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Conserved domains on  [gi|24646857|ref|NP_650374|]
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uncharacterized protein Dmel_CG8066, isoform A [Drosophila melanogaster]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
SCOP:  4001013

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
6-93 1.23e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 45.88  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857      6 IVGGISQLEGNErKEALELLDATLAQLANGDGPSYK--ALNVTSVTGQVVAGRLNTYEVQLDNGSEIKQG---------- 73
Cdd:smart00043   2 CLGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlencpfld 80
                           90       100
                   ....*....|....*....|....*.
gi 24646857     74 ------TVQIWSRAWLkENGTNIKIK 93
Cdd:smart00043  81 qgekfcTAKVWEKPWE-NKIKLVEFK 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
6-93 1.23e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.88  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857      6 IVGGISQLEGNErKEALELLDATLAQLANGDGPSYK--ALNVTSVTGQVVAGRLNTYEVQLDNGSEIKQG---------- 73
Cdd:smart00043   2 CLGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlencpfld 80
                           90       100
                   ....*....|....*....|....*.
gi 24646857     74 ------TVQIWSRAWLkENGTNIKIK 93
Cdd:smart00043  81 qgekfcTAKVWEKPWE-NKIKLVEFK 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
8-93 1.26e-07

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 45.40  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857     8 GGISQLEGNErKEALELLDATLAQLANG-DGPSYKALNVTSVTGQVVAGrLNTY-EVQLDNGSEIKQGTVQ---IW-SRA 81
Cdd:pfam00031   1 GGLSPIPDNS-PELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAG-TNYFiKVEVGETDCSKSKKLLedcPLlDEK 78
                          90
                  ....*....|..
gi 24646857    82 WLKENGTNIKIK 93
Cdd:pfam00031  79 WLGLCSAQVYKV 90
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
8-84 3.25e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 36.68  E-value: 3.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857   8 GGISQLEGNErKEALELLDATLAQLANGDGPSY-KALNVTSVTGQVVAGRLNTYEVQLDNGS------------------ 68
Cdd:cd00042   1 GGPSDIPAND-PEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTNckkssvpldcpdckllee 79
                        90
                ....*....|....*..
gi 24646857  69 -EIKQGTVQIWSRAWLK 84
Cdd:cd00042  80 gKKKFCTAKVWEKPWEN 96
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
6-93 1.23e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 45.88  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857      6 IVGGISQLEGNErKEALELLDATLAQLANGDGPSYK--ALNVTSVTGQVVAGRLNTYEVQLDNGSEIKQG---------- 73
Cdd:smart00043   2 CLGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlencpfld 80
                           90       100
                   ....*....|....*....|....*.
gi 24646857     74 ------TVQIWSRAWLkENGTNIKIK 93
Cdd:smart00043  81 qgekfcTAKVWEKPWE-NKIKLVEFK 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
8-93 1.26e-07

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 45.40  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857     8 GGISQLEGNErKEALELLDATLAQLANG-DGPSYKALNVTSVTGQVVAGrLNTY-EVQLDNGSEIKQGTVQ---IW-SRA 81
Cdd:pfam00031   1 GGLSPIPDNS-PELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAG-TNYFiKVEVGETDCSKSKKLLedcPLlDEK 78
                          90
                  ....*....|..
gi 24646857    82 WLKENGTNIKIK 93
Cdd:pfam00031  79 WLGLCSAQVYKV 90
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
8-84 3.25e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 36.68  E-value: 3.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646857   8 GGISQLEGNErKEALELLDATLAQLANGDGPSY-KALNVTSVTGQVVAGRLNTYEVQLDNGS------------------ 68
Cdd:cd00042   1 GGPSDIPAND-PEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTNckkssvpldcpdckllee 79
                        90
                ....*....|....*..
gi 24646857  69 -EIKQGTVQIWSRAWLK 84
Cdd:cd00042  80 gKKKFCTAKVWEKPWEN 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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