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Conserved domains on  [gi|21356269|ref|NP_649255|]
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uncharacterized protein Dmel_CG11396 [Drosophila melanogaster]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-457 5.10e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 5.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAeqkIAVSRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVC 407
Cdd:COG0457  11 YNNLGLAYRRLGRYEEA---IEDYEKALELD--PDDAEaLYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21356269 408 LLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEA 132
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-457 5.10e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 5.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAeqkIAVSRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVC 407
Cdd:COG0457  11 YNNLGLAYRRLGRYEEA---IEDYEKALELD--PDDAEaLYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21356269 408 LLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEA 132
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 366-429 1.60e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.85  E-value: 1.60e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356269 366 DLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNP 429
Cdd:cd24142   2 ELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
TPR_12 pfam13424
Tetratricopeptide repeat;
367-430 2.46e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356269   367 LVDKGLIAVAKNDFPEAYVIFQKAL----------HLDTGNTmiLNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALeiarrllgpdHPLTATT--LLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 400-430 1.03e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21356269    400 ILNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 371-446 5.40e-04

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 40.81  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269  371 GLIAVAKNDFPEAYVIFQKALHL---DTGNTMILNNMGvcLLYA--GKLKDAINLYERAINLNPQKSlneSLLVNLSTLY 445
Cdd:PRK02603  42 GMSAQADGEYAEALENYEEALKLeedPNDRSYILYNMG--IIYAsnGEHDKALEYYHQALELNPKQP---SALNNIAVIY 116


                 .
gi 21356269  446 E 446
Cdd:PRK02603 117 H 117
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 324-469 1.51e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269   324 DRRSLYSAWGRIYLQIGDIFGAEQKIAVSRRLrEINSAPDLRDLVDkglIAVAKNDFPEAYVIFQKALHLDTGNTMILNN 403
Cdd:TIGR02917 463 DNASLHNLLGAIYLGKGDLAKAREAFEKALSI-EPDFFPAAANLAR---IDIQEGNPDDAIQRFEKVLTIDPKNLRAILA 538

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21356269   404 MGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYelESNNSKAKKYNLLRLINRYKPD 469
Cdd:TIGR02917 539 LAGLYLRTGNEEEAVAWLEKAAELNPQ---EIEPALALAQYY--LGKGQLKKALAILNEAADAAPD 599
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-457 5.10e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 5.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAeqkIAVSRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVC 407
Cdd:COG0457  11 YNNLGLAYRRLGRYEEA---IEDYEKALELD--PDDAEaLYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21356269 408 LLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG0457  86 LQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEA 132
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 333-457 6.44e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.90  E-value: 6.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 333 GRIYLQIGDIFGAEQKIavsRRLREINSApDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAG 412
Cdd:COG4783  11 AQALLLAGDYDEAEALL---EKALELDPD-NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21356269 413 KLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG4783  87 DYDEALALLEKALKLDPE---HPEAYLRLARAYRALGRPDEAIAA 128
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 314-457 2.82e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 61.51  E-value: 2.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 314 LLKRSNLSKEDRRSLYSAWGRIYLQIGDIFGAEQKIAVSRRLREINSAPDLRDLVDKGLIAVAKNDFPEAYVIFQKALHL 393
Cdd:COG5010   4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356269 394 DTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG5010  84 DPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---NPNAYSNLAALLLSLGQDDEAKAA 144
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-457 5.17e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 5.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAeqkIAVSRRLREINSApDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCL 408
Cdd:COG0457  45 LYNLGLAYLRLGRYEEA---LADYEQALELDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAL 120

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 21356269 409 LYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG0457 121 LELGRYDEAIEAYERALELDPD---DADALYNLGIALEKLGRYEEALEL 166
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 363-469 1.22e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 363 DLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLS 442
Cdd:COG4235  16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPD---NPEALYLLG 92

                        90       100
                ....*....|....*....|....*..
gi 21356269 443 TLYELESNNSKAKKYnLLRLINRYKPD 469
Cdd:COG4235  93 LAAFQQGDYAEAIAA-WQKLLALLPAD 118
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
373-457 6.81e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 55.95  E-value: 6.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 373 IAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINlYERAINLNPQkslNESLLVNLSTLYELESNNS 452
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPN---NAEALLNLAELLLELGDYD 76


                ....*
gi 21356269 453 KAKKY 457
Cdd:COG3063  77 EALAY 81
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 329-465 7.91e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 7.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAEQKIavsRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVC 407
Cdd:COG3914 115 LFNLGNLLLALGRLEEALAAL---RRALALN--PDFAEaYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21356269 408 LLYAGKLKDAINLYERAINLNPQKSLNESLLvnLSTLYELESNNSKAKKYNLLRLINR 465
Cdd:COG3914 190 LQDLGRLEEAIAAYRRALELDPDNADAHSNL--LFALRQACDWEVYDRFEELLAALAR 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 353-470 2.95e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.24  E-value: 2.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 353 RRLREINSAPDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQks 432
Cdd:COG3914  67 AAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPD-- 144

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21356269 433 lNESLLVNLSTLYELESNNSKAKKYnlLRLINRYKPDL 470
Cdd:COG3914 145 -FAEAYLNLGEALRRLGRLEEAIAA--LRRALELDPDN 179
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 361-457 3.36e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 3.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 361 APDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVN 440
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD---EPEARLN 77

                        90
                ....*....|....*..
gi 21356269 441 LSTLYELESNNSKAKKY 457
Cdd:COG4783  78 LGLALLKAGDYDEALAL 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 314-429 1.61e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.81  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 314 LLKRSNLSKEDRRSLYSAWGRIYLQIGDIFGAEQKIAVSRRLREINSAPdlrdLVDKGLIAVAKNDFPEAYVIFQKALHL 393
Cdd:COG5010  42 LAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL----YYNLALLYSRSGDKDEAKEYYEKALAL 117

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21356269 394 DTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNP 429
Cdd:COG5010 118 SPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
333-456 3.90e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.77  E-value: 3.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 333 GRIYLQIGDIfgaEQKIAVSRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYA 411
Cdd:COG4785  80 GVAYDSLGDY---DLAIADFDQALELD--PDLAEaYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYL 154

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21356269 412 GKLKDAINLYERAINLNPQKSLNeSLLVNLStlyELESNNSKAKK 456
Cdd:COG4785 155 GRYELAIADLEKALELDPNDPER-ALWLYLA---ERKLDPEKALA 195
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
335-429 1.47e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.40  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 335 IYLQIGDIFGAEQKIavsRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYViFQKALHLDTGNTMILNNMGVCLLYAGK 413
Cdd:COG3063   1 LYLKLGDLEEAEEYY---EKALELD--PDNADaLNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD 74

                        90
                ....*....|....*.
gi 21356269 414 LKDAINLYERAINLNP 429
Cdd:COG3063  75 YDEALAYLERALELDP 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 333-466 1.67e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 1.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 333 GRIYLQIGDIfgaEQKIAVSRRLREINSApDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAG 412
Cdd:COG2956 151 AELYLEQGDY---DEAIEALEKALKLDPD-CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLG 226

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21356269 413 KLKDAINLYERAINLNPqkslNESLLVNLSTLYELESNNSKAKKYnLLRLINRY 466
Cdd:COG2956 227 DPEEALELLRKALELDP----SDDLLLALADLLERKEGLEAALAL-LERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 314-465 2.28e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 2.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 314 LLKRSnlskEDRRSLYSAWGRIYLQIGDifgAEQKIAVSRRLREINSApDLRDLVDKGLIAVAKNDFPEAYVIFQKALHL 393
Cdd:COG2956  68 LLERD----PDRAEALLELAQDYLKAGL---LDRAEELLEKLLELDPD-DAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21356269 394 DTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKYnLLRLINR 465
Cdd:COG2956 140 GPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPD---CARALLLLAELYLEQGDYEEAIAA-LERALEQ 207
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 329-430 2.91e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 2.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIFGAEQKIavsRRLREINsaPDLRD-LVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVC 407
Cdd:COG4783  41 FALLGEILLQLGDLDEAIVLL---HEALELD--PDEPEaRLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115

                        90       100
                ....*....|....*....|...
gi 21356269 408 LLYAGKLKDAINLYERAINLNPQ 430
Cdd:COG4783 116 YRALGRPDEAIAALEKALELDPD 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
329-466 5.03e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 5.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 329 YSAWGRIYLQIGDIfgaEQKIAVSRRLREINSApDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCL 408
Cdd:COG0457  79 LNNLGLALQALGRY---EEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL 154

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21356269 409 LYAGKLKDAINLYERAINLNPQKSLNESLLVNLSTLYELESNNSKAKKYNLLRLINRY 466
Cdd:COG0457 155 EKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLA 212
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 370-457 1.77e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 370 KGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELES 449
Cdd:COG2956  14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPD---RAEALLELAQDYLKAG 90


                ....*...
gi 21356269 450 NNSKAKKY 457
Cdd:COG2956  91 LLDRAEEL 98
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 333-476 6.73e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 6.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 333 GRIYLQIGDIfgaEQKIAVSRRLREINsaPDLRDLVDK-GLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYA 411
Cdd:COG2956  15 GLNYLLNGQP---DKAIDLLEEALELD--PETVEAHLAlGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21356269 412 GKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKYnLLRLINRYKPDLNISIEI 476
Cdd:COG2956  90 GLLDRAEELLEKLLELDPD---DAEALRLLAEIYEQEGDWEKAIEV-LERLLKLGPENAHAYCEL 150
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
322-430 1.31e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 322 KEDRRSLYSAWGRIYLQIGDIFGAEQKIAVSRRLREINSAPDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMIL 401
Cdd:COG4785  31 FAAVLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAY 110

                        90       100
                ....*....|....*....|....*....
gi 21356269 402 NNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:COG4785 111 NNRGLAYLLLGDYDAALEDFDRALELDPD 139
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 366-429 1.60e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 46.85  E-value: 1.60e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356269 366 DLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNP 429
Cdd:cd24142   2 ELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 372-466 2.21e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.44  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 372 LIAVAKNDFPEAYVIFQKALHLDTGNTMI---LNNMGVCLLYAGKLKDAINLYERAINLNPQKSLNESLLVNLSTLYELE 448
Cdd:COG1729   1 KALLKAGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLEL 80

                        90
                ....*....|....*...
gi 21356269 449 SNNSKAKKYnLLRLINRY 466
Cdd:COG1729  81 GDYDKARAT-LEELIKKY 97
TPR_12 pfam13424
Tetratricopeptide repeat;
367-430 2.46e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356269   367 LVDKGLIAVAKNDFPEAYVIFQKAL----------HLDTGNTmiLNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALeiarrllgpdHPLTATT--LLNLGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 400-430 1.03e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.35  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 21356269    400 ILNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
TPR_1 pfam00515
Tetratricopeptide repeat;
400-430 1.10e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21356269   400 ILNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR_19 pfam14559
Tetratricopeptide repeat;
378-430 1.33e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 39.87  E-value: 1.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21356269   378 NDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPD 54
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 400-430 1.89e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 38.66  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 21356269   400 ILNNMGVCLLYAGKLKDAINLYERAINLNPQ 430
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
391-457 2.92e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 2.92e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21356269 391 LHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPD---DAEALYNLGLAYLRLGRYEEALAD 64
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 387-457 3.06e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 3.06e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21356269 387 FQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG4235   6 LRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---NADALLDLAEALLAAGDTEEAEEL 73
PRK02603 PRK02603
photosystem I assembly protein Ycf3; Provisional
 371-446 5.40e-04

photosystem I assembly protein Ycf3; Provisional


Pssm-ID: 179448 [Multi-domain]  Cd Length: 172  Bit Score: 40.81  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269  371 GLIAVAKNDFPEAYVIFQKALHL---DTGNTMILNNMGvcLLYA--GKLKDAINLYERAINLNPQKSlneSLLVNLSTLY 445
Cdd:PRK02603  42 GMSAQADGEYAEALENYEEALKLeedPNDRSYILYNMG--IIYAsnGEHDKALEYYHQALELNPKQP---SALNNIAVIY 116


                 .
gi 21356269  446 E 446
Cdd:PRK02603 117 H 117
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 324-469 1.51e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269   324 DRRSLYSAWGRIYLQIGDIFGAEQKIAVSRRLrEINSAPDLRDLVDkglIAVAKNDFPEAYVIFQKALHLDTGNTMILNN 403
Cdd:TIGR02917 463 DNASLHNLLGAIYLGKGDLAKAREAFEKALSI-EPDFFPAAANLAR---IDIQEGNPDDAIQRFEKVLTIDPKNLRAILA 538

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21356269   404 MGVCLLYAGKLKDAINLYERAINLNPQkslNESLLVNLSTLYelESNNSKAKKYNLLRLINRYKPD 469
Cdd:TIGR02917 539 LAGLYLRTGNEEEAVAWLEKAAELNPQ---EIEPALALAQYY--LGKGQLKKALAILNEAADAAPD 599
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 345-457 2.12e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.79  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356269 345 AEQKIAVSRRLREINSAPDLRDLVDKGLIAVAKNDFPEAYVIFQKALHLDTGNTMILNNMGVCLLYAGKLKDAINLYERA 424
Cdd:COG5010   1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 21356269 425 INLNPQkslNESLLVNLSTLYELESNNSKAKKY 457
Cdd:COG5010  81 LQLDPN---NPELYYNLALLYSRSGDKDEAKEY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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