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Conserved domains on  [gi|85815871|ref|NP_651681|]
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uncharacterized protein Dmel_CG14515 [Drosophila melanogaster]

Protein Classification

Reeler domain-containing protein( domain architecture ID 10170792)

Reeler N-terminal domain-containing protein similar to extracellular matrix protein F-spondin that mediates axon guidance during neuronal development, and to putative defense proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 30-163 4.12e-39

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


:

Pssm-ID: 260081  Cd Length: 135  Bit Score: 129.43  E-value: 4.12e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85815871  30 TCVkqRANQPNHGKARSQpaHSNPYEVVADAQTYHPGQQISVVIYphSDQSTVFRGFFLQARDANSNEWIGEWVQ--SEN 107
Cdd:cd08544   1 ACT--DMPVPGHGGDPQT--TPSPYSITVSGNTYKPGQTYTVTLS--GSRPTPFRGFLLQARDASSNEPVGTFQLppDSG 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 85815871 108 TKTIPEC---SAITHSDNRDKLGAKLIWKAPQNKRGQVYFTGTVLQEYGTFWSDIVNKV 163
Cdd:cd08544  75 TKLLTCCpsgNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKT 133
 
Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 30-163 4.12e-39

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 129.43  E-value: 4.12e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85815871  30 TCVkqRANQPNHGKARSQpaHSNPYEVVADAQTYHPGQQISVVIYphSDQSTVFRGFFLQARDANSNEWIGEWVQ--SEN 107
Cdd:cd08544   1 ACT--DMPVPGHGGDPQT--TPSPYSITVSGNTYKPGQTYTVTLS--GSRPTPFRGFLLQARDASSNEPVGTFQLppDSG 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 85815871 108 TKTIPEC---SAITHSDNRDKLGAKLIWKAPQNKRGQVYFTGTVLQEYGTFWSDIVNKV 163
Cdd:cd08544  75 TKLLTCCpsgNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKT 133
Reeler pfam02014
Reeler domain;
39-156 1.09e-32

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 112.83  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85815871    39 PNHGKARSQPAhSNPYEVVADAQTYHPGQQISVVIYPHSDQSTvFRGFFLQARDANSNEW--IGEW--VQSENTKTIPEC 114
Cdd:pfam02014   6 PQHGNAPQTSP-PSPYTITVSSTSYRPGETITVTLSGASGGPS-FKGFLLQARDADSGDPdpVGSFslPDDADTKFLLDC 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 85815871   115 ----SAITHSDNRDKLGAKLIWKAPQNKRGQVYFTGTVLQEYGTFW 156
Cdd:pfam02014  84 sgkgNAVTHSNTNKKSSVTVTWTAPASGSGCVVFRATVVQNYDTFW 129
 
Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 30-163 4.12e-39

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 129.43  E-value: 4.12e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85815871  30 TCVkqRANQPNHGKARSQpaHSNPYEVVADAQTYHPGQQISVVIYphSDQSTVFRGFFLQARDANSNEWIGEWVQ--SEN 107
Cdd:cd08544   1 ACT--DMPVPGHGGDPQT--TPSPYSITVSGNTYKPGQTYTVTLS--GSRPTPFRGFLLQARDASSNEPVGTFQLppDSG 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 85815871 108 TKTIPEC---SAITHSDNRDKLGAKLIWKAPQNKRGQVYFTGTVLQEYGTFWSDIVNKV 163
Cdd:cd08544  75 TKLLTCCpsgNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKT 133
Reeler pfam02014
Reeler domain;
39-156 1.09e-32

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 112.83  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85815871    39 PNHGKARSQPAhSNPYEVVADAQTYHPGQQISVVIYPHSDQSTvFRGFFLQARDANSNEW--IGEW--VQSENTKTIPEC 114
Cdd:pfam02014   6 PQHGNAPQTSP-PSPYTITVSSTSYRPGETITVTLSGASGGPS-FKGFLLQARDADSGDPdpVGSFslPDDADTKFLLDC 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 85815871   115 ----SAITHSDNRDKLGAKLIWKAPQNKRGQVYFTGTVLQEYGTFW 156
Cdd:pfam02014  84 sgkgNAVTHSNTNKKSSVTVTWTAPASGSGCVVFRATVVQNYDTFW 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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