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Conserved domains on  [gi|62484312|ref|NP_650972|]
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spermathreecae, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5329 super family cl34984
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
197-565 9.65e-115

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5329:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 364.79  E-value: 9.65e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  197 KIFDETDSFYFSFDCDITNNLQRHEAKSEESQ-SQPDERFFWNKHMIRDLINLNDK---------TWILPIIQGFMQVEN 266
Cdd:COG5329  126 KKLLSNGTFYFSYDFDITNSLQKNLSEGLEASvDRADLIFMWNSFLLEEFINHRSKlsslekqfdNFLTTVIRGFAETVD 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  267 CVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLD 346
Cdd:COG5329  206 IKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVT 285
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  347 RGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDA 426
Cdd:COG5329  286 RSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYL 365
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  427 VGPEAGAMGFHWRD-QRGMICN-QKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSpfmvLWA 504
Cdd:COG5329  366 IEQDLLEFGYFAYDiNEGKSISeQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPFLQIHRE----LWA 441
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62484312  505 NNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRYYLARFKDSYRQATIDLMLG 565
Cdd:COG5329  442 DNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
591-696 1.35e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


:

Pssm-ID: 463592  Cd Length: 115  Bit Score: 104.98  E-value: 1.35e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    591 AEQAKLLVEDCRRLLLG-TAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRL 669
Cdd:pfam12456    7 PKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDIDR 86
                           90       100
                   ....*....|....*....|....*....
gi 62484312    670 IELGM--HQQTKIFQGSAPAHLCLRLNYS 696
Cdd:pfam12456   87 IQLGTyiTSTLSLAQRDERRNYGLRIHYD 115
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
197-565 9.65e-115

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 364.79  E-value: 9.65e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  197 KIFDETDSFYFSFDCDITNNLQRHEAKSEESQ-SQPDERFFWNKHMIRDLINLNDK---------TWILPIIQGFMQVEN 266
Cdd:COG5329  126 KKLLSNGTFYFSYDFDITNSLQKNLSEGLEASvDRADLIFMWNSFLLEEFINHRSKlsslekqfdNFLTTVIRGFAETVD 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  267 CVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLD 346
Cdd:COG5329  206 IKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVT 285
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  347 RGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDA 426
Cdd:COG5329  286 RSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYL 365
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  427 VGPEAGAMGFHWRD-QRGMICN-QKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSpfmvLWA 504
Cdd:COG5329  366 IEQDLLEFGYFAYDiNEGKSISeQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPFLQIHRE----LWA 441
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62484312  505 NNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRYYLARFKDSYRQATIDLMLG 565
Cdd:COG5329  442 DNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
49-413 5.97e-109

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 339.55  E-value: 5.97e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312     49 HGIVGVISLPNVYepHLVVVKEASAVGVLyPPHLVYKIKSICILSADDPDTDlpnctkHTKSNQSTPthsvstsnnnnas 128
Cdd:pfam02383    1 YGILGLIRLLSGY--YLIVITKREQVGQI-GGHPIYKITDVEFIPLNSSLSD------TQLAKKEHP------------- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    129 vpssgggsskstklfegmnktwgavksagntiknttqqaanlatkqvkssvgireprhIERRITEELhKIFDETDSFYFS 208
Cdd:pfam02383   59 ----------------------------------------------------------DEERLLKLL-KLFLSSGSFYFS 79
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    209 FDCDITNNLQRHEAKSEESQSQP-DERFFWNKHMIRDLINLNDKT--WILPIIQGFMQVENCVIGNECFTLALVSRRSRH 285
Cdd:pfam02383   80 YDYDLTNSLQRNLTRSRSPSFDSlDDRFFWNRHLLKPLIDFQLDLdrWILPLIQGFVEQGKLSVFGRSVTLTLISRRSRK 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    286 RAGTRYKRRGVDEKGNCANYVETEQILSF-----RHHQLSFTQVRGSVPIYWSQ-PGYKYRPPPRLDRgVAETQQAFELH 359
Cdd:pfam02383  160 RAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQdPNLKYKPKIQITR-PEATQPAFKKH 238
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62484312    360 FTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLN---NDRLIYVTFDFHDYCR 413
Cdd:pfam02383  239 FDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNqflPDKLRYTAFDFHHECK 295
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
591-696 1.35e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 104.98  E-value: 1.35e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    591 AEQAKLLVEDCRRLLLG-TAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRL 669
Cdd:pfam12456    7 PKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDIDR 86
                           90       100
                   ....*....|....*....|....*....
gi 62484312    670 IELGM--HQQTKIFQGSAPAHLCLRLNYS 696
Cdd:pfam12456   87 IQLGTyiTSTLSLAQRDERRNYGLRIHYD 115
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
197-565 9.65e-115

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 364.79  E-value: 9.65e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  197 KIFDETDSFYFSFDCDITNNLQRHEAKSEESQ-SQPDERFFWNKHMIRDLINLNDK---------TWILPIIQGFMQVEN 266
Cdd:COG5329  126 KKLLSNGTFYFSYDFDITNSLQKNLSEGLEASvDRADLIFMWNSFLLEEFINHRSKlsslekqfdNFLTTVIRGFAETVD 205
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  267 CVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLD 346
Cdd:COG5329  206 IKVGGNTISLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVTDSQYIFSFTQVRGSIPLFWEQSNLLYGPKIKVT 285
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  347 RGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDA 426
Cdd:COG5329  286 RSSEAAQSAFDKHFDKLREKYGDVYVVNLLKTKGYEAPLLELYEKHLDLSKKPKIHYTEFDFHKETSQDGFDDVKKLLYL 365
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312  427 VGPEAGAMGFHWRD-QRGMICN-QKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSpfmvLWA 504
Cdd:COG5329  366 IEQDLLEFGYFAYDiNEGKSISeQDGVFRTNCLDCLDRTNVIQSLISRVLLEQFRSEGVISDGYSPFLQIHRE----LWA 441
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62484312  505 NNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRYYLARFKDSYRQATIDLMLG 565
Cdd:COG5329  442 DNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
49-413 5.97e-109

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 339.55  E-value: 5.97e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312     49 HGIVGVISLPNVYepHLVVVKEASAVGVLyPPHLVYKIKSICILSADDPDTDlpnctkHTKSNQSTPthsvstsnnnnas 128
Cdd:pfam02383    1 YGILGLIRLLSGY--YLIVITKREQVGQI-GGHPIYKITDVEFIPLNSSLSD------TQLAKKEHP------------- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    129 vpssgggsskstklfegmnktwgavksagntiknttqqaanlatkqvkssvgireprhIERRITEELhKIFDETDSFYFS 208
Cdd:pfam02383   59 ----------------------------------------------------------DEERLLKLL-KLFLSSGSFYFS 79
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    209 FDCDITNNLQRHEAKSEESQSQP-DERFFWNKHMIRDLINLNDKT--WILPIIQGFMQVENCVIGNECFTLALVSRRSRH 285
Cdd:pfam02383   80 YDYDLTNSLQRNLTRSRSPSFDSlDDRFFWNRHLLKPLIDFQLDLdrWILPLIQGFVEQGKLSVFGRSVTLTLISRRSRK 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    286 RAGTRYKRRGVDEKGNCANYVETEQILSF-----RHHQLSFTQVRGSVPIYWSQ-PGYKYRPPPRLDRgVAETQQAFELH 359
Cdd:pfam02383  160 RAGTRYLRRGIDDDGNVANFVETEQIVSLntsnsEGKIFSFVQIRGSIPLFWSQdPNLKYKPKIQITR-PEATQPAFKKH 238
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62484312    360 FTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLN---NDRLIYVTFDFHDYCR 413
Cdd:pfam02383  239 FDDLIERYGPVHIVNLVEKKGRESKLSEAYEEAVKYLNqflPDKLRYTAFDFHHECK 295
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
591-696 1.35e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 104.98  E-value: 1.35e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484312    591 AEQAKLLVEDCRRLLLG-TAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRL 669
Cdd:pfam12456    7 PKIREQAIEDCKKLVLAdEDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDIDR 86
                           90       100
                   ....*....|....*....|....*....
gi 62484312    670 IELGM--HQQTKIFQGSAPAHLCLRLNYS 696
Cdd:pfam12456   87 IQLGTyiTSTLSLAQRDERRNYGLRIHYD 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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