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Conserved domains on  [gi|45550781|ref|NP_650939|]
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Rho GTPase activating protein at 93B [Drosophila melanogaster]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 11108663)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1133-1320 1.44e-112

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239854  Cd Length: 187  Bit Score: 350.54  E-value: 1.44e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1133 FGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDykNTLVDAHTPAS 1212
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPL--SGLEDPHVPAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1213 LLKLWYRELYDPLIPDAYYEDCV-NTEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPN 1291
Cdd:cd04389   79 LLKLWLRELEEPLIPDALYQQCIsASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPN 158

                        170       180
                 ....*....|....*....|....*....
gi 45550781 1292 CLRCTSEDPKVILENARKEMSFMRTLIQH 1320
Cdd:cd04389  159 ILRCTSDDPRVIFENTRKEMSFLRTLIEH 187
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 1004-1122 1.43e-35

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


:

Pssm-ID: 459939  Cd Length: 105  Bit Score: 130.78  E-value: 1.43e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781   1004 AIEIISASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDpsfatcfmevsk 1083
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHAD------------ 68

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 45550781   1084 wPIHVQISHYATVCCRRLDRIGSSGRRMaKKPTVDEVEQ 1122
Cdd:pfam00784   69 -DPSREVGKYAQFCLKRLKRTLKNGGRK-YPPSREEIEA 105
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
1-75 2.07e-05

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 48.92  E-value: 2.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550781    1 MSSSCERIEWVEIIEPRTKEHMYaNLTTGECVWDPPEDVpIKRTD---SSQWWELFDTNTQRFYYYNAATQKTVWHRP 75
Cdd:COG5104    8 MASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKEL-LKGSEedlDVDPWKECRTADGKVYYYNSITRESRWKIP 83
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 737-892 2.69e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    737 ENVEAVLEGiggNATEPSAPTATAPKPKPryQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQQ- 815
Cdd:pfam09770  197 EEVEAAMRA---QAKKPAQQPAPAPAQPP--AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQs 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    816 ---------------QLHLEPSDTKQKQSQTLPSPNRQISRLAGAGHQGSGPAASskeetGHSTVAGQQQvtvgtvtpAS 880
Cdd:pfam09770  272 pqpdpaqpsiqpqaqQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP-----APAHQAHRQQ--------GS 338

                          170
                   ....*....|..
gi 45550781    881 LSRPGHKMAPPS 892
Cdd:pfam09770  339 FGRQAPIITHPQ 350
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1133-1320 1.44e-112

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 350.54  E-value: 1.44e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1133 FGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDykNTLVDAHTPAS 1212
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPL--SGLEDPHVPAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1213 LLKLWYRELYDPLIPDAYYEDCV-NTEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPN 1291
Cdd:cd04389   79 LLKLWLRELEEPLIPDALYQQCIsASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPN 158

                        170       180
                 ....*....|....*....|....*....
gi 45550781 1292 CLRCTSEDPKVILENARKEMSFMRTLIQH 1320
Cdd:cd04389  159 ILRCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1154-1297 4.31e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 153.85  E-value: 4.31e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781   1154 PWIQTTLSEHvLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED 1233
Cdd:pfam00620    1 PLIVRKCVEY-LEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45550781   1234 CVN-------TEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCLRCTS 1297
Cdd:pfam00620   80 FIEaaklpdeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV--NKMNAHNLAIVFGPTLLRPPD 148
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 1004-1122 1.43e-35

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 130.78  E-value: 1.43e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781   1004 AIEIISASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDpsfatcfmevsk 1083
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHAD------------ 68

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 45550781   1084 wPIHVQISHYATVCCRRLDRIGSSGRRMaKKPTVDEVEQ 1122
Cdd:pfam00784   69 -DPSREVGKYAQFCLKRLKRTLKNGGRK-YPPSREEIEA 105
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 956-1122 9.15e-34

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 127.48  E-value: 9.15e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781     956 WTAEAISRPMLALSrDKADKKTAIELFKLVQIYMADRKARIGMTLNSVAIEIISASLPQQQLRDELYVQLCRQTTENPKR 1035
Cdd:smart00139    1 YTKDPIKTSLLKLE-SDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLVQFILQKGLDHPELRDEIYCQLIKQLTDNPSR 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1036 DSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDPSFATcfmevskwpihvqisHYATVCCRRLDRIGSSGRRmAKKP 1115
Cdd:smart00139   80 QSEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQ---------------GLAKYCLYRLERTLKNGAR-KQPP 143


                    ....*..
gi 45550781    1116 TVDEVEQ 1122
Cdd:smart00139  144 SRLELEA 150
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1165-1320 3.21e-32

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 123.92  E-value: 3.21e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1165 LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTEDPD 1241
Cdd:smart00324   14 LEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEfieAAKLEDET 93

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1242 KA----KEIVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKeMSFMRTL 1317
Cdd:smart00324   94 ERlralRELLSLLPPANRATLRYLLAHLNRVAEHSEE--NKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFL 170


                    ...
gi 45550781    1318 IQH 1320
Cdd:smart00324  171 IEN 173
PRP40 COG5104
Splicing factor [RNA processing and modification];
1-75 2.07e-05

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 48.92  E-value: 2.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550781    1 MSSSCERIEWVEIIEPRTKEHMYaNLTTGECVWDPPEDVpIKRTD---SSQWWELFDTNTQRFYYYNAATQKTVWHRP 75
Cdd:COG5104    8 MASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKEL-LKGSEedlDVDPWKECRTADGKVYYYNSITRESRWKIP 83
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 50-75 1.17e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 40.18  E-value: 1.17e-04
                           10        20
                   ....*....|....*....|....*.
gi 45550781     50 WELFDTNTQRFYYYNAATQKTVWHRP 75
Cdd:pfam00397    5 WEERWDPDGRVYYYNHETGETQWEKP 30
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 737-892 2.69e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    737 ENVEAVLEGiggNATEPSAPTATAPKPKPryQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQQ- 815
Cdd:pfam09770  197 EEVEAAMRA---QAKKPAQQPAPAPAQPP--AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQs 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    816 ---------------QLHLEPSDTKQKQSQTLPSPNRQISRLAGAGHQGSGPAASskeetGHSTVAGQQQvtvgtvtpAS 880
Cdd:pfam09770  272 pqpdpaqpsiqpqaqQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP-----APAHQAHRQQ--------GS 338

                          170
                   ....*....|..
gi 45550781    881 LSRPGHKMAPPS 892
Cdd:pfam09770  339 FGRQAPIITHPQ 350
 
Name Accession Description Interval E-value
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1133-1320 1.44e-112

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 350.54  E-value: 1.44e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1133 FGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDykNTLVDAHTPAS 1212
Cdd:cd04389    1 FGSSLEEIMDRQKEKYPELKLPWILTFLSEKVLALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPL--SGLEDPHVPAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1213 LLKLWYRELYDPLIPDAYYEDCV-NTEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSCTKMDSSNLAMVFAPN 1291
Cdd:cd04389   79 LLKLWLRELEEPLIPDALYQQCIsASEDPDKAVEIVQKLPIINRLVLCYLINFLQVFAQPENVAHTKMDVSNLAMVFAPN 158

                        170       180
                 ....*....|....*....|....*....
gi 45550781 1292 CLRCTSEDPKVILENARKEMSFMRTLIQH 1320
Cdd:cd04389  159 ILRCTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 1154-1297 4.31e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 153.85  E-value: 4.31e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781   1154 PWIQTTLSEHvLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED 1233
Cdd:pfam00620    1 PLIVRKCVEY-LEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEE 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45550781   1234 CVN-------TEDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCLRCTS 1297
Cdd:pfam00620   80 FIEaaklpdeEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV--NKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1165-1320 1.00e-36

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 136.66  E-value: 1.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1165 LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNtLVDAHTPASLLKLWYRELYDPLIPDAYYEDCVN-------T 1237
Cdd:cd00159   11 LEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFELYDEFIElakiedeE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1238 EDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCLRCTSEDPKvILENARKEMSFMRTL 1317
Cdd:cd00159   90 ERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV--NKMTASNLAIVFAPTLLRPPDSDDE-LLEDIKKLNEIVEFL 166


                 ...
gi 45550781 1318 IQH 1320
Cdd:cd00159  167 IEN 169
MyTH4 pfam00784
MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also ...
 1004-1122 1.43e-35

MyTH4 domain; Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 459939  Cd Length: 105  Bit Score: 130.78  E-value: 1.43e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781   1004 AIEIISASLPQQQLRDELYVQLCRQTTENPKRDSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDpsfatcfmevsk 1083
Cdd:pfam00784    1 AQNILQKGLKRPELRDEIYCQLIKQTTNNPKPESLLRGWQLLALCLGTFPPSKKLLKYLLKFLKRHAD------------ 68

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 45550781   1084 wPIHVQISHYATVCCRRLDRIGSSGRRMaKKPTVDEVEQ 1122
Cdd:pfam00784   69 -DPSREVGKYAQFCLKRLKRTLKNGGRK-YPPSREEIEA 105
MyTH4 smart00139
Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 ...
 956-1122 9.15e-34

Domain in Myosin and Kinesin Tails; Domain present twice in myosin-VIIa, and also present in 3 other myosins.


Pssm-ID: 214535  Cd Length: 152  Bit Score: 127.48  E-value: 9.15e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781     956 WTAEAISRPMLALSrDKADKKTAIELFKLVQIYMADRKARIGMTLNSVAIEIISASLPQQQLRDELYVQLCRQTTENPKR 1035
Cdd:smart00139    1 YTKDPIKTSLLKLE-SDELQKEAVKIFKAILKFMGDIPLPRPDSHLDLVQFILQKGLDHPELRDEIYCQLIKQLTDNPSR 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1036 DSLIRGWELMAICLSYVPPSPTFQPTLLNYVNRHRDPSFATcfmevskwpihvqisHYATVCCRRLDRIGSSGRRmAKKP 1115
Cdd:smart00139   80 QSEERGWQLLYLCTSLFPPSERLLPYLLQFLSRRADPGSEQ---------------GLAKYCLYRLERTLKNGAR-KQPP 143


                    ....*..
gi 45550781    1116 TVDEVEQ 1122
Cdd:smart00139  144 SRLELEA 150
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1165-1320 3.21e-32

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 123.92  E-value: 3.21e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1165 LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTEDPD 1241
Cdd:smart00324   14 LEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEEfieAAKLEDET 93

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    1242 KA----KEIVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKeMSFMRTL 1317
Cdd:smart00324   94 ERlralRELLSLLPPANRATLRYLLAHLNRVAEHSEE--NKMTARNLAIVFGPTLLRPPDGEVASLKDIRHQ-NTVIEFL 170


                    ...
gi 45550781    1318 IQH 1320
Cdd:smart00324  171 IEN 173
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1165-1322 1.20e-25

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 105.50  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1165 LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDvPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCV------NTE 1238
Cdd:cd04404   34 LQAHALTTEGIFRRSANTQVVKEVQQKYNMGE-PVDFDQYEDVHLPAVILKTFLRELPEPLLTFDLYDDIVgflnvdKEE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1239 DPDKAKEIVNKLPEINQLVLTYLIHFLQQfaipevVSC----TKMDSSNLAMVFAPNCLRctSEDPKVILENARKEMSFM 1314
Cdd:cd04404  113 RVERVKQLLQTLPEENYQVLKYLIKFLVQ------VSAhsdqNKMTNSNLAVVFGPNLLW--AKDASMSLSAINPINTFT 184


                 ....*...
gi 45550781 1315 RTLIQHMD 1322
Cdd:cd04404  185 KFLLDHQD 192
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1132-1320 2.10e-22

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 96.36  E-value: 2.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1132 MFGNTLSEVMDLQKeKFPFRKLPWIQTTLSEHVLLlNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTlVDAHTPA 1211
Cdd:cd04390    2 VFGQRLEDTVAYER-KFGPRLVPILVEQCVDFIRE-HGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSD-TDVHTVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1212 SLLKLWYRELYDPLIPDAYYED---CVNTEDPDKAK---EIVNK---LPEINQLVLTYLIHFLqqFAIPEVVSCTKMDSS 1282
Cdd:cd04390   79 SLLKLYLRELPEPVIPWAQYEDflsCAQLLSKDEEKglgELMKQvsiLPKVNYNLLSYICRFL--DEVQSNSSVNKMSVQ 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 45550781 1283 NLAMVFAPNCLRCTSEDPKVILENARKEMSFMRTLIQH 1320
Cdd:cd04390  157 NLATVFGPNILRPKVEDPATIMEGTPQIQQLMTVMISK 194
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1165-1293 7.20e-21

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 92.13  E-value: 7.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1165 LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDV-PDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCV---NTEDP 1240
Cdd:cd04386   31 LLETGMNEEGLFRVGGGASKLKRLKAALDAGTFsLPLDEFYSDPHAVASALKSYLRELPDPLLTYNLYEDWVqaaNKPDE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 45550781 1241 DKAKE----IVNKLPEINQLVLTYLIHFLQQFAIPEVVscTKMDSSNLAMVFAPNCL 1293
Cdd:cd04386  111 DERLQaiwrILNKLPRENRDNLRYLIKFLSKLAQKSDE--NKMSPSNIAIVLAPNLL 165
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1132-1292 2.79e-19

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 87.13  E-value: 2.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1132 MFGNTLSEvmdLQKEKFPFRKLPWIQTTLSEHvLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTlVDAHTPA 1211
Cdd:cd04393    2 VFGVPLQE---LQQAGQPENGVPAVVRHIVEY-LEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKE-ADVCSAA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1212 SLLKLWYRELYDPLIPDA-------YYEDCVNT-EDPDKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSN 1283
Cdd:cd04393   77 SLLRLFLQELPEGLIPASlqirlmqLYQDYNGEdEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHEN--RMTAEN 154


                 ....*....
gi 45550781 1284 LAMVFAPNC 1292
Cdd:cd04393  155 LAAVFGPDV 163
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1169-1323 3.44e-18

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 83.99  E-value: 3.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRLDRwDV--------PDYKNtlvDAHTPASLLKLWYRELYDPLIPDAYYE---DCVNT 1237
Cdd:cd04398   31 GLNLEGIYRLSGNVSRVNKLKELFDK-DPlnvllispEDYES---DIHSVASLLKLFFRELPEPLLTKALSRefiEAAKI 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1238 EDP----DKAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLRCTSEDPkvilenarKEMSF 1313
Cdd:cd04398  107 EDEsrrrDALHGLINDLPDANYATLRALMFHLARIKEHESVN--RMSVNNLAIIWGPTLMNAAPDNA--------ADMSF 176

                        170
                 ....*....|....
gi 45550781 1314 ----MRTLIQHMDT 1323
Cdd:cd04398  177 qsrvIETLLDNAYQ 190
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1151-1318 2.67e-16

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 78.63  E-value: 2.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1151 RKLPWIQTTLSEHVLLlNGKQTEGIFRVSADVDEVGCMKNRLD----RWDVPDYKntlvdAHTPASLLKLWYRELYDPLI 1226
Cdd:cd04377   13 RSVPLVLEKLLEHIEM-HGLYTEGIYRKSGSANKIKELRQGLDtdpdSVNLEDYP-----IHVITSVLKQWLRELPEPLM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1227 PDAYYEDCVN-TEDPDKAKE------IVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLRCT-SE 1298
Cdd:cd04377   87 TFELYENFLRaMELEEKQERvralysVLEQLPRANLNTLERLIFHLVRVALQEEVN--RMSANALAIVFAPCILRCPdTA 164

                        170       180
                 ....*....|....*....|
gi 45550781 1299 DPKVILENARKEMSFMRTLI 1318
Cdd:cd04377  165 DPLQSLQDVSKTTTCVETLI 184
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1169-1322 5.26e-16

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 78.25  E-value: 5.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRLDRWDvpdyKNTLVDAHTP---ASLLKLWYRELYDPLIPDAYYEDCVNTE--DPDKA 1243
Cdd:cd04376   24 GLQTVGIFRVGSSKKRVRQLREEFDRGI----DVVLDENHSVhdvAALLKEFFRDMPDPLLPRELYTAFIGTAllEPDEQ 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1244 KE----IVNKLPEINQLVLTYLIHFLQQFAI---------PEVVSCTKMDSSNLAMVFAPNCLRCT------SEDPKVIL 1304
Cdd:cd04376  100 LEalqlLIYLLPPCNCDTLHRLLKFLHTVAEhaadsidedGQEVSGNKMTSLNLATIFGPNLLHKQksgereFVQASLRI 179

                        170
                 ....*....|....*...
gi 45550781 1305 ENARKEMSFMRTLIQHMD 1322
Cdd:cd04376  180 EESTAIINVVQTMIDNYE 197
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1147-1320 6.47e-16

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 77.90  E-value: 6.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1147 KFPFRKLPWIQTTLSEHV---------LLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAhtpASLLKLW 1217
Cdd:cd04394    3 GVPLHSLPHSTVPEYGNVpkflvdactFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPCDV---AGLLKQF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1218 YRELYDPLIPDAYYEDCVNTEDPDKAKE-------IVNKLPEINQLVLTYLIHFLQqfAIPEVVSCTKMDSSNLAMVFAP 1290
Cdd:cd04394   80 FRELPEPLLPYDLHEALLKAQELPTDEErksatllLTCLLPDEHVNTLRYFFSFLY--DVAQRCSENKMDSSNLAVIFAP 157

                        170       180       190
                 ....*....|....*....|....*....|...
gi 45550781 1291 NCLRCTSEDPKVILENA---RKEMSFMRTLIQH 1320
Cdd:cd04394  158 NLFQSEEGGEKMSSSTEkrlRLQAAVVQTLIDN 190
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1167-1320 8.77e-16

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 77.08  E-value: 8.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1167 LNGKQTEGIFRVSADVDEVGCMKNRLDRWDVP-DYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYED---CVNTEDPDK 1242
Cdd:cd04383   31 LYGLQHQGIFRVSGSQVEVNDIKNAFERGEDPlADDQNDHDINSVAGVLKLYFRGLENPLFPKERFEDlmsCVKLENPTE 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1243 ----AKEIVNKLPEINQLVLTYLIHFLQ---QFAIPEVvsctkMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMsfMR 1315
Cdd:cd04383  111 rvhqIREILSTLPRSVIIVMRYLFAFLNhlsQFSDENM-----MDPYNLAICFGPTLMPVPEGQDQVSCQAHVNEL--IK 183


                 ....*
gi 45550781 1316 TLIQH 1320
Cdd:cd04383  184 TIIIH 188
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1169-1322 1.02e-15

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 77.06  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRL-----------DRWDvpdykntlvDAHTPASLLKLWYRELYDPLIPDAYYEDCVNT 1237
Cdd:cd04395   33 GLETVGIYRVPGNNAAISALQEELnrggfdidlqdPRWR---------DVNVVSSLLKSFFRKLPEPLFTNELYPDFIEA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1238 ---EDPD----KAKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLRcTSEDPkviLENARKE 1310
Cdd:cd04395  104 nriEDPVerlkELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVN--KMEPRNLAIVFGPTLVR-TSDDN---METMVTH 177

                        170
                 ....*....|....*.
gi 45550781 1311 MS----FMRTLIQHMD 1322
Cdd:cd04395  178 MPdqckIVETLIQHYD 193
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1140-1319 3.88e-15

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 75.03  E-value: 3.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1140 VMDLQKEKFPfrkLPWIQTTLSEHVLLlNGKQTEGIFRVSADVDEVGCMKNRLDRwDVPDYKNTLVDAHTPASLLKLWYR 1219
Cdd:cd04407    5 VGSLTSNKTS---VPIVLEKLLEHVEM-HGLYTEGIYRKSGSANRMKELHQLLQA-DPENVKLENYPIHAITGLLKQWLR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1220 ELYDPLIPDAYYEDCVNT-EDPDKAKE------IVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNC 1292
Cdd:cd04407   80 ELPEPLMTFAQYNDFLRAvELPEKQEQlqaiyrVLEQLPTANHNTLERLIFHLVKVALEEDVN--RMSPNALAIVFAPCL 157

                        170       180
                 ....*....|....*....|....*...
gi 45550781 1293 LRC-TSEDPKVILENARKEMSFMRTLIQ 1319
Cdd:cd04407  158 LRCpDSSDPLTSMKDVAKTTTCVEMLIK 185
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1132-1320 1.51e-14

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 73.49  E-value: 1.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1132 MFGNTLSEVmdLQKEKFPfrklPWIQTTLSehVLLLNGKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVdaHTPA 1211
Cdd:cd04402    1 LFGQPLSNI--CEDDNLP----KPILDMLS--LLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPV--LLLA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1212 SLLKLWYRELYDPLIPDAYYEDCV------NTEDPDKA-KEIVNKLPEINQLVLTYLIHFLQQfaIPEVVSCTKMDSSNL 1284
Cdd:cd04402   71 SVLKDFLRNIPGSLLSSDLYEEWMsaldqeNEEEKIAElQRLLDKLPRPNVLLLKHLICVLHN--ISQNSETNKMDAFNL 148

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 45550781 1285 AMVFAPNCLrCTSEDPKVILENARKEMSFMRTLIQH 1320
Cdd:cd04402  149 AVCIAPSLL-WPPASSELQNEDLKKVTSLVQFLIEN 183
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 1152-1302 1.95e-14

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 73.42  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1152 KLPWIQTTLSEHVLLlNGKQTEGIFRVSADVDEVGCMKNRLDrwdvPDYKNTLV-----DAHTPASLLKLWYRELYDPLI 1226
Cdd:cd04387   15 KVPYIVRQCVEEVER-RGMEEVGIYRISGVATDIQALKAAFD----TNNKDVSVmlsemDVNAIAGTLKLYFRELPEPLF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1227 PDAYY---EDCVNTEDPdKAKE-----IVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLRCTSE 1298
Cdd:cd04387   90 TDELYpnfAEGIALSDP-VAKEscmlnLLLSLPDPNLVTFLFLLHHLKRVAEREEVN--KMSLHNLATVFGPTLLRPSEK 166


                 ....
gi 45550781 1299 DPKV 1302
Cdd:cd04387  167 ESKI 170
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1169-1323 1.98e-14

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 73.32  E-value: 1.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRLDR-WDVPDYKNTLV-DAHTPASLLKLWYRELYDPLIP-DAY--YEDCVNTEDPDK- 1242
Cdd:cd04372   31 GLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISATVYpDINVITGALKLYFRDLPIPVITyDTYpkFIDAAKISNPDEr 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1243 ---AKEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMSFMRTLIQ 1319
Cdd:cd04372  111 leaVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDN--KMNAENLGIVFGPTLMRPPEDSALTTLNDMRYQILIVQLLIT 188


                 ....
gi 45550781 1320 HMDT 1323
Cdd:cd04372  189 NEDV 192
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 1133-1290 5.38e-14

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 72.01  E-value: 5.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1133 FGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHVLLLNGKQTEGIFRVSADVDEVGCMKNRLD-RWDVPDYKNTLV-DAHTP 1210
Cdd:cd04400    2 FGSPLEEAVELSSHKYNGRDLPSVVYRCIEYLDKNRAIYEEGIFRLSGSASVIKQLKERFNtEYDVDLFSSSLYpDVHTV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1211 ASLLKLWYRELYDPLIPDAYYED--CVNTEDPDKA------KEIVNKLPEINQLVLTYLIHFLQQfaIPEVVSCTKMDSS 1282
Cdd:cd04400   82 AGLLKLYLRELPTLILGGELHNDfkRLVEENHDRSqralelKDLVSQLPQANYDLLYVLFSFLRK--IIEHSDVNKMNLR 159


                 ....*...
gi 45550781 1283 NLAMVFAP 1290
Cdd:cd04400  160 NVCIVFSP 167
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1132-1322 7.74e-14

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 71.99  E-value: 7.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1132 MFGNTLSEVMDLQKEKFPFRKLPWIQTTLSEHvLLLNGKQTEGIFRVSADVDEVGCMKNRLDR---WDVPDYKNtlVDAH 1208
Cdd:cd04391    1 LFGVPLSTLLERDQKKVPGSKVPLIFQKLINK-LEERGLETEGILRIPGSAQRVKFLCQELEAkfyEGTFLWDQ--VKQH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1209 TPASLLKLWYRELYDPLIP----DAYY--EDCVNTEDPDKAKEI-VNKLPEINQLVLTYLIHFLQQfaipeVVSC---TK 1278
Cdd:cd04391   78 DAASLLKLFIRELPQPLLTveylPAFYsvQGLPSKKDQLQALNLlVLLLPEANRDTLKALLEFLQK-----VVDHeekNK 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 45550781 1279 MDSSNLAMVFAPNCLRCTSEDPKVILENArKEM-------SFMRTLIQHMD 1322
Cdd:cd04391  153 MNLWNVAMIMAPNLFPPRGKHSKDNESLQ-EEVnmaagcaNIMRLLIRYQD 202
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1169-1317 8.96e-14

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 71.17  E-value: 8.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRLDRWD-VPDYKNtlVDAHTPASLLKLWYRELYDPLIPDAY---YEDCVNTEDPDKA- 1243
Cdd:cd04382   32 GLTEEGLYRVSGSEREVKALKEKFLRGKtVPNLSK--VDIHVICGCLKDFLRSLKEPLITFALwkeFMEAAEILDEDNSr 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1244 ---KEIVNKLPEINQLVLTYLIHFLQQFA-IPEVvsctKMDSSNLAMVFAPNCLRCTSEDPK--VILENARKEMSFMRTL 1317
Cdd:cd04382  110 aalYQAISELPQPNRDTLAFLILHLQRVAqSPEC----KMDINNLARVFGPTIVGYSVPNPDpmTILQDTVRQPRVVERL 185
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1169-1294 2.20e-13

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 69.79  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCV-------NTEDPD 1241
Cdd:cd04373   30 GLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFTVNAVAGALKSFFSELPDPLIPYSMHLELVeaakindREQRLH 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 45550781 1242 KAKEIVNKLPEINQLVLTYLIHFLQQfaipevVSC----TKMDSSNLAMVFAPNCLR 1294
Cdd:cd04373  110 ALKELLKKFPPENFDVFKYVITHLNK------VSQnskvNLMTSENLSICFWPTLMR 160
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 1133-1294 1.31e-11

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 64.72  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1133 FGNTLSEVmdLQKEKfpfRKLPWIQTTLSEHVLLlNGKQTEGIFRVS---ADVDEVGCMKNRLDRWDVPDYKNTlvDAHT 1209
Cdd:cd04403    1 FGCHLEAL--CQREN---STVPKFVRLCIEAVEK-RGLDVDGIYRVSgnlAVIQKLRFAVDHDEKLDLDDSKWE--DIHV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1210 PASLLKLWYRELYDPLIPDAYYEDCVNT---EDP----DKAKEIVNKLPEINQLVLTYLIHFLQQFAipEVVSCTKMDSS 1282
Cdd:cd04403   73 ITGALKLFFRELPEPLFPYSLFNDFVAAiklSDYeqrvSAVKDLIKSLPKPNHDTLKMLFRHLCRVI--EHGEKNRMTTQ 150

                        170
                 ....*....|..
gi 45550781 1283 NLAMVFAPNCLR 1294
Cdd:cd04403  151 NLAIVFGPTLLR 162
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1173-1294 7.30e-11

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 62.91  E-value: 7.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1173 EGIFRVSADVDEVGCMKNRLDRWDVPDYKNT--LVDAHTPASLLKLWYRELYDPLIPDAYYEDCVN--TEDPD-----KA 1243
Cdd:cd04384   36 DGIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyIQDIHSVSSLCKLYFRELPNPLLTYQLYEKFSEavSAASDeerleKI 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 45550781 1244 KEIVNKLPEINQLVLTYLIHFLQQFAipEVVSCTKMDSSNLAMVFAPNCLR 1294
Cdd:cd04384  116 HDVIQQLPPPHYRTLEFLMRHLSRLA--KYCSITNMHAKNLAIVWAPNLLR 164
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1169-1290 1.39e-10

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 61.68  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVS---ADVDEVGCMKNRLDRWDVPDYkntlvDAHTPASLLKLWYRELYDPLIPDA----YYEDCVNTEDPD 1241
Cdd:cd04381   35 GMKCEGIYKVSgikSKVDELKAAYNRRESPNLEEY-----EPPTVASLLKQYLRELPEPLLTKElmprFEEACGRPTEAE 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 45550781 1242 KAKE---IVNKLPEINQLVLTYLIHFLQQFAIPEVvsCTKMDSSNLAMVFAP 1290
Cdd:cd04381  110 REQElqrLLKELPECNRLLLAWLIVHMDHVIAQEL--ETKMNIQNISIVLSP 159
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1163-1323 1.73e-09

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 59.28  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1163 HVLLLNGKQTEGIFRVSADVDEVGCMKNR----LDRWDVPdykNTLVDAHTPASLLKLWYRELYDPLIPDAYYE---DCV 1235
Cdd:cd04380   59 DYLYTRGLAQEGLFEEPGLPSEPGELLAEirdaLDTGSPF---NSPGSAESVAEALLLFLESLPDPIIPYSLYErllEAV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1236 NTeDPDKAKEIVN-KLPEINQLVLTYLIHFLQQFAipEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMSfm 1314
Cdd:cd04380  136 AN-NEEDKRQVIRiSLPPVHRNVFVYLCSFLRELL--SESADRGLDENTLATIFGRVLLRDPPRAGGKERRAERDRKR-- 210


                 ....*....
gi 45550781 1315 RTLIQHMDT 1323
Cdd:cd04380  211 AFIEQFLLN 219
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1172-1320 1.77e-09

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 59.01  E-value: 1.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1172 TEGIFRVSADVDEVGCMKNRLDRWDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYY-------EDCVNTED----- 1239
Cdd:cd04392   26 VEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHAHDCATVLKGFLGELPEPLLTHAHYpahlqiaDLCQFDEKgnkts 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1240 -PDKAKEIVNK------LPEINQLVLTYLIHFLQQFAIPEvvSCTKMDSSNLAMVFAPNCLRCTSEDPKVILENARKEMS 1312
Cdd:cd04392  106 aPDKERLLEALqlllllLPEENRNLLKLILDLLYQTAKHE--DKNKMSADNLALLFTPHLICPRNLTPEDLHENAQKLNS 183


                 ....*...
gi 45550781 1313 FMRTLIQH 1320
Cdd:cd04392  184 IVTFMIKH 191
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 1169-1320 4.00e-09

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 57.70  E-value: 4.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1169 GKQTEGIFRVSADVDEVGCM--KNRLDRWDV---PDyKNTLVDAhtpASLLKLWYRELYDPLIPD---AYYEDCVNTEDP 1240
Cdd:cd04385   30 GLMSEGIYRKNGKNSSVKKLleAFRKDARSVqlrEG-EYTVHDV---ADVLKRFLRDLPDPLLTSelhAEWIEAAELENK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1241 D----KAKEIVNKLPEINQLVLTYLI---HFLQQFAipevvSCTKMDSSNLAMVFAPnCLRCTSEDPkviLENARKEMSF 1313
Cdd:cd04385  106 DeriaRYKELIRRLPPINRATLKVLIghlYRVQKHS-----DENQMSVHNLALVFGP-TLFQTDEHS---VGQTSHEVKV 176


                 ....*..
gi 45550781 1314 MRTLIQH 1320
Cdd:cd04385  177 IEDLIDN 183
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1168-1322 1.11e-08

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 57.03  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1168 NGKQTEGIFRVSADVDEVGCMKNRLDRwdVPDYKNTLVD----AHTPASLLKLWYRELYDPLIPDAYYE----------- 1232
Cdd:cd04396   46 NATEVEGIFRVAGSSKRIRELQLIFST--PPDYGKSFDWdgytVHDAASVLRRYLNNLPEPLVPLDLYEefrnplrkrpr 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1233 ---------DCVNTEDPDKA----KEIVNKLPEINQLVLTYLIHFLQQFAIPEVVSctKMDSSNLAMVFAPNCLrcTSED 1299
Cdd:cd04396  124 ilqymkgriNEPLNTDIDQAikeyRDLITRLPNLNRQLLLYLLDLLAVFARNSDKN--LMTASNLAAIFQPGIL--SHPD 199

                        170       180
                 ....*....|....*....|...
gi 45550781 1300 PKVILENARKEMSFMRTLIQHMD 1322
Cdd:cd04396  200 HEMDPKEYKLSRLVVEFLIEHQD 222
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1151-1300 1.58e-08

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 55.78  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1151 RKLPWIQTTLSEHVLLlNGKQTEGIFRVSADVDEVGCMKNRLDRwDVPDYKNTLVDAHTPASLLKLWYRELYDPLIPDAY 1230
Cdd:cd04406   13 RSVPLVVEKLINYIEM-HGLYTEGIYRKSGSTNKIKELRQGLDT-DANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFEL 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550781 1231 YEDCVNTEDPDKAKEIVNKLPE-INQLVLTY------LIHFLQQFAIPEvvSCTKMDSSNLAMVFAPNCLRC-TSEDP 1300
Cdd:cd04406   91 YEEFLRAMGLQERRETVRGVYSvIDQLSRTHlntlerLIFHLVRIALQE--ETNRMSANALAIVFAPCILRCpDTTDP 166
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1173-1300 9.66e-08

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 53.91  E-value: 9.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1173 EGIFRVSADVDEVGCMKNRLDR--WDVPDY-KNTLVDAhtpASLLKLWYRELYDPLIPDAYYEDCVNT---EDPDKAKEI 1246
Cdd:cd04397   46 EGVFRKNGNIRRLKELTEEIDKnpTEVPDLsKENPVQL---AALLKKFLRELPDPLLTFKLYRLWISSqkiEDEEERKRV 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45550781 1247 VN----KLPEINQLVLTYLIHFLQ---QFAIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDP 1300
Cdd:cd04397  123 LHlvycLLPKYHRDTMEVLFSFLKwvsSFSHIDEETGSKMDIHNLATVITPNILYSKTDNP 183
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 1204-1294 1.35e-06

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 50.50  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1204 LVD-----AHTPASLLKLWYRELYDPLIPDAYYEDC---------VNTEDPD------------KAKEIVNKLPEINQLV 1257
Cdd:cd04378   60 LVElselsPHDISSVLKLFLRQLPEPLILFRLYNDFialakeiqrDTEEDKApntpievnriirKLKDLLRQLPASNYNT 139

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 45550781 1258 LTYLIHFLQQFAipEVVSCTKMDSSNLAMVFAPNCLR 1294
Cdd:cd04378  140 LQHLIAHLYRVA--EQFEENKMSPNNLGIVFGPTLIR 174
PRP40 COG5104
Splicing factor [RNA processing and modification];
1-75 2.07e-05

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 48.92  E-value: 2.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45550781    1 MSSSCERIEWVEIIEPRTKEHMYaNLTTGECVWDPPEDVpIKRTD---SSQWWELFDTNTQRFYYYNAATQKTVWHRP 75
Cdd:COG5104    8 MASGEARSEWEELKAPDGRIYYY-NKRTGKSSWEKPKEL-LKGSEedlDVDPWKECRTADGKVYYYNSITRESRWKIP 83
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 1163-1298 4.17e-05

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 46.23  E-value: 4.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1163 HVLLLNGKQTEGIFRVSADVDEVGCMKNRL------DRWDVpDYKNTLVDAHTPASLLKLWYRELYDPLIPDAYYEDCVN 1236
Cdd:cd04374   37 EAVETRGINEQGLYRVVGVNSKVQKLLSLGldpktsTPGDV-DLDNSEWEIKTITSALKTYLRNLPEPLMTYELHNDFIN 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45550781 1237 ---TEDPD-KAKEI---VNKLPEINQLVLTYLIHFLQQFAipEVVSCTKMDSSNLAMVFAPNCLRCTSE 1298
Cdd:cd04374  116 aakSENLEsRVNAIhslVHKLPEKNREMLELLIKHLTNVS--DHSKKNLMTVSNLGVVFGPTLLRPQEE 182
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 50-75 1.17e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 40.18  E-value: 1.17e-04
                           10        20
                   ....*....|....*....|....*.
gi 45550781     50 WELFDTNTQRFYYYNAATQKTVWHRP 75
Cdd:pfam00397    5 WEERWDPDGRVYYYNHETGETQWEKP 30
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1207-1304 2.32e-04

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 44.03  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1207 AHTPASLLKLWYRELYDPLIPDAYYEDC---------VNTEDPD--------------------KAKEIVNKLPEINQLV 1257
Cdd:cd04409   68 PHDISNVLKLYLRQLPEPLILFRLYNEFiglakesqhVNETQEAkknsdkkwpnmctelnrillKSKDLLRQLPAPNYNT 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 45550781 1258 LTYLIHFLQQfaIPEVVSCTKMDSSNLAMVFAPNCLRCTSEDPKVIL 1304
Cdd:cd04409  148 LQFLIVHLHR--VSEQAEENKMSASNLGIIFGPTLIRPRPTDATVSL 192
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1131-1290 3.93e-04

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 43.56  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1131 SMFGNTLseVMDLQKEKFPFRK-----LPWIQTTLSEHVlllngkqteGIFRVSADVDEVGCMKNRLDRWDvpdyKNTLV 1205
Cdd:cd04375    3 NVFGVPL--LVNLQRTGQPLPRsiqqaMRWLRNNALDQV---------GLFRKSGVKSRIQKLRSMIESST----DNVNY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1206 D---AHTPASLLKLWYRELYDPLIPD-------AYYEDCVNTEDPDKAKEIVNKLPEINQLVLTYLIHFLQQfaipeVVS 1275
Cdd:cd04375   68 DgqqAYDVADMLKQYFRDLPEPLLTNklsetfiAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSD-----VAA 142

                        170
                 ....*....|....*...
gi 45550781 1276 CTK---MDSSNLAMVFAP 1290
Cdd:cd04375  143 NSQenqMTATNLAVCLAP 160
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 1208-1294 4.74e-04

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 42.88  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781 1208 HTPASLLKLWYRELYDPLIPDAYYEDCVNT-----EDPDKA--------------KEIVNKLPEINQLVLTYLIHFLqqF 1268
Cdd:cd04408   69 HDITSVLKHFLKELPEPVLPFQLYDDFIALakelqRDSEKAaespsiveniirslKELLGRLPVSNYNTLRHLMAHL--Y 146

                         90       100
                 ....*....|....*....|....*.
gi 45550781 1269 AIPEVVSCTKMDSSNLAMVFAPNCLR 1294
Cdd:cd04408  147 RVAERFEDNKMSPNNLGIVFGPTLLR 172
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 737-892 2.69e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    737 ENVEAVLEGiggNATEPSAPTATAPKPKPryQISYYDTVSHSPSAGSGYHGQQLYSNTPPYSGHGHGHHVPPPSLPHQQ- 815
Cdd:pfam09770  197 EEVEAAMRA---QAKKPAQQPAPAPAQPP--AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQs 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550781    816 ---------------QLHLEPSDTKQKQSQTLPSPNRQISRLAGAGHQGSGPAASskeetGHSTVAGQQQvtvgtvtpAS 880
Cdd:pfam09770  272 pqpdpaqpsiqpqaqQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP-----APAHQAHRQQ--------GS 338

                          170
                   ....*....|..
gi 45550781    881 LSRPGHKMAPPS 892
Cdd:pfam09770  339 FGRQAPIITHPQ 350
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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