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Conserved domains on  [gi|281361343|ref|NP_649798|]
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uncharacterized protein Dmel_CG7963 [Drosophila melanogaster]

Protein Classification

zinc-finger associated domain-containing protein( domain architecture ID 10544311)

zinc-finger associated domain (ZAD)-containing protein similar to Drosophila melanogaster zinc finger protein hangover, zinc finger protein kipf and protein phyllopod

CATH:  3.40.1800.20
Gene Ontology:  GO:0008270
SCOP:  4001830

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 10-80 2.94e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.93  E-value: 2.94e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281361343   10 CRVCLKQDELLVDIYEIVEEmQVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKICVESEKL 80
Cdd:pfam07776   2 CRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQEL 71
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
184-250 4.59e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 4.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281361343 184 KRGHKCLECGKCLQSASSLASHIRLHTDEWPFTC--DQCAKAFRTNGALEVHQRRHKQVLQHKCLHCGR 250
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 10-80 2.94e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.93  E-value: 2.94e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281361343   10 CRVCLKQDELLVDIYEIVEEmQVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKICVESEKL 80
Cdd:pfam07776   2 CRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQEL 71
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 9-80 1.35e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 54.06  E-value: 1.35e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281361343     9 RCRVCLKQDELLVDIYEIVEEmqVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKICVESEKL 80
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSE--ASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDEL 70
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-250 4.59e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 4.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281361343 184 KRGHKCLECGKCLQSASSLASHIRLHTDEWPFTC--DQCAKAFRTNGALEVHQRRHKQVLQHKCLHCGR 250
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 10-80 2.94e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.93  E-value: 2.94e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281361343   10 CRVCLKQDELLVDIYEIVEEmQVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKICVESEKL 80
Cdd:pfam07776   2 CRLCLDESDELIPIFDPSDS-EKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQEL 71
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 9-80 1.35e-09

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 54.06  E-value: 1.35e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281361343     9 RCRVCLKQDELLVDIYEIVEEmqVDLCTLLETCGGIKVDRRDVQPMYLCQECTNELLIAAKFRKICVESEKL 80
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSE--ASLAEKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDEL 70
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
184-250 4.59e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 4.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281361343 184 KRGHKCLECGKCLQSASSLASHIRLHTDEWPFTC--DQCAKAFRTNGALEVHQRRHKQVLQHKCLHCGR 250
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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