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Conserved domains on  [gi|21356407|ref|NP_649214|]
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Toll-9, isoform A [Drosophila melanogaster]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
751-891 5.81e-24

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 98.55  E-value: 5.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407    751 YDIFISYCQNDrtWVLNELLPNVEETGDVS-ICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA 829
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYgLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356407    830 QHRIFEVSKEHLILVFLEDIPR--RKRPKTLQYLMdVKTYIKWPtaKEDRKLFWKRLKRSLEVI 891
Cdd:smart00255  80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
198-537 1.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 198 LLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCsieyv 277
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 278 skEAFRNVSNLRRLFMSDNKIMTIShDTFYYVQGVQYLDLSFTNFLTysyqlqLPTlemalsliyglkiqqnVFKYLPEL 357
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD------LPE----------------PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 358 IYLDLSHSKMTRNSAvAFAHLgDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPylsyniIDDAFDGIAN--TLKYL 435
Cdd:COG4886 162 KSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ------LTDLPEPLANltNLETL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 436 YFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMfqSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINML 515
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       330       340
                ....*....|....*....|..
gi 21356407 516 SNEMLKDFERLDYLSLGDNDFI 537
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGL 333
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
751-891 5.81e-24

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 98.55  E-value: 5.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407    751 YDIFISYCQNDrtWVLNELLPNVEETGDVS-ICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA 829
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYgLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356407    830 QHRIFEVSKEHLILVFLEDIPR--RKRPKTLQYLMdVKTYIKWPtaKEDRKLFWKRLKRSLEVI 891
Cdd:smart00255  80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
198-537 1.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 198 LLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCsieyv 277
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 278 skEAFRNVSNLRRLFMSDNKIMTIShDTFYYVQGVQYLDLSFTNFLTysyqlqLPTlemalsliyglkiqqnVFKYLPEL 357
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD------LPE----------------PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 358 IYLDLSHSKMTRNSAvAFAHLgDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPylsyniIDDAFDGIAN--TLKYL 435
Cdd:COG4886 162 KSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ------LTDLPEPLANltNLETL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 436 YFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMfqSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINML 515
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       330       340
                ....*....|....*....|..
gi 21356407 516 SNEMLKDFERLDYLSLGDNDFI 537
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGL 333
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 751-889 3.45e-13

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 68.16  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   751 YDIFISYCQND-RTWVLNELLPNVEETGdVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA 829
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELKQKG-IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21356407   830 QHRIFEvSKEHLILVFLEDIPRRKR------PKTLQYL---MDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
Cdd:pfam01582  80 LECALD-LGQKVIPIFYEVDPSDVRkqtgsfGKAFKKHkkvLTEEKVLKWRGALNEVANIWHSKSVSDE 147
LRR_8 pfam13855
Leucine rich repeat;
431-488 3.62e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   431 TLKYLYFERSNIKDL--EWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV 488
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 449-536 3.45e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 3.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 449 KSLKNLQVLGLagnNINALTP-------AMFQSLESLEILDLSSNHVGNWYRSAFHN-----NSALRVLNLRSNTINMLS 516
Cdd:cd00116 190 KANCNLEVLDL---NNNGLTDegasalaETLASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITDDG 266

                        90       100
                ....*....|....*....|....
gi 21356407 517 NEML----KDFERLDYLSLGDNDF 536
Cdd:cd00116 267 AKDLaevlAEKESLLELDLRGNKF 290
PLN03150 PLN03150
hypothetical protein; Provisional
 446-512 5.32e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 5.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21356407  446 EWSKsLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTI 512
Cdd:PLN03150 437 DISK-LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
751-891 5.81e-24

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 98.55  E-value: 5.81e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407    751 YDIFISYCQNDrtWVLNELLPNVEETGDVS-ICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA 829
Cdd:smart00255   2 YDVFISYSGKE--DVRNEFLSHLLEKLRGYgLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAA 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356407    830 QHRIFEVSKEHLILVFLEDIPR--RKRPKTLQYLMdVKTYIKWPtaKEDRKLFWKRLKRSLEVI 891
Cdd:smart00255  80 LENALEEGGLRVIPIFYEVIPSdvRKQPGKFRKVF-KKNYLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
198-537 1.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 198 LLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCsieyv 277
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 278 skEAFRNVSNLRRLFMSDNKIMTIShDTFYYVQGVQYLDLSFTNFLTysyqlqLPTlemalsliyglkiqqnVFKYLPEL 357
Cdd:COG4886 107 --EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD------LPE----------------PLGNLTNL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 358 IYLDLSHSKMTRNSAvAFAHLgDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPylsyniIDDAFDGIAN--TLKYL 435
Cdd:COG4886 162 KSLDLSNNQLTDLPE-ELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ------LTDLPEPLANltNLETL 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 436 YFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMfqSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINML 515
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       330       340
                ....*....|....*....|..
gi 21356407 516 SNEMLKDFERLDYLSLGDNDFI 537
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGL 333
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 751-889 3.45e-13

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 68.16  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   751 YDIFISYCQND-RTWVLNELLPNVEETGdVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA 829
Cdd:pfam01582   1 YDVFLSFRGSDtREWFVSHLLKELKQKG-IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21356407   830 QHRIFEvSKEHLILVFLEDIPRRKR------PKTLQYL---MDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
Cdd:pfam01582  80 LECALD-LGQKVIPIFYEVDPSDVRkqtgsfGKAFKKHkkvLTEEKVLKWRGALNEVANIWHSKSVSDE 147
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 753-861 4.46e-12

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 63.49  E-value: 4.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   753 IFISYCQNDRTWVLnELLPNVEETGdVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHR 832
Cdd:pfam13676   1 VFISYAGEDRAWAE-WLADALEAAG-YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD 78

                          90       100
                  ....*....|....*....|....*....
gi 21356407   833 ifEVSKEHLILVFLEDIPRRKRPKTLQYL 861
Cdd:pfam13676  79 --PEGRKRLIPVRLECDLELPGLAGLQYI 105
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 343-546 2.77e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.11  E-value: 2.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 343 GLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAhlgDKLKflslcytaipmvsstifKNTVLEGLDLSGNpylsyNIID 422
Cdd:COG5238 224 GAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA---EALK-----------------NNTTVETLYLSGN-----QIGA 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 423 DAFDGIAN------TLKYLYFERSNIKDLEW---SKSLKN---LQVLGLAGNNI-----NALTPAMfQSLESLEILDLSS 485
Cdd:COG5238 279 EGAIALAKalqgntTLTSLDLSVNRIGDEGAialAEGLQGnktLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLSD 357

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 486 NHVGNWYRSAF----HNNSALRVLNLRSNTI-----NMLSNEMLKDfeRLDYLSLGDNDFICDCHLRAVV 546
Cdd:COG5238 358 NQIGDEGAIALakylEGNTTLRELNLGKNNIgkqgaEALIDALQTN--RLHTLILDGNLIGAEAQQRLEQ 425
LRR_8 pfam13855
Leucine rich repeat;
431-488 3.62e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   431 TLKYLYFERSNIKDL--EWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV 488
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
477-536 8.07e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 8.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407   477 SLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDF 536
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
262-322 1.29e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.29e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21356407   262 PRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNF 322
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
352-536 1.91e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 352 KYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANT 431
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 432 LKYLYFERS-NIKDLEWSKSLKNLQVLGLAGNNINALtPAMFQSLESLEILDLSSNHVGNwYRSAFHNNSALRVLNLRSN 510
Cdd:COG4886  92 LGDLTNLTElDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTD-LPEPLGNLTNLKSLDLSNN 169

                       170       180
                ....*....|....*....|....*.
gi 21356407 511 TINMLSNEmLKDFERLDYLSLGDNDF 536
Cdd:COG4886 170 QLTDLPEE-LGNLTNLKELDLSNNQI 194
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 449-536 3.45e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 3.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 449 KSLKNLQVLGLagnNINALTP-------AMFQSLESLEILDLSSNHVGNWYRSAFHN-----NSALRVLNLRSNTINMLS 516
Cdd:cd00116 190 KANCNLEVLDL---NNNGLTDegasalaETLASLKSLEVLNLGDNNLTDAGAAALASallspNISLLTLSLSCNDITDDG 266

                        90       100
                ....*....|....*....|....
gi 21356407 517 NEML----KDFERLDYLSLGDNDF 536
Cdd:cd00116 267 AKDLaevlAEKESLLELDLRGNKF 290
PLN03150 PLN03150
hypothetical protein; Provisional
 446-512 5.32e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.12  E-value: 5.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21356407  446 EWSKsLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTI 512
Cdd:PLN03150 437 DISK-LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 427-488 7.81e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 7.81e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21356407 427 GIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTP--AMFQSLESLEILDLSSNHV 488
Cdd:cd21340 117 ALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
251-298 2.05e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 21356407   251 QSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKI 298
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 452-512 2.41e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.41e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21356407 452 KNLQVLGLAGNNINALTPamFQSLESLEILDLSSNHVGNWYR--SAFHNNSALRVLNLRSNTI 512
Cdd:cd21340 120 NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 401-585 4.60e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 401 KNTVLEGLDLSGNPylsynIIDDAFDGIANTLKYLYFERS------NIKD---LEWSKSLKN---LQVLGLAGNNINALT 468
Cdd:COG5238 206 QNTTVTTLWLKRNP-----IGDEGAEILAEALKGNKSLTTldlsnnQIGDegvIALAEALKNnttVETLYLSGNQIGAEG 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407 469 PA----MFQSLESLEILDLSSNHVGNwyRSA------FHNNSALRVLNLRSNTI-----NMLSnEMLKDFERLDYLSLGD 533
Cdd:COG5238 281 AIalakALQGNTTLTSLDLSVNRIGD--EGAialaegLQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLSD 357

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 21356407 534 NDfICDCHLRAVVEvAAANNKdadcSYRLLNYSQNAVGEE-VISLAESLIIDR 585
Cdd:COG5238 358 NQ-IGDEGAIALAK-YLEGNT----TLRELNLGKNNIGKQgAEALIDALQTNR 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-534 1.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356407  428 IANTLKYLYFERSNIKDLEWSKSLKN----LQVLGLAGNNINA-LTPAMFQsLESLEILDLSSNHV-GNWYRSAFHNNSA 501
Cdd:PLN00113  41 INDPLKYLSNWNSSADVCLWQGITCNnssrVVSIDLSGKNISGkISSAIFR-LPYIQTINLSNNQLsGPIPDDIFTTSSS 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21356407  502 LRVLNLRSNTI-------------------NMLSNEMLKD---FERLDYLSLGDN 534
Cdd:PLN00113 120 LRYLNLSNNNFtgsiprgsipnletldlsnNMLSGEIPNDigsFSSLKVLDLGGN 174
LRR_8 pfam13855
Leucine rich repeat;
344-387 7.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 7.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 21356407   344 LKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLgDKLKFLSL 387
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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