|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
36-320 |
1.18e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 114.24 E-value: 1.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 36 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR-FPSPVLKVQ 114
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 115 FDPrnDNRLLVCPMRYAAVLV-EVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEVVASFRIIVG 193
Cdd:COG2319 212 FSP--DGKLLASGSADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 194 tssatAVKSIEFARRGDAFLINTSDRVIRVYD---SKEIITLgkDGEPEPIQKLqdlvnkttwkkcCFSGDGEYICAGSA 270
Cdd:COG2319 290 -----GVNSVAFSPDGKLLASGSDDGTVRLWDlatGKLLRTL--TGHTGAVRSV------------AFSPDGKTLASGSD 350
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 24667373 271 rQHALYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIW 320
Cdd:COG2319 351 -DGTVRLWDLATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSAdGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
28-321 |
3.68e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 102.03 E-value: 3.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 28 VTC-AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR- 105
Cdd:cd00200 12 VTCvAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 106 FPSPVLKVQFDPrnDNRLLVCPMRYAAVLV---EVGGTHRCLPlDSDGDLNIVAsFDRRGKHIYTGNAKGKILVLDVETF 182
Cdd:cd00200 92 HTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvETGKCLTTLR-GHTDWVNSVA-FSPDGTFVASSSQDGTIKLWDLRTG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 183 EVVASFriivgTSSATAVKSIEFARRGDAFLINTSDRVIRVYDSKEiitlgkdgepepIQKLQDLVNKTTWKKCC-FSGD 261
Cdd:cd00200 168 KCVATL-----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST------------GKCLGTLRGHENGVNSVaFSPD 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24667373 262 GEYICAGSARQHaLYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIWA 321
Cdd:cd00200 231 GYLLASGSEDGT-IRVWDLRTGECVQTLSGHTNS-VTSLAWSPDGKRLASGSAdGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
60-94 |
1.20e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.20e-06
10 20 30
....*....|....*....|....*....|....*
gi 24667373 60 KIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWD 94
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
60-94 |
2.04e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 2.04e-05
10 20 30
....*....|....*....|....*....|....*
gi 24667373 60 KIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWD 94
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
36-320 |
1.18e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 114.24 E-value: 1.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 36 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR-FPSPVLKVQ 114
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 115 FDPrnDNRLLVCPMRYAAVLV-EVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEVVASFRIIVG 193
Cdd:COG2319 212 FSP--DGKLLASGSADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 194 tssatAVKSIEFARRGDAFLINTSDRVIRVYD---SKEIITLgkDGEPEPIQKLqdlvnkttwkkcCFSGDGEYICAGSA 270
Cdd:COG2319 290 -----GVNSVAFSPDGKLLASGSDDGTVRLWDlatGKLLRTL--TGHTGAVRSV------------AFSPDGKTLASGSD 350
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 24667373 271 rQHALYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIW 320
Cdd:COG2319 351 -DGTVRLWDLATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSAdGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
25-320 |
4.01e-26 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.00 E-value: 4.01e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 25 SLAVTCAFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKY 104
Cdd:COG2319 79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 105 RFPS-PVLKVQFDPrnDNRLLVCPMRYAAVLVEVGGTHRCLP--LDSDGDLNIVAsFDRRGKHIYTGNAKGKILVLDVET 181
Cdd:COG2319 159 TGHSgAVTSVAFSP--DGKLLASGSDDGTVRLWDLATGKLLRtlTGHTGAVRSVA-FSPDGKLLASGSADGTVRLWDLAT 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 182 FEVVASFriivgTSSATAVKSIEFARRGDAFLINTSDRVIRVYD---SKEIITLgkDGEPEPIQKLqdlvnkttwkkcCF 258
Cdd:COG2319 236 GKLLRTL-----TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatGELLRTL--TGHSGGVNSV------------AF 296
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24667373 259 SGDGEYICAGSaRQHALYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIW 320
Cdd:COG2319 297 SPDGKLLASGS-DDGTVRLWDLATGKLLRTLTGHTGA-VRSVAFSPDGKTLASGSDdGTVRLW 357
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
28-321 |
3.68e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 102.03 E-value: 3.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 28 VTC-AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR- 105
Cdd:cd00200 12 VTCvAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 106 FPSPVLKVQFDPrnDNRLLVCPMRYAAVLV---EVGGTHRCLPlDSDGDLNIVAsFDRRGKHIYTGNAKGKILVLDVETF 182
Cdd:cd00200 92 HTSYVSSVAFSP--DGRILSSSSRDKTIKVwdvETGKCLTTLR-GHTDWVNSVA-FSPDGTFVASSSQDGTIKLWDLRTG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 183 EVVASFriivgTSSATAVKSIEFARRGDAFLINTSDRVIRVYDSKEiitlgkdgepepIQKLQDLVNKTTWKKCC-FSGD 261
Cdd:cd00200 168 KCVATL-----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST------------GKCLGTLRGHENGVNSVaFSPD 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24667373 262 GEYICAGSARQHaLYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIWA 321
Cdd:cd00200 231 GYLLASGSEDGT-IRVWDLRTGECVQTLSGHTNS-VTSLAWSPDGKRLASGSAdGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
31-225 |
1.17e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 93.82 E-value: 1.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 31 AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR-FPSP 109
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 110 VLKVQFDPrnDNRLLVCPMRYAAVLVEVGGTHRCL-PLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEVVASF 188
Cdd:COG2319 291 VNSVAFSP--DGKLLASGSDDGTVRLWDLATGKLLrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368
|
170 180 190
....*....|....*....|....*....|....*..
gi 24667373 189 RiivGTSSatAVKSIEFARRGDAFLINTSDRVIRVYD 225
Cdd:COG2319 369 T---GHTG--AVTSVAFSPDGRTLASGSADGTVRLWD 400
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
25-320 |
6.66e-18 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 85.73 E-value: 6.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 25 SLAVTCAFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKY 104
Cdd:COG2319 37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 105 R-FPSPVLKVQFDPrnDNRLLVCPMRYAAVLV-EVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETF 182
Cdd:COG2319 117 TgHTGAVRSVAFSP--DGKTLASGSADGTVRLwDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 183 EVVASFriivgTSSATAVKSIEFARRGDAFLINTSDRVIRVYD---SKEIITLGkdGEPEPIQKLqdlvnkttwkkcCFS 259
Cdd:COG2319 195 KLLRTL-----TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDlatGKLLRTLT--GHSGSVRSV------------AFS 255
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24667373 260 GDGEYICAGSaRQHALYIWEKSIGNLVKILHGTKGElLLDVVWHPVRPIIASISS-GLVSIW 320
Cdd:COG2319 256 PDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-VNSVAFSPDGKLLASGSDdGTVRLW 315
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
31-181 |
3.87e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 80.34 E-value: 3.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 31 AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYR-FPSP 109
Cdd:COG2319 253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGA 332
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24667373 110 VLKVQFDPrNDNRLLVCPMRYAAVLVEVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVET 181
Cdd:COG2319 333 VRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
20-126 |
3.43e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 70.06 E-value: 3.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 20 SLDCISLAVTC-AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTG 98
Cdd:cd00200 130 TLRGHTDWVNSvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209
|
90 100
....*....|....*....|....*....
gi 24667373 99 ELEHKYR-FPSPVLKVQFDPrnDNRLLVC 126
Cdd:cd00200 210 KCLGTLRgHENGVNSVAFSP--DGYLLAS 236
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
60-94 |
1.20e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.20e-06
10 20 30
....*....|....*....|....*....|....*
gi 24667373 60 KIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWD 94
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
60-94 |
2.04e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.56 E-value: 2.04e-05
10 20 30
....*....|....*....|....*....|....*
gi 24667373 60 KIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWD 94
Cdd:pfam00400 5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
17-77 |
1.07e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 38.03 E-value: 1.07e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24667373 17 FDGSLDCISLAVTC-AFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAHVHPVCSLSWTRN 77
Cdd:pfam12894 30 WTLSPDKEDLEVTSlAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
|
|
| 8prop_hemeD1_NirF |
cd20778 |
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ... |
139-228 |
4.16e-03 |
|
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.
Pssm-ID: 467722 [Multi-domain] Cd Length: 381 Bit Score: 39.57 E-value: 4.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24667373 139 GTHRCLPLDSdGDLNIVASFDRRGKHIYT--------------GNAKGKILVLDVETFEVVASFRiiVGtssaTAVKSIE 204
Cdd:cd20778 259 GEHRVLVYDT-NDWKFIKSIPLAGQPVFAvarpdgryvwvnfsGPDNDTVQVIDTKTLKVVKTLE--PG----KRVLHME 331
|
90 100
....*....|....*....|....*.
gi 24667373 205 FARRGDAFLI--NTSDRVIrVYDSKE 228
Cdd:cd20778 332 FTPRGEAVYIsvNDDNKVV-VYDTRT 356
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
27-52 |
4.82e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.98 E-value: 4.82e-03
10 20
....*....|....*....|....*..
gi 24667373 27 AVTC-AFNKYGTLLAVGCNDGRIVIWD 52
Cdd:smart00320 14 PVTSvAFSPDGKYLASGSDDGTIKLWD 40
|
|
| |
