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Conserved domains on  [gi|24650971|ref|NP_651673|]
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Alg13 UDP-N-acetylglucosaminyltransferase subunit [Drosophila melanogaster]

Protein Classification

glycosyltransferase family protein; glycosyltransferase family 4 protein( domain architecture ID 10513712)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein| glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 5-168 2.01e-40

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


:

Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 133.99  E-value: 2.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971     5 TVYITVGTTKFDALISTASTEPALKALQNrkCTKLVIQHGNSQpltDDEIQLIRKNYGIQIEQYNFRPN-TEDIKSADLI 83
Cdd:pfam04101   1 TILVTGGSQGARALNELVLSVLPLLELKG--ELQVLHQTGKGD---LEEVKIDYAELGINYEVFPFIDNmAEYIKAADLV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971    84 IGHAGAGTCMDILNNQKPGLIVINDT----LMDNHQLELAKQLAAENYLYYC-KVTDVDAQLATLDFEALKPYETKPENL 158
Cdd:pfam04101  76 ISRAGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKElTPEKLIEALLKLLLNPLRLAEMAKASK 155

                         170
                  ....*....|.
gi 24650971   159 -SKFVSAINQL 168
Cdd:pfam04101 156 aSGFKDAAKRL 166
 
Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 5-168 2.01e-40

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 133.99  E-value: 2.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971     5 TVYITVGTTKFDALISTASTEPALKALQNrkCTKLVIQHGNSQpltDDEIQLIRKNYGIQIEQYNFRPN-TEDIKSADLI 83
Cdd:pfam04101   1 TILVTGGSQGARALNELVLSVLPLLELKG--ELQVLHQTGKGD---LEEVKIDYAELGINYEVFPFIDNmAEYIKAADLV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971    84 IGHAGAGTCMDILNNQKPGLIVINDT----LMDNHQLELAKQLAAENYLYYC-KVTDVDAQLATLDFEALKPYETKPENL 158
Cdd:pfam04101  76 ISRAGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKElTPEKLIEALLKLLLNPLRLAEMAKASK 155

                         170
                  ....*....|.
gi 24650971   159 -SKFVSAINQL 168
Cdd:pfam04101 156 aSGFKDAAKRL 166
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
6-163 5.87e-21

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 83.34  E-value: 5.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971    6 VYITVGTTKFDALIstastEPALKALQNRKCTKLVIQHGNSQpltddeiqLIRKNYgiqieqyNFRPNTEDIKS----AD 81
Cdd:NF041548   1 IFVTVGTTRFDSLI-----KAIDELIEGLIDYEVTFQIGDGK--------YIPKNG-------EYFDFLEEIDEyykkAD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971   82 LIIGHAGAGTCMDILNNQKPGLIVINDTLMDNHQLELAKQLAAENYLYYCK-VTDVDAQLATLDFEALKPYETKPENLSK 160
Cdd:NF041548  61 LIITHAGAGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPYEKNPFFIAD 140


                 ...
gi 24650971  161 FVS 163
Cdd:NF041548 141 EII 143
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 52-161 1.20e-09

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 55.68  E-value: 1.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971  52 DEIQLIRKNYGIQIEQYNFRPNTED-IKSADLIIGHAGAGTCMDILNNQKPGLIVINDTLMDNHQLELAKQLAAENYLYY 130
Cdd:cd03785 224 DEVKKLYEDLGINVKVFPFIDDMAAaYAAADLVISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAGAAIV 303

                        90       100       110
                ....*....|....*....|....*....|.
gi 24650971 131 CKVTDVDAQlaTLdFEALKPYETKPENLSKF 161
Cdd:cd03785 304 IDQEELTPE--VL-AEAILDLLNDPERLKKM 331
COG4671 COG4671
Predicted glycosyl transferase [General function prediction only];
55-105 2.29e-06

Predicted glycosyl transferase [General function prediction only];


Pssm-ID: 443708 [Multi-domain]  Cd Length: 391  Bit Score: 46.38  E-value: 2.29e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 24650971  55 QLIRKNYGIQIEqyNFRPNTED-IKSADLIIGHAGAGTCMDILNNQKPGLIV 105
Cdd:COG4671 268 ARAAALPNVTVE--RFTPDFEAlLAAADLSVSMGGYNTVCEILSTGKPALIV 317
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 27-127 2.59e-04

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 40.11  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971   27 ALKALqnRKCTKLVIQHGnsqpltDDEIQLIRKNY--GIQIEQYNFrpnTEDI----KSADLIIGHAGAGTCMDILNNQK 100
Cdd:PRK00726 205 ALALL--PEALQVIHQTG------KGDLEEVRAAYaaGINAEVVPF---IDDMaaayAAADLVICRAGASTVAELAAAGL 273

                         90       100
                 ....*....|....*....|....*....
gi 24650971  101 PGLIV--INDTlmDNHQLELAKQLAAENY 127
Cdd:PRK00726 274 PAILVplPHAA--DDHQTANARALVDAGA 300
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 6-105 2.46e-03

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 37.36  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971     6 VYITVGT--TKFDALISTAstepaLKALQNRKCTKLVIQHGNSQPltdDEIQLIRKNygiqIEQYNFRPNTEDIKSADLI 83
Cdd:TIGR01426 228 VLISLGTvfNNQPSFYRTC-----VEAFRDLDWHVVLSVGRGVDP---ADLGELPPN----VEVRQWVPQLEILKKADAF 295

                          90       100
                  ....*....|....*....|..
gi 24650971    84 IGHAGAGTCMDILNNQKPGLIV 105
Cdd:TIGR01426 296 ITHGGMNSTMEALFNGVPMVAV 317
 
Name Accession Description Interval E-value
Glyco_tran_28_C pfam04101
Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes ...
 5-168 2.01e-40

Glycosyltransferase family 28 C-terminal domain; The glycosyltransferase family 28 includes monogalactosyldiacylglycerol synthase (EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.


Pssm-ID: 427711 [Multi-domain]  Cd Length: 166  Bit Score: 133.99  E-value: 2.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971     5 TVYITVGTTKFDALISTASTEPALKALQNrkCTKLVIQHGNSQpltDDEIQLIRKNYGIQIEQYNFRPN-TEDIKSADLI 83
Cdd:pfam04101   1 TILVTGGSQGARALNELVLSVLPLLELKG--ELQVLHQTGKGD---LEEVKIDYAELGINYEVFPFIDNmAEYIKAADLV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971    84 IGHAGAGTCMDILNNQKPGLIVINDT----LMDNHQLELAKQLAAENYLYYC-KVTDVDAQLATLDFEALKPYETKPENL 158
Cdd:pfam04101  76 ISRAGAGTIAELLALGKPAILVPNPSaargHQDNNAKELVKAGAALVILQKElTPEKLIEALLKLLLNPLRLAEMAKASK 155

                         170
                  ....*....|.
gi 24650971   159 -SKFVSAINQL 168
Cdd:pfam04101 156 aSGFKDAAKRL 166
PssE NF041548
PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;
6-163 5.87e-21

PssE/Cps14G family polysaccharide biosynthesis glycosyltransferase;


Pssm-ID: 469433 [Multi-domain]  Cd Length: 146  Bit Score: 83.34  E-value: 5.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971    6 VYITVGTTKFDALIstastEPALKALQNRKCTKLVIQHGNSQpltddeiqLIRKNYgiqieqyNFRPNTEDIKS----AD 81
Cdd:NF041548   1 IFVTVGTTRFDSLI-----KAIDELIEGLIDYEVTFQIGDGK--------YIPKNG-------EYFDFLEEIDEyykkAD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971   82 LIIGHAGAGTCMDILNNQKPGLIVINDTLMDNHQLELAKQLAAENYLYYCK-VTDVDAQLATLDFEALKPYETKPENLSK 160
Cdd:NF041548  61 LIITHAGAGTIYSLLELGKKVIVVPNLERVDDHQLDLAEYVEENGYALVCYdLDELEDAIKEAENFKPNPYEKNPFFIAD 140


                 ...
gi 24650971  161 FVS 163
Cdd:NF041548 141 EII 143
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 52-161 1.20e-09

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 55.68  E-value: 1.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971  52 DEIQLIRKNYGIQIEQYNFRPNTED-IKSADLIIGHAGAGTCMDILNNQKPGLIVINDTLMDNHQLELAKQLAAENYLYY 130
Cdd:cd03785 224 DEVKKLYEDLGINVKVFPFIDDMAAaYAAADLVISRAGASTIAELTAAGKPAILIPYPYAADDHQEANARALEKAGAAIV 303

                        90       100       110
                ....*....|....*....|....*....|.
gi 24650971 131 CKVTDVDAQlaTLdFEALKPYETKPENLSKF 161
Cdd:cd03785 304 IDQEELTPE--VL-AEAILDLLNDPERLKKM 331
COG4671 COG4671
Predicted glycosyl transferase [General function prediction only];
55-105 2.29e-06

Predicted glycosyl transferase [General function prediction only];


Pssm-ID: 443708 [Multi-domain]  Cd Length: 391  Bit Score: 46.38  E-value: 2.29e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 24650971  55 QLIRKNYGIQIEqyNFRPNTED-IKSADLIIGHAGAGTCMDILNNQKPGLIV 105
Cdd:COG4671 268 ARAAALPNVTVE--RFTPDFEAlLAAADLSVSMGGYNTVCEILSTGKPALIV 317
MurG COG0707
UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope ...
 27-125 8.17e-06

UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440471 [Multi-domain]  Cd Length: 363  Bit Score: 44.73  E-value: 8.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971  27 ALKALQNRKCtKLVIQHGnsqpltDDEIQLIRKNYGIQI-EQYNFRPNTEDI----KSADLIIGHAGAGTCMDILNNQKP 101
Cdd:COG0707 208 ALAALLEARL-QVVHQTG------KGDYEEVRAAYAAAIrPNAEVFPFIDDMadayAAADLVISRAGASTVAELAALGKP 280

                        90       100
                ....*....|....*....|....*...
gi 24650971 102 GLIVINDTLMDNHQ----LELAKQLAAE 125
Cdd:COG0707 281 AILVPLPHAADDHQtknaRALVEAGAAV 308
YjiC COG1819
UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];
6-124 1.68e-05

UDP:flavonoid glycosyltransferase YjiC, YdhE family [Carbohydrate transport and metabolism];


Pssm-ID: 441424 [Multi-domain]  Cd Length: 268  Bit Score: 43.69  E-value: 1.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971   6 VYITVGTTKFDAlisTASTEPALKALQNRKCTkLVIQHGNSQPltdDEIQLIRKNygiqIEQYNFRPNTEDIKSADLIIG 85
Cdd:COG1819 123 VYVTLGTSANDR---ADLLRAVLEALADLGVR-VVVTTGGLDP---AELGPLPDN----VRVVDYVPQDALLPRADAVVH 191

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 24650971  86 HAGAGTCMDILNNQKPGLIV--INDtlmdnhQLELAKQLAA 124
Cdd:COG1819 192 HGGAGTTAEALRAGVPQVVVpfGGD------QPLNAARVER 226
murG PRK00726
undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional
 27-127 2.59e-04

undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional


Pssm-ID: 234825 [Multi-domain]  Cd Length: 357  Bit Score: 40.11  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971   27 ALKALqnRKCTKLVIQHGnsqpltDDEIQLIRKNY--GIQIEQYNFrpnTEDI----KSADLIIGHAGAGTCMDILNNQK 100
Cdd:PRK00726 205 ALALL--PEALQVIHQTG------KGDLEEVRAAYaaGINAEVVPF---IDDMaaayAAADLVICRAGASTVAELAAAGL 273

                         90       100
                 ....*....|....*....|....*....
gi 24650971  101 PGLIV--INDTlmDNHQLELAKQLAAENY 127
Cdd:PRK00726 274 PAILVplPHAA--DDHQTANARALVDAGA 300
MGT TIGR01426
glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) ...
 6-105 2.46e-03

glycosyltransferase, MGT family; This model describes the MGT (macroside glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273616 [Multi-domain]  Cd Length: 392  Bit Score: 37.36  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24650971     6 VYITVGT--TKFDALISTAstepaLKALQNRKCTKLVIQHGNSQPltdDEIQLIRKNygiqIEQYNFRPNTEDIKSADLI 83
Cdd:TIGR01426 228 VLISLGTvfNNQPSFYRTC-----VEAFRDLDWHVVLSVGRGVDP---ADLGELPPN----VEVRQWVPQLEILKKADAF 295

                          90       100
                  ....*....|....*....|..
gi 24650971    84 IGHAGAGTCMDILNNQKPGLIV 105
Cdd:TIGR01426 296 ITHGGMNSTMEALFNGVPMVAV 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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