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Conserved domains on  [gi|21357005|ref|NP_650723|]
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WD repeat domain 37 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-476 3.12e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.90  E-value: 3.12e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 153 VREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqaa 232
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 233 vnwevpkkghsseeelddsdeQVEDRDRVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLP 312
Cdd:cd00200  79 ---------------------DLETGECVRTLT----------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 313 LQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPaVSVFQGHTETVTSSVFARD-DKVVSGSDDRTIKVWEL 391
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 392 RnMRSALATIRT-DSSVNRLAVSTGG-IIAIPHDNRQIRLFDL-NGQRVARLprtsrQGHRRMVSSVAWAEEPlldCDLF 468
Cdd:cd00200 207 S-TGKCLGTLRGhENGVNSVAFSPDGyLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWSPDG---KRLA 277


                ....*...
gi 21357005 469 SCGFDRRV 476
Cdd:cd00200 278 SGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-476 3.12e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.90  E-value: 3.12e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 153 VREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqaa 232
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 233 vnwevpkkghsseeelddsdeQVEDRDRVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLP 312
Cdd:cd00200  79 ---------------------DLETGECVRTLT----------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 313 LQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPaVSVFQGHTETVTSSVFARD-DKVVSGSDDRTIKVWEL 391
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 392 RnMRSALATIRT-DSSVNRLAVSTGG-IIAIPHDNRQIRLFDL-NGQRVARLprtsrQGHRRMVSSVAWAEEPlldCDLF 468
Cdd:cd00200 207 S-TGKCLGTLRGhENGVNSVAFSPDGyLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWSPDG---KRLA 277


                ....*...
gi 21357005 469 SCGFDRRV 476
Cdd:cd00200 278 SGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
68-481 1.34e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 1.34e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005  68 PPDARSAAGGSMSTQASSAALATPATQTDEVAGSFLAAASSTHKSLKAKLSSATGGSKAKASNKIKAQTSRIVSSfkapt 147
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG----- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 148 vvsTVVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAH 227
Cdd:COG2319 111 ---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 228 IWQaavnwevpkkghsseeelddsdeqVEDRDRVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDV 307
Cdd:COG2319 188 LWD------------------------LATGKLLRTLT----------GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 308 ETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAiPAVSVFQGHTETVTSSVFARDDK-VVSGSDDRTI 386
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTV 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 387 KVWELRNmRSALATIR-TDSSVNRLAVS-TGGIIAIPHDNRQIRLFDLNGQRVARlprtSRQGHRRMVSSVAWAEEPLLd 464
Cdd:COG2319 313 RLWDLAT-GKLLRTLTgHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLR----TLTGHTGAVTSVAFSPDGRT- 386

                       410
                ....*....|....*..
gi 21357005 465 cdLFSCGFDRRVFGWSI 481
Cdd:COG2319 387 --LASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-229 1.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21357005    191 SARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIW 229
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
193-229 2.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21357005   193 RCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIW 229
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 288-406 2.96e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005  288 SSMDQIITGSWDRTAILWDVETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPAVSVFQGHTETVT 367
Cdd:PTZ00421 136 SAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 21357005  368 SSVFA-RDDKVV----SGSDDRTIKVWELRNMRSALATIRTDSS 406
Cdd:PTZ00421 216 RCLWAkRKDLIItlgcSKSQQRQIMLWDTRKMASPYSTVDLDQS 259
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-476 3.12e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.90  E-value: 3.12e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 153 VREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqaa 232
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW--- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 233 vnwevpkkghsseeelddsdeQVEDRDRVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLP 312
Cdd:cd00200  79 ---------------------DLETGECVRTLT----------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 313 LQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPaVSVFQGHTETVTSSVFARD-DKVVSGSDDRTIKVWEL 391
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDL 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 392 RnMRSALATIRT-DSSVNRLAVSTGG-IIAIPHDNRQIRLFDL-NGQRVARLprtsrQGHRRMVSSVAWAEEPlldCDLF 468
Cdd:cd00200 207 S-TGKCLGTLRGhENGVNSVAFSPDGyLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWSPDG---KRLA 277


                ....*...
gi 21357005 469 SCGFDRRV 476
Cdd:cd00200 278 SGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
68-481 1.34e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 1.34e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005  68 PPDARSAAGGSMSTQASSAALATPATQTDEVAGSFLAAASSTHKSLKAKLSSATGGSKAKASNKIKAQTSRIVSSfkapt 147
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG----- 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 148 vvsTVVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAH 227
Cdd:COG2319 111 ---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 228 IWQaavnwevpkkghsseeelddsdeqVEDRDRVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDV 307
Cdd:COG2319 188 LWD------------------------LATGKLLRTLT----------GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 308 ETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAiPAVSVFQGHTETVTSSVFARDDK-VVSGSDDRTI 386
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVAFSPDGKlLASGSDDGTV 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 387 KVWELRNmRSALATIR-TDSSVNRLAVS-TGGIIAIPHDNRQIRLFDLNGQRVARlprtSRQGHRRMVSSVAWAEEPLLd 464
Cdd:COG2319 313 RLWDLAT-GKLLRTLTgHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLATGELLR----TLTGHTGAVTSVAFSPDGRT- 386

                       410
                ....*....|....*..
gi 21357005 465 cdLFSCGFDRRVFGWSI 481
Cdd:COG2319 387 --LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-481 1.79e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 1.79e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 194 CLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqaavnwevpkkghsseeelddsdeqveDRDRVDTLRTpLCeftg 273
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---------------------------DLETGELLRT-LK---- 48

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 274 pgGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAi 353
Cdd:cd00200  49 --GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 354 PAVSVFQGHTETVTSSVFARDDK-VVSGSDDRTIKVWELRNMRSaLATIRT-DSSVNRLAVS-TGGIIAIPHDNRQIRLF 430
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGKC-VATLTGhTGEVNSVAFSpDGEKLLSSSSDGTIKLW 204

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21357005 431 DLNGQRVARLPRtsrqGHRRMVSSVAWAEEPLLdcdLFSCGFDRRVFGWSI 481
Cdd:cd00200 205 DLSTGKCLGTLR----GHENGVNSVAFSPDGYL---LASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-390 3.27e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 3.27e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 152 VVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqa 231
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW-- 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 232 avnwevpkkghsseeelDDSDEQVedrdrVDTLRtplceftgpgGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGL 311
Cdd:cd00200 163 -----------------DLRTGKC-----VATLT----------GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 312 PLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPaVSVFQGHTETVTSSVFARDDK-VVSGSDDRTIKVWE 390
Cdd:cd00200 211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
134-481 6.41e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 6.41e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 134 AQTSRIVSSFKAPTVVSTVVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQ 213
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 214 RDLVLTGSGDGTAHIWQAAvnwevpkkghsseeelddsdeqvedrdrvdtlrTPLCEFTgPGGHLSVVVAADWLSSMDQI 293
Cdd:COG2319  90 GRLLASASADGTVRLWDLA---------------------------------TGLLLRT-LTGHTGAVRSVAFSPDGKTL 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 294 ITGSWDRTAILWDVETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAiPAVSVFQGHTETVTSSVFAR 373
Cdd:COG2319 136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSP 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 374 DDK-VVSGSDDRTIKVWELRNmRSALATIRTDSS-VNRLAVSTGG-IIAIPHDNRQIRLFDLNGQRVARLPRtsrqGHRR 450
Cdd:COG2319 215 DGKlLASGSADGTVRLWDLAT-GKLLRTLTGHSGsVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLT----GHSG 289

                       330       340       350
                ....*....|....*....|....*....|.
gi 21357005 451 MVSSVAWAEEPLLdcdLFSCGFDRRVFGWSI 481
Cdd:COG2319 290 GVNSVAFSPDGKL---LASGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
153-393 7.76e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 7.76e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 153 VREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWqaa 232
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW--- 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 233 vnwevpkkghsseeelddsdeQVEDRDRVDTLrtplceftgpGGHLSVVVAADWLSSMDQIITGSWDRTAILWDVETGLP 312
Cdd:COG2319 274 ---------------------DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 313 LQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDfREAIPAVSVFQGHTETVTSSVFARDDK-VVSGSDDRTIKVWEL 391
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWDL 401


                ..
gi 21357005 392 RN 393
Cdd:COG2319 402 AT 403
WD40 COG2319
WD40 repeat [General function prediction only];
151-232 1.21e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005 151 TVVREFGGHKDGIWQVAAKAGQPIIGTASADHTACIWGVESARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIWQ 230
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                ..
gi 21357005 231 AA 232
Cdd:COG2319 401 LA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-229 1.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21357005    191 SARCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIW 229
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
193-229 2.14e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21357005   193 RCLLQYQGHAGSVNSIKFHQQRDLVLTGSGDGTAHIW 229
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-348 1.64e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.64e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21357005    309 TGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWD 348
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 288-406 2.96e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005  288 SSMDQIITGSWDRTAILWDVETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPAVSVFQGHTETVT 367
Cdd:PTZ00421 136 SAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 21357005  368 SSVFA-RDDKVV----SGSDDRTIKVWELRNMRSALATIRTDSS 406
Cdd:PTZ00421 216 RCLWAkRKDLIItlgcSKSQQRQIMLWDTRKMASPYSTVDLDQS 259
WD40 pfam00400
WD domain, G-beta repeat;
356-390 4.77e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21357005   356 VSVFQGHTETVTSSVFARDDK-VVSGSDDRTIKVWE 390
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 356-390 5.24e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.24e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 21357005    356 VSVFQGHTETVTSSVFARDDK-VVSGSDDRTIKVWE 390
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-348 5.75e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.75e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21357005   310 GLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWD 348
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 287-391 2.46e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 40.46  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357005  287 LSSMDQII--TGSWDRTAILWDVETGLPLQPLTGHDHELTHVSAHPTQRLVVTASRDTTFRLWDFREAIPAVSVFQGHTE 364
Cdd:PLN00181 583 YSSADPTLlaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*..
gi 21357005  365 TVTSSVFARDDKVVSGSDDRTIKVWEL 391
Cdd:PLN00181 663 TVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 276-306 2.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.73e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21357005    276 GHLSVVVAADWLSSMDQIITGSWDRTAILWD 306
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
276-306 7.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21357005   276 GHLSVVVAADWLSSMDQIITGSWDRTAILWD 306
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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