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Conserved domains on  [gi|21355909|ref|NP_649915|]
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uncharacterized protein Dmel_CG8301 [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 15933290)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677|GO:0003700
PubMed:  22803940|11179890|12665246|11361095|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-508 3.82e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 198 NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV--CGKKYGDRHNLRHHVEKYHSETDF 275
Cdd:COG5048  13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 276 ECALCE-KRFYTRKSLNYHMKWHNPDRQFKCRHSGC--------------ERLFISQRHLMC-----HEATHSGTSSRKS 335
Cdd:COG5048  93 LNSKSLpLSNSKASSSSLSSSSSNSNDNNLLSSHSLppssrdpqlpdllsISNLRNNPLPGNnsssvNTPQSNSLHPPLP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 336 EHCGFCGKTFIHLKTLRW---HIYRQHggekpykcANCTEVFASYAEKRI---HMLERHRENLTAIERS---ECMLCRQP 406
Cdd:COG5048 173 ANSLSKDPSSNLSLLISSnvsTSIPSS--------SENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSqlsPKSLLSQS 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 407 FSSEPDLIHHMSA----EHLQRPGAPIIANNKRVLQQKRERQYSgLFQCGSCSQRFNMKSALERH--AAVHS-EKDRPHA 479
Cdd:COG5048 245 PSSLSSSDSSSSAsespRSSLPTASSQSSSPNESDSSSEKGFSL-PIKSKQCNISFSRSSPLTRHlrSVNHSgESLKPFS 323

                       330       340       350
                ....*....|....*....|....*....|.
gi 21355909 480 CPH--CSKRFKRAQDMKWHIKTHEKEKPNVC 508
Cdd:COG5048 324 CPYslCGKLFSRNDALKRHILLHTSISPAKE 354
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 3-88 7.19e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 41.29  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909     3 TCRTCaismfvcdfenGSNNSHFLDLHHPNCWPSEMAQIRLQFanWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQE 82
Cdd:pfam07776   1 VCRLC-----------LDESDELIPIFDPSDSEKTLAEILEDC--TGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67


                  ....*.
gi 21355909    83 AQLKLS 88
Cdd:pfam07776  68 SQELLQ 73
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 536-586 1.11e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.11e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 21355909 536 KCNVCGRAYLFEKSLRLHQRTHTgktyYKCDLCQERFVTHIKLKTHMQKAH 586
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-508 3.82e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 198 NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV--CGKKYGDRHNLRHHVEKYHSETDF 275
Cdd:COG5048  13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 276 ECALCE-KRFYTRKSLNYHMKWHNPDRQFKCRHSGC--------------ERLFISQRHLMC-----HEATHSGTSSRKS 335
Cdd:COG5048  93 LNSKSLpLSNSKASSSSLSSSSSNSNDNNLLSSHSLppssrdpqlpdllsISNLRNNPLPGNnsssvNTPQSNSLHPPLP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 336 EHCGFCGKTFIHLKTLRW---HIYRQHggekpykcANCTEVFASYAEKRI---HMLERHRENLTAIERS---ECMLCRQP 406
Cdd:COG5048 173 ANSLSKDPSSNLSLLISSnvsTSIPSS--------SENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSqlsPKSLLSQS 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 407 FSSEPDLIHHMSA----EHLQRPGAPIIANNKRVLQQKRERQYSgLFQCGSCSQRFNMKSALERH--AAVHS-EKDRPHA 479
Cdd:COG5048 245 PSSLSSSDSSSSAsespRSSLPTASSQSSSPNESDSSSEKGFSL-PIKSKQCNISFSRSSPLTRHlrSVNHSgESLKPFS 323

                       330       340       350
                ....*....|....*....|....*....|.
gi 21355909 480 CPH--CSKRFKRAQDMKWHIKTHEKEKPNVC 508
Cdd:COG5048 324 CPYslCGKLFSRNDALKRHILLHTSISPAKE 354
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 3-88 7.19e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 41.29  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909     3 TCRTCaismfvcdfenGSNNSHFLDLHHPNCWPSEMAQIRLQFanWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQE 82
Cdd:pfam07776   1 VCRLC-----------LDESDELIPIFDPSDSEKTLAEILEDC--TGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67


                  ....*.
gi 21355909    83 AQLKLS 88
Cdd:pfam07776  68 SQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 49-87 8.08e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 40.96  E-value: 8.08e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21355909     49 NLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKL 87
Cdd:smart00868  33 GIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 536-586 1.11e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.11e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 21355909 536 KCNVCGRAYLFEKSLRLHQRTHTgktyYKCDLCQERFVTHIKLKTHMQKAH 586
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 338-396 7.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21355909 338 CGFCGKTFIHLKTLRwhiyrQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
Cdd:cd20908   4 CYYCDREFDDEKILI-----QHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVP 57
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-508 3.82e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 198 NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV--CGKKYGDRHNLRHHVEKYHSETDF 275
Cdd:COG5048  13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 276 ECALCE-KRFYTRKSLNYHMKWHNPDRQFKCRHSGC--------------ERLFISQRHLMC-----HEATHSGTSSRKS 335
Cdd:COG5048  93 LNSKSLpLSNSKASSSSLSSSSSNSNDNNLLSSHSLppssrdpqlpdllsISNLRNNPLPGNnsssvNTPQSNSLHPPLP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 336 EHCGFCGKTFIHLKTLRW---HIYRQHggekpykcANCTEVFASYAEKRI---HMLERHRENLTAIERS---ECMLCRQP 406
Cdd:COG5048 173 ANSLSKDPSSNLSLLISSnvsTSIPSS--------SENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSqlsPKSLLSQS 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909 407 FSSEPDLIHHMSA----EHLQRPGAPIIANNKRVLQQKRERQYSgLFQCGSCSQRFNMKSALERH--AAVHS-EKDRPHA 479
Cdd:COG5048 245 PSSLSSSDSSSSAsespRSSLPTASSQSSSPNESDSSSEKGFSL-PIKSKQCNISFSRSSPLTRHlrSVNHSgESLKPFS 323

                       330       340       350
                ....*....|....*....|....*....|.
gi 21355909 480 CPH--CSKRFKRAQDMKWHIKTHEKEKPNVC 508
Cdd:COG5048 324 CPYslCGKLFSRNDALKRHILLHTSISPAKE 354
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 3-88 7.19e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 41.29  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355909     3 TCRTCaismfvcdfenGSNNSHFLDLHHPNCWPSEMAQIRLQFanWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQE 82
Cdd:pfam07776   1 VCRLC-----------LDESDELIPIFDPSDSEKTLAEILEDC--TGIELDPNDLLPKQICERCLSKLQEFYSFRERCLE 67


                  ....*.
gi 21355909    83 AQLKLS 88
Cdd:pfam07776  68 SQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 49-87 8.08e-05

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 40.96  E-value: 8.08e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 21355909     49 NLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKL 87
Cdd:smart00868  33 GIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELL 71
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 536-586 1.11e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.11e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 21355909 536 KCNVCGRAYLFEKSLRLHQRTHTgktyYKCDLCQERFVTHIKLKTHMQKAH 586
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 338-396 7.04e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21355909 338 CGFCGKTFIHLKTLRwhiyrQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
Cdd:cd20908   4 CYYCDREFDDEKILI-----QHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETLTKVP 57
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
453-528 7.96e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 7.96e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355909 453 SCSQRFNMKSalERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALK--YVLTQHRLSH 528
Cdd:COG5048  11 SNNSVLSSTP--KSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTH 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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