|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
167-577 |
2.45e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.60 E-value: 2.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319 51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319 231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVRE 565
Cdd:COG2319 288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
|
410
....*....|..
gi 31542010 566 FSGHHGQINDMV 577
Cdd:COG2319 368 LTGHTGAVTSVA 379
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
102-367 |
1.87e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 94.71 E-value: 1.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 102 VHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKISTILHpstyLNKVLLGSEQGSLQL 178
Cdd:cd00200 2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 179 WNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPC 258
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 259 GHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDgpagEGRLLRFRMGHSASLTKIRYyGQN 338
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230
|
250 260 270
....*....|....*....|....*....|
gi 31542010 339 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 367
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
204-288 |
1.68e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 40.72 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 204 PAVDVVAIGLVSGQVVIHNIkydetlmKFHQDWG--------PITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQm 275
Cdd:pfam12894 5 PTMDLIALATEDGELLLHRL-------NWQRVWTlspdkedlEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH- 75
|
90
....*....|...
gi 31542010 276 RNAHSTAISGLTF 288
Cdd:pfam12894 76 FSAGSDLITCLGW 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
167-577 |
2.45e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.60 E-value: 2.45e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319 51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHS 326
Cdd:COG2319 131 DGKTLASGSAD-GTVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 205 GAVRSVAF-SPDGKLLASGSADGT-----------------------------------VRL------------------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDdkaH 486
Cdd:COG2319 231 -------------WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG---H 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVRE 565
Cdd:COG2319 288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT 367
|
410
....*....|..
gi 31542010 566 FSGHHGQINDMV 577
Cdd:COG2319 368 LTGHTGAVTSVA 379
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
96-352 |
2.52e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.60 E-value: 2.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 96 ARNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKIStiLHPStylNKVLL-GS 171
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVA--FSPD---GKLLAsGS 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 172 EQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHPI 251
Cdd:COG2319 224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 252 MAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHSASLTK 331
Cdd:COG2319 304 ASGSDD-GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTS 377
|
250 260
....*....|....*....|.
gi 31542010 332 IRYyGQNGQQILSASQDGTLQ 352
Cdd:COG2319 378 VAF-SPDGRTLASGSADGTVR 397
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
102-367 |
1.87e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 94.71 E-value: 1.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 102 VHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLT-FDKSVFKISTILHpstyLNKVLLGSEQGSLQL 178
Cdd:cd00200 2 RRTLKGHTGGVTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD----GTYLASGSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 179 WNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPC 258
Cdd:cd00200 78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 259 GHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWIFDgpagEGRLLRFRMGHSASLTKIRYyGQN 338
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAF-SPD 230
|
250 260 270
....*....|....*....|....*....|
gi 31542010 339 GQQILSASQDGTLQSFSTVHEKFNKSL-GH 367
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLsGH 260
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
117-518 |
2.65e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 2.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 117 PFGDHVISVDTDSVLIIWHIYSEEEYLQLTFDKSVFKISTILHPSTYLnkvLLGSEQGSLQLWNIKSNKLLYTFPGWKVG 196
Cdd:COG2319 46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLLLRTLTGHTGA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 197 VTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQMR 276
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLT 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 277 nAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHSASLTKIRyYGQNGQQILSASQDGTLQSFST 356
Cdd:COG2319 202 -GHTGAVRSVAFSPDGKLLASGSADGTVRLW----DLATGKLLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRLWDL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 357 VHEKFNKSLGH--GLVNkkivkrkglqntmSVRLPPITQFAAEearqSDWDGIIachqgkrscSTWNYQRStigayflKP 434
Cdd:COG2319 276 ATGELLRTLTGhsGGVN-------------SVAFSPDGKLLAS----GSDDGTV---------RLWDLATG-------KL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 435 RGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAV--DGlnQLVVTAGSERLLK 512
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFspDG--RTLASGSADGTVR 397
|
....*.
gi 31542010 513 FWNFKS 518
Cdd:COG2319 398 LWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
74-351 |
4.75e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.86 E-value: 4.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 74 ICCMA--ADGRLVFAAYGN----VFSAFarNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQL 145
Cdd:cd00200 12 VTCVAfsPDGKLLATGSGDgtikVWDLE--TGELLRTLKGHTGPVRDVAasADGTYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 146 T-FDKSVFKIStiLHPSTYLnkVLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIK 224
Cdd:cd00200 90 TgHTSYVSSVA--FSPDGRI--LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 225 YDETLMKF--HQDWgpITSISFRTDGHPIMAAGSPcGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADN 302
Cdd:cd00200 166 TGKCVATLtgHTGE--VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSEDG 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 31542010 303 ALRIWifDGPAGEgRLLRFRmGHSASLTKIRYYGqNGQQILSASQDGTL 351
Cdd:cd00200 242 TIRVW--DLRTGE-CVQTLS-GHTNSVTSLAWSP-DGKRLASGSADGTI 285
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
167-577 |
1.36e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 88.04 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 167 VLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRT 246
Cdd:COG2319 9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 247 DGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIWifdgPAGEGRLLRFRMGHS 326
Cdd:COG2319 89 DGRLL-ASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 327 ASLTKIRYyGQNGQQILSASQDGTlqsfstvhekfnkslghglvnkkivkrkglqntmsVRLppitqfaaeearqsdwdg 406
Cdd:COG2319 163 GAVTSVAF-SPDGKLLASGSDDGT-----------------------------------VRL------------------ 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 407 iiachqgkrscstWNYQRStigayflKPRGVKTNSNLTATAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAH 486
Cdd:COG2319 189 -------------WDLATG-------KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGH 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 487 TGSVRGVAV--DGlnQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIV 563
Cdd:COG2319 246 SGSVRSVAFspDG--RLLASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
|
410
....*....|....
gi 31542010 564 REFSGHHGQINDMV 577
Cdd:COG2319 324 RTLTGHTGAVRSVA 337
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
79-307 |
9.09e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.73 E-value: 9.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 79 ADGRLVFAAYGN----VFSAfaRNKEIVHTFKGHKAEIHLLQ--PFGDHVISVDTDSVLIIWHIYSEEEYLQLTF-DKSV 151
Cdd:COG2319 172 PDGKLLASGSDDgtvrLWDL--ATGKLLRTLTGHTGAVRSVAfsPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSV 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 152 FKIStiLHPStylNKVLL-GSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLM 230
Cdd:COG2319 250 RSVA--FSPD---GRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31542010 231 KFHQDWGPITSISFRTDGHPImAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
279-576 |
1.13e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 83.54 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 279 HSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageGRLLRFRMGHSASLTKIRYYGqNGQQILSASQDGTLQSFSTVH 358
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 359 EKFNKSL-GHglvnkkivkrkgLQNTMSVRLPPITQFAAeearQSDWDGIIACHQGK--RSCSTWNYQRSTIgayflkpr 435
Cdd:cd00200 83 GECVRTLtGH------------TSYVSSVAFSPDGRILS----SSSRDKTIKVWDVEtgKCLTTLRGHTDWV-------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 436 gvktnsnltaTAVDITSCGNFAIIGLSSGAVDVYNMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWN 515
Cdd:cd00200 139 ----------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542010 516 FKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREFSGHHGQINDM 576
Cdd:cd00200 206 LSTGKCLGTLrGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
97-307 |
2.69e-14 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.52 E-value: 2.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 97 RNKEIVHTFKGHKAEIH--LLQPFGDHVISVDTDSVLIIWHIysEEEYLQLTFD---KSVFKIStiLHPStylNKVLLGS 171
Cdd:cd00200 81 ETGECVRTLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRghtDWVNSVA--FSPD---GTFVASS 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 172 EQ-GSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQVVIHNIKYDETLMKFHQDWGPITSISFRTDGHp 250
Cdd:cd00200 154 SQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY- 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 31542010 251 IMAAGSPCGHIGLWDLEDKKLINQMRnAHSTAISGLTFLHREPLLVTNGADNALRIW 307
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
237-525 |
5.34e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 69.67 E-value: 5.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 237 GPITSISFRTDGhPIMAAGSPCGHIGLWDLEDKKLINQMRNaHSTAISGLTFLHREPLLVTNGADNALRIWIFDGpageG 316
Cdd:cd00200 10 GGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET----G 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 317 RLLRFRMGHSASLTKIRYYgQNGQQILSASQDGTLQSFSTVHEKFNKSL-GH-GLVNkkivkrkglqntmSVRLPPITQF 394
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLrGHtDWVN-------------SVAFSPDGTF 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 395 AAeearQSDWDGIIachqgkrscSTWNyqrstigayflkPRGVKTNSNLTATAVDITSC-----GNFAIIGLSSGAVDVY 469
Cdd:cd00200 150 VA----SSSQDGTI---------KLWD------------LRTGKCVATLTGHTGEVNSVafspdGEKLLSSSSDGTIKLW 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 31542010 470 NMQSGIHRGNFgddKAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL 525
Cdd:cd00200 205 DLSTGKCLGTL---RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
484-576 |
1.61e-04 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 43.86 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 484 KAHTGSVRGVAVDGLNQLVVTAGSERLLKFWNFKSKVLIHSL-GLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKI 562
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90
....*....|....
gi 31542010 563 VREFSGHHGQINDM 576
Cdd:cd00200 86 VRTLTGHTSYVSSV 99
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
204-288 |
1.68e-04 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 40.72 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542010 204 PAVDVVAIGLVSGQVVIHNIkydetlmKFHQDWG--------PITSISFRTDGHpIMAAGSPCGHIGLWDLEDKKLINQm 275
Cdd:pfam12894 5 PTMDLIALATEDGELLLHRL-------NWQRVWTlspdkedlEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENGKIVHH- 75
|
90
....*....|...
gi 31542010 276 RNAHSTAISGLTF 288
Cdd:pfam12894 76 FSAGSDLITCLGW 88
|
|
| |
