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Conserved domains on  [gi|62484300|ref|NP_650530|]
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maternal transcript 89Ba [Drosophila melanogaster]

Protein Classification

nucleolar RNA-associated family protein( domain architecture ID 13691717)

nucleolar RNA-associated protein (NRAP) family protein such as nucleolar protein 6 (NOL6) that is involved in RNA binding, localization, and ribosome biogenesis; it interacts with pre-rRNA primary transcripts to facilitate ribosome assembly within the nucleolus

CATH:  3.30.460.10|3.30.70.3030
Gene Ontology:  GO:0003723|GO:0042255|GO:0005730|GO:0032040
PubMed:  11895476
SCOP:  4004203|4005371|4005372|4005373|4005375|4005376

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 654-842 1.64e-46

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465418  Cd Length: 201  Bit Score: 165.47  E-value: 1.64e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    654 NKLKTKLPLGQDTDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIFRYCEPQPVLPQALLVenrilASSIQRV 733
Cdd:pfam17405    3 DSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA-----YSPPIDV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    734 VIQLGQSGKWPTELGALRALKTAFLIEIGEKLEAQCRL-----------HWVMSADGLLVLK-QGYCFLIELAHNKELAL 801
Cdd:pfam17405   78 VLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLYpSGYVFRLRIHHDREETL 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 62484300    802 LKQEVTERGITTYIDNAASRSL---ERQHYILPKVSGALHSLHQ 842
Cdd:pfam17405  158 LERQLKDKGLARYQREEAAEALakyKRRFIHLPRHTQAIQTLCT 201
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 844-1003 1.99e-46

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465419  Cd Length: 157  Bit Score: 163.50  E-value: 1.99e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    844 YSAFGSTVLLAKRWLATQLLDdGLWPDMATELLVAHLFQQRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQ 923
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLL-GHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    924 EQQIADLEHNYRSNRQSYP-----PLAVATSYDmqHAGRLWTSdQSPSQRVLGHVTRLARHALEIIETSLMSKDLRfvrp 998
Cdd:pfam17406   80 AEDIKEIETRFEAWRKSDPamnhtALFVATPYD--PSGSAWTR-RGPSKVVAARLTALAKAALKLLEEQGGGLDVK---- 152


                   ....*
gi 62484300    999 aQLFR 1003
Cdd:pfam17406  153 -SLFR 156
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-461 4.48e-46

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 162.39  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    323 NFQDGLLLLKVWLRQRQLD-IGYSGFGAHILAAFIVYL------NTQRILHQSSSSYQVARTVWNQLANTDWTK-GISL- 393
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKkPIFFk 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    394 SVAPIQTEELNKFAEHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQK 461
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 177-320 8.83e-43

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


:

Pssm-ID: 461061  Cd Length: 144  Bit Score: 152.73  E-value: 8.83e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    177 VDVALEMPKESLHKEDYLNLRYDQKRALYLTYVTERMMESPDYA-EDQFNFNYYANNPLKPVLELIPV---TKQVNKHLQ 252
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdLLKVSFSYLNGDPLKPILVLRPKkteGKFSKSKFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    253 VRLFITAPLSSFKPGRFVPWNNNIRPSFYgdewDEKDPLPSTQHYNANVLFDLTLSENQAQLDKAFKS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPATD----SEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 464-619 2.73e-42

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465417  Cd Length: 159  Bit Score: 152.03  E-value: 2.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    464 LYSRVDNILKISNysCINQMLTLHSHPRIKYDFANYgYPQLLHLLTELLKKGLAERVHSIlPLETATAAWPVEKKAP--V 541
Cdd:pfam17404    1 PLLRFDLVLRIPL--PLSASLLSKFGPLEKIDFIGF-ENALLRKLYSLLKRALGDRAKLI-HIQLPSPSWSISKRKPspA 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    542 IGKYIQLGLILQPEHAYQVLNKGPAAnDDHEGAEEFRRFWGEKSNLRRFQDGSITEAVVWGTAQDSPakkRLIVRQIV 619
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSA-EDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE---RLIVEQIV 150
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 1007-1130 5.59e-27

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


:

Pssm-ID: 465420  Cd Length: 128  Bit Score: 107.01  E-value: 5.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300   1007 EGYDLVIQFKPDLVPNSLSYDLGSPFVSF----SQPNFSLPRAGSDYIARIVGLLRSAYSDFAAFFYNPHGGKELGIVWR 1082
Cdd:pfam17407    2 EDYDFVIHLKPKALPRLSSAPGILSKSKFknldLRLTSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIGGLWN 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 62484300   1083 pPTEFAAKPFKVTELQACSPCGNKKVQVLKETLLEDFKLLLKDFYLRI 1130
Cdd:pfam17407   82 -PAVLKPRKFKVNLGYNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 654-842 1.64e-46

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 165.47  E-value: 1.64e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    654 NKLKTKLPLGQDTDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIFRYCEPQPVLPQALLVenrilASSIQRV 733
Cdd:pfam17405    3 DSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA-----YSPPIDV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    734 VIQLGQSGKWPTELGALRALKTAFLIEIGEKLEAQCRL-----------HWVMSADGLLVLK-QGYCFLIELAHNKELAL 801
Cdd:pfam17405   78 VLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLYpSGYVFRLRIHHDREETL 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 62484300    802 LKQEVTERGITTYIDNAASRSL---ERQHYILPKVSGALHSLHQ 842
Cdd:pfam17405  158 LERQLKDKGLARYQREEAAEALakyKRRFIHLPRHTQAIQTLCT 201
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 844-1003 1.99e-46

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 163.50  E-value: 1.99e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    844 YSAFGSTVLLAKRWLATQLLDdGLWPDMATELLVAHLFQQRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQ 923
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLL-GHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    924 EQQIADLEHNYRSNRQSYP-----PLAVATSYDmqHAGRLWTSdQSPSQRVLGHVTRLARHALEIIETSLMSKDLRfvrp 998
Cdd:pfam17406   80 AEDIKEIETRFEAWRKSDPamnhtALFVATPYD--PSGSAWTR-RGPSKVVAARLTALAKAALKLLEEQGGGLDVK---- 152


                   ....*
gi 62484300    999 aQLFR 1003
Cdd:pfam17406  153 -SLFR 156
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-461 4.48e-46

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 162.39  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    323 NFQDGLLLLKVWLRQRQLD-IGYSGFGAHILAAFIVYL------NTQRILHQSSSSYQVARTVWNQLANTDWTK-GISL- 393
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKkPIFFk 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    394 SVAPIQTEELNKFAEHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQK 461
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 177-320 8.83e-43

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 152.73  E-value: 8.83e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    177 VDVALEMPKESLHKEDYLNLRYDQKRALYLTYVTERMMESPDYA-EDQFNFNYYANNPLKPVLELIPV---TKQVNKHLQ 252
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdLLKVSFSYLNGDPLKPILVLRPKkteGKFSKSKFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    253 VRLFITAPLSSFKPGRFVPWNNNIRPSFYgdewDEKDPLPSTQHYNANVLFDLTLSENQAQLDKAFKS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPATD----SEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 464-619 2.73e-42

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 152.03  E-value: 2.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    464 LYSRVDNILKISNysCINQMLTLHSHPRIKYDFANYgYPQLLHLLTELLKKGLAERVHSIlPLETATAAWPVEKKAP--V 541
Cdd:pfam17404    1 PLLRFDLVLRIPL--PLSASLLSKFGPLEKIDFIGF-ENALLRKLYSLLKRALGDRAKLI-HIQLPSPSWSISKRKPspA 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    542 IGKYIQLGLILQPEHAYQVLNKGPAAnDDHEGAEEFRRFWGEKSNLRRFQDGSITEAVVWGTAQDSPakkRLIVRQIV 619
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSA-EDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE---RLIVEQIV 150
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 1007-1130 5.59e-27

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 107.01  E-value: 5.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300   1007 EGYDLVIQFKPDLVPNSLSYDLGSPFVSF----SQPNFSLPRAGSDYIARIVGLLRSAYSDFAAFFYNPHGGKELGIVWR 1082
Cdd:pfam17407    2 EDYDFVIHLKPKALPRLSSAPGILSKSKFknldLRLTSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIGGLWN 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 62484300   1083 pPTEFAAKPFKVTELQACSPCGNKKVQVLKETLLEDFKLLLKDFYLRI 1130
Cdd:pfam17407   82 -PAVLKPRKFKVNLGYNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Name Accession Description Interval E-value
Nrap_D4 pfam17405
Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar ...
 654-842 1.64e-46

Nrap protein nucleotidyltransferase domain 4; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465418  Cd Length: 201  Bit Score: 165.47  E-value: 1.64e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    654 NKLKTKLPLGQDTDAEALSPHVIRCYDELARQLHGLNDLPLEIVSISGVSPIFRYCEPQPVLPQALLVenrilASSIQRV 733
Cdd:pfam17405    3 DSLLPPSSSEQSVTSEESFLAVMKAFDELEKDLRSLEDLPLSIRSVQPASPALRYTSVFPPVPFPLAA-----YSPPIDV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    734 VIQLGQSGKWPTELGALRALKTAFLIEIGEKLEAQCRL-----------HWVMSADGLLVLK-QGYCFLIELAHNKELAL 801
Cdd:pfam17405   78 VLQFESSGKWPDDLEAIQRTKTAFLLKIAELLESKNSGykarvgldnsiPPILNQAFLDVLYpSGYVFRLRIHHDREETL 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 62484300    802 LKQEVTERGITTYIDNAASRSL---ERQHYILPKVSGALHSLHQ 842
Cdd:pfam17405  158 LERQLKDKGLARYQREEAAEALakyKRRFIHLPRHTQAIQTLCT 201
Nrap_D5 pfam17406
Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated ...
 844-1003 1.99e-46

Nrap protein PAP/OAS1-like domain 5; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465419  Cd Length: 157  Bit Score: 163.50  E-value: 1.99e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    844 YSAFGSTVLLAKRWLATQLLDdGLWPDMATELLVAHLFQQRYAPQSIAAPQTGFIRFLQLLSHSDFNGELFLLNFNNSWQ 923
Cdd:pfam17406    1 FPAYSPTVRLAKRWLASHLLL-GHVSEELVELLVASVFLQPAPWSPPSSPETGFLRFLHLLSTWDWREEPLIVDLNNSLT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    924 EQQIADLEHNYRSNRQSYP-----PLAVATSYDmqHAGRLWTSdQSPSQRVLGHVTRLARHALEIIETSLMSKDLRfvrp 998
Cdd:pfam17406   80 AEDIKEIETRFEAWRKSDPamnhtALFVATPYD--PSGSAWTR-RGPSKVVAARLTALAKAALKLLEEQGGGLDVK---- 152


                   ....*
gi 62484300    999 aQLFR 1003
Cdd:pfam17406  153 -SLFR 156
Nrap_D2 pfam17403
Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins ...
 323-461 4.48e-46

Nrap protein PAP/OAS-like domain; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465416 [Multi-domain]  Cd Length: 148  Bit Score: 162.39  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    323 NFQDGLLLLKVWLRQRQLD-IGYSGFGAHILAAFIVYL------NTQRILHQSSSSYQVARTVWNQLANTDWTK-GISL- 393
Cdd:pfam17403    1 AFKDACILLKVWLRQRGFGsSSKGGFGGFEWAMLLALLlqgggpNGNKKLSKGMSSYQLFKATLQFLATTDLTKkPIFFk 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    394 SVAPIQTEELNKFAEHYDVCFIDFTGQHNLCANIPLYLYQRVREEAKLAVELLNDMKLNSFPLIFMQK 461
Cdd:pfam17403   81 SDSDSKYPSEEEFHQHFDPVFVDPSGGLNLLAKMTPSSYQLLRHEAKLTLELLNDSSVDGFDPLFLTK 148
Nrap pfam03813
Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 177-320 8.83e-43

Nrap protein domain 1; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.


Pssm-ID: 461061  Cd Length: 144  Bit Score: 152.73  E-value: 8.83e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    177 VDVALEMPKESLHKEDYLNLRYDQKRALYLTYVTERMMESPDYA-EDQFNFNYYANNPLKPVLELIPV---TKQVNKHLQ 252
Cdd:pfam03813    1 VDLAVEMPKSLFQEKDYLNYRYFYKRAYYLAYLAAHLSKSLKKDdLLKVSFSYLNGDPLKPILVLRPKkteGKFSKSKFT 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    253 VRLFITAPLSSFKPGRFVPWNNNIRPSFYgdewDEKDPLPSTQHYNANVLFDLTLSENQAQLDKAFKS 320
Cdd:pfam03813   81 IRIIPCAPSGLFPLSKLLPSKNNIRPATD----SEETTLPPTPFYNSSILSDLTLLAYLKLLHKTKKS 144
Nrap_D3 pfam17404
Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 464-619 2.73e-42

Nrap protein domain 3; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465417  Cd Length: 159  Bit Score: 152.03  E-value: 2.73e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300    464 LYSRVDNILKISNysCINQMLTLHSHPRIKYDFANYgYPQLLHLLTELLKKGLAERVHSIlPLETATAAWPVEKKAP--V 541
Cdd:pfam17404    1 PLLRFDLVLRIPL--PLSASLLSKFGPLEKIDFIGF-ENALLRKLYSLLKRALGDRAKLI-HIQLPSPSWSISKRKPspA 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62484300    542 IGKYIQLGLILQPEHAYQVLNKGPAAnDDHEGAEEFRRFWGEKSNLRRFQDGSITEAVVWGTAQDSPakkRLIVRQIV 619
Cdd:pfam17404   77 NPSSILIGLLLNPENAFRLVDHGPSA-EDKEEAAEFREFWGEKAELRRFKDGSILESVVWESSSSSE---RLIVEQIV 150
Nrap_D6 pfam17407
Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) ...
 1007-1130 5.59e-27

Nrap protein domain 6; Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localized in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript.


Pssm-ID: 465420  Cd Length: 128  Bit Score: 107.01  E-value: 5.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62484300   1007 EGYDLVIQFKPDLVPNSLSYDLGSPFVSF----SQPNFSLPRAGSDYIARIVGLLRSAYSDFAAFFYNPHGGKELGIVWR 1082
Cdd:pfam17407    2 EDYDFVIHLKPKALPRLSSAPGILSKSKFknldLRLTSDKLRVGFDPVQLLVRELNRKYGDTILFFYDKYGGNVIGGLWN 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 62484300   1083 pPTEFAAKPFKVTELQACSPCGNKKVQVLKETLLEDFKLLLKDFYLRI 1130
Cdd:pfam17407   82 -PAVLKPRKFKVNLGYNTKPVDKKEVVLNKEAILEEIARLGGDLVKSI 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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