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Conserved domains on  [gi|28571655|ref|NP_650111|]
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uncharacterized protein Dmel_CG14722 [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-438 2.29e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.29e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 156 EDFITDICFHPDRDIiaLATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLK 235
Cdd:cd00200   9 TGGVTCVAFSPDGKL--LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 236 KLYeTAHDDAINTLHVLNEN--LFASGDDaGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNI 313
Cdd:cd00200  87 RTL-TGHTSYVSSVAFSPDGriLSSSSRD-KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 314 SARKMYVQSEPYEEELNCMGVYRGDSKLVVGTSKG--RLYTYNWGQFGYhcdMYPGIKSPI-SLMIPITDRIACVAGEDG 390
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtiKLWDLSTGKCLG---TLRGHENGVnSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 28571655 391 NIRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWN 438
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-438 2.29e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.29e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 156 EDFITDICFHPDRDIiaLATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLK 235
Cdd:cd00200   9 TGGVTCVAFSPDGKL--LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 236 KLYeTAHDDAINTLHVLNEN--LFASGDDaGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNI 313
Cdd:cd00200  87 RTL-TGHTSYVSSVAFSPDGriLSSSSRD-KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 314 SARKMYVQSEPYEEELNCMGVYRGDSKLVVGTSKG--RLYTYNWGQFGYhcdMYPGIKSPI-SLMIPITDRIACVAGEDG 390
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtiKLWDLSTGKCLG---TLRGHENGVnSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 28571655 391 NIRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWN 438
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
156-440 5.82e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 5.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 156 EDFITDICFHPDRDIIALATIIGDVHLyeYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLK 235
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 236 KLYeTAHDDAINTLHVL-NENLFASGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNIS 314
Cdd:COG2319 198 RTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 315 ARKMYVQSEPYEEELNCMgVYRGDSK-LVVGTSKGRLYTYNWGQfGYHCDMYPGIKSPI-SLMI-PITDRIAcVAGEDGN 391
Cdd:COG2319 277 TGELLRTLTGHSGGVNSV-AFSPDGKlLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVrSVAFsPDGKTLA-SGSDDGT 353

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 28571655 392 IRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWNVK 440
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-228 4.49e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28571655    191 KLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTD 228
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
190-228 5.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28571655   190 NKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTD 228
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 205-347 7.11e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655  205 DVEFTE-DGRFLLTCSKDKCVMVTDMETEKLKK------LYETAHDD--AINTLHVLNENLFASGDDAGTVKLWDLRTKN 275
Cdd:PTZ00421  80 DVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpiVHLQGHTKkvGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28571655  276 AIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISARKMYVQSEPYE--EELNCMGVYRGDSKLVVGTSK 347
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIITLGCSK 233
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 156-438 2.29e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.29e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 156 EDFITDICFHPDRDIiaLATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLK 235
Cdd:cd00200   9 TGGVTCVAFSPDGKL--LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 236 KLYeTAHDDAINTLHVLNEN--LFASGDDaGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNI 313
Cdd:cd00200  87 RTL-TGHTSYVSSVAFSPDGriLSSSSRD-KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 314 SARKMYVQSEPYEEELNCMGVYRGDSKLVVGTSKG--RLYTYNWGQFGYhcdMYPGIKSPI-SLMIPITDRIACVAGEDG 390
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtiKLWDLSTGKCLG---TLRGHENGVnSVAFSPDGYLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 28571655 391 NIRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWN 438
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
156-440 5.82e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 5.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 156 EDFITDICFHPDRDIIALATIIGDVHLyeYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLK 235
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 236 KLYeTAHDDAINTLHVL-NENLFASGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNIS 314
Cdd:COG2319 198 RTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 315 ARKMYVQSEPYEEELNCMgVYRGDSK-LVVGTSKGRLYTYNWGQfGYHCDMYPGIKSPI-SLMI-PITDRIAcVAGEDGN 391
Cdd:COG2319 277 TGELLRTLTGHSGGVNSV-AFSPDGKlLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVrSVAFsPDGKTLA-SGSDDGT 353

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 28571655 392 IRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWNVK 440
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
157-440 4.13e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 4.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 157 DFITDICFHPDRDIIALATIIGDVHLYEYDNeaNKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKK 236
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 237 LYeTAHDDAINTLHVL-NENLFASGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISA 315
Cdd:COG2319 157 TL-TGHSGAVTSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 316 RKMYVQSEPYEEELNCMgVYRGDSKLVVGTSKG---RLYTYNWGQFGYhcdMYPGIKSPISLMI--PITDRIAcVAGEDG 390
Cdd:COG2319 236 GKLLRTLTGHSGSVRSV-AFSPDGRLLASGSADgtvRLWDLATGELLR---TLTGHSGGVNSVAfsPDGKLLA-SGSDDG 310

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 28571655 391 NIRACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWNVK 440
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-440 2.71e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 2.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 192 LLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKKLYeTAHDDAINTLHVL--NENLFASGDDaGTVKLW 269
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASadGTYLASGSSD-KTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 270 DLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISARKmyvqsepyeeelnCMGVYRGDSKLVvgtskgr 349
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK-------------CLTTLRGHTDWV------- 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 350 lytynwgqfgYHCDMYPgikspislmipiTDRIACVAGEDGNIRACHIapyRNLGVVGQ---HNMPIESLDVNASGELIA 426
Cdd:cd00200 139 ----------NSVAFSP------------DGTFVASSSQDGTIKLWDL---RTGKCVATltgHTGEVNSVAFSPDGEKLL 193

                       250
                ....*....|....
gi 28571655 427 SSSHNNDVRFWNVK 440
Cdd:cd00200 194 SSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
157-273 1.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.63e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 157 DFITDICFHPDRDIIALATIIGDVHLYeyDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKK 236
Cdd:COG2319 289 GGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28571655 237 LYeTAHDDAINTLHVL-NENLFASGDDAGTVKLWDLRT 273
Cdd:COG2319 367 TL-TGHTGAVTSVAFSpDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
167-440 3.55e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 3.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 167 DRDIIALATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKKLYETAHDDAI 246
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 247 NTLHVLNENLFASGDDAGTVKLWDLRTKNAIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISARKMYVQSEPYE 326
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655 327 EELNCMgVYRGDSKLVVGTSKG---RLYTYNWGQfgyhcdmypgiksPISLMIPITDRIACVA-----------GEDGNI 392
Cdd:COG2319 163 GAVTSV-AFSPDGKLLASGSDDgtvRLWDLATGK-------------LLRTLTGHTGAVRSVAfspdgkllasgSADGTV 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 28571655 393 RACHIAPYRNLGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWNVK 440
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
156-231 2.47e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 2.47e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28571655 156 EDFITDICFHPDRDIIALATIIGDVHLYeyDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMET 231
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-228 4.49e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 28571655    191 KLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTD 228
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
190-228 5.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 28571655   190 NKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTD 228
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 205-347 7.11e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 7.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571655  205 DVEFTE-DGRFLLTCSKDKCVMVTDMETEKLKK------LYETAHDD--AINTLHVLNENLFASGDDAGTVKLWDLRTKN 275
Cdd:PTZ00421  80 DVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpiVHLQGHTKkvGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28571655  276 AIFELKELEDQITQLTTNEQSKLLLATSADGYLTTFNISARKMYVQSEPYE--EELNCMGVYRGDSKLVVGTSK 347
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIITLGCSK 233
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 409-438 1.56e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.56e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 28571655    409 HNMPIESLDVNASGELIASSSHNNDVRFWN 438
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 240-270 3.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 3.54e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 28571655    240 TAHDDAINTLHVL-NENLFASGDDAGTVKLWD 270
Cdd:smart00320   9 KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
403-438 7.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 7.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 28571655   403 LGVVGQHNMPIESLDVNASGELIASSSHNNDVRFWN 438
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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