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Conserved domains on  [gi|21355417|ref|NP_650462|]
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heineken-cup [Drosophila melanogaster]

Protein Classification

bMERB family protein( domain architecture ID 581919)

bMERB (bivalent Mical/EHBP Rab binding) family protein is a DUF3585 domain-containing protein; similar to Homo sapiens bMERB domain-containing protein 1 and Schistosoma mansoni circulating cathodic antigen

Gene Ontology:  GO:0032482|GO:0031267
PubMed:  27552051

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SIKE super family cl47935
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 12-173 1.49e-27

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


The actual alignment was detected with superfamily member pfam05769:

Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 104.27  E-value: 1.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    12 GLIKEYKDFAKCLDELEFKTDELLIDAKMVDQELANCHKFREDqlLKHLTE-------------KNDDDEQ-MQLLRENI 77
Cdd:pfam05769   6 QILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEE--LKELNEaakhrphslliagIQQENRQiRELQQENR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    78 ELKATGVEFQHGIELIMEKYREHSEGDMLIDTYQLREHYLA-GLSKVVEEQDARIERMVDVMKLTVDFEDRSSAENQQII 156
Cdd:pfam05769  84 ELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSlQLSEEVEQQAEKIEEMAAVMRKAIEVDEENSQKEQEII 163

                         170
                  ....*....|....*..
gi 21355417   157 CQLTDENEQLRRQLQIS 173
Cdd:pfam05769 164 AQLETENKGLRELLQIS 180
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 12-173 1.49e-27

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 104.27  E-value: 1.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    12 GLIKEYKDFAKCLDELEFKTDELLIDAKMVDQELANCHKFREDqlLKHLTE-------------KNDDDEQ-MQLLRENI 77
Cdd:pfam05769   6 QILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEE--LKELNEaakhrphslliagIQQENRQiRELQQENR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    78 ELKATGVEFQHGIELIMEKYREHSEGDMLIDTYQLREHYLA-GLSKVVEEQDARIERMVDVMKLTVDFEDRSSAENQQII 156
Cdd:pfam05769  84 ELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSlQLSEEVEQQAEKIEEMAAVMRKAIEVDEENSQKEQEII 163

                         170
                  ....*....|....*..
gi 21355417   157 CQLTDENEQLRRQLQIS 173
Cdd:pfam05769 164 AQLETENKGLRELLQIS 180
 
Name Accession Description Interval E-value
SIKE pfam05769
SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) ...
 12-173 1.49e-27

SIKE family; This family consists of several eukaryotic proteins. Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1, which are two IKK-related kinases involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke), and FGFR1 oncogene partner 2, which may be involved in wound healing pathway.


Pssm-ID: 461735 [Multi-domain]  Cd Length: 180  Bit Score: 104.27  E-value: 1.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    12 GLIKEYKDFAKCLDELEFKTDELLIDAKMVDQELANCHKFREDqlLKHLTE-------------KNDDDEQ-MQLLRENI 77
Cdd:pfam05769   6 QILADAKRLVGRLKEHDTAADSLIEQAQALNKKIEAMKQYQEE--LKELNEaakhrphslliagIQQENRQiRELQQENR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355417    78 ELKATGVEFQHGIELIMEKYREHSEGDMLIDTYQLREHYLA-GLSKVVEEQDARIERMVDVMKLTVDFEDRSSAENQQII 156
Cdd:pfam05769  84 ELRASLEEHQSALELIMSKYREQVLQLLLASKFNFTDAYLSlQLSEEVEQQAEKIEEMAAVMRKAIEVDEENSQKEQEII 163

                         170
                  ....*....|....*..
gi 21355417   157 CQLTDENEQLRRQLQIS 173
Cdd:pfam05769 164 AQLETENKGLRELLQIS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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