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Conserved domains on  [gi|24647411|ref|NP_650535|]
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uncharacterized protein Dmel_CG14879, isoform B [Drosophila melanogaster]

Protein Classification

GLECT domain-containing protein( domain architecture ID 10448425)

GLECT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 21-138 1.13e-22

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


:

Pssm-ID: 459768  Cd Length: 124  Bit Score: 86.54  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWsslHQE--KYLNIFDE-SSFCLEFAFD 97
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQW---GQEerEGGFPFQPgQPFELTILVG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24647411    98 yaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 138
Cdd:pfam00337  85 --DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 21-138 1.13e-22

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 86.54  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWsslHQE--KYLNIFDE-SSFCLEFAFD 97
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQW---GQEerEGGFPFQPgQPFELTILVG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24647411    98 yaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 138
Cdd:pfam00337  85 --DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-138 1.95e-18

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 75.71  E-value: 1.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411     22 RLSISGNLLQDPQQFSVNFVNSPDctDNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDESSFCLEFAFDYANS 101
Cdd:smart00908   9 SITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELEILVEEDEF 86

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 24647411    102 MMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 138
Cdd:smart00908  87 KVAV------NGQHFLEFPHRLPLESIDTLEISGDVQ 117
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 22-138 1.74e-10

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 54.95  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411  22 RLSISGNLLQDPQQFSVNFVNSPDctdNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDESSFCLEFAFDYANS 101
Cdd:cd00070  15 TLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPGQPFELTILVEEDKF 91

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24647411 102 MMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 138
Cdd:cd00070  92 QIFV------NGQHFFSFPHRLPLESIDYLSINGDVS 122
 
Name Accession Description Interval E-value
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 21-138 1.13e-22

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 86.54  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411    21 TRLSISGNLLQDPQQFSVNFVNSPDCTDNITYHFKVVIPTQTIIENYKRNGEWsslHQE--KYLNIFDE-SSFCLEFAFD 97
Cdd:pfam00337   8 SSLTIKGIVLPDAQRFSINLQTGVGPSDDIALHFNPRFDENVIVRNSRQNGQW---GQEerEGGFPFQPgQPFELTILVG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24647411    98 yaNSMMRVYQGRDSGHNFITEyetlFSLSDIQAVQVWGDVQ 138
Cdd:pfam00337  85 --DDHFKIYVNGQHFTTFKHR----LPPEDIDALQVRGDVK 119
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 22-138 1.95e-18

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 75.71  E-value: 1.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411     22 RLSISGNLLQDPQQFSVNFVNSPDctDNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDESSFCLEFAFDYANS 101
Cdd:smart00908   9 SITIRGIVLPDAKRFSINLQCGPN--ADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELEILVEEDEF 86

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 24647411    102 MMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 138
Cdd:smart00908  87 KVAV------NGQHFLEFPHRLPLESIDTLEISGDVQ 117
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 22-138 1.74e-10

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 54.95  E-value: 1.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411  22 RLSISGNLLQDPQQFSVNFVNSPDctdNITYHFKVVIPTQTIIENYKRNGEWSSLHQEKYLNIFDESSFCLEFAFDYANS 101
Cdd:cd00070  15 TLTVKGRVLPNAKRFSINLGTGSS---DIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPGQPFELTILVEEDKF 91

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24647411 102 MMRVyqgrdsGHNFITEYETLFSLSDIQAVQVWGDVQ 138
Cdd:cd00070  92 QIFV------NGQHFFSFPHRLPLESIDYLSINGDVS 122
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 21-138 2.89e-05

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 41.06  E-value: 2.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647411     21 TRLSISGNLLQDPQQFSVNFVNSPdctDNITYHFKVVIPTQTIIENYKRNGEWSS--------LHQEKYLNI---FDESS 89
Cdd:smart00276  13 QTLTVRGIVLPDAKRFSINLLTGG---DDIALHFNPRFNENKIVCNSKLNGSWGSeereggfpFQPGQPFDLtiiVQPDH 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 24647411     90 FclEFAFDYAnsmmrvyqgrdsghnFITEYETLFSLSDIQAVQVWGDVQ 138
Cdd:smart00276  90 F--QIFVNGV---------------HITTFPHRLPLESIDYLSINGDVQ 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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