|
Name |
Accession |
Description |
Interval |
E-value |
| adm_rel |
TIGR01431 |
adenosine deaminase-related growth factor; Members of this family have been described as ... |
56-515 |
0e+00 |
|
adenosine deaminase-related growth factor; Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, mollusks, and vertebrates.
Pssm-ID: 273620 [Multi-domain] Cd Length: 479 Bit Score: 566.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 56 MGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEVQKSPIFNLIKGMPKGGALHAHDTALCSTDYL 135
Cdd:TIGR01431 17 LGGKLVLTTKEKLANERIMTLKIAEMKEAMRTPLIFPPSMHFFQAKHLIERSQVFKILRMMPKGAALHLHDLGIVSMDWL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 136 I-SLTYRKNLWICTAEEGCKAIAFRFSKEEPKEKPVKesiWEPMEEFRERRGEENVTKYLTRRFSMYPFSKFISN---NQ 211
Cdd:TIGR01431 97 VrNVTYRPNLHICFTKRNIMVLRFRHPTPRPSECCSK---WILLEDYRKSQNVEEFDDSLLRNFTLVTTHPEVDYttqNV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 212 AWAHFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPD 291
Cdd:TIGR01431 174 VWSRFETIFFTLSGLLHYAPVFRDYYFRALEEFYEDNVQYMELRSRLFPLYELSGTHHDEEWSVKTYKEVTEKFVEEHPD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 292 FIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRPLIDFVEPLLKM--PEHINFYFHAGETNWF 369
Cdd:TIGR01431 254 FIGIKIIYSDLRSKDVEEIAEYIKMAMGLRIKYPDFVAGFDLVGQEDTGHSLLDYKDALLIPsiGVKLPYFFHAGETNWQ 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 370 GSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDP 449
Cdd:TIGR01431 334 GTSVDRNLLDALLLNTTRIGHGFALSKHPAVRTYSKERDIPIEVCPISNQVLKLVSDLRNHPVATLMADNYPMVISSDDP 413
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24666073 450 SFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEKRVGYRKWQEKWDKWIDDVV 515
Cdd:TIGR01431 414 AFWGAKGLSYDFYEAFMGIAGMKADLRTLKQLALNSIKYSALSEEEKNTAMAKWKKQWDKFIDDVL 479
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
93-507 |
1.35e-161 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 462.13 E-value: 1.35e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 93 PGQHIFKTLAEVQKSPIFNLIKGMPKGGALHAHDTALCSTDYLISLTYRKnlwictaeegckaiafrfskeepkekpvke 172
Cdd:cd01321 1 PGMHFFKAKDLIENSTLFKIIQKMPKGALLHVHDTAMVSSDWLIKNATYR------------------------------ 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 173 siwepmeefrerrgeenvtkyltrrfsmypfskfisnnqawahFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYL 252
Cdd:cd01321 51 -------------------------------------------FEQIFDIIDGLLTYLPIFRDYYRRLLEELYEDNVQYV 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 253 ELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPDFIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFD 332
Cdd:cd01321 88 ELRSSFSPLYDLDGREYDYEETVQLLEEVVEKFKKTHPDFIGLKIIYATLRNFNDSEIKESMEQCLNLKKKFPDFIAGFD 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 333 LVGQEELGRPLIDFVEPLLKMPE---HINFYFHAGETNWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGI 409
Cdd:cd01321 168 LVGQEDAGRPLLDFLPQLLWFPKqcaEIPFFFHAGETNGDGTETDENLVDALLLNTKRIGHGFALPKHPLLMDLVKKKNI 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 410 AIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYS 489
Cdd:cd01321 248 AIEVCPISNQVLGLVSDLRNHPAAALLARGVPVVISSDDPGFWGAKGLSHDFYQAFMGLAPADAGLRGLKQLAENSIRYS 327
|
410
....*....|....*...
gi 24666073 490 ALVGEEKRVGYRKWQEKW 507
Cdd:cd01321 328 ALSDQEKDEAVAKWEKKW 345
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
238-512 |
1.97e-36 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 137.52 E-value: 1.97e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELRslLPPLYCIDGDmLTIRDTVAIYNSELERFRADHPdfIGSKLIYAPLRGVEPSVVEQYVKTA 317
Cdd:COG1816 71 YEYLEDAAADGVRYAEIR--FDPQLHTRRG-LSLEEVVEAVLDGLREAEREFG--ISVRLILCALRHLSPEAAFETLELA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 318 VEL-NKEFpnfmVGFDLVGqEELGRPLIDFvEPLLKMPEHINFYF--HAGEtnwFGSPidENLVDAI-LLGTKRIGHGYA 393
Cdd:COG1816 146 LRYrDRGV----VGFGLAG-DERGFPPEKF-AEAFARAREAGLHLtaHAGE---AGGP--ESIWEALdLLGAERIGHGVR 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 394 ITKHPmmmRLAKLL---GIAIEVCPVSNqvLQLGV--DYRNHPAALLLAANVPIVISSDDPSFWHCaPLSHDF-----YF 463
Cdd:COG1816 215 AIEDP---ALVARLadrGIPLEVCPTSN--VQLGVvpSLAEHPLRRLLDAGVRVTLNTDDPLYFGT-TLTDEYelaaeAF 288
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 24666073 464 AFlgiapmkaDLRFLKSLAINSIRYSALVGEEKrvgyRKWQEKWDKWID 512
Cdd:COG1816 289 GL--------SDADLAQLARNAIEASFLPEEEK----AALLAELDAYFA 325
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
240-497 |
8.57e-29 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 116.81 E-value: 8.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 240 ALKEFAEDGVQYLELRslLPPLYCIDGDmLTIRDTVAIYNSELERFRADHPdfIGSKLIYAPLRGVEPsvvEQYVKTAVE 319
Cdd:PRK09358 86 YLEDAAADGVVYAEIR--FDPQLHTERG-LPLEEVVEAVLDGLRAAEAEFG--ISVRLILCFMRHFGE---EAAARELEA 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 320 LNKEF-PNFMVGFDLVGqEELGRPLIDFVEPLLKMPE-HINFYFHAGEtnwFGSPidENLVDAI-LLGTKRIGHGYAITK 396
Cdd:PRK09358 158 LAARYrDDGVVGFDLAG-DELGFPPSKFARAFDRARDaGLRLTAHAGE---AGGP--ESIWEALdELGAERIGHGVRAIE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 397 HPmmmRLAKLL---GIAIEVCPVSNqvLQLGV--DYRNHPAALLLAANVPIVISSDDPSFWHCApLSHDFYFAF--LGIA 469
Cdd:PRK09358 232 DP---ALMARLadrRIPLEVCPTSN--VQTGAvpSLAEHPLKTLLDAGVRVTINTDDPLVFGTT-LTEEYEALAeaFGLS 305
|
250 260
....*....|....*....|....*...
gi 24666073 470 pmKADLRflkSLAINSIRYSALVGEEKR 497
Cdd:PRK09358 306 --DEDLA---QLARNALEAAFLSEEEKA 328
|
|
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
238-497 |
9.63e-20 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 90.18 E-value: 9.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELR----SLLPPLYCIDGDMLTIRDTVAiynsELERfradhpDF-IGSKLIYAPLRGVEPSvveq 312
Cdd:pfam00962 75 FEYAEDVAKDGVVYAEVRydpqSHASRGLSPDTVVDAVLDAVD----AAER------EFgITVRLIVCAMRHEHPE---- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 313 YVKTAVELNKEF-PNFMVGFDLVGQEE-LGRPLI-DFVEPLLKMPEH-INFYFHAGETnwfGSPidENLVDAI-LLGTKR 387
Cdd:pfam00962 141 CSREIAELAPRYrDQGIVAFGLAGDEKgFPPSLFrDHVEAFARARDAgLHLTVHAGEA---GGP--QSVWEALdDLGAER 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 388 IGHGYAITKHPMMM-RLAKlLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHcAPLSHDFYFA-- 464
Cdd:pfam00962 216 IGHGVRSAEDPRLLdRLAD-RQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFG-SDLLDEYQVAkr 293
|
250 260 270
....*....|....*....|....*....|...
gi 24666073 465 FLGIapmkaDLRFLKSLAINSIRYSALVGEEKR 497
Cdd:pfam00962 294 APGF-----DEEELARLAKNAVKGSFLPADEKR 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| adm_rel |
TIGR01431 |
adenosine deaminase-related growth factor; Members of this family have been described as ... |
56-515 |
0e+00 |
|
adenosine deaminase-related growth factor; Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, mollusks, and vertebrates.
Pssm-ID: 273620 [Multi-domain] Cd Length: 479 Bit Score: 566.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 56 MGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEVQKSPIFNLIKGMPKGGALHAHDTALCSTDYL 135
Cdd:TIGR01431 17 LGGKLVLTTKEKLANERIMTLKIAEMKEAMRTPLIFPPSMHFFQAKHLIERSQVFKILRMMPKGAALHLHDLGIVSMDWL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 136 I-SLTYRKNLWICTAEEGCKAIAFRFSKEEPKEKPVKesiWEPMEEFRERRGEENVTKYLTRRFSMYPFSKFISN---NQ 211
Cdd:TIGR01431 97 VrNVTYRPNLHICFTKRNIMVLRFRHPTPRPSECCSK---WILLEDYRKSQNVEEFDDSLLRNFTLVTTHPEVDYttqNV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 212 AWAHFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPD 291
Cdd:TIGR01431 174 VWSRFETIFFTLSGLLHYAPVFRDYYFRALEEFYEDNVQYMELRSRLFPLYELSGTHHDEEWSVKTYKEVTEKFVEEHPD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 292 FIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRPLIDFVEPLLKM--PEHINFYFHAGETNWF 369
Cdd:TIGR01431 254 FIGIKIIYSDLRSKDVEEIAEYIKMAMGLRIKYPDFVAGFDLVGQEDTGHSLLDYKDALLIPsiGVKLPYFFHAGETNWQ 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 370 GSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDP 449
Cdd:TIGR01431 334 GTSVDRNLLDALLLNTTRIGHGFALSKHPAVRTYSKERDIPIEVCPISNQVLKLVSDLRNHPVATLMADNYPMVISSDDP 413
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24666073 450 SFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEKRVGYRKWQEKWDKWIDDVV 515
Cdd:TIGR01431 414 AFWGAKGLSYDFYEAFMGIAGMKADLRTLKQLALNSIKYSALSEEEKNTAMAKWKKQWDKFIDDVL 479
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
93-507 |
1.35e-161 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 462.13 E-value: 1.35e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 93 PGQHIFKTLAEVQKSPIFNLIKGMPKGGALHAHDTALCSTDYLISLTYRKnlwictaeegckaiafrfskeepkekpvke 172
Cdd:cd01321 1 PGMHFFKAKDLIENSTLFKIIQKMPKGALLHVHDTAMVSSDWLIKNATYR------------------------------ 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 173 siwepmeefrerrgeenvtkyltrrfsmypfskfisnnqawahFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYL 252
Cdd:cd01321 51 -------------------------------------------FEQIFDIIDGLLTYLPIFRDYYRRLLEELYEDNVQYV 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 253 ELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPDFIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFD 332
Cdd:cd01321 88 ELRSSFSPLYDLDGREYDYEETVQLLEEVVEKFKKTHPDFIGLKIIYATLRNFNDSEIKESMEQCLNLKKKFPDFIAGFD 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 333 LVGQEELGRPLIDFVEPLLKMPE---HINFYFHAGETNWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGI 409
Cdd:cd01321 168 LVGQEDAGRPLLDFLPQLLWFPKqcaEIPFFFHAGETNGDGTETDENLVDALLLNTKRIGHGFALPKHPLLMDLVKKKNI 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 410 AIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYS 489
Cdd:cd01321 248 AIEVCPISNQVLGLVSDLRNHPAAALLARGVPVVISSDDPGFWGAKGLSHDFYQAFMGLAPADAGLRGLKQLAENSIRYS 327
|
410
....*....|....*...
gi 24666073 490 ALVGEEKRVGYRKWQEKW 507
Cdd:cd01321 328 ALSDQEKDEAVAKWEKKW 345
|
|
| ADA_AMPD |
cd00443 |
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ... |
212-507 |
1.12e-52 |
|
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250 Cd Length: 305 Bit Score: 180.62 E-value: 1.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 212 AWAHFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYLELRSLLPPLYCIDGdmLTIRDTVAIYNSELERFRADHPd 291
Cdd:cd00443 23 IKKEFFEKFLLVHNLLQKGEALARALKEVIEEFAEDNVQYLELRTTPRLLETEKG--LTKEQYWLLVIEGISEAKQWFP- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 292 FIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGR-PLIDFVEPL--LKMPEHINFYFHAGETNW 368
Cdd:cd00443 100 PIKVRLILSVDRRGPYVQNYLVASEILELAKFLSNYVVGIDLVGDESKGEnPLRDFYSYYeyARRLGLLGLTLHCGETGN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 369 FGSpidenLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDD 448
Cdd:cd00443 180 REE-----LLQALLLLPDRIGHGIFLLKHPELIYLVKLRNIPIEVCPTSNVVLGTVQSYEKHPFMRFFKAGLPVSLSTDD 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24666073 449 PSFWHcAPLSHDFYfaflgIAPMKADLRF--LKSLAINSIRYSALVGEEKrvgyRKWQEKW 507
Cdd:cd00443 255 PGIFG-TSLSEEYS-----LAAKTFGLTFedLCELNRNSVLSSFAKDEEK----KSLLEVL 305
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
238-512 |
1.97e-36 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 137.52 E-value: 1.97e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELRslLPPLYCIDGDmLTIRDTVAIYNSELERFRADHPdfIGSKLIYAPLRGVEPSVVEQYVKTA 317
Cdd:COG1816 71 YEYLEDAAADGVRYAEIR--FDPQLHTRRG-LSLEEVVEAVLDGLREAEREFG--ISVRLILCALRHLSPEAAFETLELA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 318 VEL-NKEFpnfmVGFDLVGqEELGRPLIDFvEPLLKMPEHINFYF--HAGEtnwFGSPidENLVDAI-LLGTKRIGHGYA 393
Cdd:COG1816 146 LRYrDRGV----VGFGLAG-DERGFPPEKF-AEAFARAREAGLHLtaHAGE---AGGP--ESIWEALdLLGAERIGHGVR 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 394 ITKHPmmmRLAKLL---GIAIEVCPVSNqvLQLGV--DYRNHPAALLLAANVPIVISSDDPSFWHCaPLSHDF-----YF 463
Cdd:COG1816 215 AIEDP---ALVARLadrGIPLEVCPTSN--VQLGVvpSLAEHPLRRLLDAGVRVTLNTDDPLYFGT-TLTDEYelaaeAF 288
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 24666073 464 AFlgiapmkaDLRFLKSLAINSIRYSALVGEEKrvgyRKWQEKWDKWID 512
Cdd:COG1816 289 GL--------SDADLAQLARNAIEASFLPEEEK----AALLAELDAYFA 325
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
238-502 |
1.79e-32 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 126.55 E-value: 1.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELRslLPPLYCIDGDmLTIRDTVAIYNSELERFRADHPdfIGSKLIYAPLRGVEPSVVEQYVKTA 317
Cdd:cd01320 76 YEYLEDAAADGVVYAEIR--FSPQLHTRRG-LSFDEVVEAVLRGLDEAEAEFG--IKARLILCGLRHLSPESAQETLELA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 318 VELNKEFpnfMVGFDLVGqEELGRPLIDFVEPLLKMPEH-INFYFHAGETnwfGSPidENLVDAI-LLGTKRIGHGYAIT 395
Cdd:cd01320 151 LKYRDKG---VVGFDLAG-DEVGFPPEKFVRAFQRAREAgLRLTAHAGEA---GGP--ESVRDALdLLGAERIGHGIRAI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 396 KHPMMMRLAKLLGIAIEVCPVSNqvLQLGV--DYRNHPAALLLAANVPIVISSDDPSFWHCApLSHDFYFA--FLGIapm 471
Cdd:cd01320 222 EDPELVKRLAERNIPLEVCPTSN--VQTGAvkSLAEHPLRELLDAGVKVTINTDDPTVFGTY-LTDEYELLaeAFGL--- 295
|
250 260 270
....*....|....*....|....*....|.
gi 24666073 472 kaDLRFLKSLAINSIRySALVGEEKRVGYRK 502
Cdd:cd01320 296 --TEEELKKLARNAVE-ASFLSEEEKAELLK 323
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
240-497 |
8.57e-29 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 116.81 E-value: 8.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 240 ALKEFAEDGVQYLELRslLPPLYCIDGDmLTIRDTVAIYNSELERFRADHPdfIGSKLIYAPLRGVEPsvvEQYVKTAVE 319
Cdd:PRK09358 86 YLEDAAADGVVYAEIR--FDPQLHTERG-LPLEEVVEAVLDGLRAAEAEFG--ISVRLILCFMRHFGE---EAAARELEA 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 320 LNKEF-PNFMVGFDLVGqEELGRPLIDFVEPLLKMPE-HINFYFHAGEtnwFGSPidENLVDAI-LLGTKRIGHGYAITK 396
Cdd:PRK09358 158 LAARYrDDGVVGFDLAG-DELGFPPSKFARAFDRARDaGLRLTAHAGE---AGGP--ESIWEALdELGAERIGHGVRAIE 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 397 HPmmmRLAKLL---GIAIEVCPVSNqvLQLGV--DYRNHPAALLLAANVPIVISSDDPSFWHCApLSHDFYFAF--LGIA 469
Cdd:PRK09358 232 DP---ALMARLadrRIPLEVCPTSN--VQTGAvpSLAEHPLKTLLDAGVRVTINTDDPLVFGTT-LTEEYEALAeaFGLS 305
|
250 260
....*....|....*....|....*...
gi 24666073 470 pmKADLRflkSLAINSIRYSALVGEEKR 497
Cdd:PRK09358 306 --DEDLA---QLARNALEAAFLSEEEKA 328
|
|
| aden_deam |
TIGR01430 |
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of ... |
238-496 |
1.53e-21 |
|
adenosine deaminase; This family includes the experimentally verified adenosine deaminases of mammals and E. coli. Other members of this family are predicted also to be adenosine deaminase, an enzyme of nucleotide degradation. This family is distantly related to AMP deaminase.
Pssm-ID: 273619 Cd Length: 324 Bit Score: 95.50 E-value: 1.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELRsllpplycIDGDMLTIR--DTVAIYNSELERFRADHPDF-IGSKLIYAPLRGVEPSVVEQyv 314
Cdd:TIGR01430 75 YEYVEKAAKDGVVYAEVF--------FDPQLHTNRgiSPDTVVEAVLDGLDEAERDFgIKSRLILCGMRHKQPEAAEE-- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 315 ktAVELNKEFPN-FMVGFDLVGqEELGRPLIDFVEPLLKMPE-HINFYFHAGETnwfGSPidENLVDAI-LLGTKRIGHG 391
Cdd:TIGR01430 145 --TLELAKPYKEqTIVGFGLAG-DERGGPPPDFVRAFAIARElGLHLTVHAGEL---GGP--ESVREALdDLGATRIGHG 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 392 YAITKHPMMMRLAKLLGIAIEVCPVSNqvLQLGVDYR--NHPAALLLAANVPIVISSDDPSFWHCApLSHDFYFAFLGIA 469
Cdd:TIGR01430 217 VRALEDPELLKRLAQENITLEVCPTSN--VALGVVKSlaEHPLRRFLEAGVKVTLNSDDPAYFGSY-LTEEYEIAAKHAG 293
|
250 260
....*....|....*....|....*..
gi 24666073 470 PMKADlrfLKSLAINSIRYSALVGEEK 496
Cdd:TIGR01430 294 LTEEE---LKQLARNALEGSFLSDDEK 317
|
|
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
238-497 |
9.63e-20 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 90.18 E-value: 9.63e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 238 YNALKEFAEDGVQYLELR----SLLPPLYCIDGDMLTIRDTVAiynsELERfradhpDF-IGSKLIYAPLRGVEPSvveq 312
Cdd:pfam00962 75 FEYAEDVAKDGVVYAEVRydpqSHASRGLSPDTVVDAVLDAVD----AAER------EFgITVRLIVCAMRHEHPE---- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 313 YVKTAVELNKEF-PNFMVGFDLVGQEE-LGRPLI-DFVEPLLKMPEH-INFYFHAGETnwfGSPidENLVDAI-LLGTKR 387
Cdd:pfam00962 141 CSREIAELAPRYrDQGIVAFGLAGDEKgFPPSLFrDHVEAFARARDAgLHLTVHAGEA---GGP--QSVWEALdDLGAER 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 388 IGHGYAITKHPMMM-RLAKlLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHcAPLSHDFYFA-- 464
Cdd:pfam00962 216 IGHGVRSAEDPRLLdRLAD-RQIPLEICPTSNVQTGAVASLAEHPLKTFLRAGVPVSLNTDDPLMFG-SDLLDEYQVAkr 293
|
250 260 270
....*....|....*....|....*....|...
gi 24666073 465 FLGIapmkaDLRFLKSLAINSIRYSALVGEEKR 497
Cdd:pfam00962 294 APGF-----DEEELARLAKNAVKGSFLPADEKR 321
|
|
| metallo-dependent_hydrolases |
cd01292 |
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ... |
240-488 |
3.79e-14 |
|
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Pssm-ID: 238617 [Multi-domain] Cd Length: 275 Bit Score: 72.75 E-value: 3.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 240 ALKEFAEDGVQYLELRSLLPPLYCIDGDMLTIRDtvaiYNSELERFRADHPDFIGSklIYAPLRGVEPSVVEQyvktavE 319
Cdd:cd01292 40 ALEALLAGGVTTVVDMGSTPPPTTTKAAIEAVAE----AARASAGIRVVLGLGIPG--VPAAVDEDAEALLLE------L 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 320 LNKEFPNFMVGFDLVGQEELGRPLIDFVEPLLK-MPEH-INFYFHAGETNWFGSPIDEnLVDAILLG-TKRIGHGYAITK 396
Cdd:cd01292 108 LRRGLELGAVGLKLAGPYTATGLSDESLRRVLEeARKLgLPVVIHAGELPDPTRALED-LVALLRLGgRVVIGHVSHLDP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 397 HpmMMRLAKLLGIAIEVCPVSNQVLQLGVdYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLR 476
Cdd:cd01292 187 E--LLELLKEAGVSLEVCPLSNYLLGRDG-EGAEALRRLLELGIRVTLGTDGPPHPLGTDLLALLRLLLKVLRLGLSLEE 263
|
250
....*....|..
gi 24666073 477 FLKSLAINSIRY 488
Cdd:cd01292 264 ALRLATINPARA 275
|
|
| PTZ00124 |
PTZ00124 |
adenosine deaminase; Provisional |
329-449 |
2.69e-13 |
|
adenosine deaminase; Provisional
Pssm-ID: 173415 Cd Length: 362 Bit Score: 71.44 E-value: 2.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 329 VGFDLVGQEELGRPLIDFVEPLLKmpEHINFYFHAGETNwfgSPIDEN--LVDAILLGTKRIGHGYAITKHPMMMRLAKL 406
Cdd:PTZ00124 194 VGFDHAGHEVDLKPFKDIFDYVRE--AGVNLTVHAGEDV---TLPNLNtlYSAIQVLKVKRIGHGIRVAESQELIDMVKE 268
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 24666073 407 LGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDP 449
Cdd:PTZ00124 269 KDILLEVCPISNVLLNNAKSMDTHPIRKLYDAGVKVSVNSDDP 311
|
|
| A_deaminase_N |
pfam08451 |
Adenosine/AMP deaminase N-terminal; This domain is found to the N-terminus of the Adenosine ... |
36-113 |
3.38e-11 |
|
Adenosine/AMP deaminase N-terminal; This domain is found to the N-terminus of the Adenosine/AMP deaminase domain (pfam00962) in metazoan proteins such as the Cat eye syndrome critical region protein 1 and its homologs.
Pssm-ID: 462481 Cd Length: 95 Bit Score: 59.62 E-value: 3.38e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24666073 36 SPTAFKTLRQAIAKVGHLNIMGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEVQKSPIFNLI 113
Cdd:pfam08451 18 TEERYERLRQALLSKEERLRLGGNLELSPLEEKANDILMAIKQVELAEGFRNWENYPPAPHFFLAKDLINESDLFKFL 95
|
|
| PLN03055 |
PLN03055 |
AMP deaminase; Provisional |
357-464 |
5.29e-05 |
|
AMP deaminase; Provisional
Pssm-ID: 178613 Cd Length: 602 Bit Score: 46.01 E-value: 5.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 357 INFYFHAGEtnwfGSPIDeNLVDAILLgTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLgvDYRNHPAALLL 436
Cdd:PLN03055 417 IKFRPHAGE----AGDID-HLAAAFLL-AHNIAHGNNLRKSPGLQYLYYLAQIGLAMSPLSNNSLFL--DYHRNPFPMFF 488
|
90 100 110
....*....|....*....|....*....|
gi 24666073 437 AANVPIVISSDDPSFWHCA--PLSHDFYFA 464
Cdd:PLN03055 489 ARGLNVSLSTDDPLQIHLTkePLVEEYSIA 518
|
|
| AMPD |
cd01319 |
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ... |
362-497 |
5.39e-05 |
|
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644 Cd Length: 496 Bit Score: 45.82 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 362 HAGETnwfGSPidENLVDAILLgTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLgvDYRNHPAALLLAANVP 441
Cdd:cd01319 332 HCGEA---GDI--DHLASAFLL-AHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFL--SYEKNPFPEFFKRGLN 403
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24666073 442 IVISSDDPSFWHCA--PLSHDFyfaflGIApmkADLRFLKS-----LAINSIRYSALVGEEKR 497
Cdd:cd01319 404 VSLSTDDPLQFHFTkePLMEEY-----SIA---AQVWKLSTcdmceLARNSVLQSGFEHSIKR 458
|
|
| PTZ00310 |
PTZ00310 |
AMP deaminase; Provisional |
371-498 |
2.86e-03 |
|
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain] Cd Length: 1453 Bit Score: 40.56 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 371 SPIDENLVDAILLGtKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLgVDYRNHPAALLLAANVPIVISSDDPS 450
Cdd:PTZ00310 489 APAYDQLISSYLLG-DVITRATSIADYPVLQYLCGLHRVGLTVSPLRDHALSI-TAYFDHPLPKFLHRCLRVSISTSDPL 566
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24666073 451 FWH--CAPLSHDFYFA--FLGIAPMKadlrfLKSLAINSIRYSALVGEEKRV 498
Cdd:PTZ00310 567 YFHhhSQPLIEEYATAmkLFSLSPLD-----TTELARNSVLNSSFPPEVKQQ 613
|
|
| PLN02768 |
PLN02768 |
AMP deaminase |
357-449 |
5.04e-03 |
|
AMP deaminase
Pssm-ID: 215411 Cd Length: 835 Bit Score: 39.84 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24666073 357 INFYFHAGETNwfgspiDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLgvDYRNHPAALLL 436
Cdd:PLN02768 650 IKFRPHSGEAG------DIDHLAATFLTCHNIAHGINLRKSPVLQYLYYLAQIGLAMSPLSNNSLFL--DYHRNPFPMFF 721
|
90
....*....|...
gi 24666073 437 AANVPIVISSDDP 449
Cdd:PLN02768 722 LRGLNVSLSTDDP 734
|
|
| |
