|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
18-226 |
2.83e-113 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 336.86 E-value: 2.83e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRhkETPWGPKEIGALVISPTRELARQ 97
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKR--KANLKKGQVGALIISPTRELATQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 98 ISEVLAQFLEHEdLEHLNQQLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDdlnlAAQVKSLEFLVLDEADR 177
Cdd:cd17960 79 IYEVLQSFLEHH-LPKLKCQLLIGGTNVEEDVKKFKRNGPNILVGTPGRLEELLSRKAD----KVKVKSLEVLVLDEADR 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 21355559 178 LLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17960 154 LLDLGFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
14-424 |
4.59e-109 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 334.04 E-value: 4.59e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHketpwgPKEIGALVISPTRE 93
Cdd:COG0513 9 LSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSR------PRAPQALILAPTRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLRReTPCILVCTPGRLEDLFQRKGddLNLaaqvKSLEFLVLD 173
Cdd:COG0513 83 LALQVAEELRKLAKYLGLRVA---TVYGGVSIGRQIRALKR-GVDIVVATPGRLLDLIERGA--LDL----SGVETLVLD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 174 EADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVKEKASvnTPARLQNFYRIVEPELKFV 253
Cdd:COG0513 153 EADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENA--TAETIEQRYYLVDKRDKLE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 254 ALLEFLSSPAtvIGKVMVFFPTCACVEYWAEAlpplLPKR--TVLGIHGKM-KNKRANVVEKFRNTPQAVLLCTDVLARG 330
Cdd:COG0513 231 LLRRLLRDED--PERAIVFCNTKRGADRLAEK----LQKRgiSAAALHGDLsQGQRERALDAFRNGKIRVLVATDVAARG 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 331 LDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSEDAYVHFL--KINQKVELTKLLTEEAEDADREKKKL 408
Cdd:COG0513 305 IDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIekLIGQKIEEEELPGFEPVEEKRLERLK 384
|
410
....*....|....*.
gi 21355559 409 PAVLDQLHRLQAADKG 424
Cdd:COG0513 385 PKIKEKLKGKKAGRGG 400
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
18-226 |
2.37e-69 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 223.09 E-value: 2.37e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKEtpwGPKEIGALVISPTRELARQ 97
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKK---KGRGPQALVLAPTRELAMQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 98 ISEVLAQFLEHEDLehlNQQLIVGGNSIEEDIATLRReTPCILVCTPGRLEDLFQRKgdDLNLaaqvKSLEFLVLDEADR 177
Cdd:cd00268 78 IAEVARKLGKGTGL---KVAAIYGGAPIKKQIEALKK-GPDIVVGTPGRLLDLIERG--KLDL----SNVKYLVLDEADR 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 21355559 178 LLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd00268 148 MLDMGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
1-390 |
9.55e-65 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 219.67 E-value: 9.55e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 1 MSRKKWSSLdkpPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgp 80
Cdd:PRK11776 1 MSMTAFSTL---PLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQ--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 81 keigALVISPTRELARQIS-EV--LAQFLEhedlehlNQQLIV--GGNSIEEDIATLRReTPCILVCTPGRLEDLFQRkg 155
Cdd:PRK11776 75 ----ALVLCPTRELADQVAkEIrrLARFIP-------NIKVLTlcGGVPMGPQIDSLEH-GAHIIVGTPGRILDHLRK-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 156 DDLNLAAqvksLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVKEKASvnT 235
Cdd:PRK11776 141 GTLDLDA----LNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTHD--L 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 236 PARLQNFYRiVEPELKFVALLEFLSS--PATVIgkvmVFFPTCACVEYWAEALPPLlpKRTVLGIHGKMKNK-RANVVEK 312
Cdd:PRK11776 215 PAIEQRFYE-VSPDERLPALQRLLLHhqPESCV----VFCNTKKECQEVADALNAQ--GFSALALHGDLEQRdRDQVLVR 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355559 313 FRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSEDAYVHFLKINQKVEL 390
Cdd:PRK11776 288 FANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDYLGRKL 365
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
26-227 |
3.26e-61 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 201.75 E-value: 3.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 26 GFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHketpWGPKE-IGALVISPTRELARQISEVLAQ 104
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRER----WTPEDgLGALIISPTRELAMQIFEVLRK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 105 FLEHEDLehlNQQLIVGGNSIEEDiaTLRRETPCILVCTPGRLedlFQRKGDDLNLAAQvkSLEFLVLDEADRLLDLGFK 184
Cdd:cd17941 85 VGKYHSF---SAGLIIGGKDVKEE--KERINRMNILVCTPGRL---LQHMDETPGFDTS--NLQMLVLDEADRILDMGFK 154
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 21355559 185 TSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd17941 155 ETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
18-226 |
6.34e-61 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 200.94 E-value: 6.34e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWgpkeIGALVISPTRELARQ 97
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAA----TRVLVLVPTRELAMQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 98 ISEVLAQFLEHEDLEHlnqQLIVGGNSIEEDIATLRREtPCILVCTPGRLEDLFqrkgddLNLAA-QVKSLEFLVLDEAD 176
Cdd:cd17947 77 CFSVLQQLAQFTDITF---ALAVGGLSLKAQEAALRAR-PDIVIATPGRLIDHL------RNSPSfDLDSIEILVLDEAD 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17947 147 RMLEEGFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
14-225 |
3.21e-56 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 188.67 E-value: 3.21e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETpwgpkEIGALVISPTRE 93
Cdd:cd17959 8 LSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV-----GARALILSPTRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLrRETPCILVCTPGRLEDLFQRkgDDLNLaaqvKSLEFLVLD 173
Cdd:cd17959 83 LALQTLKVTKELGKFTDLRTA---LLVGGDSLEEQFEAL-ASNPDIIIATPGRLLHLLVE--MNLKL----SSVEYVVFD 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 21355559 174 EADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLV 225
Cdd:cd17959 153 EADRLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
14-220 |
7.31e-55 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 185.48 E-value: 7.31e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLA-RKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgPKEIGALVISPTR 92
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGR--RSGVSALIISPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 93 ELARQISEVLAQFLEHedLEHLNQQLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFqrkgDDLNLAAQVKSLEFLVL 172
Cdd:cd17964 79 ELALQIAAEAKKLLQG--LRKLRVQSAVGGTSRRAELNRLRRGRPDILVATPGRLIDHL----ENPGVAKAFTDLDYLVL 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 21355559 173 DEADRLLDLGFKTSVNNILGYLP----RQRRTGLFSATQTTEVTDLIRAGLR 220
Cdd:cd17964 153 DEADRLLDMGFRPDLEQILRHLPeknaDPRQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
14-226 |
1.53e-54 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 184.06 E-value: 1.53e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRhketpwgPKEIGALVISPTRE 93
Cdd:cd17954 7 VCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLEN-------PQRFFALVLAPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEvlaQFLEHEDLEHLNQQLIVGG-NSIEEDIATLRRetPCILVCTPGRLED-LFQRKGDDLnlaaqvKSLEFLV 171
Cdd:cd17954 80 LAQQISE---QFEALGSSIGLKSAVLVGGmDMMAQAIALAKK--PHVIVATPGRLVDhLENTKGFSL------KSLKFLV 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 172 LDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17954 149 MDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
8-368 |
4.62e-54 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 190.79 E-value: 4.62e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 8 SLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRrHKETPWGPKEIGALV 87
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLIT-RQPHAKGRRPVRALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 88 ISPTRELARQISEVLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLNlaaqvkSL 167
Cdd:PRK10590 81 LTPTRELAAQIGENVRDYSKYLNIRSL---VVFGGVSINPQMMKLRGGVD-VLVATPGRLLDLEHQNAVKLD------QV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 168 EFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVkekASVNTPA-RLQNFYRIV 246
Cdd:PRK10590 151 EILVLDEADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEV---ARRNTASeQVTQHVHFV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 247 EPELKfvalLEFLSSpatVIGK-----VMVFFPTcacvEYWAEALPPLLPKR--TVLGIHG-KMKNKRANVVEKFRNTPQ 318
Cdd:PRK10590 228 DKKRK----RELLSQ---MIGKgnwqqVLVFTRT----KHGANHLAEQLNKDgiRSAAIHGnKSQGARTRALADFKSGDI 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 21355559 319 AVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNAL 368
Cdd:PRK10590 297 RVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEAL 346
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
6-367 |
2.31e-53 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 188.23 E-value: 2.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 6 WSSLDkppLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQ---RRHKetpwGPKE 82
Cdd:PRK11192 3 FSELE---LDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLdfpRRKS----GPPR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 83 IgaLVISPTRELARQISEVLAQFLEHEdleHLNQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKGDDLnlaa 162
Cdd:PRK11192 76 I--LILTPTRELAMQVADQARELAKHT---HLDIATITGGVAYMNHAEVFS-ENQDIVVATPGRLLQYIKEENFDC---- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 163 qvKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTE-VTDLIRAGLRNPVLV----SVKEKASVNtpa 237
Cdd:PRK11192 146 --RAVETLILDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEVeaepSRRERKKIH--- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 238 rlQNFYRIVEPELKFVALLEFLSSPATviGKVMVFFPTCACVEYWAEalppLLPKRtvlGIH-----GKM-KNKRANVVE 311
Cdd:PRK11192 221 --QWYYRADDLEHKTALLCHLLKQPEV--TRSIVFVRTRERVHELAG----WLRKA---GINccyleGEMvQAKRNEAIK 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 312 KFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNA 367
Cdd:PRK11192 290 RLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTA 345
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
8-408 |
1.18e-52 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 189.21 E-value: 1.18e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 8 SLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP-MLEILQRRHKETPWGPKeigAL 86
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPaIVHINAQPLLRYGDGPI---VL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 87 VISPTRELARQISEVLAQFLEHEDLEHlnqQLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLnlaaqvKS 166
Cdd:PTZ00110 208 VLAPTRELAEQIREQCNKFGASSKIRN---TVAYGGVPKRGQIYALRRGVE-ILIACPGRLIDFLESNVTNL------RR 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 167 LEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRN-PVLV---SVKEKASVNTParlQNF 242
Cdd:PTZ00110 278 VTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVnvgSLDLTACHNIK---QEV 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 243 YRIVEPElKFVALLEFLSSPATVIGKVMVFFPTCACVEYWAEALPplLPKRTVLGIHG-KMKNKRANVVEKFRNTPQAVL 321
Cdd:PTZ00110 355 FVVEEHE-KRGKLKMLLQRIMRDGDKILIFVETKKGADFLTKELR--LDGWPALCIHGdKKQEERTWVLNEFKTGKSPIM 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 322 LCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSedayvhflKINQKVELTKLLTEEAEDA 401
Cdd:PTZ00110 432 IATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPD--------KYRLARDLVKVLREAKQPV 503
|
....*..
gi 21355559 402 DREKKKL 408
Cdd:PTZ00110 504 PPELEKL 510
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
19-226 |
5.04e-52 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 177.17 E-value: 5.04e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 19 LQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRrhkeTPWGPKE-IGALVISPTRELARQ 97
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYK----LKFKPRNgTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 98 ISEVLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLRRETpCILVCTPGRLEDLFQRKGDDLnlaaqVKSLEFLVLDEADR 177
Cdd:cd17942 78 IYGVAKELLKYHSQTFG---IVIGGANRKAEAEKLGKGV-NILVATPGRLLDHLQNTKGFL-----YKNLQCLIIDEADR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 178 LLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRN-PVLVS 226
Cdd:cd17942 149 ILEIGFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKkPLYVG 198
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
14-371 |
1.46e-50 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 185.05 E-value: 1.46e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpwGPKeigALVISPTRE 93
Cdd:PRK11634 13 LKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELK----APQ---ILVLAPTRE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHedLEHLNQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVLD 173
Cdd:PRK11634 86 LAVQVAEAMTDFSKH--MRGVNVVALYGGQRYDVQLRALR-QGPQIVVGTPGRLLDHLKRGTLDLS------KLSGLVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 174 EADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVKekASVNTPARLQNFYRIVEPELKFV 253
Cdd:PRK11634 157 EADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQ--SSVTTRPDISQSYWTVWGMRKNE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 254 ALLEFLSspATVIGKVMVFFPTCACVEYWAEALppllpKRT---VLGIHGKMKNK-RANVVEKFRNTPQAVLLCTDVLAR 329
Cdd:PRK11634 235 ALVRFLE--AEDFDAAIIFVRTKNATLEVAEAL-----ERNgynSAALNGDMNQAlREQTLERLKDGRLDILIATDVAAR 307
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 21355559 330 GLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFL 371
Cdd:PRK11634 308 GLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
18-226 |
1.03e-49 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 171.73 E-value: 1.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPW----GPKeigALVISPTRE 93
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEEtkddGPY---ALILAPTRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHEDLEHLNqqlIVGGNSIEEDIATLRREtpC-ILVCTPGRLEDLFQRKGDDLNlaaQVkslEFLVL 172
Cdd:cd17945 78 LAQQIEEETQKFAKPLGIRVVS---IVGGHSIEEQAFSLRNG--CeILIATPGRLLDCLERRLLVLN---QC---TYVVL 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 173 DEADRLLDLGFKTSVNNILGYLP--------------------RQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17945 147 DEADRMIDMGFEPQVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
6-396 |
2.38e-49 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 180.53 E-value: 2.38e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 6 WSSLDKPPlsdAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWGPKEIGA 85
Cdd:PRK04537 11 FSSFDLHP---ALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDPRA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 86 LVISPTRELARQISEVLAQFleHEDLeHLNQQLIVGGNSIEEDIATLRRETPCIlVCTPGRLEDLFQRKgddlnlaaQVK 165
Cdd:PRK04537 88 LILAPTRELAIQIHKDAVKF--GADL-GLRFALVYGGVDYDKQRELLQQGVDVI-IATPGRLIDYVKQH--------KVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 166 SL---EFLVLDEADRLLDLGFKTSVNNILGYLPRQ--RRTGLFSATQTTEVTDLIRAGLRNPVLVsVKEKASVNTPARLQ 240
Cdd:PRK04537 156 SLhacEICVLDEADRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKL-VVETETITAARVRQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 241 NFYRIVEPElKFVALLEFLSSPATVigKVMVFFPTCACVEYWAEALPPLLPKRTVLGihGKM-KNKRANVVEKFRNTPQA 319
Cdd:PRK04537 235 RIYFPADEE-KQTLLLGLLSRSEGA--RTMVFVNTKAFVERVARTLERHGYRVGVLS--GDVpQKKRESLLNRFQKGQLE 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 320 VLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFL-------LPSEDAYvhflkINQKVELTK 392
Cdd:PRK04537 310 ILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFAceryamsLPDIEAY-----IEQKIPVEP 384
|
....
gi 21355559 393 LLTE 396
Cdd:PRK04537 385 VTAE 388
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
31-214 |
3.28e-49 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 168.57 E-value: 3.28e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 31 TPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpwGPKeigALVISPTRELARQISEVLAQFLEHED 110
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDN----GPQ---ALVLAPTRELAEQIYEELKKLGKGLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 111 LEHLnqqLIVGGNSIEEDIATLRRetPCILVCTPGRLEDLFQRKGDdlnlaaqVKSLEFLVLDEADRLLDLGFKTSVNNI 190
Cdd:pfam00270 74 LKVA---SLLGGDSRKEQLEKLKG--PDILVGTPGRLLDLLQERKL-------LKNLKLLVLDEAHRLLDMGFGPDLEEI 141
|
170 180
....*....|....*....|....
gi 21355559 191 LGYLPRQRRTGLFSATQTTEVTDL 214
Cdd:pfam00270 142 LRRLPKKRQILLLSATLPRNLEDL 165
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
14-378 |
7.10e-49 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 177.41 E-value: 7.10e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQrrhkETPwGPK-----EIGALVI 88
Cdd:PRK01297 94 LAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLL----QTP-PPKerymgEPRALII 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 89 SPTRELARQISEVLAQFLEHEDlehLNQQLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDDLNLaaqvksLE 168
Cdd:PRK01297 169 APTRELVVQIAKDAAALTKYTG---LNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDM------VE 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 169 FLVLDEADRLLDLGFKTSVNNILGYLPR--QRRTGLFSATQTTEVTDLIRAGLRNPVLVSVkEKASVNTPARLQNFYRIV 246
Cdd:PRK01297 240 VMVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEI-EPENVASDTVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 247 EPElKFVALLEFLSSPAtvIGKVMVFFPTCACVEYWAEALppllpKRTvlGIHGKM------KNKRANVVEKFRNTPQAV 320
Cdd:PRK01297 319 GSD-KYKLLYNLVTQNP--WERVMVFANRKDEVRRIEERL-----VKD--GINAAQlsgdvpQHKRIKTLEGFREGKIRV 388
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 21355559 321 LLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFlLPSEDAY 378
Cdd:PRK01297 389 LVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF-AGEDDAF 445
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
14-225 |
4.65e-46 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 161.60 E-value: 4.65e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLE-ILQRrhKETPWGPKEIGALVISPTR 92
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQkILKA--KAESGEEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 93 ELARQISEVLAQFLEH--EDLEHLNqqliVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDDLnlaaqVKSLEFL 170
Cdd:cd17961 79 ELAQQVSKVLEQLTAYcrKDVRVVN----LSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLL-----LSTLKYL 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 171 VLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLV 225
Cdd:cd17961 150 VIDEADLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
4-223 |
8.53e-46 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 161.39 E-value: 8.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 4 KKWSSLDkppLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPML-EILQRRHKETPWGPKe 82
Cdd:cd17953 12 QKWSQCG---LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrHIKDQRPVKPGEGPI- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 83 igALVISPTRELARQISEVLAQFLEHEDlehLNQQLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLF-QRKGDDLNLa 161
Cdd:cd17953 88 --GLIMAPTRELALQIYVECKKFSKALG---LRVVCVYGGSGISEQIAELKRGAE-IVVCTPGRMIDILtANNGRVTNL- 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355559 162 aqvKSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPV 223
Cdd:cd17953 161 ---RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
8-375 |
1.93e-45 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 165.77 E-value: 1.93e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 8 SLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgpkeigALV 87
Cdd:PTZ00424 29 SFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ-------ALI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 88 ISPTRELARQISEV---LAQFLEhedlehLNQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKgddlnlAAQV 164
Cdd:PTZ00424 102 LAPTRELAQQIQKVvlaLGDYLK------VRCHACVGGTVVRDDINKLK-AGVHMVVGTPGRVYDMIDKR------HLRV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 165 KSLEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVKEKASvnTPARLQNFYR 244
Cdd:PTZ00424 169 DDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDEL--TLEGIRQFYV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 245 IVE-PELKFVALLEFLSSpaTVIGKVMVFFPTCACVEYWAEALPPLLpkRTVLGIHGKMKNK-RANVVEKFRNTPQAVLL 322
Cdd:PTZ00424 247 AVEkEEWKFDTLCDLYET--LTITQAIIYCNTRRKVDYLTKKMHERD--FTVSCMHGDMDQKdRDLIMREFRSGSTRVLI 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 21355559 323 CTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSE 375
Cdd:PTZ00424 323 TTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDD 375
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
13-226 |
5.28e-45 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 158.54 E-value: 5.28e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 13 PLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILqrrhKETPWGpkeIGALVISPTR 92
Cdd:cd17955 5 GLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL----SEDPYG---IFALVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 93 ELARQISEvlaQFLEHEDLEHLNQQLIVGGNSIEEDIATLRREtPCILVCTPGRLEDLFQrkgDDLNLAAQVKSLEFLVL 172
Cdd:cd17955 78 ELAYQIAE---QFRALGAPLGLRCCVIVGGMDMVKQALELSKR-PHIVVATPGRLADHLR---SSDDTTKVLSRVKFLVL 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 21355559 173 DEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17955 151 DEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
26-227 |
5.58e-44 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 155.44 E-value: 5.58e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 26 GFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKEtpwgpKEIGALVISPTRELARQISEVLAQF 105
Cdd:cd17957 9 GYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRKK-----KGLRALILAPTRELASQIYRELLKL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 106 LEHEDLEhlnQQLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVLDEADRLLDLGFKT 185
Cdd:cd17957 84 SKGTGLR---IVLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLS------SVEYLVLDEADKLFEPGFRE 154
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 21355559 186 SVNNILGYLPRQR-RTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd17957 155 QTDEILAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRIIV 197
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
22-232 |
7.59e-44 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 155.34 E-value: 7.59e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 22 VQSFGFQQMTPVQTAAIPLLLAR-KDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpwgpkeIGALVISPTRELARQISE 100
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKG--------GRVLVLVPTRELAEQWAE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 101 VLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDDLnlaaqvKSLEFLVLDEADRLLD 180
Cdd:smart00487 73 ELKKLGPSLGLKVV---GLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSL------SNVDLVILDEAHRLLD 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 21355559 181 LGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVKEKAS 232
Cdd:smart00487 144 GGFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
18-226 |
3.66e-43 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 153.90 E-value: 3.66e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRrhKETPWgPKEIG--ALVISPTRELA 95
Cdd:cd17949 2 VSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLS--LEPRV-DRSDGtlALVLVPTRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 96 RQISEVlaqflehedLEHLNQQ-------LIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQrkgddlNLAA-QVKSL 167
Cdd:cd17949 79 LQIYEV---------LEKLLKPfhwivpgYLIGGEKRKSEKARLRKGVN-ILIATPGRLLDHLK------NTQSfDVSNL 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355559 168 EFLVLDEADRLLDLGFKTSVNNILGYL-------------PRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17949 143 RWLVLDEADRLLDMGFEKDITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
239-371 |
5.45e-43 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 150.35 E-value: 5.45e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 239 LQNFYRIVEPELKFVALLEFLSSPATvIGKVMVFFPTCACVEYWAEALPPLlpKRTVLGIHGKMK-NKRANVVEKFRNTP 317
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLK-PGKAIIFVNTKKRVDRLAELLEEL--GIKVAALHGDLSqEERERALKKFRSGK 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 21355559 318 QAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFL 371
Cdd:cd18787 78 VRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
8-227 |
2.07e-42 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 152.26 E-value: 2.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 8 SLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPML-EILQ--------RRHKETPW 78
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIIsKLLEdgppsvgrGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 79 gpkeigALVISPTRELARQISEVLAQFLEHedlEHLNQQLIVGGNSIEEDIATLRREtpC-ILVCTPGRLEDLFQRkgDD 157
Cdd:cd17967 81 ------ALILAPTRELAIQIYEEARKFSYR---SGVRSVVVYGGADVVHQQLQLLRG--CdILVATPGRLVDFIER--GR 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 158 LNLAaqvkSLEFLVLDEADRLLDLGFKTSVNNILGY----LPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd17967 148 ISLS----SIKFLVLDEADRMLDMGFEPQIRKIVEHpdmpPKGERQTLMFSATFPREIQRLAADFLKNYIFLTV 217
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
1-370 |
2.28e-42 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 157.83 E-value: 2.28e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 1 MSRKKWSSLdkpPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWGP 80
Cdd:PRK04837 5 LTEQKFSDF---ALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 81 KEIGALVISPTRELARQI---SEVLAQflehedLEHLNQQLIVGGNSIEEDIATLrRETPCILVCTPGRLEDLFQRKGDD 157
Cdd:PRK04837 82 NQPRALIMAPTRELAVQIhadAEPLAQ------ATGLKLGLAYGGDGYDKQLKVL-ESGVDILIGTTGRLIDYAKQNHIN 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 158 LNlAAQVkslefLVLDEADRLLDLGFKTSVNNILGYLP--RQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVK--EKASV 233
Cdd:PRK04837 155 LG-AIQV-----VVLDEADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEpeQKTGH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 234 NTPARLqnFYriveP--ELKFVALLEFLSS--PAtvigKVMVFFPT---CACVEYWAEAlpplLPKRTVLGIHGKMKNKR 306
Cdd:PRK04837 229 RIKEEL--FY----PsnEEKMRLLQTLIEEewPD----RAIIFANTkhrCEEIWGHLAA----DGHRVGLLTGDVAQKKR 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 307 ANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVF 370
Cdd:PRK04837 295 LRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
26-223 |
3.00e-41 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 148.21 E-value: 3.00e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 26 GFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQrrhketpwgPKE--IGALVISPTRELARQISEVLA 103
Cdd:cd17940 18 GFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID---------PKKdvIQALILVPTRELALQTSQVCK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 104 QFLEHEDLEHLnqqLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKgddlnlAAQVKSLEFLVLDEADRLLDLGF 183
Cdd:cd17940 89 ELGKHMGVKVM---VTTGGTSLRDDIMRLY-QTVHVLVGTPGRILDLAKKG------VADLSHCKTLVLDEADKLLSQDF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 21355559 184 KTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPV 223
Cdd:cd17940 159 QPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
14-371 |
5.72e-40 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 153.02 E-value: 5.72e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWGPKEIGALVISPTRE 93
Cdd:PLN00206 128 LPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGHPSEQRNPLAMVLTPTRE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISE---VLAQFLEhedlehLNQQLIVGGNSIEEDIATLRRETPCIlVCTPGRLEDLFQRKgdDLNLAaqvkSLEFL 170
Cdd:PLN00206 208 LCVQVEDqakVLGKGLP------FKTALVVGGDAMPQQLYRIQQGVELI-VGTPGRLIDLLSKH--DIELD----NVSVL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 171 VLDEADRLLDLGFKTSVNNILGYLPrQRRTGLFSATQTTEVTDLIRAGLRNPVLVSVkekASVNTPARLQNFYRI-VEPE 249
Cdd:PLN00206 275 VLDEVDCMLERGFRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISI---GNPNRPNKAVKQLAIwVETK 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 250 LKFVALLEFLSSPATVIGKVMVFFPTCACVEYWAEALPpLLPKRTVLGIHGK--MKNKRaNVVEKFRNTPQAVLLCTDVL 327
Cdd:PLN00206 351 QKKQKLFDILKSKQHFKPPAVVFVSSRLGADLLANAIT-VVTGLKALSIHGEksMKERR-EVMKSFLVGEVPVIVATGVL 428
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 21355559 328 ARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFL 371
Cdd:PLN00206 429 GRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
18-225 |
6.07e-40 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 144.79 E-value: 6.07e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWGPKEiG--ALVISPTRELA 95
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKGE-GpyGLIVCPSRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 96 RQISEVLAQF---LEHEDLEHLNQQLIVGGNSIEEDIATLRRETPCIlVCTPGRLEDLFQRKGDDLNLAaqvkslEFLVL 172
Cdd:cd17951 80 RQTHEVIEYYckaLQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIV-VATPGRLMDMLNKKKINLDIC------RYLCL 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 21355559 173 DEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLV 225
Cdd:cd17951 153 DEADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
13-223 |
4.70e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 142.08 E-value: 4.70e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 13 PLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgpkeigALVISPTR 92
Cdd:cd17939 3 GLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQ-------ALVLAPTR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 93 ELARQISEV---LAQFLEHEdlehlnQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKgddlnlAAQVKSLEF 169
Cdd:cd17939 76 ELAQQIQKVvkaLGDYMGVK------VHACIGGTSVREDRRKLQ-YGPHIVVGTPGRVFDMLQRR------SLRTDKIKM 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 21355559 170 LVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPV 223
Cdd:cd17939 143 FVLDEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
18-226 |
1.22e-37 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 138.17 E-value: 1.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEIL--QRRHKEtpwgpkeigALVISPTRELA 95
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLdlERRHPQ---------VLILAPTREIA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 96 RQISEVLAQFLEHedLEHLNQQLIVGGNSIEEDIATLRRetPCILVCTPGRLEDLFQrkgddlNLAAQVKSLEFLVLDEA 175
Cdd:cd17943 72 VQIHDVFKKIGKK--LEGLKCEVFIGGTPVKEDKKKLKG--CHIAVGTPGRIKQLIE------LGALNVSHVRLFVLDEA 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 21355559 176 DRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17943 142 DKLMEGSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
18-208 |
1.36e-36 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 136.60 E-value: 1.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPL-LLARKDVSAEAVTGSGKTLAFLVPMLE-ILQRRHKETPWGP-KEIGALVISPTREL 94
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILErLLSQKSSNGVGGKqKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 95 ARQISEVLAQFLEHEDLEHLNqqlIVGGNSIEEDIATLRREtPCILVCTPGRLEDLFQrKGDDlnLAAQVKSLEFLVLDE 174
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIAS---IVGGLAVQKQERLLKKR-PEIVVATPGRLWELIQ-EGNE--HLANLKSLRFLVLDE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 21355559 175 ADRLLDLGFKTSVNNILGYLP-------RQRRTGLFSATQT 208
Cdd:cd17946 154 ADRMLEKGHFAELEKILELLNkdragkkRKRQTFVFSATLT 194
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
18-226 |
3.17e-36 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 134.46 E-value: 3.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPML-EILQRRHKETPWGPKeigALVISPTRELAR 96
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvHIMDQRELEKGEGPI---AVIVAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISEVLAQFLEhedLEHLNQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKGDDLNLAAqvksleFLVLDEAD 176
Cdd:cd17952 78 QIYLEAKKFGK---AYNLRVVAVYGGGSKWEQAKALQ-EGAEIVVATPGRLIDMVKKKATNLQRVT------YLVLDEAD 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17952 148 RMFDMGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
20-225 |
3.41e-36 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 134.37 E-value: 3.41e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 20 QVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQrrhketpwgpkeigALVISPTRELARQIS 99
Cdd:cd17938 12 KAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV--------------ALILEPSRELAEQTY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 100 EVLAQFLEHEDLEHLNQQLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVLDEADRLL 179
Cdd:cd17938 78 NCIENFKKYLDNPKLRVALLIGGVKAREQLKRLESGVD-IVVGTPGRLEDLIKTGKLDLS------SVRFFVLDEADRLL 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 21355559 180 DLGFKTSVNNILGYLPRQRRTG------LFSAT-QTTEVTDLIRAGLRNPVLV 225
Cdd:cd17938 151 SQGNLETINRIYNRIPKITSDGkrlqviVCSATlHSFEVKKLADKIMHFPTWV 203
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
18-226 |
6.71e-36 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 133.26 E-value: 6.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP-MLEILQRRHKETPWGPKeigALVISPTRELAR 96
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPaIVHINAQPPLERGDGPI---VLVLAPTRELAQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISEVLAQFLEHEDLEhlnQQLIVGGNSIEEDIATLRReTPCILVCTPGRLEDLFQRKGDDLnlaaqvKSLEFLVLDEAD 176
Cdd:cd17966 78 QIQQEANKFGGSSRLR---NTCVYGGAPKGPQIRDLRR-GVEICIATPGRLIDFLDQGKTNL------RRVTYLVLDEAD 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17966 148 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
7-214 |
8.75e-35 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 132.40 E-value: 8.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 7 SSLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETP--WGPKEIG 84
Cdd:cd18052 43 LTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGLTASsfSEVQEPQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 85 ALVISPTRELARQIsevlaqFLEHEDLEH---LNQQLIVGGNSIEEDIATLRREtpC-ILVCTPGRLEDLFQRKGDDLnl 160
Cdd:cd18052 123 ALIVAPTRELANQI------FLEARKFSYgtcIRPVVVYGGVSVGHQIRQIEKG--ChILVATPGRLLDFIGRGKISL-- 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 21355559 161 aaqvKSLEFLVLDEADRLLDLGFKTSVNNILGYL--PR--QRRTGLFSATQTTEVTDL 214
Cdd:cd18052 193 ----SKLKYLILDEADRMLDMGFGPEIRKLVSEPgmPSkeDRQTLMFSATFPEEIQRL 246
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
18-225 |
1.90e-33 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 126.81 E-value: 1.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP-MLEI-LQRRHKETPWGPkeiGALVISPTRELA 95
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgFIHLdLQPIPREQRNGP---GVLVLTPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 96 RQISEVLAQFLeHEDLEHLnqqLIVGGNSIEEDIATLRREtPCILVCTPGRLEDLfqrkgdDLNLAAQVKSLEFLVLDEA 175
Cdd:cd17958 78 LQIEAECSKYS-YKGLKSV---CVYGGGNRNEQIEDLSKG-VDIIIATPGRLNDL------QMNNVINLKSITYLVLDEA 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 176 DRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLV 225
Cdd:cd17958 147 DRMLDMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
7-227 |
3.06e-33 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 127.85 E-value: 3.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 7 SSLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPmleILQRRHKETPWGPKEIG-- 84
Cdd:cd18051 21 ETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLP---ILSQIYEQGPGESLPSEsg 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 85 ----------ALVISPTRELARQISEVLAQFLEHedlEHLNQQLIVGGNSIEEDIATLRREtpC-ILVCTPGRLEDLFQR 153
Cdd:cd18051 98 yygrrkqyplALVLAPTRELASQIYDEARKFAYR---SRVRPCVVYGGADIGQQMRDLERG--ChLLVATPGRLVDMLER 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21355559 154 KGDDLNlaaQVKsleFLVLDEADRLLDLGFKTSVNNIL--GYLPR--QRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd18051 173 GKIGLD---YCK---YLVLDEADRMLDMGFEPQIRRIVeqDTMPPtgERQTLMFSATFPKEIQMLARDFLDNYIFLAV 244
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
18-226 |
5.29e-33 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 126.59 E-value: 5.29e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLA---------RKDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpwgpKEIGALVI 88
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPsskstppyrPGDLCVSAPTGSGKTLAYVLPIVQALSKRVV------PRLRALIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 89 SPTRELARQISEVLAQFLEHEDLEHLnqqLIVGGNSIEEDIATLR-------RETPCILVCTPGRLED-LFQRKGDDLnl 160
Cdd:cd17956 75 VPTKELVQQVYKVFESLCKGTGLKVV---SLSGQKSFKKEQKLLLvdtsgryLSRVDILVATPGRLVDhLNSTPGFTL-- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 161 aaqvKSLEFLVLDEADRLLDLGFK---TSVNNILGYLPRQRRTG-----------------LFSATQTTEVTDLIRAGLR 220
Cdd:cd17956 150 ----KHLRFLVIDEADRLLNQSFQdwlETVMKALGRPTAPDLGSfgdanllersvrplqklLFSATLTRDPEKLSSLKLH 225
|
....*.
gi 21355559 221 NPVLVS 226
Cdd:cd17956 226 RPRLFT 231
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
14-223 |
1.47e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 121.40 E-value: 1.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVpmlEILQRRHKETpwgpKEIGALVISPTRE 93
Cdd:cd18046 6 LKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSI---SILQQIDTSL----KATQALVLAPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHEDLehlNQQLIVGGNSIEEDIATLRrETPCILVCTPGRLEDLFQRKgddlnlAAQVKSLEFLVLD 173
Cdd:cd18046 79 LAQQIQKVVMALGDYMGI---KCHACIGGTSVRDDAQKLQ-AGPHIVVGTPGRVFDMINRR------YLRTDYIKMFVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 21355559 174 EADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPV 223
Cdd:cd18046 149 EADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
14-227 |
1.99e-30 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 118.60 E-value: 1.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLvpmLEILQRRHKEtpwgPKEIGALVISPTRE 93
Cdd:cd17950 9 LKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFV---LSTLQQLEPV----DGQVSVLVICHTRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHedLEHLNQQLIVGGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKgddlnlAAQVKSLEFLVLD 173
Cdd:cd17950 82 LAFQISNEYERFSKY--MPNVKTAVFFGGVPIKKDIEVLKNKCPHIVVGTPGRILALVREK------KLKLSHVKHFVLD 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 174 EADRLL-DLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd17950 154 ECDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
14-223 |
2.32e-30 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 117.95 E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgpkeigALVISPTRE 93
Cdd:cd18045 6 LREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQ-------ALILSPTRE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 94 LARQISEVLAQFLEHedlehLNQQL--IVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKgddlnlAAQVKSLEFLV 171
Cdd:cd18045 79 LAVQIQKVLLALGDY-----MNVQChaCIGGTSVGDDIRKLDYGQH-IVSGTPGRVFDMIRRR------SLRTRHIKMLV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 21355559 172 LDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPV 223
Cdd:cd18045 147 LDEADEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPI 198
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
26-226 |
8.00e-29 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 113.41 E-value: 8.00e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 26 GFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLeILQRRHKETPwgpkeiGALVISPTRELARQIsEVLAQF 105
Cdd:cd17962 9 GYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI-IRCLTEHRNP------SALILTPTRELAVQI-EDQAKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 106 LeHEDLEHLNQQLIVGGNSIEEDIATLRRETPCIlVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVLDEADRLLDLGFKT 185
Cdd:cd17962 81 L-MKGLPPMKTALLVGGLPLPPQLYRLQQGVKVI-IATPGRLLDILKQSSVELD------NIKIVVVDEADTMLKMGFQQ 152
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 21355559 186 SVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVS 226
Cdd:cd17962 153 QVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
18-227 |
1.39e-27 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 111.25 E-value: 1.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP-MLEILQRRHKETPWGPKeigALVISPTRELAR 96
Cdd:cd18049 35 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPaIVHINHQPFLERGDGPI---CLVLAPTRELAQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISEVLAqflEHEDLEHLNQQLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLNLAAqvksleFLVLDEAD 176
Cdd:cd18049 112 QVQQVAA---EYGRACRLKSTCIYGGAPKGPQIRDLERGVE-ICIATPGRLIDFLEAGKTNLRRCT------YLVLDEAD 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd18049 182 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
14-216 |
1.76e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 109.59 E-value: 1.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLA--RKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPwgpkeigALVISPT 91
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSdpPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQ-------ALCLAPT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 92 RELARQISEVLAQFLEHEDLEhlnQQLIVGGNsieeDIATLRRETPCILVCTPGRLEDLFQRKGDDLnlaaqvKSLEFLV 171
Cdd:cd17963 74 RELARQIGEVVEKMGKFTGVK---VALAVPGN----DVPRGKKITAQIVIGTPGTVLDWLKKRQLDL------KKIKILV 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 21355559 172 LDEADRLLDL-GFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIR 216
Cdd:cd17963 141 LDEADVMLDTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAE 186
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
18-227 |
2.60e-26 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 108.56 E-value: 2.60e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP-MLEILQRRHKETPWGPKeigALVISPTRELAR 96
Cdd:cd18050 73 VMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPaIVHINHQPYLERGDGPI---CLVLAPTRELAQ 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISEVLaqfLEHEDLEHLNQQLIVGGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLnlaaqvKSLEFLVLDEAD 176
Cdd:cd18050 150 QVQQVA---DDYGKSSRLKSTCIYGGAPKGPQIRDLERGVE-ICIATPGRLIDFLEAGKTNL------RRCTYLVLDEAD 219
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNPVLVSV 227
Cdd:cd18050 220 RMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
18-235 |
3.20e-25 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 104.37 E-value: 3.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 18 VLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRhKETPWGP-KEIGALVISPTRELAR 96
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRY-KLLAEGPfNAPRGLVITPSRELAE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISEVLAQFLEHEDlehLNQQLIVGGNSiEEDIATLRRETPCILVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVLDEAD 176
Cdd:cd17948 80 QIGSVAQSLTEGLG---LKVKVITGGRT-KRQIRNPHFEEVDILVATPGALSKLLTSRIYSLE------QLRHLVLDEAD 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 177 RLLDLGFKTSVNNILGYLPRQRR-----TGLFSATQTTEVTDLIRAGLRNpVLVSVKEKASVNT 235
Cdd:cd17948 150 TLLDDSFNEKLSHFLRRFPLASRrsentDGLDPGTQLVLVSATMPSGVGE-VLSKVIDVDSIET 212
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
251-362 |
3.62e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 94.58 E-value: 3.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 251 KFVALLEFLSSpaTVIGKVMVFFPTCACVEywAEALPPLLpKRTVLGIHGKMKNK-RANVVEKFRNTPQAVLLCTDVLAR 329
Cdd:pfam00271 2 KLEALLELLKK--ERGGKVLIFSQTKKTLE--AELLLEKE-GIKVARLHGDLSQEeREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110
....*....|....*....|....*....|...
gi 21355559 330 GLDVPEIEWVVQWDPPSTASSFVHRVGRTARQG 362
Cdd:pfam00271 77 GLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
19-206 |
1.16e-21 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 93.37 E-value: 1.16e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 19 LQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETPWG--PKeigALVISPTRELAR 96
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGraPK---VLVLAPTRELAN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 QISevlaqflehEDLEHLNQQLIV----GGNSIEEDIATLRRETPcILVCTPGRLEDLFQRKGDDLNlaaqvkSLEFLVL 172
Cdd:cd17944 79 QVT---------KDFKDITRKLSVacfyGGTPYQQQIFAIRNGID-ILVGTPGRIKDHLQNGRLDLT------KLKHVVL 142
|
170 180 190
....*....|....*....|....*....|....*....
gi 21355559 173 DEADRLLDLGFKTSVNNILGYLPRQR-----RTGLFSAT 206
Cdd:cd17944 143 DEVDQMLDMGFAEQVEEILSVSYKKDsednpQTLLFSAT 181
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
12-206 |
6.52e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 89.36 E-value: 6.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 12 PPLSDAVLQVVQSFGFQQM-----TPVQTAAIPLLL------ARKDVSAE----------AVTGSGKTLAFLVPMLEILQ 70
Cdd:cd17965 8 PSVREAIIKEILKGSNKTDeeikpSPIQTLAIKKLLktlmrkVTKQTSNEepklevfllaAETGSGKTLAYLAPLLDYLK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 71 RRHKETPWGPKE----------IGALVISPTRELARQISEVLAQFLEHEDLehlnqqlivGGNSIEEDIATLRRETPC-- 138
Cdd:cd17965 88 RQEQEPFEEAEEeyesakdtgrPRSVILVPTHELVEQVYSVLKKLSHTVKL---------GIKTFSSGFGPSYQRLQLaf 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355559 139 -----ILVCTPGRLEDLFQrkgDDLNLAAQVkslEFLVLDEADRLLDLGFKTSVNNILGYLPRQRRTGLFSAT 206
Cdd:cd17965 159 kgridILVTTPGKLASLAK---SRPKILSRV---THLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225
|
|
| DUF4217 |
pfam13959 |
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ... |
414-470 |
6.67e-19 |
|
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.
Pssm-ID: 464056 [Multi-domain] Cd Length: 59 Bit Score: 80.52 E-value: 6.67e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 21355559 414 QLHRLQAADKGVYDKGMRAFVSHVRAYTKHECSAILRLKDLDLGKMATAYGLLQLPR 470
Cdd:pfam13959 3 QLEKLVLKDRELKELAQKAFVSYVRAYSKHLAKSIFNVKKLDLGHLAKSFGLLRAPK 59
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
298-362 |
3.58e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 79.18 E-value: 3.58e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 298 IHGKM-KNKRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQG 362
Cdd:smart00490 17 LHGGLsQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
43-371 |
4.63e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 78.14 E-value: 4.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 43 ARKDVSAEAVTGSGKTLAFLVPMLEILQRRHketpwgpkeigALVISPTRELARQISEVLAQFLEHEdlehlnqqlIVGG 122
Cdd:COG1061 99 GGGRGLVVAPTGTGKTVLALALAAELLRGKR-----------VLVLVPRRELLEQWAEELRRFLGDP---------LAGG 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 123 NSIEED-------IATLRREtpcilvctpGRLEDLFQRKGddlnlaaqvksleFLVLDEADRLLDLGFKtsvnNILGYLP 195
Cdd:COG1061 159 GKKDSDapitvatYQSLARR---------AHLDELGDRFG-------------LVIIDEAHHAGAPSYR----RILEAFP 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 196 RQRRTGLfSAT----------------QTTEVT--DLIRAG-LRNPVLVSVK----EKASVNTPARLQNFYRIVEPELKF 252
Cdd:COG1061 213 AAYRLGL-TATpfrsdgreillflfdgIVYEYSlkEAIEDGyLAPPEYYGIRvdltDERAEYDALSERLREALAADAERK 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 253 VALLEFLSSPATVIGKVMVFFPTCACVEYWAEALPPLLPKRTVlgIHGKMKNK-RANVVEKFRNTPQAVLLCTDVLARGL 331
Cdd:COG1061 292 DKILRELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAV--VTGDTPKKeREEILEAFRDGELRILVTVDVLNEGV 369
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 21355559 332 DVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFL 371
Cdd:COG1061 370 DVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVY 409
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
45-206 |
5.68e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.44 E-value: 5.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 45 KDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpwgpkeiGALVISPTRELARQISEVLAQFLEHedleHLNQQLIVGGNS 124
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKGK---------KVLVLVPTKALALQTAERLRELFGP----GIRVAVLVGGSS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 125 IEEDIATLRRETPcILVCTPGRLEDLFQRkgddlNLAAQVKSLEFLVLDEADRLLDLGFKTsVNNILGYLPRQR---RTG 201
Cdd:cd00046 69 AEEREKNKLGDAD-IIIATPDMLLNLLLR-----EDRLFLKDLKLIIVDEAHALLIDSRGA-LILDLAVRKAGLknaQVI 141
|
....*
gi 21355559 202 LFSAT 206
Cdd:cd00046 142 LLSAT 146
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
34-175 |
1.31e-13 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 69.54 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 34 QTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETpwgpkeigALVISPTRELA----RQISEVLAQFLEHE 109
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSR--------ALYLYPTKALAqdqlRSLRELLEQLGLGI 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 110 DLEHLNqqlivgGNSIEEDIATLRRETPCILVCTPGRLEDLFQRKGDdlNLAAQVKSLEFLVLDEA 175
Cdd:cd17923 77 RVATYD------GDTPREERRAIIRNPPRILLTNPDMLHYALLPHHD--RWARFLRNLRYVVLDEA 134
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
8-206 |
1.49e-10 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 61.58 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 8 SLDKPPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLAR--KDVSAEAVTGSGKTLAFLVPMLEILQRRHKEtpwgPKeigA 85
Cdd:cd18048 19 SFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY----PQ---C 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 86 LVISPTRELARQISEVLAQFLEH-EDLEHLnqqLIVGGNSIEEDiatlRRETPCILVCTPGRLED-LFQRKGDDlnlaaq 163
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFcVGIQVI---YAIRGNRPGKG----TDIEAQIVIGTPGTVLDwCFKLRLID------ 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 21355559 164 VKSLEFLVLDEADRLLDL-GFKTSVNNILGYLPRQRRTGLFSAT 206
Cdd:cd18048 159 VTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSAT 202
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
14-175 |
7.68e-10 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 61.45 E-value: 7.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIP-LLLARKDVSAEAVTGSGKTL-AFLvPMLEILQRRHKetpwgpkeigALVISPT 91
Cdd:COG1204 7 PLEKVIEFLKERGIEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLiAEL-AILKALLNGGK----------ALYIVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 92 RELARQISEVLAQFLEHEdlehlnqQLIVGGNS--IEEDIATLRRETpcILVCTPGRLeDLFQRKGDDLnlaaqVKSLEF 169
Cdd:COG1204 76 RALASEKYREFKRDFEEL-------GIKVGVSTgdYDSDDEWLGRYD--ILVATPEKL-DSLLRNGPSW-----LRDVDL 140
|
....*.
gi 21355559 170 LVLDEA 175
Cdd:COG1204 141 VVVDEA 146
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
12-111 |
1.84e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 60.62 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 12 PPLSDAVLQVVQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLEILQRRHKETpwgpkeigALVISPT 91
Cdd:COG1205 39 DWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPGAT--------ALYLYPT 110
|
90 100
....*....|....*....|.
gi 21355559 92 RELAR-QISEvLAQFLEHEDL 111
Cdd:COG1205 111 KALARdQLRR-LRELAEALGL 130
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
51-206 |
3.70e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 56.05 E-value: 3.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 51 AVTGSGKTLA-FLVPMLEILQRrhketpwGPKEIGALVISPTRELARQISEVLAQFLEHEDLEhlnqqLIVG---GNSIE 126
Cdd:cd17922 8 APTGSGKTEAaFLPALSSLADE-------PEKGVQVLYISPLKALINDQERRLEEPLDEIDLE-----IPVAvrhGDTSQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 127 EDIATLRRETPCILVCTPGRLEDLFQRKGDDLNLAaqvkSLEFLVLDEADRLLD----LGFKTSVNNILGYL-PRQRRTG 201
Cdd:cd17922 76 SEKAKQLKNPPGILITTPESLELLLVNKKLRELFA----GLRYVVVDEIHALLGskrgVQLELLLERLRKLTgRPLRRIG 151
|
....*
gi 21355559 202 LfSAT 206
Cdd:cd17922 152 L-SAT 155
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
27-357 |
1.22e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 58.19 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 27 FQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLA-FLVPMLEILQRRHKETPwgPKEIGALVISPTRELARQISEVLAQF 105
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAaFLPALDELARRPRPGEL--PDGLRVLYISPLKALANDIERNLRAP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 106 LEhEdlehLNQQLIVGGNSIEEDIAT----------LRRETPCILVCTPgrlEDLF----QRKGDDLnlaaqVKSLEFLV 171
Cdd:COG1201 100 LE-E----IGEAAGLPLPEIRVGVRTgdtpaserqrQRRRPPHILITTP---ESLAllltSPDAREL-----LRGVRTVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 172 LDE----AD------------RLLDLgfktsvnnilgyLPRQ-RRTGLfSATQ--------------TTEVTDLIRAGLR 220
Cdd:COG1201 167 VDEihalAGskrgvhlalsleRLRAL------------APRPlQRIGL-SATVgpleevarflvgyeDPRPVTIVDAGAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 221 NP----VLVSVKEKASVNTPARLQNFYriVEPElkfvaLLEFLSSPATVIgkvmVFFPTCACVEYWAEALPPLLPKRTVL 296
Cdd:COG1201 234 KKpdleVLVPVEDLIERFPWAGHLWPH--LYPR-----VLDLIEAHRTTL----VFTNTRSQAERLFQRLNELNPEDALP 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 297 -GI-HGKM-KNKRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGR 357
Cdd:COG1201 303 iAAhHGSLsREQRLEVEEALKAGELRAVVATSSLELGIDIGDVDLVIQVGSPKSVARLLQRIGR 366
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
14-206 |
2.44e-08 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 54.73 E-value: 2.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQSFGFQQMTPVQTAAIPLLLAR--KDVSAEAVTGSGKTLAFLVPMLEILQRRHKetpWGPkeigALVISPT 91
Cdd:cd18047 8 LKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANK---YPQ----CLCLSPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 92 RELARQISEVLAQFLEHedLEHLNQQLIVGGNSIEEDIatlrRETPCILVCTPGRLEDLFQRkgddLNLaAQVKSLEFLV 171
Cdd:cd18047 81 YELALQTGKVIEQMGKF--YPELKLAYAVRGNKLERGQ----KISEQIVIGTPGTVLDWCSK----LKF-IDPKKIKVFV 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 21355559 172 LDEADRLLDL-GFKTSVNNILGYLPRQRRTGLFSAT 206
Cdd:cd18047 150 LDEADVMIATqGHQDQSIRIQRMLPRNCQMLLFSAT 185
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
319-373 |
7.00e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.01 E-value: 7.00e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 319 AVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGnALVFLLP 373
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE-GEVILFV 77
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
30-175 |
2.28e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 51.11 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 30 MTPVQTAAIPLLLARKD-VSAEAVTGSGKTlafLVPMLEILQRRHKETPWgpkeigALVISPTRELArqiSEVLAQFleH 108
Cdd:cd17921 2 LNPIQREALRALYLSGDsVLVSAPTSSGKT---LIAELAILRALATSGGK------AVYIAPTRALV---NQKEADL--R 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355559 109 EDLEHLNQQLIVGGNSIEEDIATLRRETpcILVCTPGRLEDLFQRKGDDLnlaaqVKSLEFLVLDEA 175
Cdd:cd17921 68 ERFGPLGKNVGLLTGDPSVNKLLLAEAD--ILVATPEKLDLLLRNGGERL-----IQDVRLVVVDEA 127
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
9-410 |
2.40e-07 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 53.95 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 9 LDKPPLSDAVLQvvQSFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLeilqrrhketpwgPKEIGALVI 88
Cdd:PRK11057 7 LNLESLAKQVLQ--ETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPAL-------------VLDGLTLVV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 89 SPTRELAR-QISEVLAQFLEHEDL---EHLNQQLIVggnsieedIATLRRETPCILVCTPGRL-EDLFQRKGDDLNLAaq 163
Cdd:PRK11057 72 SPLISLMKdQVDQLLANGVAAACLnstQTREQQLEV--------MAGCRTGQIKLLYIAPERLmMDNFLEHLAHWNPA-- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 164 vksleFLVLDEADRLLDLG--FKTSVNNiLGYLpRQRRTGL----FSAT--QTTEVTDLIRAGLRNPvLVSVkekASVNT 235
Cdd:PRK11057 142 -----LLAVDEAHCISQWGhdFRPEYAA-LGQL-RQRFPTLpfmaLTATadDTTRQDIVRLLGLNDP-LIQI---SSFDR 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 236 ParlqNF-YRIVEpelKFVALLEFLSSPATVIGKVMVFFptC---ACVEYWAEAlpplLPKR--TVLGIHGKMKN-KRAN 308
Cdd:PRK11057 211 P----NIrYTLVE---KFKPLDQLMRYVQEQRGKSGIIY--CnsrAKVEDTAAR----LQSRgiSAAAYHAGLDNdVRAD 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 309 VVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEGNALVFLLPSEDAYvhflkinqkv 388
Cdd:PRK11057 278 VQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAW---------- 347
|
410 420
....*....|....*....|....
gi 21355559 389 eLTKLLTEEAEDA--DREKKKLPA 410
Cdd:PRK11057 348 -LRRCLEEKPAGQqqDIERHKLNA 370
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
309-371 |
2.97e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.05 E-value: 2.97e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21355559 309 VVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQgNEGNALVFL 371
Cdd:cd18801 82 VIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGRK-RQGRVVVLL 143
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
309-363 |
8.96e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 48.74 E-value: 8.96e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 309 VVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRtARQGN 363
Cdd:cd18802 82 TLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPN 135
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
268-364 |
1.71e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 48.03 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 268 KVMVFFPTCACVEYWAEALPPLLPKRTVLGI----HGKM-KNKRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQW 342
Cdd:cd18796 40 STLVFTNTRSQAERLAQRLRELCPDRVPPDFialhHGSLsRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQI 119
|
90 100
....*....|....*....|..
gi 21355559 343 DPPSTASSFVHRVGRTARQGNE 364
Cdd:cd18796 120 GSPKSVARLLQRLGRSGHRPGA 141
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
50-408 |
3.33e-06 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 50.08 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 50 EAVTGSGKTLAFLVPMLEILQRRHKEtpwgpkeiGALVISPTRELARQISEVLAQFLEHEDLEH-----LNQQLIVGGNS 124
Cdd:COG1203 153 TAPTGGGKTEAALLFALRLAAKHGGR--------RIIYALPFTSIINQTYDRLRDLFGEDVLLHhsladLDLLEEEEEYE 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 125 IEEDIATLRRE---TPcILVCTPGRL-EDLF-QRKGDDLNLAAQVKSLefLVLDEAD----RLLDLgfktsVNNILGYLP 195
Cdd:COG1203 225 SEARWLKLLKElwdAP-VVVTTIDQLfESLFsNRKGQERRLHNLANSV--IILDEVQayppYMLAL-----LLRLLEWLK 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 196 RQRRTGLF-SATQttevTDLIRAGLRNPV--LVSVKEKASVNTPARLQNFYRIVEPELKFVALLEFLSSPATVIGKVMVF 272
Cdd:COG1203 297 NLGGSVILmTATL----PPLLREELLEAYelIPDEPEELPEYFRAFVRKRVELKEGPLSDEELAELILEALHKGKSVLVI 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 273 FPTCA-CVEYWaEALPPLLPKRTVLGIHGKM-----KNKRANVVEKFRNTPQAVLLCTDVLARGLDVpEIEWVVQwDpPS 346
Cdd:COG1203 373 VNTVKdAQELY-EALKEKLPDEEVYLLHSRFcpadrSEIEKEIKERLERGKPCILVSTQVVEAGVDI-DFDVVIR-D-LA 448
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21355559 347 TASSFVHRVGRTARQG-NEGNALVFLLPSEDAYVHFLKINQKVELT-KLLTEEAEDADREKKKL 408
Cdd:COG1203 449 PLDSLIQRAGRCNRHGrKEEEGNVYVFDPEDEGGGYVYDKPLLERTrELLREHDEILPEDKREL 512
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
47-175 |
5.77e-06 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 47.29 E-value: 5.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 47 VSAEAVTGSGKTLAFLVPMLEiLQRRHKetpwGPKEIGALvisPTRELARQISEVLAQFLEHEDLE------HLNQQLIV 120
Cdd:cd17930 4 VILEAPTGSGKTEAALLWALK-LAARGG----KRRIIYAL---PTRATINQMYERIREILGRLDDEdkvlllHSKAALEL 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355559 121 GGNSIEEDIATLRRET-----------PcILVCTPGR-LEDLFQRKGDDLNLAAQVKSLefLVLDEA 175
Cdd:cd17930 76 LESDEEPDDDPVEAVDwalllkrswlaP-IVVTTIDQlLESLLKYKHFERRLHGLANSV--VVLDEV 139
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
305-369 |
6.55e-06 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 49.34 E-value: 6.55e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355559 305 KRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGnEGNALV 369
Cdd:COG1111 399 EQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKR-EGRVVV 462
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
50-396 |
6.12e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 45.50 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 50 EAVTGSGKTLAFLVPMLEILQRRHKEtpwgpKEIGALvisPTRELARQISEVLAQFLEHEDLEHLnqqlIVGGNSIEEDI 129
Cdd:cd09639 5 EAPTGYGKTEAALLWALHSLKSQKAD-----RVIIAL---PTRATINAMYRRAKEAFGETGLYHS----SILSSRIKEMG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 130 ATLRRETPC--------------ILVCTPGRLEDLFQR--KGDDLNLAAQVKSLefLVLDEADRLLDlgfkTSVNNILGY 193
Cdd:cd09639 73 DSEEFEHLFplyihsndtlfldpITVCTIDQVLKSVFGefGHYEFTLASIANSL--LIFDEVHFYDE----YTLALILAV 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 194 LPRQRRTG----LFSATqtteVTDLIRAGLRNpVLVSVKEKASVNTPARLQNFYRIVE---PELKFV-ALLEFLSSPatv 265
Cdd:cd09639 147 LEVLKDNDvpilLMSAT----LPKFLKEYAEK-IGYVEENEPLDLKPNERAPFIKIESdkvGEISSLeRLLEFIKKG--- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 266 iGKVMVFFPTCACVEYWAEALPPLLPKRTVLGIHGKMK-----NKRANVVEKFRNTPQAVLLCTDVLARGLDVpEIEWVV 340
Cdd:cd09639 219 -GSVAIIVNTVDRAQEFYQQLKEKGPEEEIMLIHSRFTekdraKKEAELLLEFKKSEKFVIVATQVIEASLDI-SVDVMI 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 21355559 341 QwdPPSTASSFVHRVGRTARQG-NEGNALVFLLPSEDAYVHFLKINQKVELT-KLLTE 396
Cdd:cd09639 297 T--ELAPIDSLIQRLGRLHRYGeKNGEEVYIITDAPDGKGQKPYPYDLVERTiELLEE 352
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
17-222 |
1.10e-04 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 43.78 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 17 AVLQVVqsFGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVPMLeILQRRHKetpwGPkeigALVISPTRELAR 96
Cdd:cd18018 2 KLLRRV--FGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL-LLRRRGP----GL----TLVVSPLIALMK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 97 -QISevlaqFLEHedleHLNQQLIVGGNSIEEDIATLRR----ETPCILVcTPGRLedlfqRKGDDLNLAAQVKSLEFLV 171
Cdd:cd18018 71 dQVD-----ALPR----AIKAAALNSSLTREERRRILEKlragEVKILYV-SPERL-----VNESFRELLRQTPPISLLV 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 172 LDEADRLLDLG--FKTS---VNNILGYLPRQRRTGLFSATQTTEVTDLIRAGLRNP 222
Cdd:cd18018 136 VDEAHCISEWShnFRPDylrLCRVLRELLGAPPVLALTATATKRVVEDIASHLGIP 191
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
27-144 |
1.62e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 44.88 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 27 FQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTL-AFLVPMLEILQRRHKETPwgPKEIGALVISPTRELARQISEVLAqf 105
Cdd:PRK13767 30 FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLaAFLAIIDELFRLGREGEL--EDKVYCLYVSPLRALNNDIHRNLE-- 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 21355559 106 lehEDLEHLNQQLIVGGNSIEEDIATLR-------------RETPCILVCTP 144
Cdd:PRK13767 106 ---EPLTEIREIAKERGEELPEIRVAIRtgdtssyekqkmlKKPPHILITTP 154
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
267-400 |
2.18e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 41.95 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 267 GKVMVFFPTCACVEYWAEALPPLLPKRTVLGIHGKM-KNKRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPP 345
Cdd:cd18810 26 GQVFYVHNRIESIEKLATQLRQLVPEARIAIAHGQMtENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERAD 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 21355559 346 STASSFVH----RVGRTARQgnegnalvfllpsedAYVHFLKINQKVeltklLTEEAED 400
Cdd:cd18810 106 KFGLAQLYqlrgRVGRSKER---------------AYAYFLYPDQKK-----LTEDALK 144
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
309-369 |
2.62e-04 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 44.09 E-value: 2.62e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355559 309 VVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQgNEGNALV 369
Cdd:PRK13766 415 ILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGRQ-EEGRVVV 474
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
14-413 |
6.43e-04 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 42.44 E-value: 6.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 14 LSDAVLQVVQS-FGFQQMTPVQTAAIPLLLARKDVSAEAVTGSGKTLAFLVP--MLEilqrrhketpwGPkeigALVISP 90
Cdd:COG0514 1 LRDDALEVLKRvFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPalLLP-----------GL----TLVVSP 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 91 --------TRELARQ-ISevlAQFLehedlehlnqqlivggNS---------IEEDIA--TLRretpcILVCTPGRLEdl 150
Cdd:COG0514 66 lialmkdqVDALRAAgIR---AAFL----------------NSslsaeerreVLRALRagELK-----LLYVAPERLL-- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 151 fqrKGDDLNLAAQVKsLEFLVLDEA--------D------RLLDLgfktsvnniLGYLPRQRRTGLfSATQTTEVTDLIR 216
Cdd:COG0514 120 ---NPRFLELLRRLK-ISLFAIDEAhcisqwghDfrpdyrRLGEL---------RERLPNVPVLAL-TATATPRVRADIA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 217 A--GLRNPVLVsvkeKASVNTParlqN-FYRIVE--PELKFVALLEFLSSPATVIGkvMVFFPTCACVEYWAEALppllp 291
Cdd:COG0514 186 EqlGLEDPRVF----VGSFDRP----NlRLEVVPkpPDDKLAQLLDFLKEHPGGSG--IVYCLSRKKVEELAEWL----- 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 292 krTVLGI-----HGKMKNK-RANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVHRVGRTARQGNEG 365
Cdd:COG0514 251 --REAGIraaayHAGLDAEeREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPA 328
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 21355559 366 NALvfLLPS-EDAYVHFLKINQKveltkllTEEAEDADREKKKLPAVLD 413
Cdd:COG0514 329 EAL--LLYGpEDVAIQRFFIEQS-------PPDEERKRVERAKLDAMLA 368
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
279-362 |
9.55e-04 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 40.33 E-value: 9.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 279 VEYWAEALPPLLPKRTVLGIHGKMK-NKRANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVH---- 353
Cdd:cd18792 47 IEALAEELKELVPEARVALLHGKMTeDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHqlrg 126
|
....*....
gi 21355559 354 RVGRTARQG 362
Cdd:cd18792 127 RVGRGKHQS 135
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
51-206 |
1.47e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 39.21 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 51 AVTGSGKTLAflvpMLEILQRRHKETpwgpkeigALVISPTRELARQISEVLAQFLEHEDLehlnqQLIVGGNSIEEDIA 130
Cdd:cd17926 25 LPTGSGKTLT----ALALIAYLKELR--------TLIVVPTDALLDQWKERFEDFLGDSSI-----GLIGGGKKKDFDDA 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 131 TLRRETPCILVCTPGRLEDLFQRKGddlnlaaqvksleFLVLDEADRLLDLGFKtsvnNILGYLPRQRRTGlFSAT 206
Cdd:cd17926 88 NVVVATYQSLSNLAEEEKDLFDQFG-------------LLIVDEAHHLPAKTFS----EILKELNAKYRLG-LTAT 145
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
280-361 |
2.09e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 39.25 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 280 EYWAEALpplLPKRTVLGIHGKMKNK-RANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDPPSTASSFVH----R 354
Cdd:cd18811 52 EYLKERF---RPELNVGLLHGRLKSDeKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHqlrgR 128
|
....*..
gi 21355559 355 VGRTARQ 361
Cdd:cd18811 129 VGRGDHQ 135
|
|
| VirD4 |
COG3505 |
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ... |
53-105 |
2.25e-03 |
|
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442728 [Multi-domain] Cd Length: 402 Bit Score: 40.74 E-value: 2.25e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 21355559 53 TGSGKTLAFLVPMLEILQRRHketpwgpkeiGALVISPTRELARQISEVLAQF 105
Cdd:COG3505 8 TGSGKTVGLVIPNLTQLARGE----------SVVVTDPKGDLAELTAGFRRRA 50
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
267-372 |
2.48e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 38.77 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 267 GKVMVFFPTCACVEYWAEALppLLPkrtvlGIHGKMKNK-RANVVEKFRNTPQAVLLCTDVLARGLDVPEIEWVVQWDpp 345
Cdd:cd18789 50 DKIIVFTDNVEALYRYAKRL--LKP-----FITGETPQSeREEILQNFREGEYNTLVVSKVGDEGIDLPEANVAIQIS-- 120
|
90 100 110
....*....|....*....|....*....|..
gi 21355559 346 STASS---FVHRVGRTAR--QGNEGNALVFLL 372
Cdd:cd18789 121 GHGGSrrqEAQRLGRILRpkKGGGKNAFFYSL 152
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
53-206 |
3.23e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.81 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 53 TGSGKTLAFLVPMLEILQRRHKETpwgpkeigALVISPTRELARQISEVLAQFLEhedlEHLNQQLIVGGNSIEEDIATL 132
Cdd:pfam04851 32 TGSGKTLTAAKLIARLFKKGPIKK--------VLFLVPRKDLLEQALEEFKKFLP----NYVEIGEIISGDKKDESVDDN 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21355559 133 RretpcILVCTPgrledlfQRKGDDLNLAAQVKSLEF---LVLDEADRLLDLGFKtsvnNILGYLPRQRRTGlFSAT 206
Cdd:pfam04851 100 K-----IVVTTI-------QSLYKALELASLELLPDFfdvIIIDEAHRSGASSYR----NILEYFKPAFLLG-LTAT 159
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
33-97 |
4.18e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 38.88 E-value: 4.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21355559 33 VQTAAIPLLL-ARKDVSAEAVTGSGKTLAFLVPMLEILQRRhKETPWGpkEIGALVISPTRELARQ 97
Cdd:cd18023 5 IQSEVFPDLLySDKNFVVSAPTGSGKTVLFELAILRLLKER-NPLPWG--NRKVVYIAPIKALCSE 67
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
53-175 |
7.68e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 38.02 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355559 53 TGSGKTL-AFLVpMLEILQRRHKETPwgPKEIgALVISPTRELARQISEVLAQFLEHEDLEHLNQQLIVGGNSIEEDIAT 131
Cdd:cd18034 25 TGSGKTLiAVML-IKEMGELNRKEKN--PKKR-AVFLVPTVPLVAQQAEAIRSHTDLKVGEYSGEMGVDKWTKERWKEEL 100
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 21355559 132 LRREtpcILVCTPGRLEDLFQR---KGDDLNLaaqvkslefLVLDEA 175
Cdd:cd18034 101 EKYD---VLVMTAQILLDALRHgflSLSDINL---------LIFDEC 135
|
|
| |
