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Conserved domains on  [gi|24644650|ref|NP_649672|]
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uncharacterized protein Dmel_CG15177, isoform A [Drosophila melanogaster]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-185 4.16e-10

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 54.18  E-value: 4.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644650   112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGDDEDELIELradmtefIMKKFDVDKDGVISFEDYSSVVS 185
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEE-------LFKEFDLDKDGRISFEEFLELYS 67
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-185 4.16e-10

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 54.18  E-value: 4.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644650   112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGDDEDELIELradmtefIMKKFDVDKDGVISFEDYSSVVS 185
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEE-------LFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-179 3.08e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 3.08e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644650 116 KFAFEVYDTKNTGVIDREQVGVACEKFFhEGDDEDELIElradmtefIMKKFDVDKDGVISFED 179
Cdd:cd00051   3 REAFRLFDKDGDGTISADELKAALKSLG-EGLSEEEIDE--------MIREVDKDGDGKIDFEE 57
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
94-186 9.77e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.15  E-value: 9.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644650  94 VSPRAWVDLFELYTTEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKffhegddedelIELRADMTEFIMKKFDVDKDG 173
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTA-----------LGVSEEEADELFARLDTDGDG 118

                        90
                ....*....|...
gi 24644650 174 VISFEDYSSVVSQ 186
Cdd:COG5126 119 KISFEEFVAAVRD 131
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-185 4.16e-10

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 54.18  E-value: 4.16e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644650   112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGDDEDELIELradmtefIMKKFDVDKDGVISFEDYSSVVS 185
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEE-------LFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-179 3.08e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 40.61  E-value: 3.08e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24644650 116 KFAFEVYDTKNTGVIDREQVGVACEKFFhEGDDEDELIElradmtefIMKKFDVDKDGVISFED 179
Cdd:cd00051   3 REAFRLFDKDGDGTISADELKAALKSLG-EGLSEEEIDE--------MIREVDKDGDGKIDFEE 57
EFh_HEF_CBN cd16179
EF-hand, calcium binding motif, found in Drosophila melanogaster calbindin-32 (CBN) and ...
 107-187 3.38e-03

EF-hand, calcium binding motif, found in Drosophila melanogaster calbindin-32 (CBN) and similar proteins; CBN, the product of the cbn gene, is a Drosophila homolog to vertebrate neuronal six EF-hand calcium binding proteins. It is expressed through most of ontogenesis with a selective distribution in the nervous system and in a few small adult thoracic muscles. Its precise biological role remains unclear. CBN contains six EF-hand motifs, but some of them may not bind calcium ions due to the lack of key residues.


Pssm-ID: 320079 [Multi-domain]  Cd Length: 261  Bit Score: 37.77  E-value: 3.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644650 107 TTEDLERrmkfAFEVYDTKNTGVIDREQVGVACEKFFH---EGDDEDELielrADMTEFIMKKFDVDKDGVISFEDYSSV 183
Cdd:cd16179 186 TREDIDR----VFALYDRDNNGTIENEELTGFLKDLLElvqEDYDEQDL----EEFKEIILRGWDFNNDGKISRKELTML 257


                ....
gi 24644650 184 VSQQ 187
Cdd:cd16179 258 LLQL 261
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
94-186 9.77e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.15  E-value: 9.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644650  94 VSPRAWVDLFELYTTEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKffhegddedelIELRADMTEFIMKKFDVDKDG 173
Cdd:COG5126  50 ISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTA-----------LGVSEEEADELFARLDTDGDG 118

                        90
                ....*....|...
gi 24644650 174 VISFEDYSSVVSQ 186
Cdd:COG5126 119 KISFEEFVAAVRD 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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