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Conserved domains on  [gi|221513297|ref|NP_649238|]
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uncharacterized protein Dmel_CG5078 [Drosophila melanogaster]

Protein Classification

MFSD14 family MFS transporter( domain architecture ID 13024393)

MFSD14 family major facilitator superfamily (MFS) transporter such as MFS domain-containing 14A and 14B, also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively; MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 24-420 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 574.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  24 VGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPI 103
Cdd:cd17387    1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 104 PMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:cd17387   81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGL----SWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMG 259
Cdd:cd17387  161 VALLDICFILLAVPESLPEKMRPASWgapiSWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 260 FDFTELSTLVAFMAILGISINVTLGSIVKT-LGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVSA 338
Cdd:cd17387  241 FEYEEVAAFIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 339 YVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSDMDLDKN--------RILIGSVSGDRTVTNPFMIGAISVF 410
Cdd:cd17387  321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIkpvqsskqRMQNPSLEGAIIPGPPFLFGAISVL 400

                        410
                 ....*....|
gi 221513297 411 IGILLASYIP 420
Cdd:cd17387  401 LAILVASFIP 410
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 24-420 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 574.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  24 VGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPI 103
Cdd:cd17387    1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 104 PMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:cd17387   81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGL----SWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMG 259
Cdd:cd17387  161 VALLDICFILLAVPESLPEKMRPASWgapiSWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 260 FDFTELSTLVAFMAILGISINVTLGSIVKT-LGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVSA 338
Cdd:cd17387  241 FEYEEVAAFIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 339 YVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSDMDLDKN--------RILIGSVSGDRTVTNPFMIGAISVF 410
Cdd:cd17387  321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIkpvqsskqRMQNPSLEGAIIPGPPFLFGAISVL 400

                        410
                 ....*....|
gi 221513297 411 IGILLASYIP 420
Cdd:cd17387  401 LAILVASFIP 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-366 5.03e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.89  E-value: 5.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT-VIFTSLPIPM 105
Cdd:COG2814   15 LALGAFLSGLGIGIV-LPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGlLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISS-ISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:COG2814   93 ALAPSLWLLLAARfLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGlswkqadpfLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFT 263
Cdd:COG2814  173 LALLALLLLLRLLPESRPAARARLR---------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 264 ELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALS-SITFPAVSAYVSL 342
Cdd:COG2814  244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAE 323

                        330       340
                 ....*....|....*....|....
gi 221513297 343 YTDVETQGAVQGMITGMSGLCSGL 366
Cdd:COG2814  324 LAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
27-368 2.69e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.63  E-value: 2.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   27 ILVVVFLEYFAWGLLTMPMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLP--IP 104
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  105 MMTMDNWWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  184 VSTtnVMFVLLAVPETLQQNVRSTGLSWKQADPFLSLRRVGSDPNVLLLcVVMFTFLLPEAGEYSSVPAYLKlTMGFDFT 263
Cdd:pfam07690 160 LSL--LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQE-VLGLSAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  264 ELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFA----IGYEKWQMWLAGNVAALSSITFPAVSAY 339
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLllslTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         330       340
                  ....*....|....*....|....*....
gi 221513297  340 VSLYTDVETQGAVQGMITGMSGLCSGLGP 368
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
68-199 1.47e-09

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 56.12  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   68 KGILSFLSSPLIGALSDIYGRK-VLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSF--SVAFAYVADVTTKEERS 144
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKpVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFalVAGAALIADIYPPEERG 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221513297  145 RSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPET 199
Cdd:TIGR00880  87 VALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
59-201 9.29e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 50.69  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  59 LMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTMDN--WWFFVISSISGVLGVSFSVAFAYVAD 136
Cdd:PRK09874  54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQniWQFLILRALLGLLGGFVPNANALIAT 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221513297 137 VTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQ 201
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQ 198
 
Name Accession Description Interval E-value
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 24-420 0e+00

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 574.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  24 VGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPI 103
Cdd:cd17387    1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 104 PMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:cd17387   81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGL----SWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMG 259
Cdd:cd17387  161 VALLDICFILLAVPESLPEKMRPASWgapiSWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 260 FDFTELSTLVAFMAILGISINVTLGSIVKT-LGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVSA 338
Cdd:cd17387  241 FEYEEVAAFIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 339 YVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSDMDLDKN--------RILIGSVSGDRTVTNPFMIGAISVF 410
Cdd:cd17387  321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIkpvqsskqRMQNPSLEGAIIPGPPFLFGAISVL 400

                        410
                 ....*....|
gi 221513297 411 IGILLASYIP 420
Cdd:cd17387  401 LAILVASFIP 410
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 24-416 9.38e-37

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 138.54  E-value: 9.38e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  24 VGHILVVVFLEYFAWGLLtMPMIATLKETFPDHT---FLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTS 100
Cdd:cd17388    1 LIFILVTVLLDAMGIGLI-MPVLPTLLREFVGDSadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 101 LPIPMMTMDN--WWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDrYGINTVV 178
Cdd:cd17388   80 LDYLLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 179 LVATLVSTTNVMFVLLAVPETLQQNvRSTGLSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLpeAGEyssVPAYLKLTM 258
Cdd:cd17388  159 LVAAGLNGLNFLLGLFVLPESLPPE-RRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQL--IGQ---VPATTWVLF 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 259 G---FDFTELS---TLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSIT 332
Cdd:cd17388  233 TedrFDWSPTMvglSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 333 FPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSdmdldknrilIGSVSGdrtvtNPFMIGAISVFIG 412
Cdd:cd17388  313 GPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS----------PATWPG-----LAWIIGAALYLIC 377


                 ....
gi 221513297 413 ILLA 416
Cdd:cd17388  378 LVLA 381
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 27-417 1.97e-36

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 136.94  E-value: 1.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIATL--KETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIP 104
Cdd:cd17330    1 LFLVVFLDALGFGIV-FPVLPFYvrEFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 105 MMTMDN--WWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVAT 182
Cdd:cd17330   80 LLGLSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 183 LVSTTNVMFVLLAVpetlqqnvrstglswkqadpflslrrvgsdPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDF 262
Cdd:cd17330  160 ALALLNLVLVLFFL------------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSP 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 263 TELSTLVAFMAILGISINVTLGSIV-KTLGAKNAIILGLLLELLQLILFAIG-YEKWQMWLAGNVAALSSITFPAVSAYV 340
Cdd:cd17330  210 SQIGLLLALVGIAGILAQLLLIPRLaKRLGERKLLRLGLLLAIIGLLLLPFAsSVPLLVLAAAILAFGTGIVFPALSALL 289

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221513297 341 SLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFylsdmdldknRILIGSVsgdrtvtnPFMIGAISVFIGILLAS 417
Cdd:cd17330  290 SKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY----------SFLGPGV--------PFLLAAGLLLIALFLLS 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-375 2.64e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 103.81  E-value: 2.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIATLKETFPDHTFLMnGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLI-TVIFTSLPIPM 105
Cdd:cd17325    1 LSLALFLDMLGYGII-IPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISSISGVLGVSFS--VAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:cd17325   79 AFATSYWQLLLARFLQGLASAAVwpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGLSwkqADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFT 263
Cdd:cd17325  159 LALLALVLALLLLPEPRPPPNKRAVSA---ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 264 ELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAAL-SSITFPAVSAYVSL 342
Cdd:cd17325  236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLgLGLVFPATLALLAD 315

                        330       340       350
                 ....*....|....*....|....*....|...
gi 221513297 343 YTDVETQGAVQGMITGMSGLCSGLGPALFGIVF 375
Cdd:cd17325  316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
27-366 5.03e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.89  E-value: 5.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT-VIFTSLPIPM 105
Cdd:COG2814   15 LALGAFLSGLGIGIV-LPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGlLLFALGSLLC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISS-ISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:COG2814   93 ALAPSLWLLLAARfLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTNVMFVLLAVPETLQQNVRSTGlswkqadpfLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFT 263
Cdd:COG2814  173 LALLALLLLLRLLPESRPAARARLR---------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 264 ELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALS-SITFPAVSAYVSL 342
Cdd:COG2814  244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAE 323

                        330       340
                 ....*....|....*....|....
gi 221513297 343 YTDVETQGAVQGMITGMSGLCSGL 366
Cdd:COG2814  324 LAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
27-368 2.69e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.63  E-value: 2.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   27 ILVVVFLEYFAWGLLTMPMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLP--IP 104
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  105 MMTMDNWWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  184 VSTtnVMFVLLAVPETLQQNVRSTGLSWKQADPFLSLRRVGSDPNVLLLcVVMFTFLLPEAGEYSSVPAYLKlTMGFDFT 263
Cdd:pfam07690 160 LSL--LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQE-VLGLSAL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  264 ELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFA----IGYEKWQMWLAGNVAALSSITFPAVSAY 339
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLllslTLSSLWLLLALLLLGFGFGLVFPALNAL 315

                         330       340
                  ....*....|....*....|....*....
gi 221513297  340 VSLYTDVETQGAVQGMITGMSGLCSGLGP 368
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 62-377 1.20e-17

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 84.20  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRK-VLLLITVIFTSLPIPMMTMDNWWFFVISS-ISGVL-GVSFSVAFAYVADVT 138
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKpVMLAGLLLRALGFALLGFAHSPWLFAIALvLTGFGgGLFEPASEAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 139 TKEERSRSYELVSATFAASLVIAPAMGNLIMDrYGINTVVLVATLVSTTNVMFVLLAVPETlqqnvRSTGLSWKQADPFL 218
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPET-----RPKRRAAEKTEILR 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 219 SLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLvafMAILGISINVTLGSIVKTLGAKNAIIL 298
Cdd:cd17329  192 GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL---LALNALLIVLLQFPVARLVERFRLRKI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 299 GLLLELLQLILFAIGYEKWQMWLAGNVAAL----SSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIV 374
Cdd:cd17329  269 LMIGILLFAIGFAVLAFANTLAVLILAMIVltlgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348


                 ...
gi 221513297 375 FYL 377
Cdd:cd17329  349 LDL 351
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 59-211 8.68e-17

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 81.55  E-value: 8.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  59 LMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVI--FTSLPIpmmtmdnWWF------FVISSI-SGVLGVSFSV 129
Cdd:cd17389   64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIglAISYAL-------WAVsrsftiFLLSRIvGGISKGNVSL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 130 AFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNL--IMDR-YGIN---TVVLVATLVSTTNVMFVLLAVPETLQQN 203
Cdd:cd17389  137 STAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYfaSFTRsLGEVffsMPALFALVLALADLLFIFFFLPETLPSN 216


                 ....*...
gi 221513297 204 VRSTGLSW 211
Cdd:cd17389  217 LRRLGLVY 224
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 27-198 4.22e-16

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 79.19  E-value: 4.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIAT-LKETFPDHTflMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPM 105
Cdd:cd17390    1 LYLVGFLDLFGVSMI-LPLLSThIRSLGASPT--VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISS--ISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGN-LIMDRYGINTVVLVAT 182
Cdd:cd17390   78 LGFSTSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhLAETDGGFYYVALLCS 157

                        170
                 ....*....|....*.
gi 221513297 183 LVSTTNVMFVLLAVPE 198
Cdd:cd17390  158 AIFILNAGLVWFLLSK 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 27-376 1.38e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 74.77  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLTMPMIATLKETfpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSL-PIPM 105
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALgALLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISSI--SGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGIN-TVVLVAT 182
Cdd:cd06174   79 AFAPSFWLLLLGRFllGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 183 LVSTTNVMFVLLAVPETLQQNVRSTGLSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDF 262
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 263 TELSTLVAFMAILGISINVTLGSIV-KTLGAKNAIILGLLLELLQLILFAIGYEKWQMW-LAGNVAALSSITFPAVSAYV 340
Cdd:cd06174  239 AVAGLLLSLFGLAGALGSLLLGLLSdRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLlLLLLLGFGLGGLLPLSFALI 318

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 221513297 341 SLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFY 376
Cdd:cd06174  319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 62-375 9.84e-13

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 69.18  E-value: 9.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT-----VIFTSLPIPMMTMDN--WWFFVISSISGVLGVSFSVAF-AY 133
Cdd:cd06173   37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLslWLLLVLAFLLGIASAFFGPARqAL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 134 VADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVAtLVSTTNVMFVLLAVPETLQQNVRSTGlSWKQ 213
Cdd:cd06173  117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-ALSFLLSALLLLFIRRPPPAAPGESS-SLLL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 214 ADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAK 293
Cdd:cd06173  195 RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 294 NAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITF-PAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFG 372
Cdd:cd06173  275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354


                 ...
gi 221513297 373 IVF 375
Cdd:cd06173  355 LLA 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
29-375 1.64e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 68.75  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  29 VVVFLEYFAWGLLTmPMIATLKETF---PDHTFLMNGLVMgvkgILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPM 105
Cdd:COG2223   12 LAFFLAFGVWYLWS-VLAPPLAEEFglsAAQLGLLFAIPV----LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDN--WWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVAT 182
Cdd:COG2223   87 LALAVsyWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 183 lvsttnVMFVLLAVPETLQQNVRSTGLSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDF 262
Cdd:COG2223  167 ------ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 263 TELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQM--WLAGNVAALSSITFPAVSAYV 340
Cdd:COG2223  241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLflVLFLLLGLALGGGNGAVFALV 320

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 221513297 341 SLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVF 375
Cdd:COG2223  321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 60-375 6.34e-11

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 63.78  E-value: 6.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  60 MNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLP-IPMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVT 138
Cdd:cd17331   36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSyLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 139 TKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPE---TLQQNVRSTGLSWKQAD 215
Cdd:cd17331  116 DPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSntkSKREKEAKESASPPSVF 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 216 PFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNa 295
Cdd:cd17331  196 NLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGER- 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 296 iilglLLELLQLILFAIGYekWQMWLAGNVAALSSITFPAVSAYVSLYT----------DVETQGAVQGMITGMSGLCSG 365
Cdd:cd17331  275 -----SLLKLSVALLAIGY--LLLAFVTTVWQLLVLLLPLVIGGSVLYTvitslltkavPPEDTGTALGLSHALFSLVRT 347

                        330
                 ....*....|
gi 221513297 366 LGPALFGIVF 375
Cdd:cd17331  348 VSPTIGGALL 357
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 62-375 1.74e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 62.18  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTM--DNWWFFVISSISGV-LGVSFSVAFAYVADVT 138
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALapSFALLLLARALAGLaHGGFWAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 139 TKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTGLswkqadpFL 218
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGL-------LS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 219 SLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIIL 298
Cdd:cd17324  190 SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221513297 299 GLLLELLQLILFAIGYEKWQMwLAGNV--AALSSITFPAVSAYVSlYTDVETQGAVQGMITGMSGLCSGLGPALFGIVF 375
Cdd:cd17324  270 LLLLAAALLLLTLLGPSPLLL-LVGLVlwGLGFFAAHSALQTRVL-RLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 27-255 2.54e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.84  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLtMPMIATLKETFPDHTFLMnGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLI-TVIFTSLPIPM 105
Cdd:cd17489    1 ILLANFFFFLSFYLL-LPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIgLLIFALATLLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDN-WWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:cd17489   79 LLATSvALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 221513297 184 VSTTNVMFVLLaVPETLQQNVRSTGLSWKQADPFLSLRrvgsdpnVLLLCVVMFTFLLPEAGEYSSVPAYLK 255
Cdd:cd17489  159 LALLALLLVFL-VKDPPPVAAEEAEAGTRAFRRLVEKK-------VLPPALILFLASIAYGAISTFLPLYAA 222
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
21-374 9.20e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 60.25  E-value: 9.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  21 KPSVGHILVVVFLEYFAWGLLTM---PMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVI 97
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  98 FTSLPIPMMT-MDNWWFFVISSIsgVLGVSFS----VAFAYVADVTTKEERSRSyELVSATFAASLVIAPAMGNLIM--- 169
Cdd:COG0738   82 LMALGLLLFAlAPSYPLLLLALF--LLGLGLGlldvAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLIllg 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 170 -DRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVrstglswKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYS 248
Cdd:COG0738  159 lSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 249 SVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAAL 328
Cdd:COG0738  232 WLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 221513297 329 S-SITFPAVSAYVSLYTDVETQGAVqGMITGMSGLCSGLGPALFGIV 374
Cdd:COG0738  312 GlSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
62-375 9.69e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 59.88  E-value: 9.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSL-PIPMMTMDN-WWFFVISSISGV-LGVSFSVAFAYVADVT 138
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLaTLLFGFATSfWQLLLLRFLLGLgEAGFFPAALKLIAEWF 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 139 TKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSttnvmfVLLAVpetlqqnvrstglswkqadpfl 218
Cdd:COG2271  128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG------LLLAL---------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 219 slrrvgsdPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIIL 298
Cdd:COG2271  180 --------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 299 GLLLELLQLILFAIGY---EKWQMWLAGNVAALSSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVF 375
Cdd:COG2271  252 AIGLLLAALALLLLALlpsPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
2_A_01_02 TIGR00880
Multidrug resistance protein;
68-199 1.47e-09

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 56.12  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   68 KGILSFLSSPLIGALSDIYGRK-VLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSF--SVAFAYVADVTTKEERS 144
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKpVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFalVAGAALIADIYPPEERG 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221513297  145 RSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPET 199
Cdd:TIGR00880  87 VALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
62-436 1.11e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.75  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYG-----RKVLLLITVIFTSLPIPMM--------TMDNWWFFVISSISGVLGVSFS 128
Cdd:COG2211   49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLftapdlspTGKLIYALVTYLLLGLAYTLVN 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 129 VAF-AYVADVTT-KEERSRSYELVSATFAASLVIAPAMGNLIMDRYGIN------TVVLVATLVSTTNVMFVLLAVPETL 200
Cdd:COG2211  129 IPYsALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyrLTALIFAVLGLLAFLLTFFGTKERP 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 201 QQNVRSTGLswkqadpFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISIN 280
Cdd:COG2211  209 VPEEEKVSL-------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 281 VTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLA----------GNVAALSSITFPAVSAYVSLYTDVETQG 350
Cdd:COG2211  282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLvlaalagiglGAILVLPWAMLADVVDYDEWKTGRRREG 361

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 351 AVQGMITGMSGLCSGLGPALFGIVFYLSDMDLDKNRILiGSVSGDRTVTnpFMIGAISVFIGILLASYIP-DEKVSRGRR 429
Cdd:COG2211  362 LYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSP-SALTGIRLLF--FLLPAVLLLLAALLLLFYPlTRERHAEIR 438


                 ....*..
gi 221513297 430 EEFSALK 436
Cdd:COG2211  439 AELAARR 445
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 78-373 1.59e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.96  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  78 LIGALSDIYGRK-VLLLITVIFTSLPIPMMTMDN-WWFFVISSISGVLGVSFSV-AFAYVADVTTKEERSRSYELVSATF 154
Cdd:cd17320   53 LYGPLSDRFGRRpVLLAGLLLFILASLLCALASSiEQLLIARFLQGLGAAAGSVvARAIVRDLYSGAELAKIFSLLMMIL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 155 AASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTGLSwkqaDPFLSLRRVGSDPNVLLLCV 234
Cdd:cd17320  133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLS----SLLRAYKRVLKNRRFLGYAL 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 235 VMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGY 314
Cdd:cd17320  209 ALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAA 288

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221513297 315 EKWQMWLAGNVAALS------SITFP-AVSAYVSLYTDVE-TQGAVQGMI-TGMSGLCSGLGPALFGI 373
Cdd:cd17320  289 LLGGLSLWPLVAPLFliffgfGLIFPnATSLALEPFPHVAgTASALLGFLqFLIGALAGALVGLLPNG 356
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 74-420 1.95e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 52.97  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  74 LSSPLIGALSDIYGRKVLLLITVIFTSLPIPM--MTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVS 151
Cdd:cd17504   46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLaaFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 152 ATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSttnVMFVLLAvpetlqqnvrstglswkqadPFLSLRRVGSdPNVLL 231
Cdd:cd17504  126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA---VLLAALV--------------------PLIDLRLLRR-RNVLL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 232 LCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAF----MAILGISINVTLGSIVKTLGAKNAIILGLLLELLQL 307
Cdd:cd17504  182 ANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLlllpGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 308 ILFAI-GYEKWQMWLAGNVAAL-SSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVfylsdMDLDKN 385
Cdd:cd17504  262 LLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI-----LTTYTV 336

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 221513297 386 RILIGSVSGDRTVTNPFMIGAISVFIGILLASYIP 420
Cdd:cd17504  337 SITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 41-238 5.47e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.45  E-value: 5.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  41 LTMPMIATLKETFPDHTFLMNGLVMGVKGIL-SFLSSPLiGALSDIYGRKVLLLI-TVIFTS-LPIPMMTMDNWWFFVIS 117
Cdd:cd17472   14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFgLLLFIAgSLLAAYATSIYGLILGR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 118 SISGVLGVSfSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVP 197
Cdd:cd17472   93 ALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 221513297 198 EtlqqNVRSTGLSWKQADPFLSLRRvgsDPNVLLLCVVMFT 238
Cdd:cd17472  172 D----PPKIVQISEKEKKKLKKLLK---NKRLLRLDFSIFI 205
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 39-359 6.42e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 6.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  39 GLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSL--PIPMMTMDNWWFFVI 116
Cdd:cd17473   15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggVAGLFLDSLYALLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 117 SSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLI--MDRYGINTVVLVATLVsttnVMFVL 193
Cdd:cd17473   95 RALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALaeIGWRAPFLVYLLALPV----LILVL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 194 LAVPETLQQNVRSTGLSWKQADPFLSLRrvgsdpnVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMA 273
Cdd:cd17473  171 LFLPEPARKSKSAASPGAATAAALPWKR-------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 274 ILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAAL-SSITFPAVSAYVSLYTDVETQGAV 352
Cdd:cd17473  244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRA 323


                 ....*..
gi 221513297 353 QGMITGM 359
Cdd:cd17473  324 MGIVTSA 330
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 59-261 7.28e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 51.01  E-value: 7.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  59 LMNGLVMGVKGILSFLSSPLIGALSD-IYGRKVLLLITVIFTSLP-IPMMTMDNWWFFVI--SSISGVLGVSFSVAFAYV 134
Cdd:cd17471   32 LQIGIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGyLLFAFLRNYWVLLLvgVVLLSLGAAAFPQLFALA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 135 ADVTTKEERSRSYELVS---ATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPEtlqQNVRSTglsw 211
Cdd:cd17471  112 REYADRSSGRDATLFNSvlrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPS---VKPPAQ---- 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 221513297 212 kQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFD 261
Cdd:cd17471  185 -KATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGS 233
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
59-201 9.29e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 50.69  E-value: 9.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  59 LMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTMDN--WWFFVISSISGVLGVSFSVAFAYVAD 136
Cdd:PRK09874  54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQniWQFLILRALLGLLGGFVPNANALIAT 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221513297 137 VTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQ 201
Cdd:PRK09874 134 QVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQ 198
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 62-379 2.86e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 49.38  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLItvIFTSLPIPMMTM------DNWWFFVISSISGVLGVSFSVAF--AY 133
Cdd:COG2270   55 GYALAIAGLLVALLAPVLGAIADRSGRKKPFLA--FFTLLGVLATAAlffvapGGLWLGLLLFVLANIGFEGSLVFynAF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 134 VADVTTKEERSRsyelVSAT--------------FAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPET 199
Cdd:COG2270  133 LPDIATPEEIGR----VSGLgwalgylggvllllINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPER 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 200 LQQNVRSTGLSWKQA--DPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGI 277
Cdd:COG2270  209 PRPGPAPPRGAVRAGfrELRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAA 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 278 SINVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVS-AYVSLYTDVETQGAVQGmI 356
Cdd:COG2270  289 LGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEFFG-L 367

                        330       340
                 ....*....|....*....|....
gi 221513297 357 TGMSG-LCSGLGPALFGIVFYLSD 379
Cdd:COG2270  368 YALSGkAASFLGPLLFGLVTQLTG 391
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 62-251 3.76e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.80  E-value: 3.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTM--DNWWFFVISSISGVLGVSFSVAFAYVADVTT 139
Cdd:cd17391   39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIASQTP 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 140 KEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTGLSWKQadpfls 219
Cdd:cd17391  119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKE------ 192

                        170       180       190
                 ....*....|....*....|....*....|..
gi 221513297 220 lrRVGSDPNVLLLCVVMFTFLLPEAGEYSSVP 251
Cdd:cd17391  193 --VWNSVPNPSLLISLFVTTFIIQLANQSIEP 222
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
27-199 5.03e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 5.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLTMPMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFT----SLP 102
Cdd:COG2271  185 LALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLlaalALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 103 IPMMTMDNWWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVA 181
Cdd:COG2271  264 LLALLPSPALAIALLFLAGFgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343

                        170
                 ....*....|....*...
gi 221513297 182 TLVSTTNVMFVLLAVPET 199
Cdd:COG2271  344 AALALLAALLALLLLRET 361
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 62-374 5.67e-06

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 48.40  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLI------TVIFTSLPIPMMTMDNWWFFVISSISGVLGVSfSVAFAYVA 135
Cdd:pfam12832  37 GLITAILPLTRILAPPIWGWLADRTGKRKAVVRlasilaAVLFLSVLFIPISLTFWWLALLVVLFSFFWNA-ILPQFEVA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  136 DVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTtnvMFVLLAVPETLQQNVRSTGLSWKQAD 215
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLLPSVLFYLFA---ALMLLSLLLPLAPPEMEYESKGGSKA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  216 PFLSLRRvgsDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKlTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNA 295
Cdd:pfam12832 193 VFWNLLK---QPEVIIFFLAAFLLGFSHGPFYTFLFLYLE-NLGASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNL 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  296 IILGLLLELLQLILFAIGYEKWqmWLAGNVAALSSITFPAVSA----YVSLYTDVETQGAVQGMItgmSGLCSGLGPALF 371
Cdd:pfam12832 269 LIIALLLTALRWLLYAFFVENP--WLVLPIQFLHAISFGLTHAaaieYVRRIFPGSLQGTGQALY---SGLYFGLGGALG 343


                  ...
gi 221513297  372 GIV 374
Cdd:pfam12832 344 SLI 346
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 26-193 6.49e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.92  E-value: 6.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  26 HILVVVFLeyFAWGLLTMPMIA-TLKETFpdHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT-VIFTSLPI 103
Cdd:cd17370  204 LYLLAVAL--FALGNFSFAFLIlRAQELG--LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 104 PMMTMDNWWFFVISSI-SGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVA 181
Cdd:cd17370  280 GFALGSSLWLLLLGFIlWGLyMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359

                        170
                 ....*....|..
gi 221513297 182 TLVSTTNVMFVL 193
Cdd:cd17370  360 AVLALIALLLLL 371
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 27-292 6.68e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.50  E-value: 6.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  27 ILVVVFLEYFAWGLLTmPMIATLKETFPDHTFLMnGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT-VIFTSLPIPM 105
Cdd:COG0477   19 LALGTFLEGLDFTIVN-VALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGlLLFGLASLLC 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 106 MTMDNWWFFVISSISGVLGVS--FSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATL 183
Cdd:COG0477   97 GLAPSPELLIAARALQGIGAGglMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 184 VSTTnVMFVLLAVPETLQQNVRSTGLSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFT 263
Cdd:COG0477  177 LGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255

                        250       260
                 ....*....|....*....|....*....
gi 221513297 264 ELSTLVAFMAILGISINVTLGSIVKTLGA 292
Cdd:COG0477  256 LLLLAALLLLLLLLLLLALLLALLLLLLL 284
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 62-375 6.64e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.87  E-value: 6.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYG-RKVLLLITVIFTSLPIPMMTMDNWWFFVIssISGVLGVS----FSVAFAYVAD 136
Cdd:cd17319   41 GLIASAFFLGYALFQVPGGWLLDRFGaRKVLAVSMLLWSLFTALTGFATSLTSLYV--LRFLLGVAeagfFPGAIKALAE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 137 VTTKEERSRsyelVSATFAASLVIAPAMGNLImdrygintVVLVATLVSTtNVMFVLLAVPetlqqnvrstGLSWKqadp 216
Cdd:cd17319  119 WFPARERGR----ATGLFNSGAPLGAAIGPPL--------SGWLLLLFGW-RWAFIIEGLL----------GLLLA---- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 217 FLSLRRVgsdPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAI 296
Cdd:cd17319  172 VLWWFYL---RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 297 ILGLLLELLQLILFAIGYEKWQMWLA----GNVAALSSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFG 372
Cdd:cd17319  249 LVIIIGLLLAAVGLLLAYLTTSPVVAvillSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIG 328


                 ...
gi 221513297 373 IVF 375
Cdd:cd17319  329 YLV 331
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 67-375 1.05e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 44.19  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  67 VKGILSFLSSPLIGALSDIYGRKVLLLITVI------FTSLPIPMMTMDN--WWFF---VISSISGVLGVSFSVAFAYVA 135
Cdd:cd17386   38 MGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVglllssLILVLIVYFTTVPsvWWFYlsaIPLALFGGFTAFLSASFAYIS 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 136 DVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLavpetlqqnvrstglswkqad 215
Cdd:cd17386  118 DISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILF--------------------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 216 pFLSLrrvgsdpnVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGF---DFTELSTLVAFMAILGISINVTLGSIVKTLGA 292
Cdd:cd17386  177 -FLTL--------LILLLLAAFLTIFVLSGESDVLYLFVLEKFAWnvkDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 293 KNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVSAYVSLYTDVETQGAVQGMItgmsGLCSGLGPALFG 372
Cdd:cd17386  248 STLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLL----SVLESLSPLVAS 323


                 ...
gi 221513297 373 IVF 375
Cdd:cd17386  324 PIY 326
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
62-184 1.06e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.49  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMM--TMDNWWFFVISS--ISGVLGVSFSVAFAYVADV 137
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLalALGSLWLFLVLFllLGLALGGGNGAVFALVPDI 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 221513297 138 TTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLV 184
Cdd:COG2223  324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAV 370
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 60-295 1.47e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.75  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  60 MNGLVMGVKGILSFLSSPLIGALSDIYG-RKVLLLITVIFTSLPIPMMTM--DNWWFFVISSISGVLG---VSFSVAFAY 133
Cdd:cd17490   32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAatwVSFTVLYAS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 134 VADvttKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTGLSwkq 213
Cdd:cd17490  112 YFP---PDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELK--- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 214 adpflSLRRVGSDPNVLLLCVV-MFTFLLPEAGEYSSVPAYLKLtMGFDFTELSTL-VAFMAILGISINVTLGSIVKTLG 291
Cdd:cd17490  186 -----ELLSVLKDKKLLFFSLLaILQQMITFSTTFGFTPLIAKQ-LGASSFQLGLLsIIYLLPNALASLLSGTLFYKKLG 259


                 ....
gi 221513297 292 AKNA 295
Cdd:cd17490  260 ERNT 263
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 62-375 1.52e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.80  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTMDN--WWFFVISSISGVLGVSFS--VAFAYVADV 137
Cdd:cd17355   41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATslWQLYLLWGLLGGGGAGTLaaVAFATVAAW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 138 TTKEERSRSYELVSATFA-ASLVIAPAMGNLImDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTGLSWKQADP 216
Cdd:cd17355  121 WFERRRGLALGILTAGGGlGSLVFLPLGAALI-EAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASP 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 217 FLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLkLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAI 296
Cdd:cd17355  200 GSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 297 ILGLLLELLQLILFAIG-YEKWQMWLAGNVAALSSI-TFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIV 374
Cdd:cd17355  279 AASYALRALGLALLLLLpFPPLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358


                 .
gi 221513297 375 F 375
Cdd:cd17355  359 Y 359
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 78-213 1.71e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 43.53  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   78 LIGALSDIYGRK-VLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSFS--VAFAYVADVTTKEERSRSYELVSATF 154
Cdd:TIGR00710  59 LWGPLSDRYGRRpVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGsvISQALVRDIYPGEELSRIYSILMPVL 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  155 AASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRST-GLSWKQ 213
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQiSTYFET 198
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 63-295 3.12e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.67  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  63 LVMGVKGILSflsspliGALSDIYGRKVLLLITVI-FTSLPIPMMTMDNWW-FFVISSISGV-LGVSFSVAFAYVADVTT 139
Cdd:cd17371   45 AGGAIGGILG-------GILADRFGRVRVLVITILlFAVFTLLCGFAQNYWqLLILRALAGLgFGGEWAAGAALMAEYVP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 140 KEERSRSYELVSATFAASLVIAPAMGNLIM----DRYGINTVVLVATLVSTTnVMFVLLAVPETLQ-QNVRSTGLSWKQA 214
Cdd:cd17371  118 ARHRGKALGYVQSGWAVGWLLATLLAALLFpllpPEIAWRVLFLLGALPALL-VLFIRRFVKEPPQwQAARAARRHFADR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 215 DpflSLRRVGSDPN--VLLLCVVMFTFLLpeAGEYSS---VPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKT 289
Cdd:cd17371  197 P---SLRELFSPPLlrTTLLASLLATGAL--GGYYGIttwLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR 271


                 ....*.
gi 221513297 290 LGAKNA 295
Cdd:cd17371  272 IGRRNN 277
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 75-173 3.74e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.55  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  75 SSPLIGALSDIYGRKVLLLI-TVIFT--SLpIPMMTMDNWWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELV 150
Cdd:cd17502   46 FQPIYGKLSDLFGRKWVLLIaIVIFElgSL-LCGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADLVPPRERGKYQGYI 124

                         90       100
                 ....*....|....*....|...
gi 221513297 151 SATFAASLVIAPAMGNLIMDRYG 173
Cdd:cd17502  125 GAVFGIASVAGPLIGGAFTDHLS 147
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 55-193 5.34e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.87  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  55 DHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLP-IPMMTMDNWWFFVIssISGVLGVSFSVAF-- 131
Cdd:cd17391  236 SNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLyIPQAFVQTPWQLGI--LRFLLGLATGGLLpa 313

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221513297 132 --AYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVL 193
Cdd:cd17391  314 inSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSF 377
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 32-372 1.01e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  32 FLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLP--IPMMTMD 109
Cdd:cd17316    9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAtlLIGLLPT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 110 NWWFFVISSISGV-LGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTvvlvatlvsTTN 188
Cdd:cd17316   89 PILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW---------GWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 189 VMFVLLAVPETLqqnvrstglswkqadpFLSLRRvgsdpNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTL 268
Cdd:cd17316  160 ILFLIGALPALL----------------ALLLRR-----RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 269 VAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAI--GYEKWQMWLAGNVAA-LSSITFPAVSAYVSLYTD 345
Cdd:cd17316  219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllSGSPTLLLLLLFILSfFVGGVWGALYAYLAELFP 298

                        330       340
                 ....*....|....*....|....*..
gi 221513297 346 VETQGAVQGMITGMSGLCSGLGPALFG 372
Cdd:cd17316  299 TEVRATGVGLSYNLGRLGGGGAPPLIA 325
MFS_1 pfam07690
Major Facilitator Superfamily;
7-162 1.72e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297    7 KKLLVSLASTSGIGKPSVGHILVVVFLEYFAWGLLTMpMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIY 86
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT-YLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297   87 GRKVLLLITVIFTSL------PIPMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVI 160
Cdd:pfam07690 263 GRRRRLLLALLLLILaalgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342


                  ..
gi 221513297  161 AP 162
Cdd:pfam07690 343 GP 344
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 70-173 1.78e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 40.25  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  70 ILSFLSSPLIGA-LSDIYGRKVLLLIT-VIFTSLPIPMMTMDNWWFFVISS-ISGVLGVSF-SVAFAYVADVTTKEERSR 145
Cdd:cd17323   44 VLGFGLGPLIWApLSELYGRRPVYLVSlFIFVIFQIGCALAPNIAMLIILRfLQGFFGSSPlAIGAGTIADLFTPEERGK 123

                         90       100
                 ....*....|....*....|....*...
gi 221513297 146 SYELVSATFAASLVIAPAMGNLIMDRYG 173
Cdd:cd17323  124 AMGVYSLGPLLGPALGPIIGGFITQSLG 151
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 63-194 2.34e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.90  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  63 LVMGVKGILSFLSSPLIGALSDIYGRK---VLLLITVIFTSLPIPMMTMDNWWFFVISSISGV-LGVSFSVAFAYVADVT 138
Cdd:cd17353  253 LAVSILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFF 332

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221513297 139 TKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLL 194
Cdd:cd17353  333 GTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 44-374 3.27e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  44 PMIATLKETFpDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMT-MDNWWFFVISSISGV 122
Cdd:cd17478   17 ALLPLLIAKL-GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGfAPNYWLLLLLVALAG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 123 LGVS-FSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTnVMFVLLAVPETLQ 201
Cdd:cd17478   96 IGSAaFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLA-VALLLLRLRPLKK 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 202 QNVRSTGLSWKQADPFLSLRRVgsdpnVLLLCVVMFTFLLPEAGEYSSVPAYLKlTMGFDFTELSTLVAFMAILGISINV 281
Cdd:cd17478  175 PEAKKAAAKSSARSTLKGVWRA-----LLLLLIIVFLRSWVLSSLTTFLPFYLV-QRGYSLVFAGLLLSLFLFAGAIGTL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 282 TLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVSAYVSLYtDVETQGAVQGMITGMSG 361
Cdd:cd17478  249 IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGLMMGLSF 327

                        330
                 ....*....|...
gi 221513297 362 LCSGLGPALFGIV 374
Cdd:cd17478  328 GLGGIGAPVLGAL 340
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 62-420 3.44e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.49  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYG-RKVLLLITVIFTSLPIPMMTMDN---WWFFVISsisgVLGVSFSVAFAYVADV 137
Cdd:cd17335   35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAqifWLLLLLV----ILGAFFSAPVVPLVDS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 138 TT----KEERSRsYELV----SATFAASlviAPAMGnLIMDRYGINTVVLVATLVSttnVMFVLLAVPETLQQNVRSTGL 209
Cdd:cd17335  111 ITlqylGEERER-YGKQrlwgSIGFGIA---ALLVG-ILIDRSSTYKNYTIAFYVF---AVLMLLALLLALKFPFRPKHP 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 210 swKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLtMGFDFTELSTLVAFMAILGISINVTLGSIVKT 289
Cdd:cd17335  183 --EPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQR 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 290 LGAKNAIILGLLLELLQLILFAIGYEkwqMWLAGNVAALSSITFPAV----SAYVSLYTDVETQGAVQGMitgMSGLCSG 365
Cdd:cd17335  260 FGHVGLLYLGLLAYVVRWLLYSFLEN---PWLVLPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGL---LQGLYFG 333

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 221513297 366 LGPALFGivfylsdmdldknrILIGSVSGDRTVTNPFMIGAISVFIGILLASYIP 420
Cdd:cd17335  334 LGGGLGS--------------LIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 63-202 5.44e-03

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 39.02  E-value: 5.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  63 LVMGVKGIL-SFLSSPLIGALSDIYGRKVLLLI-------------TVIFTSLPIpmmtmdnWWFFV---ISSISGVLGV 125
Cdd:cd17449   68 LYINLGGFLvGLFSVTLLGPWSDSVGRRPVLILpslglalqaavylLVMYLQLHV-------AYFLIgriLSGLLGDFNG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 126 SFSVAFAYVADVTtkEERSRSYELvsATFAASLVIAPAMGNLIMDRYG-----INTVVLV-ATLVSTTnvMFVLLAVPET 199
Cdd:cd17449  141 ILAGCFAYVADVS--DRRSRTFRV--AVLEACLGLAGMLASIIGGQWRkaqgyINPFWLVlALNLAAA--LYAAFCVGES 214


                 ...
gi 221513297 200 LQQ 202
Cdd:cd17449  215 VKE 217
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 77-420 7.57e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 7.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  77 PLIGALSDIYGRK-VLLLITVIFT--SLpIPMMTMDNWWFFVISSISGVLG-VSFSVAFAYVADVTTKEERSRSYELVSA 152
Cdd:cd17321   49 LLAGRLGDRFGRKrVFLIGLALFGlaSL-LCALAPSLAFLIAARALQGIGAaAIMPASLALIAATFPGERRGRALGLWGA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 153 TFAASLVIAPAMGNLIMDRYG------INTVVLVATLVSTTNVMFVLLAVpetlqqnvrstglswkqadpflslrrvgsd 226
Cdd:cd17321  128 VVGIGAALGPLLGGLLLELFGwrwiflINVPIGLVALLLARTFSGAVLAA------------------------------ 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 227 pnvLLLCVVMFTFLLpeageysSVPAYLKLTMGFDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQ 306
Cdd:cd17321  178 ---FLLGAALGGLLF-------LLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297 307 LILFAI---GYEKWQMWLAGNVAAL-SSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFY--LSDM 380
Cdd:cd17321  248 LLLLALlgaDSSVWLLLPGLVLLGLgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTagLSAN 327

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 221513297 381 DLDKNRILIGSVSG---DRTVTNPFMIGAISVFIGILLASYIP 420
Cdd:cd17321  328 LGDSGVAALLSAAAaafAAGFHLAFLVAAALALLAALLALLLP 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 62-173 8.13e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 8.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRKVLLLIT---VIFTSLPIPMMTMDNWWFFVISSISGVLGVS-FSVAFAYVADV 137
Cdd:cd17477  226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCallGALAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 221513297 138 TTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYG 173
Cdd:cd17477  306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341
MFS_YxiO_like cd17482
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ...
 62-145 9.01e-03

Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341035 [Multi-domain]  Cd Length: 362  Bit Score: 37.97  E-value: 9.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  62 GLVMGVKGILSFLSSPLIGALSDIYGRK-----VLLLITVIFTSLPIpMMTMDNWWFFVISSISGVLGVSFSVAF--AYV 134
Cdd:cd17482   42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTALLF-FVTPGQWLLALLLFILANIGFSGANVFydAFL 120

                         90
                 ....*....|.
gi 221513297 135 ADVTTKEERSR 145
Cdd:cd17482  121 PDVASPERMDR 131
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 29-165 9.83e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 37.96  E-value: 9.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221513297  29 VVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMM-- 106
Cdd:cd17326    6 LTMFLSSLQFSIVLTSIWPYLQKIDPTATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILya 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221513297 107 ----TMDNWWFFVISS--ISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMG 165
Cdd:cd17326   86 laeyFPSNRKYVMLVArfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQ 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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