NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24648304|ref|NP_650849|]
View 

uncharacterized protein Dmel_CG4462 [Drosophila melanogaster]

Protein Classification

SLC22 family MFS transporter( domain architecture ID 13022872)

SLC22 (Solute carrier 22) family MFS transporter similar to Caenorhabditis elegans organic cation transporter 1; the SLC22 family includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
123-533 6.38e-95

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 293.33  E-value: 6.38e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 123 CEQFNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSL 202
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 203 HCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYW 282
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 283 TPdsprwllrhaadrfsidnveqilregaaindrsfkippdfrqqleqlserlkaqpppapwtelwkgkrakTHMVAAHL 362
Cdd:cd17317 161 LP----------------------------------------------------------------------RRTIIVGL 170
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 363 ALAFFVINFMGMLLNIRSFGRDyLVPNTIAMGFSEIIGCFLALHFTLKHNKwKWQCAGVFNILAGILGCMGWIFTNADsm 442
Cdd:cd17317 171 IWFVTSLVYYGLSLNSSNLGGN-LYLNFFLSGLVEIPAYFLALLLLDRLGR-RWTLSGSLLLAGLACLVTALLPDDEN-- 246
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 443 dadlkvSLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFS 522
Cdd:cd17317 247 ------TLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLA 320
                       410
                ....*....|.
gi 24648304 523 ILGGICTSLLL 533
Cdd:cd17317 321 LLGGLLTLLLP 331
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
123-533 6.38e-95

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 293.33  E-value: 6.38e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 123 CEQFNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSL 202
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 203 HCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYW 282
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 283 TPdsprwllrhaadrfsidnveqilregaaindrsfkippdfrqqleqlserlkaqpppapwtelwkgkrakTHMVAAHL 362
Cdd:cd17317 161 LP----------------------------------------------------------------------RRTIIVGL 170
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 363 ALAFFVINFMGMLLNIRSFGRDyLVPNTIAMGFSEIIGCFLALHFTLKHNKwKWQCAGVFNILAGILGCMGWIFTNADsm 442
Cdd:cd17317 171 IWFVTSLVYYGLSLNSSNLGGN-LYLNFFLSGLVEIPAYFLALLLLDRLGR-RWTLSGSLLLAGLACLVTALLPDDEN-- 246
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 443 dadlkvSLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFS 522
Cdd:cd17317 247 ------TLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLA 320
                       410
                ....*....|.
gi 24648304 523 ILGGICTSLLL 533
Cdd:cd17317 321 LLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
126-532 3.40e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 100.09  E-value: 3.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   126 FNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVM--------GTKMMLGISprstYCVGAVAqilcGVVTGYA 197
Cdd:TIGR00898 106 YSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVfgylsdrfGRKKVLLLS----TLVTAVS----GVLTAFS 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   198 RDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLI 277
Cdd:TIGR00898 178 PNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFF 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   278 LLLYWTPDSPRWLLRhaadRFSIDNVEQILREGAAINDRSfkiPPDFRQQLEqLSERLKAQPPPAPWTELWKGKRAKTHM 357
Cdd:TIGR00898 258 LLSWFVPESPRWLIS----QGRIEEALKILQRIAKINGKK---LPAEVLSLS-LEKDLSSSKKQYSFLDLFRTPNLRKTT 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   358 VAahLALAFFVINFM--GMLLNIRSFG-RDYLvpNTIAMGFSEIIGCFLALhFTLKHNKWKWQCAGvFNILAGIlgCMGW 434
Cdd:TIGR00898 330 LC--LMMLWFTTAFSyyGLVLDLGNLGgNIYL--DLFISGLVELPAKLITL-LLIDRLGRRYTMAA-SLLLAGV--ALLL 401
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   435 IFTNADSMDAdlkvsLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMS 514
Cdd:TIGR00898 402 LLFVPVDLYF-----LRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLP 476
                         410
                  ....*....|....*...
gi 24648304   515 LTSYCVFSILGGICTSLL 532
Cdd:TIGR00898 477 LVLFGGLALLAGILTLFL 494
MFS_1 pfam07690
Major Facilitator Superfamily;
157-481 1.01e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   157 LFGVLVGGVMGTKmmlgISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIG 236
Cdd:pfam07690  46 ALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGR 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   237 AIILYDTFWSIGVILLPGLSSFFN---SWSLIYVGITFPTIMLILLLYwtpdsprwllrhaadrfsidnveqilregaai 313
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPLLGGLLAslfGWRAAFLILAILSLLAAVLLL-------------------------------- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   314 ndrsfkIPPDFRQQLEQLSERLKAQPPPAPWTELWKGKRAkthMVAAHLALAFFVINFMGMLLNIRSFGRDY-LVPNTIA 392
Cdd:pfam07690 170 ------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL---WLLLALLLFGFAFFGLLTYLPLYQEVLGLsALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   393 MGFSEIIGCFLALHFTLKHNKWKWQCAGVFNILAGILGCMGWIFTNAdsmdADLKVSLWMIIATIPkAAVSCAQSMILAC 472
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL----TLSSLWLLLALLLLG-FGFGLVFPALNAL 315

                  ....*....
gi 24648304   473 MNELMPANK 481
Cdd:pfam07690 316 VSDLAPKEE 324
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
157-283 1.40e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 157 LFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIG 236
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGR 134
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24648304 237 AIILYDTFWSIGVILLPGLSSF---FNSWSLIYVGITFPTIMLILLLYWT 283
Cdd:COG2814 135 ALGLLGAGLGLGPALGPLLGGLladLFGWRWVFLVNAVLALLALLLLLRL 184
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
123-533 6.38e-95

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 293.33  E-value: 6.38e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 123 CEQFNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSL 202
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 203 HCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYW 282
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 283 TPdsprwllrhaadrfsidnveqilregaaindrsfkippdfrqqleqlserlkaqpppapwtelwkgkrakTHMVAAHL 362
Cdd:cd17317 161 LP----------------------------------------------------------------------RRTIIVGL 170
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 363 ALAFFVINFMGMLLNIRSFGRDyLVPNTIAMGFSEIIGCFLALHFTLKHNKwKWQCAGVFNILAGILGCMGWIFTNADsm 442
Cdd:cd17317 171 IWFVTSLVYYGLSLNSSNLGGN-LYLNFFLSGLVEIPAYFLALLLLDRLGR-RWTLSGSLLLAGLACLVTALLPDDEN-- 246
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 443 dadlkvSLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFS 522
Cdd:cd17317 247 ------TLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLA 320
                       410
                ....*....|.
gi 24648304 523 ILGGICTSLLL 533
Cdd:cd17317 321 LLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
126-532 3.40e-22

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 100.09  E-value: 3.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   126 FNYVSSFDSLIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVM--------GTKMMLGISprstYCVGAVAqilcGVVTGYA 197
Cdd:TIGR00898 106 YSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVfgylsdrfGRKKVLLLS----TLVTAVS----GVLTAFS 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   198 RDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLI 277
Cdd:TIGR00898 178 PNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFF 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   278 LLLYWTPDSPRWLLRhaadRFSIDNVEQILREGAAINDRSfkiPPDFRQQLEqLSERLKAQPPPAPWTELWKGKRAKTHM 357
Cdd:TIGR00898 258 LLSWFVPESPRWLIS----QGRIEEALKILQRIAKINGKK---LPAEVLSLS-LEKDLSSSKKQYSFLDLFRTPNLRKTT 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   358 VAahLALAFFVINFM--GMLLNIRSFG-RDYLvpNTIAMGFSEIIGCFLALhFTLKHNKWKWQCAGvFNILAGIlgCMGW 434
Cdd:TIGR00898 330 LC--LMMLWFTTAFSyyGLVLDLGNLGgNIYL--DLFISGLVELPAKLITL-LLIDRLGRRYTMAA-SLLLAGV--ALLL 401
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   435 IFTNADSMDAdlkvsLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMS 514
Cdd:TIGR00898 402 LLFVPVDLYF-----LRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLP 476
                         410
                  ....*....|....*...
gi 24648304   515 LTSYCVFSILGGICTSLL 532
Cdd:TIGR00898 477 LVLFGGLALLAGILTLFL 494
MFS_1 pfam07690
Major Facilitator Superfamily;
157-481 1.01e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 69.37  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   157 LFGVLVGGVMGTKmmlgISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIG 236
Cdd:pfam07690  46 ALAQPLAGRLSDR----FGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGR 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   237 AIILYDTFWSIGVILLPGLSSFFN---SWSLIYVGITFPTIMLILLLYwtpdsprwllrhaadrfsidnveqilregaai 313
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPLLGGLLAslfGWRAAFLILAILSLLAAVLLL-------------------------------- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   314 ndrsfkIPPDFRQQLEQLSERLKAQPPPAPWTELWKGKRAkthMVAAHLALAFFVINFMGMLLNIRSFGRDY-LVPNTIA 392
Cdd:pfam07690 170 ------LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL---WLLLALLLFGFAFFGLLTYLPLYQEVLGLsALLAGLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   393 MGFSEIIGCFLALHFTLKHNKWKWQCAGVFNILAGILGCMGWIFTNAdsmdADLKVSLWMIIATIPkAAVSCAQSMILAC 472
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL----TLSSLWLLLALLLLG-FGFGLVFPALNAL 315

                  ....*....
gi 24648304   473 MNELMPANK 481
Cdd:pfam07690 316 VSDLAPKEE 324
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
130-532 4.61e-12

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 67.32  E-value: 4.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 130 SSFDSLIMQF-NLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRC 208
Cdd:cd17374  17 SKFTSTIVTEwDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 209 LSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYWTPdspr 288
Cdd:cd17374  97 LAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP---- 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 289 wllrhaadrfsidnveqilregaaindrsfkippdfrqqleqlserlkaqpppapwtelwkgKRAkthmvaahLALAF-- 366
Cdd:cd17374 173 --------------------------------------------------------------KRT--------LILSFvw 182
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 367 --FVINFMGMLLNIRSFGRDYLVPNTIaMGFSEIIGCFLAlHFTLKHNKWKWqCAGVFNILAGILgCMGWIFTNADSMda 444
Cdd:cd17374 183 faNSFSYYGLSLDLQHLGLNVFLLQFL-FGAVEVPARCLA-LFLLNHMGRRI-SQAVLLLLAGLC-ILANIFVPQEMQ-- 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 445 dlkvSLWMIIATIPKAAVSCAQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFSIL 524
Cdd:cd17374 257 ----TLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPIL 332

                ....*...
gi 24648304 525 GGICTSLL 532
Cdd:cd17374 333 AGLLALLL 340
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
128-282 7.97e-10

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 60.44  E-value: 7.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 128 YVSSFDSLIMQFNLVC----LRDIFVAWTQYWHLFGVLVGGVM----GTKMMLGISprstyCVGAVaqiLCGVVTGYARD 199
Cdd:cd17379  14 YNTPRSSIVTEFNLVCedawKLDLFQSSLNLGFLIGSIVIGYLadrfGRKVCFLIS-----ILGNG---VSGVLMAFSPN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 200 FSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTImLILL 279
Cdd:cd17379  86 YPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNF-LFLL 164

                ...
gi 24648304 280 LYW 282
Cdd:cd17379 165 YYW 167
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
157-283 1.40e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 1.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 157 LFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIG 236
Cdd:COG2814  55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGR 134
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24648304 237 AIILYDTFWSIGVILLPGLSSF---FNSWSLIYVGITFPTIMLILLLYWT 283
Cdd:COG2814 135 ALGLLGAGLGLGPALGPLLGGLladLFGWRWVFLVNAVLALLALLLLLRL 184
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
117-289 2.48e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 50.04  E-value: 2.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 117 TGTSSeCEQFNYVSSFDSLIMQFNLVCLRDIFVAWTQywhLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGY 196
Cdd:cd17362  13 IGATS-GALLSITSPALSGTDWYNLSSLQSGLVVSGS---LLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 197 ARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNS----WSLIYVGITFP 272
Cdd:cd17362  89 APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADvvggWRYMYGLAAPP 168
                       170
                ....*....|....*..
gi 24648304 273 TIMLILLLYWTPDSPRW 289
Cdd:cd17362 169 ALLLGIGMWFLPPSPRW 185
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
157-297 6.67e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.80  E-value: 6.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 157 LFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAF---RCLSAVCCAIMfTAGQAIFADITAGMH 233
Cdd:cd17357  59 FIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLifgRFLVGIACGLS-TGFVPMYLQEISPSE 137
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 234 RIGAI-ILYDTFWSIGVIL-----LPGLSSFFNSWSLIYVGITFPTIMLILLLYWTPDSPRWLLRHAADR 297
Cdd:cd17357 138 LRGALgSLTQIGVTLGILLgqvfgLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDE 207
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
125-282 3.99e-05

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 45.92  E-value: 3.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 125 QFNYVSSFDS-LIMQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLH 203
Cdd:cd17443  13 PFSAAAGLGSnLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTF 92
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24648304 204 CAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPtiMLILLLYW 282
Cdd:cd17443  93 LVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLP--LLLLLLYW 169
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
130-284 4.24e-05

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 45.88  E-value: 4.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 130 SSFDSLI-MQFNLVCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRC 208
Cdd:cd17447  17 STFSSTIaTEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRT 96
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24648304 209 LSAVCCA---IMFTAGQAIFADITagmHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYWTP 284
Cdd:cd17447  97 LTGFALTgfsIISMVLCVEWVDIE---HRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVP 172
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
155-480 4.30e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.20  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   155 WHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHR 234
Cdd:TIGR00895  60 AGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   235 IGAIILYDTFWSIGVILLPGLSSF----FNSWSLIYVGITFPTIMLILLLYWTPDSPRWLlrhaadrfsidnveqILREG 310
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLAGWlipvFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFL---------------VSKRP 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   311 AAINDRSFKIPPDFRQQLEQLSERLKAQPPPA--PWTELWKGKRAKTHMVaahLALAFFVINFMGMLLN------IRSFG 382
Cdd:TIGR00895 205 ETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKrsVFKALFQGKTARITVL---LWLLYFMLLVGVYFLTnwlpklMVELG 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   383 RD------YLVPNTIAMGFSEIIGCFLALHFTLKHNKWKWQCAGVFNILAGILgcmgwiFTNADSMdadlkvslwMIIAT 456
Cdd:TIGR00895 282 FSlslaatGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGST------LFSPTLL---------LLLGA 346
                         330       340
                  ....*....|....*....|....
gi 24648304   457 IPKAAVSCAQSMILACMNELMPAN 480
Cdd:TIGR00895 347 IAGFFVNGGQSGLYALMALFYPTA 370
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
158-284 3.59e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.92  E-value: 3.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 158 FGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRiGA 237
Cdd:COG0738  54 LGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA-SR 132
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 24648304 238 IILYDTFWSIGVILLPGLSSFF------NSWSLIYVGITFPTIMLILLLYWTP 284
Cdd:COG0738 133 LNLLHAFFSLGALLGPLLGGLLillglsLSWHLPYLILAVLLLLLALLFLRSK 185
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
150-301 8.30e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 41.94  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   150 AWTQYWHLF--GVLVGGVMGTKMMLGISPRSTYC----VGAVAQILCGVVTGYAR---DFSLHCAFRCLSAVCCAIMFTA 220
Cdd:TIGR00879  68 YSSSLWGLVvsIFLVGGFIGALFAGWLSDRFGRKksllIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASAL 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304   221 GQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSL-----IYVGITF-PTIMLILLLYWTPDSPRWLL--- 291
Cdd:TIGR00879 148 VPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSGKVSLNNtlgwrIPLGLQLiPAGLLFLGLFFLPESPRWLVgkg 227
                         170
                  ....*....|
gi 24648304   292 RHAADRFSID 301
Cdd:TIGR00879 228 RVEEARKSLA 237
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
147-289 8.61e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 8.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 147 IFVAWTQYWHLFGVLVGGVMGTKmmlgISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFA 226
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADR----FGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIA 110
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24648304 227 DITAGMHRIGAIILYDTFWSIGVILLPGLSSFF-----NSWSLIYVGITFPTIMLILLLYWTPDSPRW 289
Cdd:cd06174 111 DLFPERERGRALGLLQAFGSVGGILGPLLGGILasslgFGWRAVFLIAAALALLAAILLLLVVPDPPE 178
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
158-404 8.75e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.79  E-value: 8.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 158 FGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRiGA 237
Cdd:cd17358  52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR-GA 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 238 IILYDTFW-SIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLLYwTPDSPRWLLRhaadRFSIDNVEQILR--EGAAIN 314
Cdd:cd17358 131 LGSLNQLLvNIGILLGYVLGSFLPWRTLALIGAIPPVVFLILLFF-IPESPRWLAK----KGREEEAEKSLQflRGKDAD 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 315 DRSFKippdfrQQLEQLSERLKAQPPPAPWTELWKGKRAKTHMVAAHLAL------AFFVINFMGMLLNIRSFGRDylvP 388
Cdd:cd17358 206 ISKEA------AEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLfqqlsgINAVIFYASSIFDEAGSGLD---P 276
                       250
                ....*....|....*...
gi 24648304 389 N--TIAMGFSEIIGCFLA 404
Cdd:cd17358 277 NtaTIIIGVVQVVGTLVA 294
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
158-282 8.81e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 8.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 158 FGVLVGGVMGTKmmlgISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGA 237
Cdd:COG2271  60 LGQIPAGLLADR----FGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 24648304 238 IILYDTFWSIGVILLPGLSSFFNS---WSLIYVGITFPTIMLILLLYW 282
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAafgWRAAFLILGLPGLLLALLRFW 183
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
158-280 1.95e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.62  E-value: 1.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 158 FGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIGA 237
Cdd:cd17477  42 LGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRV 121
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 24648304 238 IILYDTFWSIGVILLPGLSSFF--NSWSLIYVGITFPTIMLILLL 280
Cdd:cd17477 122 LGLYSTVLGLGFALGPLLLALVgtAGALPFLIAAVLLLLALVPLL 166
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
157-280 2.19e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24648304 157 LFGVLVGGVMGtKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAFRCLSAVCCAIMFTAGQAIFADITAGMHRIG 236
Cdd:cd17325 246 LASALSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24648304 237 AIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITFPTIMLILLL 280
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAA 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure