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Conserved domains on  [gi|28573195|ref|NP_649693|]
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tailor, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 245-361 1.30e-24

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


:

Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 98.40  E-value: 1.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 245 QDLCKLLSPGFPKqpLRVYKFGSRITGIGNRSSDLDLFVDIGNTfhtfehraSNATVAKLRAMRKFFCDSEDWRLINFIE 324
Cdd:cd05402   7 DRLQELIKEWFPG--AKLYPFGSYVTGLGLPGSDIDLCLLGPNH--------RVDREDFLRKLAKLLKKSGEVVEVEPII 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28573195 325 QARVPIIKTCHLPTGIECDICLNS-MGFCNTNLLKYIF 361
Cdd:cd05402  77 NARVPIIKFVDKPTGIEVDISFNNlNGIRNTKLLRAYV 114
TRF4 super family cl34961
DNA polymerase sigma [Replication, recombination and repair];
262-470 4.65e-13

DNA polymerase sigma [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG5260:

Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 71.34  E-value: 4.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 262 VYKFGSRITGIGNRSSDLDLFVdIGNTFHTFEHRA--SNATVAKLRAmrkffCDSEdwrlINFIEQARVPIIKTCHLPTG 339
Cdd:COG5260  98 LKVFGSTETGLALPKSDIDLCI-ISDPRGYKETRNagSLASHLFKKN-----LAKE----VVVVSTARVPIIKLVDPQSG 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 340 IECDICLNSMGFC-NTNLLKYIFESQPLTQYMCIYVKNWLERCKLTE----QISTYSITLMVIYFLQLQallpPIAMLQI 414
Cdd:COG5260 168 LHCDISFNNTNGIvNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDvatgTLSSYTISCMVLSFLQMH----PPFLFFD 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28573195 415 EdaanqaVLVGPWVVNFAQKSFSELglqqlkatvpvikgfLRNFFAYFAK-FDYEHF 470
Cdd:COG5260 244 N------GLLSPLKYNKNIDNLGVL---------------FDDFFELYGKsFNYSLV 279
DUF1439 super family cl06345
Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial ...
 70-120 3.91e-03

Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.


The actual alignment was detected with superfamily member pfam07273:

Pssm-ID: 446967  Cd Length: 152  Bit Score: 37.96  E-value: 3.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195    70 LTMEAH---------FFLQTLNSVNQTTNPPQLDPHLANLLERIMVGIESYLDRNPTYVL 120
Cdd:pfam07273  70 LTLEAKprydkekgaIYLRDLELVDYQVEPEKLQGVLQPLLPYLMQSLRSYLEQQPVYRL 129
 
Name Accession Description Interval E-value
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 245-361 1.30e-24

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 98.40  E-value: 1.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 245 QDLCKLLSPGFPKqpLRVYKFGSRITGIGNRSSDLDLFVDIGNTfhtfehraSNATVAKLRAMRKFFCDSEDWRLINFIE 324
Cdd:cd05402   7 DRLQELIKEWFPG--AKLYPFGSYVTGLGLPGSDIDLCLLGPNH--------RVDREDFLRKLAKLLKKSGEVVEVEPII 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28573195 325 QARVPIIKTCHLPTGIECDICLNS-MGFCNTNLLKYIF 361
Cdd:cd05402  77 NARVPIIKFVDKPTGIEVDISFNNlNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
262-470 4.65e-13

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 71.34  E-value: 4.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 262 VYKFGSRITGIGNRSSDLDLFVdIGNTFHTFEHRA--SNATVAKLRAmrkffCDSEdwrlINFIEQARVPIIKTCHLPTG 339
Cdd:COG5260  98 LKVFGSTETGLALPKSDIDLCI-ISDPRGYKETRNagSLASHLFKKN-----LAKE----VVVVSTARVPIIKLVDPQSG 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 340 IECDICLNSMGFC-NTNLLKYIFESQPLTQYMCIYVKNWLERCKLTE----QISTYSITLMVIYFLQLQallpPIAMLQI 414
Cdd:COG5260 168 LHCDISFNNTNGIvNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDvatgTLSSYTISCMVLSFLQMH----PPFLFFD 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28573195 415 EdaanqaVLVGPWVVNFAQKSFSELglqqlkatvpvikgfLRNFFAYFAK-FDYEHF 470
Cdd:COG5260 244 N------GLLSPLKYNKNIDNLGVL---------------FDDFFELYGKsFNYSLV 279
DUF1439 pfam07273
Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial ...
 70-120 3.91e-03

Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.


Pssm-ID: 429375  Cd Length: 152  Bit Score: 37.96  E-value: 3.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195    70 LTMEAH---------FFLQTLNSVNQTTNPPQLDPHLANLLERIMVGIESYLDRNPTYVL 120
Cdd:pfam07273  70 LTLEAKprydkekgaIYLRDLELVDYQVEPEKLQGVLQPLLPYLMQSLRSYLEQQPVYRL 129
 
Name Accession Description Interval E-value
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 245-361 1.30e-24

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 98.40  E-value: 1.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 245 QDLCKLLSPGFPKqpLRVYKFGSRITGIGNRSSDLDLFVDIGNTfhtfehraSNATVAKLRAMRKFFCDSEDWRLINFIE 324
Cdd:cd05402   7 DRLQELIKEWFPG--AKLYPFGSYVTGLGLPGSDIDLCLLGPNH--------RVDREDFLRKLAKLLKKSGEVVEVEPII 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28573195 325 QARVPIIKTCHLPTGIECDICLNS-MGFCNTNLLKYIF 361
Cdd:cd05402  77 NARVPIIKFVDKPTGIEVDISFNNlNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
262-470 4.65e-13

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 71.34  E-value: 4.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 262 VYKFGSRITGIGNRSSDLDLFVdIGNTFHTFEHRA--SNATVAKLRAmrkffCDSEdwrlINFIEQARVPIIKTCHLPTG 339
Cdd:COG5260  98 LKVFGSTETGLALPKSDIDLCI-ISDPRGYKETRNagSLASHLFKKN-----LAKE----VVVVSTARVPIIKLVDPQSG 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195 340 IECDICLNSMGFC-NTNLLKYIFESQPLTQYMCIYVKNWLERCKLTE----QISTYSITLMVIYFLQLQallpPIAMLQI 414
Cdd:COG5260 168 LHCDISFNNTNGIvNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDvatgTLSSYTISCMVLSFLQMH----PPFLFFD 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28573195 415 EdaanqaVLVGPWVVNFAQKSFSELglqqlkatvpvikgfLRNFFAYFAK-FDYEHF 470
Cdd:COG5260 244 N------GLLSPLKYNKNIDNLGVL---------------FDDFFELYGKsFNYSLV 279
DUF1439 pfam07273
Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial ...
 70-120 3.91e-03

Protein of unknown function (DUF1439); This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.


Pssm-ID: 429375  Cd Length: 152  Bit Score: 37.96  E-value: 3.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573195    70 LTMEAH---------FFLQTLNSVNQTTNPPQLDPHLANLLERIMVGIESYLDRNPTYVL 120
Cdd:pfam07273  70 LTLEAKprydkekgaIYLRDLELVDYQVEPEKLQGVLQPLLPYLMQSLRSYLEQQPVYRL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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