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Conserved domains on  [gi|21357095|ref|NP_650705|]
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uncharacterized protein Dmel_CG8064 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455513)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 401-693 1.14e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 401 GHQSEVRSVCFSNDSLAIGSGAG-ESFKFWDRDAMQCLRT--VPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIV 477
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTlkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 478 EEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW---TFELIDAGEGaaqtkvlsllHKNTlkleetVLCLAVSPDMKYL 554
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRG----------HTDW------VNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 555 AVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPR 634
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21357095 635 THMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
72-611 4.74e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 4.74e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  72 RVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGH 151
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGA---LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 152 NAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFI--GNLMVAGAGESGMNVYRLRkhDG 229
Cdd:COG2319  78 TAAVLSVAFSP---DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLA--TG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 230 AITETLEsaveglsiDDEDTISPISVSncgtiqragkgrtvnlvtdpservischgtndlienfyictPDevkkrlakrl 309
Cdd:COG2319 153 KLLRTLT--------GHSGAVTSVAFS-----------------------------------------PD---------- 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 310 kkekkvaedegsdeaklsteqslsdeikrlesirakqkiksidvvlGQnqelRVLVSLANNSLCLYSLEasiktrkatdp 389
Cdd:COG2319 174 ----------------------------------------------GK----LLASGSDDGTVRLWDLA----------- 192

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 390 SAKLLRSLTrlGHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGDRYVLLGMKSGK 465
Cdd:COG2319 193 TGKLLRTLT--GHTGAVRSVAFSPDGklLASGSADG-TVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGT 269

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 466 LLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNTlkleETVLCL 545
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW-----DLATG----KLLRTLTGHT----GAVRSV 336

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357095 546 AVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLN 611
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 780-884 1.54e-23

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 96.08  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095   780 PEDFLV-STLMRIRASDLEEALLLLPFSTVCEVLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAKNMKPLLVKLL 858
Cdd:pfam04003   1 NDEYLLeSVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 21357095   859 SMLKRDVGQLRDVLGWNLHGLALLQT 884
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 401-693 1.14e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 401 GHQSEVRSVCFSNDSLAIGSGAG-ESFKFWDRDAMQCLRT--VPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIV 477
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTlkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 478 EEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW---TFELIDAGEGaaqtkvlsllHKNTlkleetVLCLAVSPDMKYL 554
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRG----------HTDW------VNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 555 AVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPR 634
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21357095 635 THMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
386-690 1.05e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 1.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 386 ATDPSAKLLRSLTRL------GHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTV--PTDYILCSKFVPGDR 455
Cdd:COG2319  97 SADGTVRLWDLATGLllrtltGHTGAVRSVAFSPDGktLASGSADG-TVRLWDLATGKLLRTLtgHSGAVTSVAFSPDGK 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 456 YVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNT 535
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW-----DLATG----KLLRTLTGHS 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 536 lkleETVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDC 615
Cdd:COG2319 247 ----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21357095 616 HRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLR 690
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
72-611 4.74e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 4.74e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  72 RVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGH 151
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGA---LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 152 NAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFI--GNLMVAGAGESGMNVYRLRkhDG 229
Cdd:COG2319  78 TAAVLSVAFSP---DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLA--TG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 230 AITETLEsaveglsiDDEDTISPISVSncgtiqragkgrtvnlvtdpservischgtndlienfyictPDevkkrlakrl 309
Cdd:COG2319 153 KLLRTLT--------GHSGAVTSVAFS-----------------------------------------PD---------- 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 310 kkekkvaedegsdeaklsteqslsdeikrlesirakqkiksidvvlGQnqelRVLVSLANNSLCLYSLEasiktrkatdp 389
Cdd:COG2319 174 ----------------------------------------------GK----LLASGSDDGTVRLWDLA----------- 192

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 390 SAKLLRSLTrlGHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGDRYVLLGMKSGK 465
Cdd:COG2319 193 TGKLLRTLT--GHTGAVRSVAFSPDGklLASGSADG-TVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGT 269

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 466 LLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNTlkleETVLCL 545
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW-----DLATG----KLLRTLTGHT----GAVRSV 336

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357095 546 AVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLN 611
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-511 7.94e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 7.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  60 TLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDryyDPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDV 139
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 140 VEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFIG-NLMVAGAgesg 218
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPdGTFVASS---- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 219 mnvyrlrKHDGAITetlesaveglsiddedtispisvsncgtiqragkgrtvnlvtdpservischgtndlienfyictp 298
Cdd:cd00200 154 -------SQDGTIK------------------------------------------------------------------ 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 299 devkkrlakrlkkekkvaedegsdeaklsteqslsdeikrlesirakqkiksidvvlgqnqelrvlvslannslcLYSLE 378
Cdd:cd00200 161 ---------------------------------------------------------------------------LWDLR 165

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 379 asiktrkatdpSAKLLRSLTrlGHQSEVRSVCFSND--SLAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGD 454
Cdd:cd00200 166 -----------TGKCVATLT--GHTGEVNSVAFSPDgeKLLSSSSDG-TIKLWDLSTGKCLGTLRghENGVNSVAFSPDG 231

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21357095 455 RYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW 511
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 780-884 1.54e-23

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 96.08  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095   780 PEDFLV-STLMRIRASDLEEALLLLPFSTVCEVLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAKNMKPLLVKLL 858
Cdd:pfam04003   1 NDEYLLeSVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 21357095   859 SMLKRDVGQLRDVLGWNLHGLALLQT 884
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 pfam00400
WD domain, G-beta repeat;
571-608 4.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 4.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357095   571 FKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVW 608
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 570-608 4.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21357095    570 TFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVW 608
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 464-611 3.67e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  464 GKLLIVDVAAADIVEEIPAHEGELWSIAI-LPDQKGCVTGSGDTTVKIWTfelIDAGegaaqtkvlslLHKNTLKLEETV 542
Cdd:PLN00181 555 GVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWS---INQG-----------VSIGTIKTKANI 620

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357095  543 LCLAVSPDM-KYLAVGLLDATVkvffldtfkFYLSLYGHKLPVICL-----DISY----DSNLIVTGSADRNVKVWGLN 611
Cdd:PLN00181 621 CCVQFPSESgRSLAFGSADHKV---------YYYDLRNPKLPLCTMighskTVSYvrfvDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-183 1.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21357095    146 ARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWN 183
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
146-183 5.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357095   146 ARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWN 183
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 401-693 1.14e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.14e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 401 GHQSEVRSVCFSNDSLAIGSGAG-ESFKFWDRDAMQCLRT--VPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIV 477
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTlkGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 478 EEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW---TFELIDAGEGaaqtkvlsllHKNTlkleetVLCLAVSPDMKYL 554
Cdd:cd00200  87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdveTGKCLTTLRG----------HTDW------VNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 555 AVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPR 634
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21357095 635 THMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
386-690 1.05e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 1.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 386 ATDPSAKLLRSLTRL------GHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTV--PTDYILCSKFVPGDR 455
Cdd:COG2319  97 SADGTVRLWDLATGLllrtltGHTGAVRSVAFSPDGktLASGSADG-TVRLWDLATGKLLRTLtgHSGAVTSVAFSPDGK 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 456 YVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNT 535
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW-----DLATG----KLLRTLTGHS 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 536 lkleETVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDC 615
Cdd:COG2319 247 ----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21357095 616 HRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLR 690
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
361-700 9.49e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.57  E-value: 9.49e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 361 LRVLVSLANNSLCLYSLEASIKTRKATDPSAKLLRSLTRLGHQSEVRSVCFSNDSLAIGSGAGE-SFKFWDRDAMQCLRT 439
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 440 V--PTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliD 517
Cdd:COG2319 116 LtgHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----D 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 518 AGEGAaqtkvlsLLHknTLKL-EETVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLI 596
Cdd:COG2319 191 LATGK-------LLR--TLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 597 VTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPN 676
Cdd:COG2319 262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                       330       340
                ....*....|....*....|....
gi 21357095 677 GRYLVTCGSDRTLRMFERTDETIV 700
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 442-700 3.35e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 3.35e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 442 TDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW---TFELIDA 518
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdleTGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 519 GEGaaqtkvlsllHKNTlkleetVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVT 598
Cdd:cd00200  89 LTG----------HTSY------VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 599 GSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGR 678
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                       250       260
                ....*....|....*....|..
gi 21357095 679 YLVTCGSDRTLRMFERTDETIV 700
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
390-651 5.98e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 5.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 390 SAKLLRSLTrlGHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGDRYVLLGMKSGK 465
Cdd:COG2319 151 TGKLLRTLT--GHSGAVTSVAFSPDGklLASGSDDG-TVRLWDLATGKLLRTLTghTGAVRSVAFSPDGKLLASGSADGT 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 466 LLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNTlkleETVLCL 545
Cdd:COG2319 228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATG----ELLRTLTGHS----GGVNSV 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 546 AVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDS 625
Cdd:COG2319 295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                       250       260
                ....*....|....*....|....*.
gi 21357095 626 VMSVQFIPRTHMFFTCGKDGKVKQWD 651
Cdd:COG2319 375 VTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 479-693 7.52e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.88  E-value: 7.52e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 479 EIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWTFElidagegaaqtkvlSLLHKNTLKL-EETVLCLAVSPDMKYLAVG 557
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE--------------TGELLRTLKGhTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 558 LLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPRTHM 637
Cdd:cd00200  70 SSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21357095 638 FFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
WD40 COG2319
WD40 repeat [General function prediction only];
429-700 4.40e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 4.40e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 429 WDRDAMQCLRTVPTDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTV 508
Cdd:COG2319  23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 509 KIWTfelidagegAAQTKVLSLLHKNTlkleETVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLD 588
Cdd:COG2319 103 RLWD---------LATGLLLRTLTGHT----GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 589 ISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEA 668
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                       250       260       270
                ....*....|....*....|....*....|..
gi 21357095 669 YCLSVSPNGRYLVTCGSDRTLRMFERTDETIV 700
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
72-611 4.74e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 4.74e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  72 RVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGH 151
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGA---LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 152 NAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFI--GNLMVAGAGESGMNVYRLRkhDG 229
Cdd:COG2319  78 TAAVLSVAFSP---DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLA--TG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 230 AITETLEsaveglsiDDEDTISPISVSncgtiqragkgrtvnlvtdpservischgtndlienfyictPDevkkrlakrl 309
Cdd:COG2319 153 KLLRTLT--------GHSGAVTSVAFS-----------------------------------------PD---------- 173

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 310 kkekkvaedegsdeaklsteqslsdeikrlesirakqkiksidvvlGQnqelRVLVSLANNSLCLYSLEasiktrkatdp 389
Cdd:COG2319 174 ----------------------------------------------GK----LLASGSDDGTVRLWDLA----------- 192

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 390 SAKLLRSLTrlGHQSEVRSVCFSNDS--LAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGDRYVLLGMKSGK 465
Cdd:COG2319 193 TGKLLRTLT--GHTGAVRSVAFSPDGklLASGSADG-TVRLWDLATGKLLRTLTghSGSVRSVAFSPDGRLLASGSADGT 269

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 466 LLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIWtfeliDAGEGaaqtKVLSLLHKNTlkleETVLCL 545
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW-----DLATG----KLLRTLTGHT----GAVRSV 336

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21357095 546 AVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLN 611
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
20-511 9.10e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 9.10e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  20 TSGRANVNFAVVDKTEGRYVAAPAAENVIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRy 99
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK- 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 100 ydPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQI 179
Cdd:COG2319 154 --LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP---DGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 180 KFWNLETQFCFKTIVDNRTEVWALAFignlmvagagesgmnvyrlrkhdgaitetlesaveglsiddedtispisvsncg 259
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAF------------------------------------------------------ 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 260 tiqragkgrtvnlvtdpservischgtndlienfyicTPDevkkrlakrlkkekkvaedegsdeaklsteqslsdeikrl 339
Cdd:COG2319 255 -------------------------------------SPD---------------------------------------- 257

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 340 esirakqkiksidvvlGQnqelRVLVSLANNSLCLYSLEasiktrkatdpSAKLLRSLTrlGHQSEVRSVCFSNDS--LA 417
Cdd:COG2319 258 ----------------GR----LLASGSADGTVRLWDLA-----------TGELLRTLT--GHSGGVNSVAFSPDGklLA 304

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 418 IGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGDRYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPD 495
Cdd:COG2319 305 SGSDDG-TVRLWDLATGKLLRTLTghTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD 383

                       490
                ....*....|....*.
gi 21357095 496 QKGCVTGSGDTTVKIW 511
Cdd:COG2319 384 GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-511 7.94e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 7.94e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  60 TLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDryyDPICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDV 139
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 140 VEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFIG-NLMVAGAgesg 218
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPdGTFVASS---- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 219 mnvyrlrKHDGAITetlesaveglsiddedtispisvsncgtiqragkgrtvnlvtdpservischgtndlienfyictp 298
Cdd:cd00200 154 -------SQDGTIK------------------------------------------------------------------ 160

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 299 devkkrlakrlkkekkvaedegsdeaklsteqslsdeikrlesirakqkiksidvvlgqnqelrvlvslannslcLYSLE 378
Cdd:cd00200 161 ---------------------------------------------------------------------------LWDLR 165

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 379 asiktrkatdpSAKLLRSLTrlGHQSEVRSVCFSND--SLAIGSGAGeSFKFWDRDAMQCLRTVP--TDYILCSKFVPGD 454
Cdd:cd00200 166 -----------TGKCVATLT--GHTGEVNSVAFSPDgeKLLSSSSDG-TIKLWDLSTGKCLGTLRghENGVNSVAFSPDG 231

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21357095 455 RYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW 511
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 780-884 1.54e-23

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 96.08  E-value: 1.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095   780 PEDFLV-STLMRIRASDLEEALLLLPFSTVCEVLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAKNMKPLLVKLL 858
Cdd:pfam04003   1 NDEYLLeSVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 21357095   859 SMLKRDVGQLRDVLGWNLHGLALLQT 884
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
36-225 2.59e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  36 GRYVAAPAAENVI-VWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVS 114
Cdd:COG2319 216 GKLLASGSADGTVrLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVN 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 115 ILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIV 194
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP---DGKTLASGSDDGTVRLWDLATGELLRTLT 369

                       170       180       190
                ....*....|....*....|....*....|...
gi 21357095 195 DNRTEVWALAFI--GNLMVAGAGESGMNVYRLR 225
Cdd:COG2319 370 GHTGAVTSVAFSpdGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-608 1.11e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 1.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 102 PICTLALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFlqrLVDESIVVSCSKDTQIKF 181
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 182 WNLETQFCFKTIVDNRTEVWALAFignlmvagagesgmnvyrlrkhdgaitetlesaveglsiddedtispisvsncgti 261
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAF-------------------------------------------------------- 101

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 262 qragkgrtvnlvtDPSERVISChgtndlienfyictpdevkkrlakrlkkekkvaedegsdeaklsteqSLSDeikrles 341
Cdd:cd00200 102 -------------SPDGRILSS-----------------------------------------------SSRD------- 114

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 342 irakQKIKSIDVVLGQnqelrvlvslannslCLYSLEasiktrkatdpsakllrsltrlGHQSEVRSVCFSNDSLAIGSG 421
Cdd:cd00200 115 ----KTIKVWDVETGK---------------CLTTLR----------------------GHTDWVNSVAFSPDGTFVASS 153

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 422 AGESF-KFWDRDAMQCLRTvptdyilcskfvpgdryvllgmksgkllivdvaaadiveeIPAHEGELWSIAILPDQKGCV 500
Cdd:cd00200 154 SQDGTiKLWDLRTGKCVAT----------------------------------------LTGHTGEVNSVAFSPDGEKLL 193

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 501 TGSGDTTVKIWtfeliDAGEGaAQTKVLSlLHkntlklEETVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGH 580
Cdd:cd00200 194 SSSSDGTIKLW-----DLSTG-KCLGTLR-GH------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH 260

                       490       500
                ....*....|....*....|....*...
gi 21357095 581 KLPVICLDISYDSNLIVTGSADRNVKVW 608
Cdd:cd00200 261 TNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-232 5.00e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 5.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  47 VIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVSILRYDLQGMRLV 126
Cdd:cd00200  33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE---CVRTLTGHTSYVSSVAFSPDGRILS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 127 SGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAF- 205
Cdd:cd00200 110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP---DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFs 186

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21357095 206 -IGNLMVAGAG---------ESGMNVYRLRKHDGAIT 232
Cdd:cd00200 187 pDGEKLLSSSSdgtiklwdlSTGKCLGTLRGHENGVN 223
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-232 1.05e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.05e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  47 VIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSdryYDPICTLALHKNAVSILRYDLQGMRLV 126
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET---GKCLTTLRGHTDWVNSVAFSPDGTFVA 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 127 SGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFI 206
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP---DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFS 228

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21357095 207 --GNLMVAGAGESGMNVYRLRK---------HDGAIT 232
Cdd:cd00200 229 pdGYLLASGSEDGTIRVWDLRTgecvqtlsgHTNSVT 265
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-214 1.10e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  47 VIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVSILRYDLQGMRLV 126
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK---CVATLTGHTGEVNSVAFSPDGEKLL 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 127 SGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLETQFCFKTIVDNRTEVWALAFI 206
Cdd:cd00200 194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP---DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                       170
                ....*....|
gi 21357095 207 --GNLMVAGA 214
Cdd:cd00200 271 pdGKRLASGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
36-186 1.56e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 1.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  36 GRYVAAPAAENVI-VWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPICTLALHKNAVS 114
Cdd:COG2319 258 GRLLASGSADGTVrLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK---LLRTLTGHTGAVR 334

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21357095 115 ILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWNLET 186
Cdd:COG2319 335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP---DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-183 1.76e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  26 VNFAVVDKTEGRYVAAPAAENVIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPICT 105
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGT 214

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21357095 106 LALHKNAVSILRYDLQGMRLVSGGLDTELVVVDVVEQAGRARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWN 183
Cdd:cd00200 215 LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP---DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 615-700 2.80e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 2.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 615 CHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFER 694
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80


                ....*.
gi 21357095 695 TDETIV 700
Cdd:cd00200  81 ETGECV 86
WD40 COG2319
WD40 repeat [General function prediction only];
546-696 1.11e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 1.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095 546 AVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVWGLNFGDCHRSIFAHDDS 625
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21357095 626 VMSVQFIPRTHMFFTCGKDGKVKQWDGDNFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFERTD 696
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-131 1.89e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 1.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  25 NVNFAVVDKTEGRYVAAPAAENVIVWDLRMGDRKLTLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFDLSSDRyydPIC 104
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE---CVQ 255

                        90       100
                ....*....|....*....|....*..
gi 21357095 105 TLALHKNAVSILRYDLQGMRLVSGGLD 131
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSAD 282
WD40 pfam00400
WD domain, G-beta repeat;
571-608 4.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 4.37e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357095   571 FKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVW 608
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 570-608 4.44e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.44e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21357095    570 TFKFYLSLYGHKLPVICLDISYDSNLIVTGSADRNVKVW 608
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 654-693 4.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.57e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21357095    654 NFEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 613-651 4.70e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.70e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21357095    613 GDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWD 651
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 464-611 3.67e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 3.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21357095  464 GKLLIVDVAAADIVEEIPAHEGELWSIAI-LPDQKGCVTGSGDTTVKIWTfelIDAGegaaqtkvlslLHKNTLKLEETV 542
Cdd:PLN00181 555 GVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWS---INQG-----------VSIGTIKTKANI 620

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21357095  543 LCLAVSPDM-KYLAVGLLDATVkvffldtfkFYLSLYGHKLPVICL-----DISY----DSNLIVTGSADRNVKVWGLN 611
Cdd:PLN00181 621 CCVQFPSESgRSLAFGSADHKV---------YYYDLRNPKLPLCTMighskTVSYvrfvDSSTLVSSSTDNTLKLWDLS 690
WD40 pfam00400
WD domain, G-beta repeat;
655-693 4.92e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21357095   655 FEKILTLPGHIGEAYCLSVSPNGRYLVTCGSDRTLRMFE 693
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
613-651 4.97e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.97e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 21357095   613 GDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVKQWD 651
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 477-511 2.01e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 21357095    477 VEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW 511
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
477-511 2.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 21357095   477 VEEIPAHEGELWSIAILPDQKGCVTGSGDTTVKIW 511
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-183 1.10e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21357095    146 ARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWN 183
Cdd:smart00320   6 KTLKGHTGPVTSVAFSP---DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-93 3.26e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 21357095     60 TLRREKFEVTSLRVSPDHLHIAVGYADGMVQIFD 93
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
146-183 5.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 21357095   146 ARLSGHNAAITDAHFLQrlvDESIVVSCSKDTQIKFWN 183
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP---DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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