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Conserved domains on  [gi|24646797|ref|NP_650353|]
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intraflagellar transport 54 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP-T3_C pfam17749
Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both ...
 444-588 5.33e-52

Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


:

Pssm-ID: 465481 [Multi-domain]  Cd Length: 154  Bit Score: 175.33  E-value: 5.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   444 GQLDAQGRLVQQILETQKELVNQGAEVEPPP---------AQAGRQTSARQVNDVRDVVQKLTKSIGPLGKLLDCIPEDF 514
Cdd:pfam17749   1 EDEDAQGGLVKKILETKKEYEKGGAEAEPGEsdrslqessAKKGRTVSASDINQLRESIQTLTKSANPLGKLLDFIQDDI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24646797   515 DAMQLELTMWRDTYTQASTELKREQTLTASATEPLQHQLQQIQASIAEYRELIDESRHKILQNNARILKLMMEQ 588
Cdd:pfam17749  81 DSMQRELQMWRSEYRQNAQALQNEQRATDEALQPLYAQLAELEEAIKDQKEKISNVKAQILKNEARIQKMVKSI 154
MIP-T3 super family cl25761
Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both ...
 9-119 3.56e-35

Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


The actual alignment was detected with superfamily member pfam10243:

Pssm-ID: 463020  Cd Length: 113  Bit Score: 128.33  E-value: 3.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797     9 IILETQKVLGKYIKKPPLTEKLLKKPPFRFLMDVFSNFIKQSGTFDGLYTPEEQMFENITSREDKIRFLQKMIDATKLTT 88
Cdd:pfam10243   1 FVEPTQELLGAVIQKPKLTEKLLSKPPFKYIHDIIMETIKATGFPKGLYTDDELDSNNVNDKDAKIAFLQKLIDLVEMGS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24646797    89 KLDLKVRTSKIVAGQEPELTNELLQAMASVA 119
Cdd:pfam10243  81 GKPVAAKPAKIVAGLEPEKTNELLQMLGRCA 111
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 146-395 5.03e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   146 PPKETKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDE----TKLSRQNSKQ 221
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPPPP 2705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   222 KSPSPVKQK--SKAKLQPSTESDNLSQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAE--- 296
Cdd:PHA03247 2706 PTPEPAPHAlvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRltr 2785

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   297 -PESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEA-----KREVPLTRENSKEVNQRPRTSLR 370
Cdd:PHA03247 2786 pAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTappppPGPPPPSLPLGGSVAPGGDVRRR 2865

                         250       260
                  ....*....|....*....|....*
gi 24646797   371 PPSaRPASARPGAPRRRNVEIVLQP 395
Cdd:PHA03247 2866 PPS-RSPAAKPAAPARPPVRRLARP 2889
 
Name Accession Description Interval E-value
MIP-T3_C pfam17749
Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both ...
 444-588 5.33e-52

Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


Pssm-ID: 465481 [Multi-domain]  Cd Length: 154  Bit Score: 175.33  E-value: 5.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   444 GQLDAQGRLVQQILETQKELVNQGAEVEPPP---------AQAGRQTSARQVNDVRDVVQKLTKSIGPLGKLLDCIPEDF 514
Cdd:pfam17749   1 EDEDAQGGLVKKILETKKEYEKGGAEAEPGEsdrslqessAKKGRTVSASDINQLRESIQTLTKSANPLGKLLDFIQDDI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24646797   515 DAMQLELTMWRDTYTQASTELKREQTLTASATEPLQHQLQQIQASIAEYRELIDESRHKILQNNARILKLMMEQ 588
Cdd:pfam17749  81 DSMQRELQMWRSEYRQNAQALQNEQRATDEALQPLYAQLAELEEAIKDQKEKISNVKAQILKNEARIQKMVKSI 154
MIP-T3 pfam10243
Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both ...
 9-119 3.56e-35

Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


Pssm-ID: 463020  Cd Length: 113  Bit Score: 128.33  E-value: 3.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797     9 IILETQKVLGKYIKKPPLTEKLLKKPPFRFLMDVFSNFIKQSGTFDGLYTPEEQMFENITSREDKIRFLQKMIDATKLTT 88
Cdd:pfam10243   1 FVEPTQELLGAVIQKPKLTEKLLSKPPFKYIHDIIMETIKATGFPKGLYTDDELDSNNVNDKDAKIAFLQKLIDLVEMGS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24646797    89 KLDLKVRTSKIVAGQEPELTNELLQAMASVA 119
Cdd:pfam10243  81 GKPVAAKPAKIVAGLEPEKTNELLQMLGRCA 111
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-395 5.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   146 PPKETKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDE----TKLSRQNSKQ 221
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPPPP 2705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   222 KSPSPVKQK--SKAKLQPSTESDNLSQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAE--- 296
Cdd:PHA03247 2706 PTPEPAPHAlvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRltr 2785

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   297 -PESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEA-----KREVPLTRENSKEVNQRPRTSLR 370
Cdd:PHA03247 2786 pAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTappppPGPPPPSLPLGGSVAPGGDVRRR 2865

                         250       260
                  ....*....|....*....|....*
gi 24646797   371 PPSaRPASARPGAPRRRNVEIVLQP 395
Cdd:PHA03247 2866 PPS-RSPAAKPAAPARPPVRRLARP 2889
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 66-342 4.42e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   66 NITSREDKIRFLQKMIDATKLTTKLDLKVRTSKIVAGQE-PELTNELLQAMASVAEKNLEWDSIVDQVVISHSKTPLTLT 144
Cdd:NF033838 198 KEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEaKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  145 KPPKETKNSSKN------PSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPP----------TEKD-KASQKKSKA 207
Cdd:NF033838 278 KKENDAKSSDSSvgeetlPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYPTntyktleleiAESDvKVKEAELEL 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  208 PKDETKLSRQNSKQKSPspvKQKSKAKLQPSTESDNLSQSMSPVEEGST-----------KPAASESAPSKPEPEMVPPL 276
Cdd:NF033838 358 VKEEAKEPRNEEKIKQA---KAKVESKKAEATRLEKIKTDRKKAEEEAKrkaaeedkvkeKPAEQPQPAPAPQPEKPAPK 434

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24646797  277 KEKEAvVRPVQETPTAPPAEPESRKSSSRsrrssgshrqpEPNPIPNesQSQPAVQSSETSSPPET 342
Cdd:NF033838 435 PEKPA-EQPKAEKPADQQAEEDYARRSEE-----------EYNRLTQ--QQPPKTEKPAQPSTPKT 486
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 142-398 5.61e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   142 TLTKPPKETKNSSknPSPAgkdEDAKRRKEKRISPQEQKLR----KVKEQ-VSRSTPPTEKDKAS-------QKKSKAPK 209
Cdd:pfam03154  61 SMKKSSKKIKEEA--PSPL---KSAKRQREKGASDTEEPERatakKSKTQeISRPNSPSEGEGESsdgrsvnDEGSSDPK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   210 DETKLSR---------QNSKQKSPSPVKQKSKAKLQPSTESDNlsQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKE 280
Cdd:pfam03154 136 DIDQDNRstspsipspQDNESDSDSSAQQQILQTQPPVLQAQS--GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   281 AVVRPVQETPTAPP-------AEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEAKREVPL 353
Cdd:pfam03154 214 TSQPPNQTQSTAAPhtliqqtPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV 293

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 24646797   354 TRENSKEVNQRPRTSLRPPsarPASARPGAPRRRNVEIVLQPNDQ 398
Cdd:pfam03154 294 PPQPFPLTPQSSQSQVPPG---PSPAAPGQSQQRIHTPPSQSQLQ 335
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 148-395 6.04e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.37  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  148 KETKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDETKLSRQNSKqKSPSPV 227
Cdd:NF033839 235 KELDELKKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEK-KEVKPE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  228 KQKSKAKLQPSTESdnlsQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQET--PTAPPAEPESRKSSSR 305
Cdd:NF033839 314 PETPKPEVKPQLEK----PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQPEKpkPEVKPQPETPKPEVKP 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  306 SRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAPR 385
Cdd:NF033839 390 QPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPE 469

                        250
                 ....*....|
gi 24646797  386 RRNVEIVLQP 395
Cdd:NF033839 470 KPKPEVKPQP 479
 
Name Accession Description Interval E-value
MIP-T3_C pfam17749
Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both ...
 444-588 5.33e-52

Microtubule-binding protein MIP-T3 C-terminal region; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


Pssm-ID: 465481 [Multi-domain]  Cd Length: 154  Bit Score: 175.33  E-value: 5.33e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   444 GQLDAQGRLVQQILETQKELVNQGAEVEPPP---------AQAGRQTSARQVNDVRDVVQKLTKSIGPLGKLLDCIPEDF 514
Cdd:pfam17749   1 EDEDAQGGLVKKILETKKEYEKGGAEAEPGEsdrslqessAKKGRTVSASDINQLRESIQTLTKSANPLGKLLDFIQDDI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24646797   515 DAMQLELTMWRDTYTQASTELKREQTLTASATEPLQHQLQQIQASIAEYRELIDESRHKILQNNARILKLMMEQ 588
Cdd:pfam17749  81 DSMQRELQMWRSEYRQNAQALQNEQRATDEALQPLYAQLAELEEAIKDQKEKISNVKAQILKNEARIQKMVKSI 154
MIP-T3 pfam10243
Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both ...
 9-119 3.56e-35

Microtubule-binding protein MIP-T3 CH-like domain; This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.


Pssm-ID: 463020  Cd Length: 113  Bit Score: 128.33  E-value: 3.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797     9 IILETQKVLGKYIKKPPLTEKLLKKPPFRFLMDVFSNFIKQSGTFDGLYTPEEQMFENITSREDKIRFLQKMIDATKLTT 88
Cdd:pfam10243   1 FVEPTQELLGAVIQKPKLTEKLLSKPPFKYIHDIIMETIKATGFPKGLYTDDELDSNNVNDKDAKIAFLQKLIDLVEMGS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 24646797    89 KLDLKVRTSKIVAGQEPELTNELLQAMASVA 119
Cdd:pfam10243  81 GKPVAAKPAKIVAGLEPEKTNELLQMLGRCA 111
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-395 5.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   146 PPKETKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDE----TKLSRQNSKQ 221
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPPPP 2705

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   222 KSPSPVKQK--SKAKLQPSTESDNLSQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAE--- 296
Cdd:PHA03247 2706 PTPEPAPHAlvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRltr 2785

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   297 -PESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEA-----KREVPLTRENSKEVNQRPRTSLR 370
Cdd:PHA03247 2786 pAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTappppPGPPPPSLPLGGSVAPGGDVRRR 2865

                         250       260
                  ....*....|....*....|....*
gi 24646797   371 PPSaRPASARPGAPRRRNVEIVLQP 395
Cdd:PHA03247 2866 PPS-RSPAAKPAAPARPPVRRLARP 2889
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 191-385 9.96e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 9.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   191 STPPTEKDKASQKKSKAPKDETKLSRQNSKQKSPSPVKQKSKAKLQPSTESDNLSQsmspveEGSTKPAASESAPSKPEP 270
Cdd:PHA03307  187 SSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSS------ESSGCGWGPENECPLPRP 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   271 EMVPPLKEKEAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEAKRE 350
Cdd:PHA03307  261 APITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA 340

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 24646797   351 VPLTRENSkevnqRPRTSLRPPSARPASARPGAPR 385
Cdd:PHA03307  341 VSPGPSPS-----RSPSPSRPPPPADPSSPRKRPR 370
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 138-384 7.29e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.84  E-value: 7.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  138 KTPLTLTKPPKETKNSSKNPSPAGKDEDAKRRKEKRiSPQEQKLRKV-------KEQVSRSTPPTEKDKASQKKSKAPKD 210
Cdd:PTZ00449 512 EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGG-KPGETKEGEVgkkpgpaKEHKPSKIPTLSKKPEFPKDPKHPKD 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  211 ETKLSRQNSKQKSPSPVKQKSK-----AKLQPSTESDNLSQS----------MSPVEEGSTKPAASESAPSKPEPEMVPP 275
Cdd:PTZ00449 591 PEEPKKPKRPRSAQRPTRPKSPklpelLDIPKSPKRPESPKSpkrppppqrpSSPERPEGPKIIKSPKPPKSPKPPFDPK 670

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  276 LKEK------EAVVRpVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPN-------------ESQSQPAVQSSET 336
Cdd:PTZ00449 671 FKEKfyddylDAAAK-SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPklprdeefpfepiGDPDAEQPDDIEF 749

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 24646797  337 SSPPETNS---GEAKREVPLTRENSKEVnQRPRTSLRPPSARPASARPGAP 384
Cdd:PTZ00449 750 FTPPEEERtffHETPADTPLPDILAEEF-KEEDIHAETGEPDEAMKRPDSP 799
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 196-384 1.82e-04

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 44.85  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   196 EKDKASQKKSKApKDETKLSRQNSKQ--KSPSPVKQKSKAKLQPSTESDNLSQSMS---------PVEEGSTKPAASESA 264
Cdd:PLN03237 1176 EEAREKLQRAAA-RGESGAAKKVSRQapKKPAPKKTTKKASESETTEETYGSSAMEtenvaevvkPKGRAGAKKKAPAAA 1254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   265 PSKPEPEMVPPLKEKEAVVRpVQETPTAPPAEPESRksssrsrrssgshrqPEPNPIPNESQSQPAVQSSETSsPPETNS 344
Cdd:PLN03237 1255 KEKEEEDEILDLKDRLAAYN-LDSAPAQSAKMEETV---------------KAVPARRAAARKKPLASVSVIS-DSDDDD 1317

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 24646797   345 GEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAP 384
Cdd:PLN03237 1318 DDFAVEVSLAERLKKKGGRKPAAANKKAAKPPAAAKKRGP 1357
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 257-384 1.88e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  257 KPAASESAPskpepemvpPLKEKEAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSET 336
Cdd:PRK14951 365 KPAAAAEAA---------APAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPA 435

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 24646797  337 SSPPETNSGEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAP 384
Cdd:PRK14951 436 AAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAP 483
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-387 1.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   140 PLTLTKPPKETKNSSKNPSPAGKDEDAKrrkEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKdETKLSRQNS 219
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-PPSLPLGGS 2855

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   220 KQKSpSPVKQKSKAKLQPSTESdnlSQSMSPVEEGStKPAASESAPSKPEPEMVPPlkekeavvRPVQETPTAPPAEPES 299
Cdd:PHA03247 2856 VAPG-GDVRRRPPSRSPAAKPA---APARPPVRRLA-RPAVSRSTESFALPPDQPE--------RPPQPQAPPPPQPQPQ 2922

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   300 RKSSSRSRRSSGSHRQPEPNPIPnesQSQPAVQSSETSSPPETNSGE-AKREVPLTREnskevnqrpRTSLRPPSaRPAS 378
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAP---TTDPAGAGEPSGAVPQPWLGAlVPGRVAVPRF---------RVPQPAPS-REAP 2989


                  ....*....
gi 24646797   379 ARPGAPRRR 387
Cdd:PHA03247 2990 ASSTPPLTG 2998
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 66-342 4.42e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 43.08  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   66 NITSREDKIRFLQKMIDATKLTTKLDLKVRTSKIVAGQE-PELTNELLQAMASVAEKNLEWDSIVDQVVISHSKTPLTLT 144
Cdd:NF033838 198 KEPRDEEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEaKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPD 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  145 KPPKETKNSSKN------PSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPP----------TEKD-KASQKKSKA 207
Cdd:NF033838 278 KKENDAKSSDSSvgeetlPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYPTntyktleleiAESDvKVKEAELEL 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  208 PKDETKLSRQNSKQKSPspvKQKSKAKLQPSTESDNLSQSMSPVEEGST-----------KPAASESAPSKPEPEMVPPL 276
Cdd:NF033838 358 VKEEAKEPRNEEKIKQA---KAKVESKKAEATRLEKIKTDRKKAEEEAKrkaaeedkvkeKPAEQPQPAPAPQPEKPAPK 434

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24646797  277 KEKEAvVRPVQETPTAPPAEPESRKSSSRsrrssgshrqpEPNPIPNesQSQPAVQSSETSSPPET 342
Cdd:NF033838 435 PEKPA-EQPKAEKPADQQAEEDYARRSEE-----------EYNRLTQ--QQPPKTEKPAQPSTPKT 486
PRK13914 PRK13914
invasion associated endopeptidase;
81-368 5.14e-04

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 42.87  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   81 IDATKLTTKLDlkvrTSKIVAGQEPELtNELlqAMASVAEKNLE--WDSI-----VDQVVISHSKTPLTLTKPPKE---- 149
Cdd:PRK13914  49 VDAIKKANNLT----TDKIVPGQKLQV-NEV--AAAEKTEKSVSatWLNVrsgagVDNSIITSIKGGTKVTVETTEsngw 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  150 ---TKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRST-PPTEKDKASQKKSKAPK-DETKLSRQNSKQKSP 224
Cdd:PRK13914 122 hkiTYNDGKTGFVNGKYLTDKVTSTPVAPTQEVKKETTTQQAAPAAeTKTEVKQTTQATTPAPKvAETKETPVVDQNATT 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  225 SPVKQ---------KSKAKLQPSTESDNLSQSMSPV-EEGSTKPAASESAPsKPEPEMVPPLKEKEA--VVRPVQETPTA 292
Cdd:PRK13914 202 HAVKSgdtiwalsvKYGVSVQDIMSWNNLSSSSIYVgQKLAIKQTANTATP-KAEVKTEAPAAEKQAapVVKENTNTNTA 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  293 PPAEPESRKSSSRSRRSSGSHRQPEPnpIPNES--------QSQPAVQSSETSSPPE---TNSGEAKREVPLTRENSKEV 361
Cdd:PRK13914 281 TTEKKETTTQQQTAPKAPTEAAKPAP--APSTNtnanktntNTNTNTNNTNTSTPSKntnTNTNSNTNTNSNTNANQGSS 358


                 ....*..
gi 24646797  362 NQRPRTS 368
Cdd:PRK13914 359 NNNSNSS 365
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 162-417 6.67e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.73  E-value: 6.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   162 KDEDAKRRKEKRISPQEQ----KLRKVKeqvsrstpptEKDKASQKKSKAPKDETKLSRQNSKQKSPSPVKQKSKAKLQP 237
Cdd:PTZ00108 1146 EVEEKEIAKEQRLKSKTKgkasKLRKPK----------LKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDN 1215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   238 STESDNLSQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPE 317
Cdd:PTZ00108 1216 KKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGE 1295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   318 PNPIPNESQS-QPAVQSSETSSPPETNSGEAKREVPLTRENSKEvnqrprtslRPPSARPASARPGAPRRRNVEIV-LQP 395
Cdd:PTZ00108 1296 SNGGSKPSSPtKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKT---------RVKQASASQSSRLLRRPRKKKSDsSSE 1366

                         250       260
                  ....*....|....*....|..
gi 24646797   396 NDQIKMSGINVKLETFGDLDDD 417
Cdd:PTZ00108 1367 DDDDSEVDDSEDEDDEDDEDDD 1388
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
247-387 8.95e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 8.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  247 SMSPVEEGSTKPAAS-ESAPSKPEPEMVPPLKEKEAVVRP-VQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPNE 324
Cdd:PRK07003 403 TGAAGAALAPKAAAAaAATRAEAPPAAPAPPATADRGDDAaDGDAPVPAKANARASADSRCDERDAQPPADSGSASAPAS 482

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24646797  325 SQSQPAVQSSETSSPPETNSGEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAPRRR 387
Cdd:PRK07003 483 DAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAAR 545
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 174-384 9.38e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.22  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  174 ISPQEQKLRKVKeqvSRSTPPTEKDKASQKKSKAPKDETKLSRQNSKQKSPSPVKQKSKAKLQPSTESDNLS--QSMSPV 251
Cdd:PLN03209 313 LTPMEELLAKIP---SQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKppTSPIPT 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  252 EEGSTKPAASE----SAPSKPEPEMVPPLKEKEAVVRPVQ-ETPTAPPAEP-------ESRKSSSRSRRSSGSHRQPEPN 319
Cdd:PLN03209 390 PPSSSPASSKSvdavAKPAEPDVVPSPGSASNVPEVEPAQvEAKKTRPLSPyaryedlKPPTSPSPTAPTGVSPSVSSTS 469

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24646797  320 PIPNESQSQPAVQSSETSSPPETNSgeakreVPLTRENSKEvNQRPRTSLRPPSARPASARPGAP 384
Cdd:PLN03209 470 SVPAVPDTAPATAATDAAAPPPANM------RPLSPYAVYD-DLKPPTSPSPAAPVGKVAPSSTN 527
PHA03247 PHA03247
large tegument protein UL36; Provisional
 258-387 1.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   258 PAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPaepESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETS 337
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPP---QSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24646797   338 SPPETNSGEAKREVPLTRENSKEVNQR---PRTSLRPPSARPASARPGAPRRR 387
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAPGRvsrPRRARRLGRAAQASSPPQRPRRR 2686
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 207-379 1.42e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 41.62  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  207 APKDETKLSRQNSKQKSPS---PVKQKSKAKLQPSTESDNLSQSMSPVEEGSTKPAAS----------------ESAPSK 267
Cdd:PRK08691 363 AASCDANAVIENTELQSPSaqtAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSEGKtagpvsnqenndvppwEDAPDE 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  268 PEpEMVPPLKEKEAVVRPVQEtPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPI---PNESQSQPAVQSSETSSPPETNS 344
Cdd:PRK08691 443 AQ-TAAGTAQTSAKSIQTASE-AETPPENQVSKNKAADNETDAPLSEVPSENPIqatPNDEAVETETFAHEAPAEPFYGY 520

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 24646797  345 GEAKREVPLtrENSKEVNQRPRTSLRPPSARPASA 379
Cdd:PRK08691 521 GFPDNDCPP--EDGAEIPPPDWEHAAPADTAGGGA 553
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 82-381 1.47e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.45  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   82 DATKLTTKLDLKVRTSkIVAGQEPEL-TNELLQAMASvaEKNLEWDSIVDqvVISHSKTPLT-----LTKPPketknsSK 155
Cdd:PLN03209 258 DAYKETHNLTLSEEDT-LFGGQVSNLqVAELMACMAK--NRRLSYCKVVE--VIAETTAPLTpmeelLAKIP------SQ 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  156 NPSPAgKDEDAKRRKEKRISPQEQKLRKVKEQvsrSTPPTEKDKASQKKS--------KAPKDETKLSRQNSKQKSPS-- 225
Cdd:PLN03209 327 RVPPK-ESDAADGPKPVPTKPVTPEAPSPPIE---EEPPQPKAVVPRPLSpytayedlKPPTSPIPTPPSSSPASSKSvd 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  226 PVKQKSKAKLQPSTE--SDNLSQSMSPVEEGSTKPAASESA------PSKPEPEMVPPLKEKEAVVRPVQETPTAPPAep 297
Cdd:PLN03209 403 AVAKPAEPDVVPSPGsaSNVPEVEPAQVEAKKTRPLSPYARyedlkpPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPA-- 480

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  298 esrksssrsRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGeaKREVPLTRENSKEVNQRPRTSLRP------ 371
Cdd:PLN03209 481 ---------TAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVG--KVAPSSTNEVVKVGNSAPPTALADeqhhaq 549

                        330
                 ....*....|
gi 24646797  372 PSARPASARP 381
Cdd:PLN03209 550 PKPRPLSPYT 559
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
187-385 1.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  187 QVSRSTPPTEKDKASQKKSKAPKDETKLSRQNSKQKSPSPVKQKSKAKLQPSTESDNLSQSMSPVEEGSTKPAASES--- 263
Cdd:PRK07003 375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAkan 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  264 ----APSKPEPEMVPPLKEKEAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSP 339
Cdd:PRK07003 455 arasADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24646797  340 PE-------TNSGEAKREVPLTREN----SKEVNQRPRTSLRPPSARPASARPGAPR 385
Cdd:PRK07003 535 PTpaaaapaARAGGAAAALDVLRNAgmrvSSDRGARAAAAAKPAAAPAAAPKPAAPR 591
PRK11633 PRK11633
cell division protein DedD; Provisional
 250-332 1.61e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 40.37  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  250 PVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPnESQSQP 329
Cdd:PRK11633  67 PPEGAAEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVV-EEKAAP 145


                 ...
gi 24646797  330 AVQ 332
Cdd:PRK11633 146 TGK 148
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 237-391 1.68e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   237 PSTESDNLSQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQETPTAPPAEPEsrksssrsrrssgsHRQP 316
Cdd:PHA03307   75 PGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSE--------------MLRP 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24646797   317 EPNPIPNESQSQPAVQSSETSSP-PETNSGEAKREVPLTRENSKEVNQRPRTslrPPSARPASARPGAPRRRNVEI 391
Cdd:PHA03307  141 VGSPGPPPAASPPAAGASPAAVAsDAASSRQAALPLSSPEETARAPSSPPAE---PPPSTPPAAASPRPPRRSSPI 213
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
254-384 3.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  254 GSTKPAASESAP-SKPEPEMVPPlkekeAVVRPVQETPTAPPAEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQ---P 329
Cdd:PRK12323 370 GGAGPATAAAAPvAQPAPAAAAP-----AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASargP 444

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24646797  330 AVQSSETSSPPETNSGEAKREVPLTRENSKEVNQRPRtsLRPPSARPASARPGAP 384
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA--RAAPAAAPAPADDDPP 497
PHA03247 PHA03247
large tegument protein UL36; Provisional
 139-372 4.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   139 TPLTLTKPPketknSSKNPSPAG--KDEDAKRRKEKRISP-----QEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDE 211
Cdd:PHA03247  305 APLALPAPP-----DPPPPAPAGdaEEEDDEDGAMEVVSPlprprQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRAS 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   212 TKLSRQNSKQKSPSPVKQKSKAKLQPstesdnlsQSMSPVeegstkPAASESAPSKPEPEMVPPlkekeavvRPVQETPT 291
Cdd:PHA03247  380 LPTRKRRSARHAATPFARGPGGDDQT--------RPAAPV------PASVPTPAPTPVPASAPP--------PPATPLPS 437

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   292 APPAEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGE---------------AKREVPLTRE 356
Cdd:PHA03247  438 AEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEPPGADLAEllgrhpdtagtvvrlAAREAAIARE 517

                         250
                  ....*....|....*.
gi 24646797   357 NSkEVNQRPRTSLRPP 372
Cdd:PHA03247  518 VA-ECSRLTINALRSP 532
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 142-398 5.61e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   142 TLTKPPKETKNSSknPSPAgkdEDAKRRKEKRISPQEQKLR----KVKEQ-VSRSTPPTEKDKAS-------QKKSKAPK 209
Cdd:pfam03154  61 SMKKSSKKIKEEA--PSPL---KSAKRQREKGASDTEEPERatakKSKTQeISRPNSPSEGEGESsdgrsvnDEGSSDPK 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   210 DETKLSR---------QNSKQKSPSPVKQKSKAKLQPSTESDNlsQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKE 280
Cdd:pfam03154 136 DIDQDNRstspsipspQDNESDSDSSAQQQILQTQPPVLQAQS--GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   281 AVVRPVQETPTAPP-------AEPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEAKREVPL 353
Cdd:pfam03154 214 TSQPPNQTQSTAAPhtliqqtPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPV 293

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 24646797   354 TRENSKEVNQRPRTSLRPPsarPASARPGAPRRRNVEIVLQPNDQ 398
Cdd:pfam03154 294 PPQPFPLTPQSSQSQVPPG---PSPAAPGQSQQRIHTPPSQSQLQ 335
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 148-395 6.04e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.37  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  148 KETKNSSKNPSPAGKDEDAKRRKEKRISPQEQKLRKVKEQVSRSTPPTEKDKASQKKSKAPKDETKLSRQNSKqKSPSPV 227
Cdd:NF033839 235 KELDELKKQALSEIDNVNTKVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEK-KEVKPE 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  228 KQKSKAKLQPSTESdnlsQSMSPVEEGSTKPAASESAPSKPEPEMVPPLKEKEAVVRPVQET--PTAPPAEPESRKSSSR 305
Cdd:NF033839 314 PETPKPEVKPQLEK----PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQPEKpkPEVKPQPETPKPEVKP 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797  306 SRRSSGSHRQPEPNPIPNESQSQPAVQSSETSSPPETNSGEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAPR 385
Cdd:NF033839 390 QPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPE 469

                        250
                 ....*....|
gi 24646797  386 RRNVEIVLQP 395
Cdd:NF033839 470 KPKPEVKPQP 479
PHA03247 PHA03247
large tegument protein UL36; Provisional
 140-352 8.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 8.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   140 PLTLTKPPKETKNSSKNPSPAGkdeDAKRRKEKR------ISPQEQKLRKV-KEQVSRST-----PPTEKDKASQKKSKA 207
Cdd:PHA03247 2839 PPPPPGPPPPSLPLGGSVAPGG---DVRRRPPSRspaakpAAPARPPVRRLaRPAVSRSTesfalPPDQPERPPQPQAPP 2915

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   208 PKDETKLSRQNSKQKSPSPVKQKSKAKLQPSTESDNLSQ-----------SMSPVEEGSTKPAASESAPSKPEPEMVPPL 276
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpsgavpqpwlgALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646797   277 KEKEAVVR--------PVQETPTAPPA----------EPESRKSSSRSRRSSGSHRQPEPNPIPNESQSQPAvqssetsS 338
Cdd:PHA03247 2996 LTGHSLSRvsswasslALHEETDPPPVslkqtlwppdDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFA-------H 3068

                         250
                  ....*....|....*
gi 24646797   339 PPETNSGEA-KREVP 352
Cdd:PHA03247 3069 EPDPATPEAgARESP 3083
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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