPDSFLERKKSAPDLVKDLGLEH 80


                  ....
gi 21489987   111 VPAS 114
Cdd:TIGR00562  81 VLVS 84
 
Name Accession Description Interval E-value
Prenylcys_lyase pfam07156
Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are ...
 128-493 0e+00

Prenylcysteine lyase; This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps.


Pssm-ID: 462104 [Multi-domain]  Cd Length: 364  Bit Score: 615.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   128 FEESSWFIINVIKLVWRYGFQSLRMHMWVEDLLDKFMRIYRYQSHDYAFSSVEKLMYAIGGDDYVRLLNQTLRENLKKAG 207
Cdd:pfam07156   1 FEESSWSWINLAKLLWRYGFSPLRMQMWVEDILDKFMRIYEYQAHGYAFSSVEELLHALGGDGFLNLTNQTLEEALLKAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   208 FSETFLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAADSNLWAVEGGNKVVCSGLLQASNSNLISGSVMSIEktrTKQTGT 287
Cdd:pfam07156  81 FSQLFINEIVQAVTRVNYGQSVNINGFVGAVSLAGAQSGLWAVEGGNKLVCSGLLKASKANLINGTVTSIE---LKQSGG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   288 PPKMYEVVYKTGSEIHSDFYDIVLVAAPLNRKMSNITFRNFDPPIEEFNDPYQQLVTTLIKGELNSTLFSSRHKDQFGLS 367
Cdd:pfam07156 158 STSLYEVTYKTESGTHSDLYDIVVIATPLHRKMSNITFDNFSPPIPEFPGPYQHTVATLVHGRLNPSYFGLPDPSLFPLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   368 AILVTDDSDMFINSLSIVASVSHKEGP-PPAVDGMHVWKTFSKDILTKEQISKLFLSYDYAVRKPWLSYPYYNPPQKCPS 446
Cdd:pfam07156 238 TILTTDNPSLFINSISSVSPVNISDNPrRKPPKEAAVWKIFSPEPLSKEQLKSLFSSYDSVQEKDWLAYPHYSPPETFPP 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 21489987   447 IILHDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQ 493
Cdd:pfam07156 318 FILHDGLYYLNGIEWAASAMEMSAIAAKNVALLAYHRWYGNTDKIDQ 364
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
31-343 3.29e-15

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 77.65  E-value: 3.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987  31 RAPPEKIAIVGAGIGGTSSAYYLRKKfGKDVKidVFE-REEIGGRLATLKVQGHDY--EAGGSVIHPLNLHMKRFVKELG 107
Cdd:COG1231   4 RARGKDVVIVGAGLAGLAAARELRKA-GLDVT--VLEaRDRVGGRVWTLRFGDDGLyaELGAMRIPPSHTNLLALARELG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 108 LSSVP---ASGGLVGVYNGKSLVFEESSWFIINVIKLVWRygfqslrmhmwVEDLLDKFMRIYRyqshdyafssveklmy 184
Cdd:COG1231  81 LPLEPfpnENGNALLYLGGKRVRAGEIAADLRGVAELLAK-----------LLRALAAALDPWA---------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 185 aiggDDYVRLLNQTLRENLKKAGFSETfLNEMIAPVMKVNFGQSTDLNAFVGAVSMTAA---DSNLWAVEGGNKVVCSGL 261
Cdd:COG1231 134 ----HPAAELDRESLAEWLRRNGASPS-ARRLLGLLGAGEYGADPDELSLLDLLRYAASaggGAQQFRIVGGMDQLPRAL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987 262 LQASNSNLISGS-VMSIEKTRTKqtgtppkmYEVVYKTGSEIHSDFydiVLVAAPLNrKMSNITfrnFDPPieeFNDPYQ 340
Cdd:COG1231 209 AAELGDRIRLGApVTRIRQDGDG--------VTVTTDDGGTVRADA---VIVTVPPS-VLRRIE---FDPP---LPAAKR 270


                ...
gi 21489987 341 QLV 343
Cdd:COG1231 271 AAI 273
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
39-106 1.65e-12

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 62.55  E-value: 1.65e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    39 IVGAGIGGTSSAYYLRKkfgKDVKIDVFE-REEIGGRLATLKVQGHDYEAGGSVIHPLN-LHMKRFVKEL 106
Cdd:pfam13450   1 IVGAGLAGLVAAALLAK---RGFRVLVLEkRDRLGGNAYSYRVPGYVFDYGAHIFHGSDePNVRDLLDEL 67
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 36-108 9.31e-12

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 66.78  E-value: 9.31e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFEREE-IGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGL 108
Cdd:COG1232   3 RVAVIGGGIAGLTAAYRLAK---AGHEVTVLEASDrVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLELLRELGL 73
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 36-128 3.37e-10

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 62.17  E-value: 3.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   36 KIAIVGAGIGGTSSAYYLRKKFGkDVKIDVFEREE-IGGRLATLKVQGHDYEAGGS---VIHPlnlHMKRFVKELGLssv 111
Cdd:PRK11883   2 KVAIIGGGITGLSAAYRLHKKGP-DADITLLEASDrLGGKIQTVRKDGFPIELGPEsflARKP---SAPALVKELGL--- 74

                         90
                 ....*....|....*..
gi 21489987  112 paSGGLVGVYNGKSLVF 128
Cdd:PRK11883  75 --EDELVANTTGQSYIY 89
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 44-326 4.44e-10

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 61.74  E-value: 4.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    44 IGGTSSAYYLrKKFGKDVKidVFE-REEIGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSV---PASGGLVG 119
Cdd:pfam01593   1 LAGLAAAREL-LRAGHDVT--VLEaRDRVGGRIRTVRDDGFLIELGAMWFHGAQPPLLALLKELGLEDRlvlPDPAPFYT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   120 V--YNGKSLVFE--------ESSWFIINVIKLV--WRYGFQSLRMHMW-VEDLLDKFMRIYRYQSHDYAFSSVEKLmyai 186
Cdd:pfam01593  78 VlfAGGRRYPGDfrrvpagwEGLLEFGRLLSIPekLRLGLAALASDALdEFDLDDFSLAESLLFLGRRGPGDVEVW---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   187 ggddyVRLLNQTLRENLkkAGFSETFLNEMIAPVMKVNFGQSTDLNAFVGavsmtaadsNLWAVEGGnkvvcSGLLQASN 266
Cdd:pfam01593 154 -----DRLIDPELFAAL--PFASGAFAGDPSELSAGLALPLLWALLGEGG---------SLLLPRGG-----LGALPDAL 212

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21489987   267 SNLISGS-------VMSIEKTRTKQTgtppkmyeVVYKTGSEIHSDFydiVLVAAPLnRKMSNITFR 326
Cdd:pfam01593 213 AAQLLGGdvrlntrVRSIDREGDGVT--------VTLTDGEVIEADA---VIVTVPL-GVLKRILFT 267
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 36-109 1.69e-09

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 59.86  E-value: 1.69e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEIGGRLATLKVQGHDYEAGGSViHPLNLHMKRFVKELGLS 109
Cdd:COG1233   5 DVVVIGAGIGGLAAAALLARA-GYRV--TVLEKnDTPGGRARTFERPGFRFDVGPSV-LTMPGVLERLFRELGLE 75
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 33-114 3.50e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 55.61  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987    33 PPEKIAIVGAGIGGTSSAYYLRKKF-GKDVKIDVFEREE-IGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 110
Cdd:TIGR00562   1 GKKHVVIIGGGISGLCAAYYLEKEIpELPVELTLVEASDrVGGKIQTVKEDGYLIERGPDSFLERKKSAPDLVKDLGLEH 80


                  ....
gi 21489987   111 VPAS 114
Cdd:TIGR00562  81 VLVS 84
PRK07233 PRK07233
hypothetical protein; Provisional
 36-110 2.96e-06

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 49.50  E-value: 2.96e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21489987   36 KIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEIGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSS 110
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKR-GHEV--TVFEAdDQLGGLAASFEFGGLPIERFYHHIFKSDEALLELLDELGLED 73
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
33-220 3.49e-06

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 49.34  E-value: 3.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987  33 PPEKIAIVGAGIGGTSSAYYLRKKFgkdvKIDVFEREE-IGGRLATlkvqgHDYEAGGSVIH-------------PlnlH 98
Cdd:COG2907   2 ARMRIAVIGSGISGLTAAWLLSRRH----DVTLFEANDrLGGHTHT-----VDVDLDGRTVPvdtgfivfnertyP---N 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987  99 MKRFVKELGLSSVP---------ASGGLvgVYNGKSL--VFEESSwfiiNVIKLvwRYgfqsLRMhmwVEDLLdkfmRIY 167
Cdd:COG2907  70 LTALFAELGVPTQPsdmsfsvslDGGGL--EYAGSNLngLFAQRR----NLLRP--RF----WRM---LRDIL----RFN 130

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21489987 168 RyQSHDYAfssveklmyAIGGDDyvrllNQTLRENLKKAGFSETFLNEMIAPV 220
Cdd:COG2907 131 R-EAPALL---------EAGSDD-----DLTLGEFLDRNGYSEAFRDHYLLPM 168
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
36-106 1.92e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.82  E-value: 1.92e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKKfGKDVKidVFEREEIG----GRLATLkVQGHDYEAGGSVIHPLNLHMKRFVKEL 106
Cdd:COG0665   4 DVVVIGGGIAGLSTAYHLARR-GLDVT--VLERGRPGsgasGRNAGQ-LRPGLAALADRALVRLAREALDLWREL 74
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
36-82 9.55e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 44.48  E-value: 9.55e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKkfgKDVKIDVFER-EEIGGRLATLKVQG 82
Cdd:COG3380   5 DIAIIGAGIAGLAAARALQD---AGHEVTVFEKsRGVGGRMATRRLDG 49
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 29-73 9.89e-05

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 44.74  E-value: 9.89e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21489987  29 EPRAPP--EKIAIVGAGIGGTSSAYYLRKKfGkdVKIDVFER-EEIGG 73
Cdd:COG0493 114 PPPAPRtgKKVAVVGSGPAGLAAAYQLARA-G--HEVTVFEAlDKPGG 158
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 36-106 1.86e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 43.54  E-value: 1.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21489987    36 KIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFEREEIGGRLATLK----VQGHDYEAGGSVIHPLNLHMKRFVKEL 106
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARR-GLSV--TLLERGDDPGSGASGRnaglIHPGLRYLEPSELARLALEALDLWEEL 72
PLN02576 PLN02576
protoporphyrinogen oxidase
 32-85 1.92e-04

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 43.85  E-value: 1.92e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21489987   32 APPEKIAIVGAGIGGTSSAYYLRKKFGkdVKIDVFE-REEIGGRLATlkVQGHDY 85
Cdd:PLN02576  10 ASSKDVAVVGAGVSGLAAAYALASKHG--VNVLVTEaRDRVGGNITS--VSEDGF 60
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 30-73 3.71e-04

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 42.86  E-value: 3.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 21489987   30 PRAPP--EKIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFE-REEIGG 73
Cdd:PRK11749 134 KRAPKtgKKVAVIGAGPAGLTAAHRLARK-GYDV--TIFEaRDKAGG 177
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 29-73 5.60e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 42.55  E-value: 5.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 21489987   29 EPRAPP--EKIAIVGAGIGGTSSAYYLRKKfGKDVKIdvFE-REEIGG 73
Cdd:PRK12771 130 PAPAPDtgKRVAVIGGGPAGLSAAYHLRRM-GHAVTI--FEaGPKLGG 174
PRK06753 PRK06753
hypothetical protein; Provisional
 36-98 5.73e-04

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 42.37  E-value: 5.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21489987   36 KIAIVGAGIGGTSSAYYLRKKfGKDVKidVFEREEiggrlaTLKVQGHDYEAGGSVIHPLNLH 98
Cdd:PRK06753   2 KIAIIGAGIGGLTAAALLQEQ-GHEVK--VFEKNE------SVKEVGAGIGIGDNVIKKLGNH 55
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
36-85 1.33e-03

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 40.87  E-value: 1.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKkFGKDVKidVFEREEIGGRLATLKvQGHDY 85
Cdd:COG0492   2 DVVIIGAGPAGLTAAIYAAR-AGLKTL--VIEGGEPGGQLATTK-EIENY 47
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 26-73 1.54e-03

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 41.25  E-value: 1.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 21489987   26 ASAEPRAPP------EKIAIVGAGIGGTSSAYYLRKKfGKDVKIdvFEREEIGG 73
Cdd:PRK12814 179 ESAERYIPErapksgKKVAIIGAGPAGLTAAYYLLRK-GHDVTI--FDANEQAG 229
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 37-130 2.23e-03

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 40.58  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21489987   37 IAIVGAGIGGTSSAYYLrKKFGKDVKID----VFEREE-IGGRLATLKVQGHDYEAGGSVIHPLNLHMKRFVKELGLSSV 111
Cdd:PRK12416   4 VVVIGGGITGLSTMFYL-EKLKKDYNIDlnliLVEKEEyLGGKIHSVEEKDFIMESGADSIVARNEHVMPLVKDLNLEEE 82

                         90       100
                 ....*....|....*....|.
gi 21489987  112 PasgglvgVYN--GKSLVFEE 130
Cdd:PRK12416  83 M-------VYNetGISYIYSD 96
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 37-73 2.62e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 40.23  E-value: 2.62e-03
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21489987  37 IAIVGAGIGGTSSAYYLRKKfGKDVkiDVFER-EEIGG 73
Cdd:COG2072   9 VVVIGAGQAGLAAAYHLRRA-GIDF--VVLEKaDDVGG 43
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
36-63 2.75e-03

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 40.12  E-value: 2.75e-03
                        10        20
                ....*....|....*....|....*...
gi 21489987  36 KIAIVGAGIGGTSSAYYLRKKFGKDVKI 63
Cdd:COG1252   3 RIVIVGGGFAGLEAARRLRKKLGGDAEV 30
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
33-74 4.06e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 39.55  E-value: 4.06e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 21489987  33 PPEKIAIVGAGIGGTSSAYYLRKKFGKDVKIDVFEREEIGGR 74
Cdd:COG4529   4 ARKRIAIIGGGASGTALAIHLLRRAPEPLRITLFEPRPELGR 45
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
38-76 4.88e-03

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 37.64  E-value: 4.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21489987    38 AIVGAGIGGTSSAYYL-RKKFGKDVKIDVFEREEIGGRLA 76
Cdd:pfam13454   1 AIVGGGPSGLALLERLlARAPKRPLEITLFDPSPPGAGGV 40
PLN02487 PLN02487
zeta-carotene desaturase
 30-79 9.00e-03

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 38.63  E-value: 9.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 21489987   30 PRAPPEKIAIVGAGIGGTSSAYYLRKKfGKDVkiDVFE-REEIGGRLATLK 79
Cdd:PLN02487  71 YKGPKLKVAIIGAGLAGMSTAVELLDQ-GHEV--DIYEsRPFIGGKVGSFV 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH